Cyclin 3D structures - Revision history

Michal Harel at 09:49, 17 February 2025

2025-02-17T09:49:11Z

← Older revision		Revision as of 09:49, 17 February 2025
Line 3:		Line 3:
	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
	{{#tree:id=OrganizedByTopic\|openlevels=0\|		{{#tree:id=OrganizedByTopic\|openlevels=0\|

	*CYCA
	**[[7b5l]] – hCYCA + CDK2 + NEDD8 + cullin-1 + RBX1 + SKP1 + SKP2 + CKSHS1 + p27 + UBE2L3 + Ub + ARIH1 – human - Cryo EM<br />

	*CYCA2		*CYCA2

	**[[3my5]], [[2wpa]], [[2wxv]], [[2wih]], [[2wip]], [[3f5x]], [[3eoc]], [[3eid]], [[3ej1]], [[3dog]], [[3ddp]], [[3ddq]], [[3bht]], [[2v22]], [[2uue]], [[2i40]], [[2bkz]], [[2c5n]], [[2c5o]], [[2c5v]], [[2c5x]], [[2c5y]], [[2bpm]], [[2c4g]], [[1fvv]], [[2c6t]] – hCYCA2 +CDK2+inhibitor <br />		**[[3my5]], [[2wpa]], [[2wxv]], [[2wih]], [[2wip]], [[3f5x]], [[3eoc]], [[3eid]], [[3ej1]], [[3dog]], [[3ddp]], [[3ddq]], [[3bht]], [[2v22]], [[2uue]], [[2i40]], [[2bkz]], [[2c5n]], [[2c5o]], [[2c5v]], [[2c5x]], [[2c5y]], [[2bpm]], [[2c4g]], [[1fvv]], [[2c6t]] – hCYCA2 +CDK2+inhibitor - human<br />
	**[[3bhu]], [[3bhv]], [[2uzd]], [[2uzb]], [[2uze]], [[2uzl]], [[2uzn]], [[2uzo]], [[2iw6]], [[2iw8]], [[2iw9]], [[2g9x]], [[1oi9]], [[1oiu]], [[1oiy]], [[1ogu]], [[1p5e]], [[1pkd]], [[1h1p]], [[1h1q]], [[1h1r]], [[1h1s]], [[4cfx]], [[4cfv]], [[4cfu]], [[4cfm]], [[5nev]], [[5nev]], [[5lmk]], [[5cyi]], [[7b7s]], [[7mkx]], [[7qhl]] - hCYCA2 +CDK2 T160P+inhibitor<br />		**[[3bhu]], [[3bhv]], [[2uzd]], [[2uzb]], [[2uze]], [[2uzl]], [[2uzn]], [[2uzo]], [[2iw6]], [[2iw8]], [[2iw9]], [[2g9x]], [[1oi9]], [[1oiu]], [[1oiy]], [[1ogu]], [[1p5e]], [[1pkd]], [[1h1p]], [[1h1q]], [[1h1r]], [[1h1s]], [[4cfx]], [[4cfv]], [[4cfu]], [[4cfm]], [[5nev]], [[5nev]], [[5lmk]], [[5cyi]], [[7b7s]], [[7mkx]], [[7qhl]] - hCYCA2 +CDK2 T160P+inhibitor<br />
			**[[8bzo]] - hCYCA2 +CDK2 T160P+ p27 – Cryo EM
	**[[1fin]], [[5if1]] - hCYCA2 +CDK2<br />		**[[1fin]], [[5if1]] - hCYCA2 +CDK2<br />
	**[[1vyw]] - hCYCA2 C-terminal 175-432 + hCDK2<br />		**[[1vyw]] - hCYCA2 C-terminal 175-432 + hCDK2<br />
			**[[7luo]] - hCYCA2 + SKP2 N-terminal
	**[[1jst]], [[3tnw]], [[6sg4]] - hCYCA2 +CDK2 T160P<br />		**[[1jst]], [[3tnw]], [[6sg4]] - hCYCA2 +CDK2 T160P<br />
	**[[1h24]], [[1h25]], [[1h26]], [[1h27]], [[1h28]], [[1gy3]] - hCYCA2 +CDK2 T160P+peptide<br />		**[[1h24]], [[1h25]], [[1h26]], [[1h27]], [[1h28]], [[1gy3]] - hCYCA2 +CDK2 T160P+peptide<br />
	**[[4bck]], [[4bcm]], [[4bcn]], [[4bco]], [[4bcp]], [[4bcq]], [[4cfn]], [[4cfw]], [[6gva]], [[6guf]], [[6gue]], [[6guc]], [[6gub]] - hCYCA2 +CDK2 T160P + inhibitor<br />		**[[4bck]], [[4bcm]], [[4bcn]], [[4bco]], [[4bcp]], [[4bcq]], [[4cfn]], [[4cfw]], [[6gva]], [[6guf]], [[6gue]], [[6guc]], [[6gub]], [[8b54]] - hCYCA2 +CDK2 T160P + inhibitor<br />
	**[[6ath]] - hCYCA2 +CDK2 T160P + cyclin-dependent kinase inhibitor<br />		**[[6ath]] - hCYCA2 +CDK2 T160P + cyclin-dependent kinase inhibitor<br />
	**[[4fx3]] - hCYCA2 +CDK2 + inhibitor<br />		**[[4fx3]] - hCYCA2 +CDK2 + inhibitor<br />
Line 26:		Line 25:
	**[[1jsu]] - hCYCA2 +CDK2 (mutant)+P27<br />		**[[1jsu]] - hCYCA2 +CDK2 (mutant)+P27<br />
	**[[6q6g]], [[6q6h]] – hCYCA2 in APC/C-CDC20-CDK2-CKS2 complex – Cryo EM<br />		**[[6q6g]], [[6q6h]] – hCYCA2 in APC/C-CDC20-CDK2-CKS2 complex – Cryo EM<br />
			**[[8bya]] – hCYCA2 + CDK2 + SKP1 + SKP2 + CKS1 + p27 - Cryo EM<br />
			**[[7b5l]] – hCYCA2 + CDK2 + NEDD8 + cullin-1 + RBX1 + SKP1 + SKP2 + CKSHS1 + p27 + UBE2L3 + Ub + ARIH1 - Cryo EM<br />
			**[[8roz]] – bCYCA2 + CDK2 + CDC25a – bovine - Cryo EM<br />
	**[[3qhr]], [[3khw]] - CYCA2 + P33 protein kinase + CDK2 peptide – mouse		**[[3qhr]], [[3khw]] - CYCA2 + P33 protein kinase + CDK2 peptide – mouse

