Cytochrome bc1 complex - Revision history

Alexander Berchansky at 10:45, 12 February 2023

2023-02-12T10:45:58Z

← Older revision		Revision as of 10:45, 12 February 2023
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	'''Cytochrome bc1''' (Cbc1) functions as the central pump which transfers protons across the cell membrane. The protons are used to power the rotation of ATP synthase. Cbc1 binds ubiquinol which carries hydrogen atoms. Cbc1 separates the protons and the electrons. The protons are released in the inner side of the membrane for use by ATP synthase and the electrons are transferred to cytochrome c or to the outer side of the membrane. Plants use '''cytochrome b6f''' in the same manner binding plastoquinol as a hydrogen carrier. Stigmatellin inhibits the Cbc1 electron transfer by binding to its quinone oxidation site. Antimycin inhibits Cbc1 by binding to its quinone reduction site.<ref>PMID:14977419</ref>		'''Cytochrome bc1''' (Cbc1) functions as the central pump which transfers protons across the cell membrane. The protons are used to power the rotation of ATP synthase. Cbc1 binds ubiquinol which carries hydrogen atoms. Cbc1 separates the protons and the electrons. The protons are released in the inner side of the membrane for use by ATP synthase and the electrons are transferred to cytochrome c or to the outer side of the membrane. Plants use '''cytochrome b6f''' in the same manner binding plastoquinol as a hydrogen carrier. Stigmatellin inhibits the Cbc1 electron transfer by binding to its quinone oxidation site. Antimycin inhibits Cbc1 by binding to its quinone reduction site.<ref>PMID:14977419</ref>

	More details in [[~~Complex_III_of_Electron_Transport_Chain~~]].		More details in [[Complex III of Electron Transport Chain]].

	== Structural highlights ==		== Structural highlights ==

Michal Harel at 11:28, 5 December 2022

2022-12-05T11:28:46Z

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 </StructureSection>
 ==3D structures of cytochrome bc1==
 [[Cytochrome bc1 3D structures]]
 == References ==

Michal Harel at 11:26, 5 December 2022

2022-12-05T11:26:05Z

← Older revision		Revision as of 11:26, 5 December 2022
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	</StructureSection>		</StructureSection>
	==3D structures of cytochrome bc1==		==3D structures of cytochrome bc1==

			[[Cytochrome bc1 3D structures]]

