Cullin 3D structures - Revision history

Michal Harel at 11:26, 11 February 2025

2025-02-11T11:26:12Z

← Older revision		Revision as of 11:26, 11 February 2025
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	**[[3tdu]] – hCul1 WHB domain + Dcn1-like protein + NEDD8-conjugating enzyme Ubc12 <br />		**[[3tdu]] – hCul1 WHB domain + Dcn1-like protein + NEDD8-conjugating enzyme Ubc12 <br />
	**[[3tdz]] – hCul1 WHB domain + Dcn1-like protein + stapled Ubc12 peptide <br />		**[[3tdz]] – hCul1 WHB domain + Dcn1-like protein + stapled Ubc12 peptide <br />
			**[[8caf]] – hCul1 + antibody + NEDD8<br />
	**[[1ldk]] – hCul1 + RBX1 + cyclin A/Cdk2-asociated protein + Skp2-like protein <br />		**[[1ldk]] – hCul1 + RBX1 + cyclin A/Cdk2-asociated protein + Skp2-like protein <br />
	**[[1u6g]] – hCul1 + RBX1 + TIP120 protein <br />		**[[1u6g]] – hCul1 + RBX1 + TIP120 protein <br />
Line 19:		Line 20:
	**[[7b5l]] – hCul1 + RBX1 + cyclin A + SKP1 + SKP2 + CKSHS1 + p27 + CDK2 + NEDD8 + cyclin A + Ub + UBE2L3 – Cryo EM <br />		**[[7b5l]] – hCul1 + RBX1 + cyclin A + SKP1 + SKP2 + CKSHS1 + p27 + CDK2 + NEDD8 + cyclin A + Ub + UBE2L3 – Cryo EM <br />
	**[[4f52]] – hCul1 residues 411-690 (mutant) + RBX1 + glomulin<br />		**[[4f52]] – hCul1 residues 411-690 (mutant) + RBX1 + glomulin<br />
	**[[4p5o]] – hCul1 residues 411-776 + ~~Dcn1-like protein~~ + NEDD8-conjugating enzyme Ubc12 + RBX1 + NEDD8-conjugating enzyme Ubc12 + NEDD8 <br />		**[[4p5o]] – hCul1 residues 411-776 + DCNL1 + NEDD8-conjugating enzyme Ubc12 + RBX1 + NEDD8-conjugating enzyme Ubc12 + NEDD8 <br />
	**[[6ttu]] – hCul1 + RBX1 + NEDD8 + polyubiquitin + Ube2D2 + ~~S-phase kinase-associated protein~~ + F-box/WD repeat-containing protein + IKBA peptide – Cryo EM<br />		**[[6ttu]] – hCul1 + RBX1 + NEDD8 + polyubiquitin + Ube2D2 + SKP + F-box/WD repeat-containing protein + IKBA peptide – Cryo EM<br />
	**[[~~6wcq~~]] – hCul1 + S-~~phase~~ kinase~~-associated protein~~ + F-box/WD repeat-containing protein + Kelch-like ECH-associated protein – Cryo EM<br />		**[[8vvy]] – hCul1 + CAND2 – Cryo EM<br />
			**[[7z8r]] – hCul1 + RBX1 + CAND2 – Cryo EM<br />
			**[[7zbz]] – hCul1 + RBX1 + CAND2 + SKP1 + SKP2 – Cryo EM<br />
			**[[7z8t]], [[7z8v]], [[7zbw]], [[8cdj]], [[8cdk]] – hCul1 + RBX1 + CAND1 + SKP1 + SKP2 – Cryo EM<br />
			**[[8ubt]], [[8ubu]] – hCul1 + Fbox17 + BACH1+ SKP1 – Cryo EM<br />
			**[[8ua6]] – hCul1 + Fbox22 + BACH1+ SKP – Cryo EM<br />
			**[[8or3]] – hCul1 + RBX1 + CAND1 + SKP1 + DCNL1 – Cryo EM<br />
			**[[8or0]], [[8or4]] – hCul1 + RBX1 + CAND1 + SKP1 + SKP2 + CKS-1 + cyclin-dependent kinase 2 – Cryo EM<br />
			**[[8or2]] – hCul1 + RBX1 + CAND1 + DCNL1 – Cryo EM<br />
			**[[6wcq]] – hCul1 + SKP + F-box/WD repeat-containing protein + Kelch-like ECH-associated protein – Cryo EM<br />
			**[[9jkb]] – hCul1 in SCF ubiquitin ligase complex – Cryo EM<br />