	*CYCA3		*CYCA3

	**[[1vin]] – CYCA3 - bovine<br />
	**[[1e9h]] – hCYCA3 +CDK2 T160P+inhibitor<br />		**[[1e9h]] – hCYCA3 +CDK2 T160P+inhibitor<br />
	**[[7sj3]] - hCYCA3 +CDK4 T160P + drug<br />		**[[7sj3]] - hCYCA3 +CDK4 T160P + drug<br />
			**[[1vin]] – bCYCA3 <br />

	*CYCB1 or G2/mitotic-specific CYCB1		*CYCB1 or G2/mitotic-specific CYCB1
Line 42:		Line 44:
	**[[5lqf]] – hCYCB1 + hCDK1 + CDK regulatory subunit 2 + inhibitor<br />		**[[5lqf]] – hCYCB1 + hCDK1 + CDK regulatory subunit 2 + inhibitor<br />
	**[[7nj0]] – hCYCB1 + hCDK1 + CDK regulatory subunit 1 + separin – Cryo EM<br />		**[[7nj0]] – hCYCB1 + hCDK1 + CDK regulatory subunit 1 + separin – Cryo EM<br />
			**[[8tar]], [[8tau]] – hCYCB1 in cyclosome complex – Cryo EM<br />
			**[[9fh9]] – hCYCB1 in nucleosome complex – Cryo EM<br />

	*CYCC		*CYCC

	**[[3rgf]], [[4g6l]] – hCYCC + CDK8<br />		**[[3rgf]], [[4g6l]] – hCYCC + CDK8<br />
	**[[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]], [[4f7s]], [[5idp]], [[5idn]], [[5icp]], [[5i5z]], [[5hvy]], [[5hnb]], [[5hbj]], [[5hbh]], [[5hbe]], [[5fgk]], [[5cei]], [[5bnj]], [[5xqx]], [[5xs2]], [[6qtg]], [[6qtj]], [[6r3s]], [[6t41]] – hCYCC + CDK8 + inhibitor<br />		**[[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]], [[4f7s]], [[5idp]], [[5idn]], [[5icp]], [[5i5z]], [[5hvy]], [[5hnb]], [[5hbj]], [[5hbh]], [[5hbe]], [[5fgk]], [[5cei]], [[5bnj]], [[5xqx]], [[5xs2]], [[6qtg]], [[6qtj]], [[6r3s]], [[6t41]], [[9h8c]], [[9h8s]] – hCYCC + CDK8 + inhibitor<br />
	**[[6tpa]] – hCYCC + CDK8 + drug<br />		**[[6tpa]] – hCYCC + CDK8 + drug<br />
			**[[8tq2]], [[8tqc]] – hCYCC + CDK8 + mediator of RNA polymerase transcription subunit 12,13 – Cryo EM<br />
			**[[8tqw]] – hCYCC + CDK8 + mediator of RNA polymerase transcription complex– Cryo EM<br />

			*CYCCCL1

	**[[7kue]] – hCYCCCL1 + TFB3 + Kin28 + ADP – Cryo EM<br />		**[[7kue]] – hCYCCCL1 + TFB3 + Kin28 + ADP – Cryo EM<br />
			**[[6xi8]] – yCYCCCL1 + TFB3 + Kin28 + ADP – Cryo EM<br />

	*CYCD		*CYCD
Line 56:		Line 66:
	**[[3g33]] – hCYCD3 + CDK4		**[[3g33]] – hCYCD3 + CDK4

	*~~CYCE~~		*CYCE1

	**[[1w98]] – hCYCE1 + CDK2 T160P<br />		**[[1w98]] – hCYCE1 + CDK2 T160P<br />
	**[[7kjs]] – hCYCE1 + CDK2 <br />		**[[7kjs]] – hCYCE1 + CDK2 <br />
	**[[5l2w]] – hCYCE1 + CDK2 + drug<br />		**[[5l2w]] – hCYCE1 + CDK2 + drug<br />
			**[[8h6p]], [[8h6t]], [[8vq3]], [[8vq4]] – hCYCE1 + CDK2 + inhibitor<br />
			**[[7xqk]] – hCYCE1 + CDK3 <br />
			**[[8h4r]] – hCYCE1 + CDK3 + drug<br />