	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

Michal Harel at 11:23, 5 December 2022

2022-12-05T11:23:39Z

← Older revision		Revision as of 11:23, 5 December 2022
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	[[6nhg]] - bCb in respiratory complex <BR />		[[6nhg]] - bCb in respiratory complex <BR />
	[[6fo2]] - bCb in respiratory complex – Cryo EM<BR />		[[6fo2]] - bCb in respiratory complex – Cryo EM<BR />
	[[6haw]] - bCb in respiratory complex + antimalarial inhibitor<BR />		[[6haw]], [[6zfs]], [[6zft]], [[6zfu]] - bCb in respiratory complex + antimalarial inhibitor<BR />
	[[6fo0]], [[6fo6]] - bCb in respiratory complex + antimalarial inhibitor – Cryo EM<BR />		[[6fo0]], [[6fo6]] - bCb in respiratory complex + antimalarial inhibitor – Cryo EM<BR />
			[[7o37]], [[7o3c]], [[7o3e]], [[7o3h]] - Cb in CICIII2 complex – mouse - Cryo EM<BR />
	[[3cxh]], [[3h1h]], [[1bcc]], [[3h1h]] - cCb + cCc1 + RISP - chicken<BR />		[[3cxh]], [[3h1h]], [[1bcc]], [[3h1h]] - cCb + cCc1 + RISP - chicken<BR />
	[[3cwb]], [[3h1i]], [[3h1j]], [[3h1k]], [[3h1l]], [[3l70]], [[3l71]], [[3l72]], [[3l73]], [[3l74]], [[3l75]], [[3tgu]], [[3bcc]], [[2bcc]], [[3h1i]] - cCb + cCc1 + RISP + inhibitor<BR />		[[3cwb]], [[3h1i]], [[3h1j]], [[3h1k]], [[3h1l]], [[3l70]], [[3l71]], [[3l72]], [[3l73]], [[3l74]], [[3l75]], [[3tgu]], [[3bcc]], [[2bcc]], [[3h1i]] - cCb + cCc1 + RISP + inhibitor<BR />
			[[7jrg]], [[7jrp]] - Cb in III2 complex – bean - Cryo EM <BR />
	[[2ibz]], [[1kyo]], [[1kb9]], [[1p84]] - yCb + yCc1 + RISP + inhibitor - yeast<BR />		[[2ibz]], [[1kyo]], [[1kb9]], [[1p84]] - yCb + yCc1 + RISP + inhibitor - yeast<BR />
	[[3cx5]] - yCb + yCc1 + RISP <BR />		[[3cx5]] - yCb + yCc1 + RISP <BR />
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	[[1zrt]] - Cb + Cc1 + RISP – ''Rhodobacter capsulatus''<BR />		[[1zrt]] - Cb + Cc1 + RISP – ''Rhodobacter capsulatus''<BR />
	[[2yiu]] - Cb + Cc1 + RISP – ''Paracoccus denitrificans''<BR />		[[2yiu]] - Cb + Cc1 + RISP – ''Paracoccus denitrificans''<BR />
			[[7rja]], [[7rjb]], [[7rjc]], [[7rjd]], [[7rje]] - Cb in III2 complex – ''Candida albicans'' - Cryo EM <BR />
			[[7e1v]] - MtCb in respiratory complex – ''Mycobacterium tuberculosis'' - Cryo EM <BR />
			[[7e1w]], [[7e1x]] - MtCb in respiratory complex + drug - Cryo EM <BR />
			[[7rh5]], [[7rh6]], [[7rh7]] - Cb in CIII2CIV2 complex – ''Mycobacterium smegmatis'' - Cryo EM <BR />
			[[7q21]], [[7qhm]], [[7qho]] - Cb in CIII2CIV2 complex –'' Corynebacterium glutamicum'' - Cryo EM <BR />

Michal Harel at 08:09, 17 June 2021

2021-06-17T08:09:09Z

← Older revision		Revision as of 08:09, 17 June 2021
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	[[6haw]] - bCb in respiratory complex + antimalarial inhibitor<BR />		[[6haw]] - bCb in respiratory complex + antimalarial inhibitor<BR />
	[[6fo0]], [[6fo6]] - bCb in respiratory complex + antimalarial inhibitor – Cryo EM<BR />		[[6fo0]], [[6fo6]] - bCb in respiratory complex + antimalarial inhibitor – Cryo EM<BR />
	[[3cxh]], [[3h1h]], [[1bcc]], [[3h1h]] - cCb + cCc1 + RISP - chicken<BR />		[[3cxh]], [[3h1h]], [[1bcc]], [[3h1h]] - cCb + cCc1 + RISP - chicken<BR />
	[[3cwb]], [[3h1i]], [[3h1j]], [[3h1k]], [[3h1l]], [[3l70]], [[3l71]], [[3l72]], [[3l73]], [[3l74]], [[3l75]], [[3tgu]], [[3bcc]], [[2bcc]], [[3h1i]] - cCb + cCc1 + RISP + inhibitor<BR />		[[3cwb]], [[3h1i]], [[3h1j]], [[3h1k]], [[3h1l]], [[3l70]], [[3l71]], [[3l72]], [[3l73]], [[3l74]], [[3l75]], [[3tgu]], [[3bcc]], [[2bcc]], [[3h1i]] - cCb + cCc1 + RISP + inhibitor<BR />
	[[2ibz]], [[1kyo]], [[1kb9]], [[1p84]] - yCb + yCc1 + RISP + inhibitor - yeast<BR />		[[2ibz]], [[1kyo]], [[1kb9]], [[1p84]] - yCb + yCc1 + RISP + inhibitor - yeast<BR />

