Core-binding factor - Revision history

Openfox: Fix TreeAndMenu broken list structure

2026-03-29T09:41:54Z

Fix TreeAndMenu broken list structure

Michal Harel at 10:23, 9 February 2025

2025-02-09T10:23:37Z

← Older revision		Revision as of 10:23, 9 February 2025
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	**[[6p59]] – hCBFb + elongin-B + elongin-C + virion infectivity factor<br />		**[[6p59]] – hCBFb + elongin-B + elongin-C + virion infectivity factor<br />
	**[[6nil]] – hCBFb + A3F complex + virion infectivity factor – Cryo EM<br />		**[[6nil]] – hCBFb + A3F complex + virion infectivity factor – Cryo EM<br />
			**[[8e40]], [[8h0i]], [[8j62]] – hCBFb + APOBEC + virion infectivity factor + RNA – Cryo EM<br />
			**[[8cx0]], [[8cx1]], [[8cx2]] – hCBFb + elongin-B + elongin-C + APOBEC + virion infectivity factor + RNA – Cryo EM<br />
			**[[8fvi]] – hCBFb + APOBEC + virion infectivity factor + cullin 5 + RNA – Cryo EM<br />
			**[[8fvj]] – hCBFb + elongin-B + elongin-C + virion infectivity factor + cullin 5 – Cryo EM<br />
			**[[8szk]] – hCBFb + elongin-B + elongin-C + virion infectivity factor + cullin 5 + RNA – Cryo EM<br />
	**[[6vg2]], [[6vg8]], [[6vgd]], [[6vge]], [[6vgg]] – hCBFb + Runx2 + FLI1 + DNA<br />		**[[6vg2]], [[6vg8]], [[6vgd]], [[6vge]], [[6vgg]] – hCBFb + Runx2 + FLI1 + DNA<br />
	**[[1ilf]] – mCBFb<br />		**[[1ilf]] – mCBFb<br />

Michal Harel at 09:49, 10 June 2021

2021-06-10T09:49:54Z

← Older revision		Revision as of 09:49, 10 June 2021
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	**[[6p59]] – hCBFb + elongin-B + elongin-C + virion infectivity factor<br />		**[[6p59]] – hCBFb + elongin-B + elongin-C + virion infectivity factor<br />
	**[[6nil]] – hCBFb + A3F complex + virion infectivity factor – Cryo EM<br />		**[[6nil]] – hCBFb + A3F complex + virion infectivity factor – Cryo EM<br />
			**[[6vg2]], [[6vg8]], [[6vgd]], [[6vge]], [[6vgg]] – hCBFb + Runx2 + FLI1 + DNA<br />
	**[[1ilf]] – mCBFb<br />		**[[1ilf]] – mCBFb<br />

Michal Harel at 08:31, 7 July 2020

2020-07-07T08:31:54Z

← Older revision		Revision as of 08:31, 7 July 2020
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	*Core-binding factor β subunit		*Core-binding factor β subunit

	**[[~~1ilf~~]], [[~~2jhb~~]] – ~~mCBFb~~<br />		**[[4n9f]] – hCBFb + cullin-5 + elongin-B + virion infectivity factor<br />
	**[[~~4n9f~~]] – hCBFb + ~~cullin-5 + transcription elongation factor B~~ + virion infectivity factor<br />		**[[6p59]] – hCBFb + elongin-B + elongin-C + virion infectivity factor<br />
			**[[6nil]] – hCBFb + A3F complex + virion infectivity factor – Cryo EM<br />
			**[[1ilf]] – mCBFb<br />

	*Core-binding factor α+β subunits		*Core-binding factor α+β subunits

Michal Harel at 10:31, 15 April 2018

2018-04-15T10:31:05Z

← Older revision		Revision as of 10:31, 15 April 2018
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	*Core-binding factor β subunit		*Core-binding factor β subunit

	**[[1ilf]] – mCBFb<br />		**[[1ilf]], [[2jhb]] – mCBFb<br />
	**[[4n9f]] – hCBFb + cullin-5 + transcription elongation factor B + virion infectivity factor<br />		**[[4n9f]] – hCBFb + cullin-5 + transcription elongation factor B + virion infectivity factor<br />

Joel L. Sussman at 09:39, 20 October 2017

2017-10-20T09:39:42Z

← Older revision		Revision as of 09:39, 20 October 2017
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	<StructureSection load='~~1h9d~~' size='340' side='right' caption='Human CBFα runt domain (magenta) complex with CBFβ heterodimerization domain (green) and DNA (PDB code [[1h9d]])' scene='70/708082/Cv/1'>		<StructureSection load='' size='340' side='right' caption='Human CBFα runt domain (magenta) complex with CBFβ heterodimerization domain (green) and DNA (PDB code [[1h9d]])' scene='70/708082/Cv/1'>

	== Function ==		== Function ==

Michal Harel at 14:57, 19 October 2017

2017-10-19T14:57:36Z

← Older revision		Revision as of 14:57, 19 October 2017
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	== References ==		== References ==
	<references/>		<references/>
			[[Category:Topic Page]]

Michal Harel at 10:12, 4 April 2017

2017-04-04T10:12:56Z

← Older revision		Revision as of 10:12, 4 April 2017
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	{{#tree:id=OrganizedByTopic\|openlevels=0\|		{{#tree:id=OrganizedByTopic\|openlevels=0\|