			*CYCF

			**[[9cb3]] – hCYCF + SKP1 + E2F1 peptide – Cryo EM<br />

	*CYCH		*CYCH
Line 66:		Line 83:
	**[[1kxu]], [[1jkw]] – hCYCH<br />		**[[1kxu]], [[1jkw]] – hCYCH<br />
	**[[6o9l]] – hCYCH in transcription preinitiation complex – Cryo EM<br />		**[[6o9l]] – hCYCH in transcription preinitiation complex – Cryo EM<br />
	**[[6xbz]] – hCYCH + CDK7 + MAT1 – Cryo EM<br />		**[[8pyr]] – hCYCH + CDK7 + MAT1 <br />
	**[[6xd3]], [[7b5o]], [[7b5q]] – hCYCH + CDK7 + MAT1 + inhibitor – Cryo EM<br />		**[[6xbz]], [[8orm]], [[8p6w]], [[8p6x]], [[8p73]], [[8p75]], [[8p79]] – hCYCH + CDK7 + MAT1 – Cryo EM<br />
			**[[6xd3]], [[7b5o]], [[7b5q]], [[8p6v]], [[8p6z]], [[8p70]], [[8p71]], [[8p72]], [[8p74]], [[8p76]], [[8p77]], [[8plz]], [[8s0t]] – hCYCH + CDK7 + MAT1 + inhibitor – Cryo EM<br />
			**[[8p78]] – hCYCH + CDK7 + MAT1 + drug – Cryo EM<br />
			**[[8p6y]] – hCYCH + CDK7 + MAT1 + ATPgS – Cryo EM<br />
			**[[7nvr]] – hCYCH + hCDK7 in DNA polymerase complex – Cryo EM<br />

	*CYCK		*CYCK
Line 77:		Line 98:
	**[[7nxj]] - hCYCK + CDK13 T160P + inhibitor<br />		**[[7nxj]] - hCYCK + CDK13 T160P + inhibitor<br />
	**[[4un0]], [[5acb]], [[6b3e]], [[6ckx]], [[7nxj]], [[7nxk]] - hCYCK +CDK12 T160P + inhibitor<br />		**[[4un0]], [[5acb]], [[6b3e]], [[6ckx]], [[7nxj]], [[7nxk]] - hCYCK +CDK12 T160P + inhibitor<br />
	**[[6td3]] - hCYCK +CDK12 T160P+ DDB1<br />		**[[6td3]], [[8bu1]], [[8bu2]], [[8bu3]], [[8bu4]], [[8bu5]], [[8bu6]], [[8bu7]], [[8bu9]], [[[8bua]], [[8bub]], [[8buc]], [[8bud]], [[8bue]], [[8buf]], [[8bug]], [[8buh]], [[8bui]], [[8buj]], [[8buk]], [[8bul]], [[8bum]], [[8bun]], [[8buo]], [[8bup]], [[8buq]], [[8bur]], [[8bus]], [[8but]], [[9fmr]] - hCYCK +CDK12 T160P+ DDB1 + inhibitor<br />

	*CYCT		*CYCT
Line 88:		Line 109:
	**[[3lq5]], [[3tn8]], [[3tnh]], [[3tni]], [[4bcf]], [[4bcg]], [[4bch]], [[4bci]], [[4bcj]] – hCYCT1 (mutant)+CDK9<br />		**[[3lq5]], [[3tn8]], [[3tnh]], [[3tni]], [[4bcf]], [[4bcg]], [[4bch]], [[4bci]], [[4bcj]] – hCYCT1 (mutant)+CDK9<br />
	**[[3blr]] - hCYCT1 +CDK9+inhibitor<br />		**[[3blr]] - hCYCT1 +CDK9+inhibitor<br />
	**[[6gzh]], [[6z45]], [[7nwk]] - hCYCT1 TPO160 +CDK9+inhibitor<br />		**[[6gzh]], [[6z45]], [[7nwk]], [[8i0l]] - hCYCT1 TPO160 +CDK9+inhibitor<br />
	**[[3my1]], [[4ec8]], [[4ec9]] - hCYCT1 (mutant)+CDK9 TPO160 +inhibitor<br />		**[[3my1]], [[4ec8]], [[4ec9]], [[6w9e]], [[8k5r]] - hCYCT1 (mutant)+CDK9 TPO160 +inhibitor<br />
	**[[3mi9]], [[3mia]] - hCYCT1 +CDK9+protein TAT<br />		**[[3mi9]], [[3mia]] - hCYCT1 +CDK9+ protein TAT<br />
	**[[2w2h]] - CYCT1 +protein TAT + RNA – horse<br />		**[[2w2h]] - CYCT1 + protein TAT + RNA – horse<br />
	**[[2ivx]] – hCYCT2 (mutant)		**[[2ivx]] – hCYCT2 (mutant)

Michal Harel at 10:18, 4 December 2022

2022-12-04T10:18:25Z

← Older revision		Revision as of 10:18, 4 December 2022
Line 10:		Line 10:

