Defensin - Revision history

Michal Harel at 07:59, 13 June 2024

2024-06-13T07:59:07Z

← Older revision		Revision as of 07:59, 13 June 2024
Line 4:		Line 4:

	'''Defensins''' (DEF) are small cationic defense proteins active against bacteria, fungi and viruses. DEF are found in cells of the immune system. DEF binds to microbial cell membrane forming pores and thus allowing outflow of essential nutrients thus killing them.<ref>PMID:8528769</ref> For details on plant DEF see [[Plant defensin]]. '''Alpha-, beta- and theta-defensins''' are classified according to their invariant Cys-Cys spacings and the topology of the disulphide bridges.		'''Defensins''' (DEF) are small cationic defense proteins active against bacteria, fungi and viruses. DEF are found in cells of the immune system. DEF binds to microbial cell membrane forming pores and thus allowing outflow of essential nutrients thus killing them.<ref>PMID:8528769</ref> For details on plant DEF see [[Plant defensin]]. '''Alpha-, beta- and theta-defensins''' are classified according to their invariant Cys-Cys spacings and the topology of the disulphide bridges.
	*'''alpha defensins''' are antibiotic peptides produced in the Paneth cells of the small intestines defending against pathogens<ref>PMID:24246978</ref> .		*'''alpha defensins''' are antibiotic peptides produced in the Paneth cells of the small intestines defending against pathogens<ref>PMID:24246978</ref>.
			*'''theta defensins''' are cyclic antibiotic peptides <ref>PMID:15544531</ref>.

	== Relevance ==		== Relevance ==

Michal Harel at 07:56, 13 June 2024

2024-06-13T07:56:28Z

← Older revision		Revision as of 07:56, 13 June 2024
Line 3:		Line 3:
	== Function ==		== Function ==

	'''Defensins''' (DEF) are small cationic defense proteins active against bacteria, fungi and viruses. DEF are found in cells of the immune system. DEF binds to microbial cell membrane forming pores and thus allowing outflow of essential nutrients thus killing them.<ref>PMID:8528769</ref> For details on plant DEF see [[Plant defensin]].		'''Defensins''' (DEF) are small cationic defense proteins active against bacteria, fungi and viruses. DEF are found in cells of the immune system. DEF binds to microbial cell membrane forming pores and thus allowing outflow of essential nutrients thus killing them.<ref>PMID:8528769</ref> For details on plant DEF see [[Plant defensin]]. '''Alpha-, beta- and theta-defensins''' are classified according to their invariant Cys-Cys spacings and the topology of the disulphide bridges.
	*'''alpha defensins''' are antibiotic peptides produced in the Paneth cells of the small intestines defending against pathogens<ref>PMID:24246978</ref> .		*'''alpha defensins''' are antibiotic peptides produced in the Paneth cells of the small intestines defending against pathogens<ref>PMID:24246978</ref> .

Michal Harel at 07:46, 13 June 2024

2024-06-13T07:46:38Z

← Older revision		Revision as of 07:46, 13 June 2024
Line 4:		Line 4:

	'''Defensins''' (DEF) are small cationic defense proteins active against bacteria, fungi and viruses. DEF are found in cells of the immune system. DEF binds to microbial cell membrane forming pores and thus allowing outflow of essential nutrients thus killing them.<ref>PMID:8528769</ref> For details on plant DEF see [[Plant defensin]].		'''Defensins''' (DEF) are small cationic defense proteins active against bacteria, fungi and viruses. DEF are found in cells of the immune system. DEF binds to microbial cell membrane forming pores and thus allowing outflow of essential nutrients thus killing them.<ref>PMID:8528769</ref> For details on plant DEF see [[Plant defensin]].
			*'''alpha defensins''' are antibiotic peptides produced in the Paneth cells of the small intestines defending against pathogens<ref>PMID:24246978</ref> .

	== Relevance ==		== Relevance ==

Michal Harel at 10:11, 4 June 2019

2019-06-04T10:11:05Z

@@ Line 21: / Line 21: @@
 </StructureSection>
 == References ==
 <references/>
 [[Category:Topic Page]]

Michal Harel at 10:09, 4 June 2019

2019-06-04T10:09:56Z

← Older revision		Revision as of 10:09, 4 June 2019
Line 16:		Line 16:

	DEF contains <scene name='50/509378/Cv/5'>6-8 conserved cysteine residues</scene>.		DEF contains <scene name='50/509378/Cv/5'>6-8 conserved cysteine residues</scene>.