	*Cullin-2		*Cullin-2
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	**[[4wqo]] – hCul2 residues 20-122 + PVHL + elongin-C <br />		**[[4wqo]] – hCul2 residues 20-122 + PVHL + elongin-C <br />
	**[[5n4w]] – hCul2 + PVHL + elongin-B + elongon-C + RBX1 + <br />		**[[5n4w]] – hCul2 + PVHL + elongin-B + elongon-C + RBX1 + <br />
			**[[8ij1]], [[8je1]] – hCul2 + elongin-B + elongin-C + RBX1 + FEM1B – Cryo EM<br />
			**[[8wqa]], [[8wqb]], [[8wqh]] – hCul2 + elongin-B + elongin-C + RBX1 + FEM1B + BC8 orange-interacting protein – Cryo EM<br />
			**[[8wqc]] – hCul2 + elongin-B + elongin-C + RBX1 + FEM1B + NEDD8 – Cryo EM<br />
			**[[8wqe]], [[8wqf]], [[8wqg]] – hCul2 + elongin-B + elongin-C + RBX1 + FEM1B + degron – Cryo EM<br />
			**[[8je2]] – hCul2 + elongin-B + elongin-C + RBX1 + FEM1B + FNIP1 – Cryo EM<br />
			**[[8pql]] – hCul2 + elongin-B + elongin-C + RBX1 + FEM1C + ubiquitin + polyubiquitin + ubiquitin-conjugating enzyme E2 – Cryo EM<br />
			**[[8q7r]] – hCul2 + elongin-B + elongin-C + RBX1 + FEM1C + ubiquitin + SIL1 + ubiquitin-conjugating enzyme E2 – Cryo EM<br />
			**[[8jal]], [[8jaq]], [[8jar]], [[8jas]], [[8jav]] – hCul2 + elongin-B + elongin-C + RBX1 + amyloid protein-binding protein + degron – Cryo EM<br />
			**[[8rwz]] – hCul2 + elongin-B + elongin-C + RBX1 + PVHL + HUNK1 – Cryo EM<br />
			**[[8r5h]] – hCul2 + elongin-B + elongin-C + RBX1 + ubiquitin + ubiquitin-conjugating enzyme E2 + PVHL + HUNK1 – Cryo EM<br />
			**[[8rx0]] – hCul2 + elongin-B + elongin-C + RBX1 + polyubiquitin + ubiquitin-conjugating enzyme E2 + PVHL + HUNK1 + NEDD8 – Cryo EM<br />
			**[[8qu8]] – hCul2 + elongin-B + elongin-C + RBX1 + PVHL + Kras – Cryo EM<br />
			**[[8wdk]] – hCul2 + elongin-B + elongin-C + RBX1 + PVHL + Wee1-like protein kinase – Cryo EM<br />
	**[[6r6h]], [[6r7f]], [[6r7h]], [[6r7i]], [[6r7n]] – hCul2 in signalosome COP9 – Cryo EM<br />		**[[6r6h]], [[6r7f]], [[6r7h]], [[6r7i]], [[6r7n]] – hCul2 in signalosome COP9 – Cryo EM<br />
			**[[7plo]] – hCul2 in replisome complex – Cryo EM<br />