	**[[3my5]], [[2wpa]], [[2wxv]], [[2wih]], [[2wip]], [[3f5x]], [[3eoc]], [[3eid]], [[3ej1]], [[3dog]], [[3ddp]], [[3ddq]], [[3bht]], [[2v22]], [[2uue]], [[2i40]], [[2bkz]], [[2c5n]], [[2c5o]], [[2c5v]], [[2c5x]], [[2c5y]], [[2bpm]], [[2c4g]], [[1fvv]], [[2c6t]] – hCYCA2 +CDK2+inhibitor <br />		**[[3my5]], [[2wpa]], [[2wxv]], [[2wih]], [[2wip]], [[3f5x]], [[3eoc]], [[3eid]], [[3ej1]], [[3dog]], [[3ddp]], [[3ddq]], [[3bht]], [[2v22]], [[2uue]], [[2i40]], [[2bkz]], [[2c5n]], [[2c5o]], [[2c5v]], [[2c5x]], [[2c5y]], [[2bpm]], [[2c4g]], [[1fvv]], [[2c6t]] – hCYCA2 +CDK2+inhibitor <br />
	**[[3bhu]], [[3bhv]], [[2uzd]], [[2uzb]], [[2uze]], [[2uzl]], [[2uzn]], [[2uzo]], [[2iw6]], [[2iw8]], [[2iw9]], [[2g9x]], [[1oi9]], [[1oiu]], [[1oiy]], [[1ogu]], [[1p5e]], [[1pkd]], [[1h1p]], [[1h1q]], [[1h1r]], [[1h1s]], [[4cfx]], [[4cfv]], [[4cfu]], [[4cfm]], [[5nev]], [[5nev]], [[5lmk]], [[5cyi]] - hCYCA2 +CDK2 T160P+inhibitor<br />		**[[3bhu]], [[3bhv]], [[2uzd]], [[2uzb]], [[2uze]], [[2uzl]], [[2uzn]], [[2uzo]], [[2iw6]], [[2iw8]], [[2iw9]], [[2g9x]], [[1oi9]], [[1oiu]], [[1oiy]], [[1ogu]], [[1p5e]], [[1pkd]], [[1h1p]], [[1h1q]], [[1h1r]], [[1h1s]], [[4cfx]], [[4cfv]], [[4cfu]], [[4cfm]], [[5nev]], [[5nev]], [[5lmk]], [[5cyi]], [[7b7s]], [[7mkx]], [[7qhl]] - hCYCA2 +CDK2 T160P+inhibitor<br />
	**[[1fin]], [[5if1]] - hCYCA2 +CDK2<br />		**[[1fin]], [[5if1]] - hCYCA2 +CDK2<br />
	**[[1vyw]] - hCYCA2 C-terminal 175-432 + hCDK2<br />		**[[1vyw]] - hCYCA2 C-terminal 175-432 + hCDK2<br />
Line 32:		Line 32:
	**[[1vin]] – CYCA3 - bovine<br />		**[[1vin]] – CYCA3 - bovine<br />
	**[[1e9h]] – hCYCA3 +CDK2 T160P+inhibitor<br />		**[[1e9h]] – hCYCA3 +CDK2 T160P+inhibitor<br />
			**[[7sj3]] - hCYCA3 +CDK4 T160P + drug<br />

	*CYCB1 or G2/mitotic-specific CYCB1		*CYCB1 or G2/mitotic-specific CYCB1
Line 40:		Line 41:
	**[[5hq0]], [[4yc3]], [[4y72]] – hCYCB1 + hCDK1 + CDK regulatory subunit 2<br />		**[[5hq0]], [[4yc3]], [[4y72]] – hCYCB1 + hCDK1 + CDK regulatory subunit 2<br />
	**[[5lqf]] – hCYCB1 + hCDK1 + CDK regulatory subunit 2 + inhibitor<br />		**[[5lqf]] – hCYCB1 + hCDK1 + CDK regulatory subunit 2 + inhibitor<br />
			**[[7nj0]] – hCYCB1 + hCDK1 + CDK regulatory subunit 1 + separin – Cryo EM<br />

	*CYCC		*CYCC
Line 46:		Line 48:
	**[[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]], [[4f7s]], [[5idp]], [[5idn]], [[5icp]], [[5i5z]], [[5hvy]], [[5hnb]], [[5hbj]], [[5hbh]], [[5hbe]], [[5fgk]], [[5cei]], [[5bnj]], [[5xqx]], [[5xs2]], [[6qtg]], [[6qtj]], [[6r3s]], [[6t41]] – hCYCC + CDK8 + inhibitor<br />		**[[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]], [[4f7s]], [[5idp]], [[5idn]], [[5icp]], [[5i5z]], [[5hvy]], [[5hnb]], [[5hbj]], [[5hbh]], [[5hbe]], [[5fgk]], [[5cei]], [[5bnj]], [[5xqx]], [[5xs2]], [[6qtg]], [[6qtj]], [[6r3s]], [[6t41]] – hCYCC + CDK8 + inhibitor<br />
	**[[6tpa]] – hCYCC + CDK8 + drug<br />		**[[6tpa]] – hCYCC + CDK8 + drug<br />
			**[[7kue]] – hCYCCCL1 + TFB3 + Kin28 + ADP – Cryo EM<br />

	*CYCD		*CYCD
Line 56:		Line 59:

	**[[1w98]] – hCYCE1 + CDK2 T160P<br />		**[[1w98]] – hCYCE1 + CDK2 T160P<br />
			**[[7kjs]] – hCYCE1 + CDK2 <br />
	**[[5l2w]] – hCYCE1 + CDK2 + drug<br />		**[[5l2w]] – hCYCE1 + CDK2 + drug<br />