	*Core-binding factor α		*Core-binding factor α subunit

	**[[1ean]], [[1ljm]] – hCBFα runt domain - human<br />		**[[1ean]], [[1ljm]] – hCBFα runt domain - human<br />
	**[[1cmo]] – hCBFα runt domain (mutant) - NMR<br />		**[[1cmo]], [[2n7b]] – hCBFα runt domain (mutant) - NMR<br />
	**[[1co1]] – hCBFα runt domain - NMR<br />		**[[1co1]] – hCBFα runt domain - NMR<br />
	**[[1eao]], [[1eaq]], [[2j6w]] – mCBFα runt domain (mutant) - mouse<br />		**[[1eao]], [[1eaq]], [[2j6w]] – mCBFα runt domain (mutant) - mouse<br />
	**[[1hjc]] – mCBFα runt domain + DNA <br />		**[[1hjc]] – mCBFα runt domain + DNA <br />
	**[[1hjb]] – mCBFα runt domain + hEBP β + DNA<br />		**[[1hjb]] – mCBFα runt domain + hEBP β + DNA<br />
	**[[4l0y]], [[4l0z]], [[4l18]], [[~~4wu1~~]] – mCBFα runt domain + hETS1 + DNA<br />		**[[4l0y]], [[4l0z]], [[4l18]], [[3wu1]] – mCBFα runt domain + hETS1 + DNA<br />

	*Core-binding factor α+β		*Core-binding factor β subunit

			**[[1ilf]] – mCBFb<br />
			**[[4n9f]] – hCBFb + cullin-5 + transcription elongation factor B + virion infectivity factor<br />

			*Core-binding factor α+β subunits

	**[[1e50]] – hCBFα runt domain + hCBFβ heterodimerization domain<br />		**[[1e50]] – hCBFα runt domain + hCBFβ heterodimerization domain<br />

Alexander Berchansky at 08:48, 21 December 2015

2015-12-21T08:48:15Z

← Older revision		Revision as of 08:48, 21 December 2015
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	== Function ==		== Function ==

	'''Core-binding factor''' (CBF) is a heterodimeric transcription factor which is composed of α chain which binds DNA and a regulatory β chain. CBF binds to various enhancers and promoters including murine leukemia virus and polyomavirus enhancer. <ref>PMID:11276260</ref>		'''Core-binding factor''' (CBF) is a heterodimeric transcription factor which is composed of <scene name='70/708082/Cv/2'>α chain which binds DNA and a regulatory β chain</scene>. CBF binds to various enhancers and promoters including murine leukemia virus and polyomavirus enhancer. <ref>PMID:11276260</ref>

	== Disease ==		== Disease ==

Alexander Berchansky at 08:44, 21 December 2015

2015-12-21T08:44:36Z

← Older revision		Revision as of 08:44, 21 December 2015
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	<StructureSection load='1h9d' size='340' side='right' caption='Human CBFα runt domain (~~grey and pink~~) complex with CBFβ heterodimerization domain (green ~~and yellow~~) and DNA (PDB code [[1h9d]])' scene=''>		<StructureSection load='1h9d' size='340' side='right' caption='Human CBFα runt domain (magenta) complex with CBFβ heterodimerization domain (green) and DNA (PDB code [[1h9d]])' scene='70/708082/Cv/1'>

	== Function ==		== Function ==

← Older revision		Revision as of 09:41, 29 March 2026
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	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
	{{#tree:id=OrganizedByTopic\|openlevels=0\|		{{#tree:id=OrganizedByTopic\|openlevels=0\|

	*Core-binding factor α subunit		*Core-binding factor α subunit

	**[[1ean]], [[1ljm]] – hCBFα runt domain - human<br />		**[[1ean]], [[1ljm]] – hCBFα runt domain - human<br />
	**[[1cmo]], [[2n7b]] – hCBFα runt domain (mutant) - NMR<br />		**[[1cmo]], [[2n7b]] – hCBFα runt domain (mutant) - NMR<br />
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	**[[1hjb]] – mCBFα runt domain + hEBP β + DNA<br />		**[[1hjb]] – mCBFα runt domain + hEBP β + DNA<br />
	**[[4l0y]], [[4l0z]], [[4l18]], [[3wu1]] – mCBFα runt domain + hETS1 + DNA<br />		**[[4l0y]], [[4l0z]], [[4l18]], [[3wu1]] – mCBFα runt domain + hETS1 + DNA<br />

	*Core-binding factor β subunit		*Core-binding factor β subunit

	**[[4n9f]] – hCBFb + cullin-5 + elongin-B + virion infectivity factor<br />		**[[4n9f]] – hCBFb + cullin-5 + elongin-B + virion infectivity factor<br />
	**[[6p59]] – hCBFb + elongin-B + elongin-C + virion infectivity factor<br />		**[[6p59]] – hCBFb + elongin-B + elongin-C + virion infectivity factor<br />
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	**[[6vg2]], [[6vg8]], [[6vgd]], [[6vge]], [[6vgg]] – hCBFb + Runx2 + FLI1 + DNA<br />		**[[6vg2]], [[6vg8]], [[6vgd]], [[6vge]], [[6vgg]] – hCBFb + Runx2 + FLI1 + DNA<br />
	**[[1ilf]] – mCBFb<br />		**[[1ilf]] – mCBFb<br />

	*Core-binding factor α+β subunits		*Core-binding factor α+β subunits

	**[[1e50]] – hCBFα runt domain + hCBFβ heterodimerization domain<br />		**[[1e50]] – hCBFα runt domain + hCBFβ heterodimerization domain<br />
	**[[1h9d]] – hCBFα runt domain + hCBFβ heterodimerization domain + DNA<br />		**[[1h9d]] – hCBFα runt domain + hCBFβ heterodimerization domain + DNA<br />