	*Cullin-3		*Cullin-3

			**[[8k8t]] – hCul3 + kelch-like protein – Cryo EM <br />
			**[[8k9i]], [[8khp]] – hCul3 + RBX1 + kelch-like protein – Cryo EM <br />
			**[[8i79]] – hCul3 (mutant) + KCTD7 – Cryo EM <br />
	**[[5nlb]] – hCul3 N terminal + kelch-like protein <br />		**[[5nlb]] – hCul3 N terminal + kelch-like protein <br />
	**[[6i2m]] – hCul3 (mutant) + kelch-repeat protein <br />		**[[6i2m]] – hCul3 (mutant) + kelch-repeat protein <br />
			**[[8gq6]], [[8h33]], [[8h34]], [[8h35]], [[8h36]], [[8h3r]] – hCul3 + RBX1 + kelch-repeat protein – Cryo EM <br />
			**[[8h3q]] – hCul3 + RBX1 + CAND1 – Cryo EM <br />
			**[[8h37]] – hCul3 + RBX1 + kelch-repeat protein + p85A – Cryo EM <br />
	**[[4ap2]], [[4apf]], [[4hxi]] – hCul3 N terminal (mutant) + kelch-like protein <br />		**[[4ap2]], [[4apf]], [[4hxi]] – hCul3 N terminal (mutant) + kelch-like protein <br />
	**[[4eoz]] – hCul3 N terminal (mutant) + peckle-type POZ protein <br />		**[[4eoz]] – hCul3 N terminal (mutant) + peckle-type POZ protein <br />
	**[[2myl]], [[2mym]] – hCul3 residues 49-68 - NMR <br />		**[[2myl]], [[2mym]] – hCul3 residues 49-68 - NMR <br />
			**[[8u80]], [[8u81]], [[8u82]], [[8u83]], [[8u84]] – hCul3 + KCTD5 + Gbeta1gamma2 complex – Cryo EM<br />
			**[[8h38]], [[8h3a]], [[8h3f]] – hCul3 in signalosome COP9 – Cryo EM<br />

	*Cullin-4A		*Cullin-4A
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	**[[2hye]] – hCul4A + RBX1 + DDB1 + nonstructural protein <br />		**[[2hye]] – hCul4A + RBX1 + DDB1 + nonstructural protein <br />
	**[[4a0k]] – hCul4A + RBX1 + DDB1 + DDB2 + DNA<br />		**[[4a0k]] – hCul4A + RBX1 + DDB1 + DDB2 + DNA<br />
	**[[7okq]] – ~~hCul5~~ + RBX1 + DDB1 + DCAF1 – Cryo EM<br />		**[[7okq]] – hCul4A + RBX1 + DDB1 + DCAF1 – Cryo EM<br />
			**[[8b3i]] – hCul4A + RBX1 + DDB1 + NEDD8 + CSA + E2 + Ub – Cryo EM<br />
			**[[7opc]], [[7opd]] – hCul4A in transcription- DNA repair complex – Cryo EM<br />

	*Cullin-4B		*Cullin-4B

			**[[8ei1]] – hCul4B N terminal + H316 peptide <br />
	**[[4a64]] – hCul4B residues 188-539 <br />		**[[4a64]] – hCul4B residues 188-539 <br />
	**[[2do7]] – hCul4B winged helix-turn-helix - NMR <br />		**[[2do7]] – hCul4B winged helix-turn-helix - NMR <br />
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	**[[2wzk]] – hCul5 N terminal 1-386 (mutant) <br />		**[[2wzk]] – hCul5 N terminal 1-386 (mutant) <br />
			**[[8ei2]] – hCul5 N terminal + H314 peptide <br />
	**[[3dpl]] – hCul5 C-terminal residues 401-780 (mutant) + RBX1 <br />		**[[3dpl]] – hCul5 C-terminal residues 401-780 (mutant) + RBX1 <br />
	**[[3dqv]] – hCul5 C-terminal (mutant) + RBX1 + NEDD8 <br />		**[[3dqv]] – hCul5 C-terminal (mutant) + RBX1 + NEDD8 <br />
			**[[6v9i]] – hCul5 + RBX2 – Cryo EM<br />
	**[[7oni]] – hCul5 + RBX2 + NEDD8 + ARIH2 – Cryo EM<br />		**[[7oni]] – hCul5 + RBX2 + NEDD8 + ARIH2 – Cryo EM<br />
	**[[4jgh]] – hCul5 N terminal (mutant) + SOCS-2 + transcription elongation factor B <br />		**[[4jgh]] – hCul5 N terminal (mutant) + SOCS-2 + transcription elongation factor B <br />
	**[[4n9f]] – hCul5 N terminal + core-binding factor + virion infectivity factor + transcription elongation factor B <br />		**[[4n9f]] – hCul5 N terminal + core-binding factor + virion infectivity factor + transcription elongation factor B <br />
			**[[8fvj]] – hCul5 + elongin-B + elongin-C + CBF-beta + VIF – Cryo EM<br />
			**[[8fvi]] – hCul5 + elongin-B + elongin-C + CBF-beta + VIF + APOBEC3H + RNA – Cryo EM<br />