Line 71:		Line 75:
	**[[4cxa]] - hCYCK + CDK12 T160P + AMPPNP<br />		**[[4cxa]] - hCYCK + CDK12 T160P + AMPPNP<br />
	**[[5efq]], [[4nst]] - hCYCK + CDK13 T160P + ADP<br />		**[[5efq]], [[4nst]] - hCYCK + CDK13 T160P + ADP<br />
			**[[7nxj]] - hCYCK + CDK13 T160P + inhibitor<br />
	**[[4un0]], [[5acb]], [[6b3e]], [[6ckx]], [[7nxj]], [[7nxk]] - hCYCK +CDK12 T160P + inhibitor<br />		**[[4un0]], [[5acb]], [[6b3e]], [[6ckx]], [[7nxj]], [[7nxk]] - hCYCK +CDK12 T160P + inhibitor<br />
	**[[6td3]] - hCYCK +CDK12 T160P+ DDB1<br />		**[[6td3]] - hCYCK +CDK12 T160P+ DDB1<br />
Line 83:		Line 88:
	**[[3lq5]], [[3tn8]], [[3tnh]], [[3tni]], [[4bcf]], [[4bcg]], [[4bch]], [[4bci]], [[4bcj]] – hCYCT1 (mutant)+CDK9<br />		**[[3lq5]], [[3tn8]], [[3tnh]], [[3tni]], [[4bcf]], [[4bcg]], [[4bch]], [[4bci]], [[4bcj]] – hCYCT1 (mutant)+CDK9<br />
	**[[3blr]] - hCYCT1 +CDK9+inhibitor<br />		**[[3blr]] - hCYCT1 +CDK9+inhibitor<br />
	**[[6gzh]], [[6z45]] - hCYCT1 TPO160 +CDK9+inhibitor<br />		**[[6gzh]], [[6z45]], [[7nwk]] - hCYCT1 TPO160 +CDK9+inhibitor<br />
	**[[3my1]], [[4ec8]], [[4ec9]] - hCYCT1 (mutant)+CDK9 TPO160 +inhibitor<br />		**[[3my1]], [[4ec8]], [[4ec9]] - hCYCT1 (mutant)+CDK9 TPO160 +inhibitor<br />
	**[[3mi9]], [[3mia]] - hCYCT1 +CDK9+protein TAT<br />		**[[3mi9]], [[3mia]] - hCYCT1 +CDK9+protein TAT<br />

Michal Harel at 07:52, 16 June 2021

2021-06-16T07:52:47Z

← Older revision		Revision as of 07:52, 16 June 2021
Line 3:		Line 3:
	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
	{{#tree:id=OrganizedByTopic\|openlevels=0\|		{{#tree:id=OrganizedByTopic\|openlevels=0\|

			*CYCA
			**[[7b5l]] – hCYCA + CDK2 + NEDD8 + cullin-1 + RBX1 + SKP1 + SKP2 + CKSHS1 + p27 + UBE2L3 + Ub + ARIH1 – human - Cryo EM<br />

	*CYCA2		*CYCA2

	**[[3my5]], [[2wpa]], [[2wxv]], [[2wih]], [[2wip]], [[3f5x]], [[3eoc]], [[3eid]], [[3ej1]], [[3dog]], [[3ddp]], [[3ddq]], [[3bht]], [[2v22]], [[2uue]], [[2i40]], [[2bkz]], [[2c5n]], [[2c5o]], [[2c5v]], [[2c5x]], [[2c5y]], [[2bpm]], [[2c4g]], [[1fvv]], [[2c6t]] – hCYCA2 +CDK2+inhibitor ~~- human~~<br />		**[[3my5]], [[2wpa]], [[2wxv]], [[2wih]], [[2wip]], [[3f5x]], [[3eoc]], [[3eid]], [[3ej1]], [[3dog]], [[3ddp]], [[3ddq]], [[3bht]], [[2v22]], [[2uue]], [[2i40]], [[2bkz]], [[2c5n]], [[2c5o]], [[2c5v]], [[2c5x]], [[2c5y]], [[2bpm]], [[2c4g]], [[1fvv]], [[2c6t]] – hCYCA2 +CDK2+inhibitor <br />
	**[[3bhu]], [[3bhv]], [[2uzd]], [[2uzb]], [[2uze]], [[2uzl]], [[2uzn]], [[2uzo]], [[2iw6]], [[2iw8]], [[2iw9]], [[2g9x]], [[1oi9]], [[1oiu]], [[1oiy]], [[1ogu]], [[1p5e]], [[1pkd]], [[1h1p]], [[1h1q]], [[1h1r]], [[1h1s]], [[4cfx]], [[4cfv]], [[4cfu]], [[4cfm]], [[5nev]], [[5nev]], [[5lmk]], [[5cyi]] - hCYCA2 +CDK2 T160P+inhibitor<br />		**[[3bhu]], [[3bhv]], [[2uzd]], [[2uzb]], [[2uze]], [[2uzl]], [[2uzn]], [[2uzo]], [[2iw6]], [[2iw8]], [[2iw9]], [[2g9x]], [[1oi9]], [[1oiu]], [[1oiy]], [[1ogu]], [[1p5e]], [[1pkd]], [[1h1p]], [[1h1q]], [[1h1r]], [[1h1s]], [[4cfx]], [[4cfv]], [[4cfu]], [[4cfm]], [[5nev]], [[5nev]], [[5lmk]], [[5cyi]] - hCYCA2 +CDK2 T160P+inhibitor<br />
	**[[1fin]], [[5if1]] - hCYCA2 +CDK2<br />		**[[1fin]], [[5if1]] - hCYCA2 +CDK2<br />
	**[[1vyw]] - hCYCA2 C-terminal + hCDK2<br />		**[[1vyw]] - hCYCA2 C-terminal 175-432 + hCDK2<br />
	**[[1jst]], [[3tnw]] - hCYCA2 +CDK2 T160P<br />		**[[1jst]], [[3tnw]], [[6sg4]] - hCYCA2 +CDK2 T160P<br />
	**[[1h24]], [[1h25]], [[1h26]], [[1h27]], [[1h28]], [[1gy3]] - hCYCA2 +CDK2 T160P+peptide<br />		**[[1h24]], [[1h25]], [[1h26]], [[1h27]], [[1h28]], [[1gy3]] - hCYCA2 +CDK2 T160P+peptide<br />
	**[[4bck]], [[4bcm]], [[4bcn]], [[4bco]], [[4bcp]], [[4bcq]], [[4cfn]], [[4cfw]], [[6gva]], [[6guf]], [[6gue]], [[6guc]], [[6gub]] - hCYCA2 +CDK2 T160P + inhibitor<br />		**[[4bck]], [[4bcm]], [[4bcn]], [[4bco]], [[4bcp]], [[4bcq]], [[4cfn]], [[4cfw]], [[6gva]], [[6guf]], [[6gue]], [[6guc]], [[6gub]] - hCYCA2 +CDK2 T160P + inhibitor<br />
	**[[6ath]] - hCYCA2 +CDK2 T160P + cyclin-dependent kinase inhibitor<br />		**[[6ath]] - hCYCA2 +CDK2 T160P + cyclin-dependent kinase inhibitor<br />
	**[[4fx3]] - hCYCA2 +CDK2 + inhibitor<br />		**[[4fx3]] - hCYCA2 +CDK2 + inhibitor<br />
	**[[4eoi]], [[4eoj]], [[4eok]], [[4eol]], [[4eom]], [[4eon]], [[4eoo]], [[4eop]], [[4eoq]], [[4eor]], [[4eos]] - hCYCA2 C-terminal +CDK2 T160P + inhibitor<br />		**[[4eoi]], [[4eoj]], [[4eok]], [[4eol]], [[4eom]], [[4eon]], [[4eoo]], [[4eop]], [[4eoq]], [[4eor]], [[4eos]], [[6rij]], [[7ack]] - hCYCA2 C-terminal +CDK2 T160P + inhibitor<br />
	**[[2cjm]] - hCYCA2 +CDK2 T160P Y15P<br />		**[[2cjm]] - hCYCA2 +CDK2 T160P Y15P<br />
	**[[2cch]] - hCYCA2 +CDK2 T160P+ATP analog<br />		**[[2cch]] - hCYCA2 +CDK2 T160P+ATP analog<br />
Line 42:		Line 45:
	**[[3rgf]], [[4g6l]] – hCYCC + CDK8<br />		**[[3rgf]], [[4g6l]] – hCYCC + CDK8<br />
	**[[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]], [[4f7s]], [[5idp]], [[5idn]], [[5icp]], [[5i5z]], [[5hvy]], [[5hnb]], [[5hbj]], [[5hbh]], [[5hbe]], [[5fgk]], [[5cei]], [[5bnj]], [[5xqx]], [[5xs2]], [[6qtg]], [[6qtj]], [[6r3s]], [[6t41]] – hCYCC + CDK8 + inhibitor<br />		**[[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]], [[4f7s]], [[5idp]], [[5idn]], [[5icp]], [[5i5z]], [[5hvy]], [[5hnb]], [[5hbj]], [[5hbh]], [[5hbe]], [[5fgk]], [[5cei]], [[5bnj]], [[5xqx]], [[5xs2]], [[6qtg]], [[6qtj]], [[6r3s]], [[6t41]] – hCYCC + CDK8 + inhibitor<br />
			**[[6tpa]] – hCYCC + CDK8 + drug<br />