Michal Harel at 08:08, 17 June 2021

2021-06-17T08:08:48Z

← Older revision		Revision as of 08:08, 17 June 2021
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	[[4d6u]] - bCb + bCc1 + RISP + antimalarial pyridone<BR />		[[4d6u]] - bCb + bCc1 + RISP + antimalarial pyridone<BR />
	[[1ntz]] - bCb + bCc1 + RISP + ubiquinone<BR />		[[1ntz]] - bCb + bCc1 + RISP + ubiquinone<BR />
	[[1nu1]] - bCb + bCc1 + RISP + quinolone derivative<BR />		[[1nu1]], [[6xvf]] - bCb + bCc1 + RISP + quinolone derivative<BR />
	[[~~2yiu~~]] - Cb + ~~Cc1~~ + ~~RISP~~ – ~~''Paracoccus denitrificans''~~<BR />		[[6nhg]] - bCb in respiratory complex <BR />
	[[3cxh]], [[3h1h]], [[1bcc]], [[3h1h]] - cCb + cCc1 + RISP - chicken<BR />		[[6fo2]] - bCb in respiratory complex – Cryo EM<BR />
			[[6haw]] - bCb in respiratory complex + antimalarial inhibitor<BR />
			[[6fo0]], [[6fo6]] - bCb in respiratory complex + antimalarial inhibitor – Cryo EM<BR />
			[[3cxh]], [[3h1h]], [[1bcc]], [[3h1h]] - cCb + cCc1 + RISP - chicken<BR />
	[[3cwb]], [[3h1i]], [[3h1j]], [[3h1k]], [[3h1l]], [[3l70]], [[3l71]], [[3l72]], [[3l73]], [[3l74]], [[3l75]], [[3tgu]], [[3bcc]], [[2bcc]], [[3h1i]] - cCb + cCc1 + RISP + inhibitor<BR />		[[3cwb]], [[3h1i]], [[3h1j]], [[3h1k]], [[3h1l]], [[3l70]], [[3l71]], [[3l72]], [[3l73]], [[3l74]], [[3l75]], [[3tgu]], [[3bcc]], [[2bcc]], [[3h1i]] - cCb + cCc1 + RISP + inhibitor<BR />
			[[2ibz]], [[1kyo]], [[1kb9]], [[1p84]] - yCb + yCc1 + RISP + inhibitor - yeast<BR />
			[[3cx5]] - yCb + yCc1 + RISP <BR />
			[[1ezv]] - yCb + yCc1 + RISP + antibody<BR />
			[[6giq]], [[6hu9]], [[6t0b]], [[6t15]], [[6ymx]] - yCb in respiratory complex – Cryo EM <BR />
			[[2fyn]] - RsCb (mutant) + Cc1 + RISP – ''Rhodobacter sphaeroides<''BR />
	[[2qjk]] - RsCb (mutant) + RsCc1 + RISP + inhibitor<BR />		[[2qjk]] - RsCb (mutant) + RsCc1 + RISP + inhibitor<BR />
	[[2qjp]] - RsCb + RsCc1 + RISP + inhibitor<BR />		[[2qjp]] - RsCb + RsCc1 + RISP + inhibitor<BR />
	[[2qjy]] - RsCb (mutant) + RsCc1 + RISP (mutant) + inhibitor<BR />		[[2qjy]] - RsCb (mutant) + RsCc1 + RISP (mutant) + inhibitor<BR />
	[[~~2ibz]], [[1kyo]], [[1kb9]], [[1p84]] - yCb + yCc1 + RISP + inhibitor - yeast<BR />~~		[[1zrt]] - Cb + Cc1 + RISP – ''Rhodobacter capsulatus''<BR />
	~~[[3cx5~~]] - ~~yCb~~ + ~~yCc1~~ + RISP ~~<BR />~~
	~~[[1ezv]] - yCb + yCc1 + RISP + antibody<BR />~~
	~~[[6t0b]], [[6t15]] - yCb in mitochondrial III-IV complex - Cryo EM~~ <BR />
	[[2yiu]] - Cb + Cc1 + RISP – ''Paracoccus denitrificans''<BR />		[[2yiu]] - Cb + Cc1 + RISP – ''Paracoccus denitrificans''<BR />
	~~[[2fyn]] - RsCb (mutant) + Cc1 + RISP – ''Rhodobacter sphaeroides''<BR />~~
	~~[[1zrt]] - Cb + Cc1 + RISP – ''Rhodobacter capsulatus''<BR />~~