			==3D structures of defensin==
			[[Defensin 3D structures]]

	</StructureSection>		</StructureSection>
	==3D structures of defensin==		==3D structures of defensin==
Line 50:		Line 54:
	**[[1kj6]] – hDEFB3 – NMR<BR />		**[[1kj6]] – hDEFB3 – NMR<BR />
	**[[5ki9]] – hDEFB4<br />		**[[5ki9]] – hDEFB4<br />
			**[[6cs9]] – hDEFB4A + PIP2<br />
	**[[1e4t]] – mDEFB7 – NMR<BR />		**[[1e4t]] – mDEFB7 – NMR<BR />
	**[[1e4r]] - mDEFB8 – NMR<BR />		**[[1e4r]] - mDEFB8 – NMR<BR />
Line 63:		Line 68:
	**[[3lo9]] – hDEF1 (mutant)<br />		**[[3lo9]] – hDEF1 (mutant)<br />
	**[[5nce]] – DEF1 – pine - NMR<br />		**[[5nce]] – DEF1 – pine - NMR<br />
			**[[6b9w]], [[6bam]], [[6bb6]], [[6bi5]] – DEF1 – mexican scorpion - NMR<br />

	*Defensin-2		*Defensin-2

	**[[2gl1]] – VrDEF2 - ''Vigna radiata''<br />		**[[2gl1]] – VrDEF2 - ''Vigna radiata''<br />

			*Defensin-4

			**[[6dmm]], [[6dmq]] – hDEF4 (mutant)<br />

	*Defensin-5		*Defensin-5
Line 97:		Line 107:
	**[[2lj7]] – DEF – lentil – NMR<br />		**[[2lj7]] – DEF – lentil – NMR<br />
	**[[2lr3]] – DEF – barrel medic – NMR<br />		**[[2lr3]] – DEF – barrel medic – NMR<br />
			**[[6mry]] - DEF NOD173 – ''Nicotiana occidentalis''<br />
			**[[6b55]] - DEF – ''Nicotiana alata''<br />
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Alexander Berchansky at 10:53, 21 February 2019

2019-02-21T10:53:17Z

← Older revision		Revision as of 10:53, 21 February 2019
Line 15:		Line 15:
	== Structural highlights ==		== Structural highlights ==

	DEF contains <scene name='50/509378/Cv/2'>6-8 conserved cysteine residues</scene>.		DEF contains <scene name='50/509378/Cv/5'>6-8 conserved cysteine residues</scene>.
	</StructureSection>		</StructureSection>
	==3D structures of defensin==		==3D structures of defensin==

Michal Harel at 09:25, 23 April 2018

2018-04-23T09:25:57Z

← Older revision		Revision as of 09:25, 23 April 2018
Line 49:		Line 49:
	**[[2lg6]] - cDEFB2 (mutant) – NMR<BR />		**[[2lg6]] - cDEFB2 (mutant) – NMR<BR />
	**[[1kj6]] – hDEFB3 – NMR<BR />		**[[1kj6]] – hDEFB3 – NMR<BR />
			**[[5ki9]] – hDEFB4<br />
	**[[1e4t]] – mDEFB7 – NMR<BR />		**[[1e4t]] – mDEFB7 – NMR<BR />
	**[[1e4r]] - mDEFB8 – NMR<BR />		**[[1e4r]] - mDEFB8 – NMR<BR />
Line 56:		Line 57:

	**[[1hvz]] – RmDEF1 – NMR<BR />		**[[1hvz]] – RmDEF1 – NMR<BR />
			**[[5inz]] – DEF2 - baboon<br />

	*~~Other defensins~~		*Defensin-1

	**[[1dfn]] – hDEF HNP-3 <BR />
	**[[3lo9]] – hDEF1 (mutant)<br />		**[[3lo9]] – hDEF1 (mutant)<br />
			**[[5nce]] – DEF1 – pine - NMR<br />

			*Defensin-2

			**[[2gl1]] – VrDEF2 - ''Vigna radiata''<br />

			*Defensin-5

	**[[5cui]], [[5cuj]], [[5cum]] – hDEF5 (mutant)<br />		**[[5cui]], [[5cuj]], [[5cum]] – hDEF5 (mutant)<br />
	**[[2mit]] – hDEF5 – NMR<br />		**[[2mit]] – hDEF5 – NMR<br />
	**[[4rbw]], [[4rbx]] – hDEF5 (mutant) – NMR<br />		**[[4rbw]], [[4rbx]] – hDEF5 (mutant) – NMR<br />
			**[[2ksk]] – DEF5 – Sugarcane – NMR<br />