	*CYCD		*CYCD
Line 58:		Line 62:
	**[[1kxu]], [[1jkw]] – hCYCH<br />		**[[1kxu]], [[1jkw]] – hCYCH<br />
	**[[6o9l]] – hCYCH in transcription preinitiation complex – Cryo EM<br />		**[[6o9l]] – hCYCH in transcription preinitiation complex – Cryo EM<br />
			**[[6xbz]] – hCYCH + CDK7 + MAT1 – Cryo EM<br />
			**[[6xd3]], [[7b5o]], [[7b5q]] – hCYCH + CDK7 + MAT1 + inhibitor – Cryo EM<br />

	*CYCK		*CYCK
Line 65:		Line 71:
	**[[4cxa]] - hCYCK + CDK12 T160P + AMPPNP<br />		**[[4cxa]] - hCYCK + CDK12 T160P + AMPPNP<br />
	**[[5efq]], [[4nst]] - hCYCK + CDK13 T160P + ADP<br />		**[[5efq]], [[4nst]] - hCYCK + CDK13 T160P + ADP<br />
	**[[4un0]], [[5acb]], [[6b3e]], [[6ckx]] - hCYCK +CDK12 T160P + inhibitor<br />		**[[4un0]], [[5acb]], [[6b3e]], [[6ckx]], [[7nxj]], [[7nxk]] - hCYCK +CDK12 T160P + inhibitor<br />
	**[[6td3]] - hCYCK +CDK12 T160P+ DDB1<br />		**[[6td3]] - hCYCK +CDK12 T160P+ DDB1<br />

Line 77:		Line 83:
	**[[3lq5]], [[3tn8]], [[3tnh]], [[3tni]], [[4bcf]], [[4bcg]], [[4bch]], [[4bci]], [[4bcj]] – hCYCT1 (mutant)+CDK9<br />		**[[3lq5]], [[3tn8]], [[3tnh]], [[3tni]], [[4bcf]], [[4bcg]], [[4bch]], [[4bci]], [[4bcj]] – hCYCT1 (mutant)+CDK9<br />
	**[[3blr]] - hCYCT1 +CDK9+inhibitor<br />		**[[3blr]] - hCYCT1 +CDK9+inhibitor<br />
	**[[6gzh]] - hCYCT1 TPO160 +CDK9+inhibitor<br />		**[[6gzh]], [[6z45]] - hCYCT1 TPO160 +CDK9+inhibitor<br />
	**[[3my1]], [[4ec8]], [[4ec9]] - hCYCT1 (mutant)+CDK9 TPO160 +inhibitor<br />		**[[3my1]], [[4ec8]], [[4ec9]] - hCYCT1 (mutant)+CDK9 TPO160 +inhibitor<br />
	**[[3mi9]], [[3mia]] - hCYCT1 +CDK9+protein TAT<br />		**[[3mi9]], [[3mia]] - hCYCT1 +CDK9+protein TAT<br />