Michal Harel at 09:48, 9 July 2020

2020-07-09T09:48:01Z

← Older revision		Revision as of 09:48, 9 July 2020
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	[[3cx5]] - yCb + yCc1 + RISP <BR />		[[3cx5]] - yCb + yCc1 + RISP <BR />
	[[1ezv]] - yCb + yCc1 + RISP + antibody<BR />		[[1ezv]] - yCb + yCc1 + RISP + antibody<BR />
	[[6t0b]] - yCb in mitochondrial III-IV complex - Cryo EM <BR />		[[6t0b]], [[6t15]] - yCb in mitochondrial III-IV complex - Cryo EM <BR />
	[[2yiu]] - Cb + Cc1 + RISP – ''Paracoccus denitrificans''<BR />		[[2yiu]] - Cb + Cc1 + RISP – ''Paracoccus denitrificans''<BR />
	[[2fyn]] - RsCb (mutant) + Cc1 + RISP – ''Rhodobacter sphaeroides''<BR />		[[2fyn]] - RsCb (mutant) + Cc1 + RISP – ''Rhodobacter sphaeroides''<BR />

Michal Harel at 09:45, 9 July 2020

2020-07-09T09:45:06Z

← Older revision		Revision as of 09:45, 9 July 2020
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	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

	~~[[2fyn]] - RsCb (mutant) + Cc1 + RISP – ''Rhodobacter sphaeroides''<BR />~~
	~~[[1zrt]] - Cb + Cc1 + RISP – ''Rhodobacter capsulatus''<BR />~~
	[[1bgy]], [[1be3]], [[1l0n]], [[1ntm]] - bCb + bCc1 + RISP – bovine <BR />		[[1bgy]], [[1be3]], [[1l0n]], [[1ntm]] - bCb + bCc1 + RISP – bovine <BR />
	[[1qcr]] - bCb + bCc1 + RISP – Cα model<BR />		[[1qcr]] - bCb + bCc1 + RISP – Cα model<BR />
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	[[1ntz]] - bCb + bCc1 + RISP + ubiquinone<BR />		[[1ntz]] - bCb + bCc1 + RISP + ubiquinone<BR />
	[[1nu1]] - bCb + bCc1 + RISP + quinolone derivative<BR />		[[1nu1]] - bCb + bCc1 + RISP + quinolone derivative<BR />
			[[2yiu]] - Cb + Cc1 + RISP – ''Paracoccus denitrificans''<BR />
			[[3cxh]], [[3h1h]], [[1bcc]], [[3h1h]] - cCb + cCc1 + RISP - chicken<BR />
			[[3cwb]], [[3h1i]], [[3h1j]], [[3h1k]], [[3h1l]], [[3l70]], [[3l71]], [[3l72]], [[3l73]], [[3l74]], [[3l75]], [[3tgu]], [[3bcc]], [[2bcc]], [[3h1i]] - cCb + cCc1 + RISP + inhibitor<BR />
	[[2qjk]] - RsCb (mutant) + RsCc1 + RISP + inhibitor<BR />		[[2qjk]] - RsCb (mutant) + RsCc1 + RISP + inhibitor<BR />
	[[2qjp]] - RsCb + RsCc1 + RISP + inhibitor<BR />		[[2qjp]] - RsCb + RsCc1 + RISP + inhibitor<BR />
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	[[3cx5]] - yCb + yCc1 + RISP <BR />		[[3cx5]] - yCb + yCc1 + RISP <BR />
	[[1ezv]] - yCb + yCc1 + RISP + antibody<BR />		[[1ezv]] - yCb + yCc1 + RISP + antibody<BR />
			[[6t0b]] - yCb in mitochondrial III-IV complex - Cryo EM <BR />
	[[2yiu]] - Cb + Cc1 + RISP – ''Paracoccus denitrificans''<BR />		[[2yiu]] - Cb + Cc1 + RISP – ''Paracoccus denitrificans''<BR />
	[[~~1qcr~~]] - ~~bCb~~ + ~~bCc1~~ + RISP – ~~bovine – Cα model~~<BR />		[[2fyn]] - RsCb (mutant) + Cc1 + RISP – ''Rhodobacter sphaeroides''<BR />
	[[~~3cxh]], [[3h1h]], [[1bcc]], [[3h1h~~]] - ~~cCb~~ + ~~cCc1~~ + RISP ~~- chicken<BR />~~		[[1zrt]] - Cb + Cc1 + RISP – ''Rhodobacter capsulatus''<BR />
	~~[[3cwb]], [[3h1i]], [[3h1j]], [[3h1k]], [[3h1l]], [[3l70]], [[3l71]], [[3l72]], [[3l73]], [[3l74]], [[3l75]], [[3tgu]], [[3bcc]], [[2bcc]], [[3h1i]] - cCb + cCc1 + RISP + inhibitor~~<BR />