			*Defensin


			*Other defensins

			**[[1dfn]] – hDEF HNP-3 <BR />
	**[[1fjn]] – DEF MGD-1 – Mediterranean mussel<BR />		**[[1fjn]] – DEF MGD-1 – Mediterranean mussel<BR />
	**[[1mr4]] – tDEF NAD1 – tobacco – NMR<BR />		**[[1mr4]] – tDEF NAD1 – tobacco – NMR<BR />
	**[[4aaz]], [[4ab0]] - tDEF NAD1<BR />		**[[4aaz]], [[4ab0]] - tDEF NAD1<BR />
	**[[4cqk]] - tDEF NAD1 + ligand<br />		**[[4cqk]] - tDEF NAD1 + ligand<br />
			**[[5vyp]] - tDEF NSD7<br />
			**[[5kk4]] - tDEF NSD7 + phosphatidic acid<br />
	**[[1ozz]] – AdDEF ARD1 – ''Archaeoprepona demophon'' – NMR<BR />		**[[1ozz]] – AdDEF ARD1 – ''Archaeoprepona demophon'' – NMR<BR />
	**[[1p00]], [[1p0a]] - AdDEF ARD1 (mutant) – NMR<BR />		**[[1p00]], [[1p0a]] - AdDEF ARD1 (mutant) – NMR<BR />
	**[[1ti5]] - VrDEF ~~– ''Vigna radiata''~~ – NMR~~<BR />~~		**[[1ti5]] - VrDEF – NMR<BR />
	**[[2gl1]] – VrDEF2<BR />
	**[[2b68]] - DEF – Pacific oyster – NMR<BR />		**[[2b68]] - DEF – Pacific oyster – NMR<BR />
	**[[2b5b]] - DEF – Loggerhead turtle – NMR<BR />		**[[2b5b]] - DEF – Loggerhead turtle – NMR<BR />
Line 77:		Line 95:
	**[[2rng]] - DEF – Horseshoe crab – NMR<BR />		**[[2rng]] - DEF – Horseshoe crab – NMR<BR />
	**[[3psm]] – DEF – Potato bean<BR />		**[[3psm]] – DEF – Potato bean<BR />
	**[[2ksk]] – DEF5 – Sugarcane - NMR<BR />
	**[[2lj7]] – DEF – lentil – NMR<br />		**[[2lj7]] – DEF – lentil – NMR<br />
	**[[2lr3]] – DEF – barrel medic – NMR<br />		**[[2lr3]] – DEF – barrel medic – NMR<br />

Michal Harel at 10:19, 12 April 2017

2017-04-12T10:19:33Z

← Older revision		Revision as of 10:19, 12 April 2017
Line 61:		Line 61:
	**[[1dfn]] – hDEF HNP-3 <BR />		**[[1dfn]] – hDEF HNP-3 <BR />
	**[[3lo9]] – hDEF1 (mutant)<br />		**[[3lo9]] – hDEF1 (mutant)<br />
			**[[5cui]], [[5cuj]], [[5cum]] – hDEF5 (mutant)<br />
	**[[2mit]] – hDEF5 – NMR<br />		**[[2mit]] – hDEF5 – NMR<br />
			**[[4rbw]], [[4rbx]] – hDEF5 (mutant) – NMR<br />
	**[[1fjn]] – DEF MGD-1 – Mediterranean mussel<BR />		**[[1fjn]] – DEF MGD-1 – Mediterranean mussel<BR />
	**[[1mr4]] – tDEF NAD1 – tobacco – NMR<BR />		**[[1mr4]] – tDEF NAD1 – tobacco – NMR<BR />

Michal Harel at 08:05, 1 September 2016

2016-09-01T08:05:55Z

← Older revision		Revision as of 08:05, 1 September 2016
Line 7:		Line 7:
	== Relevance ==		== Relevance ==

	There is increase in α-DEF in chronic inflammations and several cancers. DEF-mimetics are developed as antibiotics.		There is increase in α-DEF in chronic inflammations and several cancers. DEF-mimetics are developed as antibiotics<ref>PMID:2997278</ref>.

	== Disease ==		== Disease ==

	Overexpression of α-defensin is seen in chronic inflammation, several cancers and in T-cells of schizophrenia patients.		Overexpression of α-defensin is seen in chronic inflammation, several cancers and in T-cells of schizophrenia patients<ref>PMID:25265350</ref>.

	== Structural highlights ==		== Structural highlights ==

Alexander Berchansky at 11:03, 28 December 2015

2015-12-28T11:03:42Z

← Older revision		Revision as of 11:03, 28 December 2015
Line 1:		Line 1:
	<StructureSection load='2pm4' size='350' side='right' caption='Human α-defensin 1 (PDB entry [[2pm4]])' scene='50/509378/Cv/1'>		<StructureSection load='2pm4' size='350' side='right' caption='Human α-defensin 1 (PDB entry [[2pm4]])' scene='50/509378/Cv/4'>
	__TOC__		__TOC__
	== Function ==		== Function ==