Michal Harel at 06:34, 9 July 2020

2020-07-09T06:34:40Z

← Older revision		Revision as of 06:34, 9 July 2020
Line 20:		Line 20:
	**[[4i3z]], [[4ii5]] - hCYCA2 +CDK2 T160P+ADP + Mg<br />		**[[4i3z]], [[4ii5]] - hCYCA2 +CDK2 T160P+ADP + Mg<br />
	**[[2cci]] - hCYCA2 +CDK2 T160P+CDC homolog<br />		**[[2cci]] - hCYCA2 +CDK2 T160P+CDC homolog<br />
	**[[2wma]], [[2wmb]], [[2x1n]], [[2wev]], [[2wfy]], [[2whb]], [[1okv]], [[1okw]], [[1ol1]], [[1ol2]], [[1urc]], [[1qmz]], [[3qhw]] - hCYCA2 +CDK2+peptide<br />		**[[2wma]], [[2wmb]], [[2x1n]], [[2wev]], [[2wfy]], [[2whb]], [[1okv]], [[1okw]], [[1ol1]], [[1ol2]], [[1urc]], [[1qmz]], [[3qhw]], [[6p3w]] - hCYCA2 +CDK2+peptide<br />
	**[[1jsu]] - hCYCA2 +CDK2 (mutant)+P27<br />		**[[1jsu]] - hCYCA2 +CDK2 (mutant)+P27<br />
			**[[6q6g]], [[6q6h]] – hCYCA2 in APC/C-CDC20-CDK2-CKS2 complex – Cryo EM<br />
	**[[3qhr]], [[3khw]] - CYCA2 + P33 protein kinase + CDK2 peptide – mouse		**[[3qhr]], [[3khw]] - CYCA2 + P33 protein kinase + CDK2 peptide – mouse

Line 40:		Line 41:

	**[[3rgf]], [[4g6l]] – hCYCC + CDK8<br />		**[[3rgf]], [[4g6l]] – hCYCC + CDK8<br />
	**[[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]], [[4f7s]], [[5idp]], [[5idn]], [[5icp]], [[5i5z]], [[5hvy]], [[5hnb]], [[5hbj]], [[5hbh]], [[5hbe]], [[5fgk]], [[5cei]], [[5bnj]], [[5xqx]], [[5xs2]] – hCYCC + CDK8 + inhibitor<br />		**[[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]], [[4f7s]], [[5idp]], [[5idn]], [[5icp]], [[5i5z]], [[5hvy]], [[5hnb]], [[5hbj]], [[5hbh]], [[5hbe]], [[5fgk]], [[5cei]], [[5bnj]], [[5xqx]], [[5xs2]], [[6qtg]], [[6qtj]], [[6r3s]], [[6t41]] – hCYCC + CDK8 + inhibitor<br />

	*CYCD		*CYCD
Line 55:		Line 56:
	*CYCH		*CYCH

	**[[1kxu]], [[1jkw]] – hCYCH		**[[1kxu]], [[1jkw]] – hCYCH<br />
			**[[6o9l]] – hCYCH in transcription preinitiation complex – Cryo EM<br />

	*CYCK		*CYCK
Line 64:		Line 66:
	**[[5efq]], [[4nst]] - hCYCK + CDK13 T160P + ADP<br />		**[[5efq]], [[4nst]] - hCYCK + CDK13 T160P + ADP<br />
	**[[4un0]], [[5acb]], [[6b3e]], [[6ckx]] - hCYCK +CDK12 T160P + inhibitor<br />		**[[4un0]], [[5acb]], [[6b3e]], [[6ckx]] - hCYCK +CDK12 T160P + inhibitor<br />
			**[[6td3]] - hCYCK +CDK12 T160P+ DDB1<br />

	*CYCT		*CYCT

Michal Harel: New page: == 3D Structures of Cyclin == Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *CYCA2 **3my5, 2wpa, [[2wxv]...

2019-05-21T10:20:04Z

New page: == 3D Structures of Cyclin == Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *CYCA2 **3my5, 2wpa, [[2wxv]...

New page

== 3D Structures of Cyclin ==

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|

*CYCA2

**[[3my5]], [[2wpa]], [[2wxv]], [[2wih]], [[2wip]], [[3f5x]], [[3eoc]], [[3eid]], [[3ej1]], [[3dog]], [[3ddp]], [[3ddq]], [[3bht]], [[2v22]], [[2uue]], [[2i40]], [[2bkz]], [[2c5n]], [[2c5o]], [[2c5v]], [[2c5x]], [[2c5y]], [[2bpm]], [[2c4g]], [[1fvv]], [[2c6t]] – hCYCA2 +CDK2+inhibitor - human 
**[[3bhu]], [[3bhv]], [[2uzd]], [[2uzb]], [[2uze]], [[2uzl]], [[2uzn]], [[2uzo]], [[2iw6]], [[2iw8]], [[2iw9]], [[2g9x]], [[1oi9]], [[1oiu]], [[1oiy]], [[1ogu]], [[1p5e]], [[1pkd]], [[1h1p]], [[1h1q]], [[1h1r]], [[1h1s]], [[4cfx]], [[4cfv]], [[4cfu]], [[4cfm]], [[5nev]], [[5nev]], [[5lmk]], [[5cyi]] - hCYCA2 +CDK2 T160P+inhibitor 
**[[1fin]], [[5if1]] - hCYCA2 +CDK2 
**[[1vyw]] - hCYCA2 C-terminal + hCDK2 
**[[1jst]], [[3tnw]] - hCYCA2 +CDK2 T160P 
**[[1h24]], [[1h25]], [[1h26]], [[1h27]], [[1h28]], [[1gy3]] - hCYCA2 +CDK2 T160P+peptide 
**[[4bck]], [[4bcm]], [[4bcn]], [[4bco]], [[4bcp]], [[4bcq]], [[4cfn]], [[4cfw]], [[6gva]], [[6guf]], [[6gue]], [[6guc]], [[6gub]] - hCYCA2 +CDK2 T160P + inhibitor 
**[[6ath]] - hCYCA2 +CDK2 T160P + cyclin-dependent kinase inhibitor 
**[[4fx3]] - hCYCA2 +CDK2 + inhibitor 
**[[4eoi]], [[4eoj]], [[4eok]], [[4eol]], [[4eom]], [[4eon]], [[4eoo]], [[4eop]], [[4eoq]], [[4eor]], [[4eos]] - hCYCA2 C-terminal +CDK2 T160P + inhibitor 
**[[2cjm]] - hCYCA2 +CDK2 T160P Y15P 
**[[2cch]] - hCYCA2 +CDK2 T160P+ATP analog 
**[[4i3z]], [[4ii5]] - hCYCA2 +CDK2 T160P+ADP + Mg 
**[[2cci]] - hCYCA2 +CDK2 T160P+CDC homolog 
**[[2wma]], [[2wmb]], [[2x1n]], [[2wev]], [[2wfy]], [[2whb]], [[1okv]], [[1okw]], [[1ol1]], [[1ol2]], [[1urc]], [[1qmz]], [[3qhw]] - hCYCA2 +CDK2+peptide 
**[[1jsu]] - hCYCA2 +CDK2 (mutant)+P27 
**[[3qhr]], [[3khw]] - CYCA2 + P33 protein kinase + CDK2 peptide – mouse