	*Cullin-7		*Cullin-7
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	**[[2jng]] – hCul7 residues 360-460 - NMR <br />		**[[2jng]] – hCul7 residues 360-460 - NMR <br />
	**[[7z8b]] – hCul7 + RBX1 + F-box/WD repeat-containing protein 8 + S-phase kinase-associated protein – Cryo EM<br />		**[[7z8b]] – hCul7 + RBX1 + F-box/WD repeat-containing protein 8 + S-phase kinase-associated protein – Cryo EM<br />

			*Cullin-9

			**[[8q7e]], [[8rhz]] – hCul9 + RBX1 – Cryo EM<br />
			**[[8q7h]] – hCul9 + RBX1 + NEDD8 – Cryo EM<br />

	*Cullin-A		*Cullin-A

Michal Harel at 10:06, 1 December 2022

2022-12-01T10:06:51Z

← Older revision		Revision as of 10:06, 1 December 2022
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	*Cullin-4A		*Cullin-4A

	**[[2hye]] – hCul4A + RBX1 + ~~DNA damage-binding protein 1~~ + nonstructural protein <br />		**[[2hye]] – hCul4A + RBX1 + DDB1 + nonstructural protein <br />
	**[[4a0k]] – hCul4A + RBX1 + DNA ~~damage-binding protein 1~~ + ~~DNA damage-binding protein 2~~ + ~~DNA~~<br />		**[[4a0k]] – hCul4A + RBX1 + DDB1 + DDB2 + DNA<br />
			**[[7okq]] – hCul5 + RBX1 + DDB1 + DCAF1 – Cryo EM<br />

	*Cullin-4B		*Cullin-4B
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	*Cullin-5		*Cullin-5

	**[[2wzk]] – hCul5 N terminal (mutant) <br />		**[[2wzk]] – hCul5 N terminal 1-386 (mutant) <br />
	**[[3dpl]] – hCul5 residues 401-780 (mutant) + RBX1 <br />		**[[3dpl]] – hCul5 C-terminal residues 401-780 (mutant) + RBX1 <br />
	**[[3dqv]] – hCul5 ~~residues 401~~-~~780~~ (mutant) + RBX1 + NEDD8 <br />		**[[3dqv]] – hCul5 C-terminal (mutant) + RBX1 + NEDD8 <br />
			**[[7oni]] – hCul5 + RBX2 + NEDD8 + ARIH2 – Cryo EM<br />
	**[[4jgh]] – hCul5 N terminal (mutant) + SOCS-2 + transcription elongation factor B <br />		**[[4jgh]] – hCul5 N terminal (mutant) + SOCS-2 + transcription elongation factor B <br />
	**[[4n9f]] – hCul5 N terminal + core-binding factor + virion infectivity factor + transcription elongation factor B <br />		**[[4n9f]] – hCul5 N terminal + core-binding factor + virion infectivity factor + transcription elongation factor B <br />
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	**[[2jng]] – hCul7 residues 360-460 - NMR <br />		**[[2jng]] – hCul7 residues 360-460 - NMR <br />
			**[[7z8b]] – hCul7 + RBX1 + F-box/WD repeat-containing protein 8 + S-phase kinase-associated protein – Cryo EM<br />