Alexander Berchansky at 07:46, 18 February 2019

2019-02-18T07:46:52Z

← Older revision		Revision as of 07:46, 18 February 2019
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	== Structural highlights ==		== Structural highlights ==

	Cbc1 is a <scene name='49/490879/Cv/3'>dimeric protein</scene> composed of 11 proteins and cofactors which include heme-carrying proteins like <scene name='49/490879/Cv/2'>cytochrome b (Cb)</scene> and <scene name='49/490879/Cv/4'>cytochrome c1 (Cc1)</scene> and iron-sulfur cluster proteins like <scene name='49/490879/Cv/5'>Rieske Fe-S protein (RISP)</scene>. The iron containing moieties are <scene name='49/490879/Cv/8'>heme</scene>, <scene name='49/490879/Cv/9'>heme C</scene> (where vinyl side chain of heme are replaced by thioether) and <scene name='49/490879/Cv/10'>Fe2S2</scene>. <ref>PMID:16034531</ref>		Cbc1 is a <scene name='49/490879/Cv/11'>dimeric protein</scene> composed of 11 proteins and cofactors which include heme-carrying proteins like <scene name='49/490879/Cv/12'>cytochrome b (Cb)</scene> and <scene name='49/490879/Cv/13'>cytochrome c1 (Cc1)</scene> and iron-sulfur cluster proteins like <scene name='49/490879/Cv/14'>Rieske Fe-S protein (RISP)</scene>. The iron containing moieties are <scene name='49/490879/Cv/15'>heme</scene>, <scene name='49/490879/Cv/16'>heme C</scene> (where vinyl side chain of heme are replaced by thioether) and <scene name='49/490879/Cv/17'>Fe2S2</scene>. <ref>PMID:16034531</ref>
	</StructureSection>		</StructureSection>
	==3D structures of cytochrome bc1==		==3D structures of cytochrome bc1==

Joel L. Sussman at 09:51, 20 October 2017

2017-10-20T09:51:33Z

← Older revision		Revision as of 09:51, 20 October 2017
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	<StructureSection load='~~1zrt~~' size='350' side='right' caption='Cytochrome bc1 containing Cb (green), Cc1 (yellow), RISP (beige) and Fe2S2 complex with stigmatellin (PDB entry [[1zrt]])' scene='49/490879/Cv/6'>		<StructureSection load='' size='350' side='right' caption='Cytochrome bc1 containing Cb (green), Cc1 (yellow), RISP (beige) and Fe2S2 complex with stigmatellin (PDB entry [[1zrt]])' scene='49/490879/Cv/6'>

	'''Cytochrome bc1''' (Cbc1) functions as the central pump which transfers protons across the cell membrane. The protons are used to power the rotation of ATP synthase. Cbc1 binds ubiquinol which carries hydrogen atoms. Cbc1 separates the protons and the electrons. The protons are released in the inner side of the membrane for use by ATP synthase and the electrons are transferred to cytochrome c or to the outer side of the membrane. Plants use '''cytochrome b6f''' in the same manner binding plastoquinol as a hydrogen carrier. Stigmatellin inhibits the Cbc1 electron transfer by binding to its quinone oxidation site. Antimycin inhibits Cbc1 by binding to its quinone reduction site.<ref>PMID:14977419</ref>		'''Cytochrome bc1''' (Cbc1) functions as the central pump which transfers protons across the cell membrane. The protons are used to power the rotation of ATP synthase. Cbc1 binds ubiquinol which carries hydrogen atoms. Cbc1 separates the protons and the electrons. The protons are released in the inner side of the membrane for use by ATP synthase and the electrons are transferred to cytochrome c or to the outer side of the membrane. Plants use '''cytochrome b6f''' in the same manner binding plastoquinol as a hydrogen carrier. Stigmatellin inhibits the Cbc1 electron transfer by binding to its quinone oxidation site. Antimycin inhibits Cbc1 by binding to its quinone reduction site.<ref>PMID:14977419</ref>