*CYCA3

**[[1vin]] – CYCA3 - bovine 
**[[1e9h]] – hCYCA3 +CDK2 T160P+inhibitor 

*CYCB1 or G2/mitotic-specific CYCB1

**[[2b9r]] – hCYCB1 (mutant) 
**[[2jgz]] - hCYCB1 + CDK2 
**[[6gu4]], [[6gu3]], [[6gu2]] – hCYCB1 + hCDK1 + inhibitor 
**[[5hq0]], [[4yc3]], [[4y72]] – hCYCB1 + hCDK1 + CDK regulatory subunit 2 
**[[5lqf]] – hCYCB1 + hCDK1 + CDK regulatory subunit 2 + inhibitor 

*CYCC

**[[3rgf]], [[4g6l]] – hCYCC + CDK8 
**[[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]], [[4f7s]], [[5idp]], [[5idn]], [[5icp]], [[5i5z]], [[5hvy]], [[5hnb]], [[5hbj]], [[5hbh]], [[5hbe]], [[5fgk]], [[5cei]], [[5bnj]], [[5xqx]], [[5xs2]] – hCYCC + CDK8 + inhibitor 

*CYCD

**[[2w96]], [[2w99]], [[2w9f]], [[2w9z]] - hCYCD1 +CDK4 (mutant) 
**[[6ei2]] – hCYCD2 + HLA + microglobulin 
**[[3g33]] – hCYCD3 + CDK4

*CYCE

**[[1w98]] – hCYCE1 + CDK2 T160P 
**[[5l2w]] – hCYCE1 + CDK2 + drug 

*CYCH

**[[1kxu]], [[1jkw]] – hCYCH

*CYCK

**[[2i53]] – hCYCK N-terminal 
**[[4un0]] - hCYCK + CDK12 T160P 
**[[4cxa]] - hCYCK + CDK12 T160P + AMPPNP 
**[[5efq]], [[4nst]] - hCYCK + CDK13 T160P + ADP 
**[[4un0]], [[5acb]], [[6b3e]], [[6ckx]] - hCYCK +CDK12 T160P + inhibitor 

*CYCT

**[[3blh]] - hCYCT1 +CDK9 
**[[3blq]] - hCYCT1 +CDK9+ATP 
**[[4imy]], [[4or5]], [[4ogr]] - hCYCT1 +CDK9 TPO160 +AMP + AF4/MRF2 family member 4 
**[[5l1z]] - hCYCT1 +CDK9 TPO160 +AMP + AF4/MRF2 family member 4 + RNA 
**[[6cyt]] - hCYCT1 +CDK9 TPO160 +AMP + AF4/MRF2 family member 4 + TAT + RNA 
**[[3lq5]], [[3tn8]], [[3tnh]], [[3tni]], [[4bcf]], [[4bcg]], [[4bch]], [[4bci]], [[4bcj]] – hCYCT1 (mutant)+CDK9 
**[[3blr]] - hCYCT1 +CDK9+inhibitor 
**[[6gzh]] - hCYCT1 TPO160 +CDK9+inhibitor 
**[[3my1]], [[4ec8]], [[4ec9]] - hCYCT1 (mutant)+CDK9 TPO160 +inhibitor 
**[[3mi9]], [[3mia]] - hCYCT1 +CDK9+protein TAT 
**[[2w2h]] - CYCT1 +protein TAT + RNA – horse 
**[[2ivx]] – hCYCT2 (mutant)

*CYC

**[[2pk9]] – yCYC PHO80 +CDK PHO85 – yeast 
**[[2pmi]] - yCYC PHO80 +CDK PHO85+ATPgS

*Viral CYC

**[[2euf]], [[2f2c]], [[2xo2]], [[1jow]] – V-CYC+hCDK6 – Herpesvirus 
**[[1bu2]] – V-CYC 
**[[1xo2]] - V-CYC + hCDK6 + inhibitor 
**[[1g3n]] - V-CYC +hCDK6+CDK6 inhibitor 
**[[1f5q]] - V-CYC g +hCDK2

}}

[[Category:Topic Page]]