	*Cullin-A		*Cullin-A

Michal Harel at 09:33, 13 June 2021

2021-06-13T09:33:13Z

← Older revision		Revision as of 09:33, 13 June 2021
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	**[[1ldk]] – hCul1 + RBX1 + cyclin A/Cdk2-asociated protein + Skp2-like protein <br />		**[[1ldk]] – hCul1 + RBX1 + cyclin A/Cdk2-asociated protein + Skp2-like protein <br />
	**[[1u6g]] – hCul1 + RBX1 + TIP120 protein <br />		**[[1u6g]] – hCul1 + RBX1 + TIP120 protein <br />
			**[[7b5s]] – hCul1 + RBX1 + ARIH1 – Cryo EM <br />
			**[[7b5n]] – hCul1 + RBX1 + ARIH1 + NEDD8 + Ub + UBE2L3 – Cryo EM <br />
			**[[7b5m]] – hCul1 + RBX1 + ARIH1 + SKP1 + SKP2 + CKSHS1 + p27 + Ub – Cryo EM <br />
			**[[7b5r]] – hCul1 + RBX1 + cyclin A + SKP1 + SKP2 + CKSHS1 + p27 + CDK2 – Cryo EM <br />
			**[[7b5l]] – hCul1 + RBX1 + cyclin A + SKP1 + SKP2 + CKSHS1 + p27 + CDK2 + NEDD8 + cyclin A + Ub + UBE2L3 – Cryo EM <br />
	**[[4f52]] – hCul1 residues 411-690 (mutant) + RBX1 + glomulin<br />		**[[4f52]] – hCul1 residues 411-690 (mutant) + RBX1 + glomulin<br />
	**[[4p5o]] – hCul1 residues 411-776 + Dcn1-like protein + NEDD8-conjugating enzyme Ubc12 + RBX1 + NEDD8-conjugating enzyme Ubc12 + NEDD8 <br />		**[[4p5o]] – hCul1 residues 411-776 + Dcn1-like protein + NEDD8-conjugating enzyme Ubc12 + RBX1 + NEDD8-conjugating enzyme Ubc12 + NEDD8 <br />
	**[[6ttu]] – hCul1 + RBX1 + NEDD8 + polyubiquitin + Ube2D2 + S-phase kinase-associated protein + F-box/WD repeat-containing protein + IKBA peptide – Cryo EM<br />		**[[6ttu]] – hCul1 + RBX1 + NEDD8 + polyubiquitin + Ube2D2 + S-phase kinase-associated protein + F-box/WD repeat-containing protein + IKBA peptide – Cryo EM<br />
			**[[6wcq]] – hCul1 + S-phase kinase-associated protein + F-box/WD repeat-containing protein + Kelch-like ECH-associated protein – Cryo EM<br />

	*Cullin-2		*Cullin-2

Michal Harel at 09:12, 8 July 2020

2020-07-08T09:12:39Z

← Older revision		Revision as of 09:12, 8 July 2020
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	**[[4f52]] – hCul1 residues 411-690 (mutant) + RBX1 + glomulin<br />		**[[4f52]] – hCul1 residues 411-690 (mutant) + RBX1 + glomulin<br />
	**[[4p5o]] – hCul1 residues 411-776 + Dcn1-like protein + NEDD8-conjugating enzyme Ubc12 + RBX1 + NEDD8-conjugating enzyme Ubc12 + NEDD8 <br />		**[[4p5o]] – hCul1 residues 411-776 + Dcn1-like protein + NEDD8-conjugating enzyme Ubc12 + RBX1 + NEDD8-conjugating enzyme Ubc12 + NEDD8 <br />
			**[[6ttu]] – hCul1 + RBX1 + NEDD8 + polyubiquitin + Ube2D2 + S-phase kinase-associated protein + F-box/WD repeat-containing protein + IKBA peptide – Cryo EM<br />

	*Cullin-2		*Cullin-2
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	**[[4wqo]] – hCul2 residues 20-122 + PVHL + elongin-C <br />		**[[4wqo]] – hCul2 residues 20-122 + PVHL + elongin-C <br />
	**[[5n4w]] – hCul2 + PVHL + elongin-B + elongon-C + RBX1 + <br />		**[[5n4w]] – hCul2 + PVHL + elongin-B + elongon-C + RBX1 + <br />
			**[[6r6h]], [[6r7f]], [[6r7h]], [[6r7i]], [[6r7n]] – hCul2 in signalosome COP9 – Cryo EM<br />

	*Cullin-3		*Cullin-3

Michal Harel: New page: == 3D Structures of cullin== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *Cullin-1 **1ldj – hCul1 + RBX1...

2019-05-20T10:10:11Z

New page: == 3D Structures of cullin== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *Cullin-1 **1ldj – hCul1 + RBX1...

New page

== 3D Structures of cullin==

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|

*Cullin-1

**[[1ldj]] – hCul1 + RBX1 – human 
**[[3rtr]] – hCul1 residues 411-766 (mutant) + RBX1 
**[[5v89]] – hCul1 WHB domain residues 702-776 + Dcn1-like protein 
**[[3tdu]] – hCul1 WHB domain + Dcn1-like protein + NEDD8-conjugating enzyme Ubc12 
**[[3tdz]] – hCul1 WHB domain + Dcn1-like protein + stapled Ubc12 peptide 
**[[1ldk]] – hCul1 + RBX1 + cyclin A/Cdk2-asociated protein + Skp2-like protein 
**[[1u6g]] – hCul1 + RBX1 + TIP120 protein 
**[[4f52]] – hCul1 residues 411-690 (mutant) + RBX1 + glomulin 
**[[4p5o]] – hCul1 residues 411-776 + Dcn1-like protein + NEDD8-conjugating enzyme Ubc12 + RBX1 + NEDD8-conjugating enzyme Ubc12 + NEDD8 

*Cullin-2

**[[4wqo]] – hCul2 residues 20-122 + PVHL + elongin-C 
**[[5n4w]] – hCul2 + PVHL + elongin-B + elongon-C + RBX1 + 

*Cullin-3

**[[5nlb]] – hCul3 N terminal + kelch-like protein 
**[[6i2m]] – hCul3 (mutant) + kelch-repeat protein 
**[[4ap2]], [[4apf]], [[4hxi]] – hCul3 N terminal (mutant) + kelch-like protein 
**[[4eoz]] – hCul3 N terminal (mutant) + peckle-type POZ protein 
**[[2myl]], [[2mym]] – hCul3 residues 49-68 - NMR 

*Cullin-4A

**[[2hye]] – hCul4A + RBX1 + DNA damage-binding protein 1 + nonstructural protein 
**[[4a0k]] – hCul4A + RBX1 + DNA damage-binding protein 1 + DNA damage-binding protein 2 + DNA 

*Cullin-4B

**[[4a64]] – hCul4B residues 188-539 
**[[2do7]] – hCul4B winged helix-turn-helix - NMR 
**[[4a0c]] – hCul4B residues 192-913 + RBX1 + cullin-associated NEDD8-dissociated protein 
**[[4a0l]] – hCul4B + RBX1 + DNA damage-binding protein 1 + DNA damage-binding protein 2 + DNA 

*Cullin-5

**[[2wzk]] – hCul5 N terminal (mutant) 
**[[3dpl]] – hCul5 residues 401-780 (mutant) + RBX1 
**[[3dqv]] – hCul5 residues 401-780 (mutant) + RBX1 + NEDD8 
**[[4jgh]] – hCul5 N terminal (mutant) + SOCS-2 + transcription elongation factor B 
**[[4n9f]] – hCul5 N terminal + core-binding factor + virion infectivity factor + transcription elongation factor B 

*Cullin-7

**[[2jng]] – hCul7 residues 360-460 - NMR 

*Cullin-A

**[[3o2p]], [[3o6b]] – CulA residues 730-815 + defective in cullin neddylation protein - yeast
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[[Category:Topic Page]]