Dual specificity phosphatase 3D structures - Revision history

Michal Harel at 09:44, 30 April 2025

2025-04-30T09:44:40Z

← Older revision		Revision as of 09:44, 30 April 2025
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	**[[6apx]] – hDUSP 1 (mutant)/MBP + monobody<br />		**[[6apx]] – hDUSP 1 (mutant)/MBP + monobody<br />
	**[[6d65]] – hDUSP 1 (mutant)/MBP + off7<br />		**[[6d65]] – hDUSP 1 (mutant)/MBP + off7<br />
	**[[3f81]] – hDUSP 3 + inhibitor <br />		**[[8tk4]], [[8tk5]], [[8tk6]], [[9dj9]] – hDUSP 3 <br />
			**[[3f81]], [[8tk2]], [[8tk3]] – hDUSP 3 + inhibitor <br />
	**[[1j4x]] – hDUSP 3 (mutant) + peptide<br />		**[[1j4x]] – hDUSP 3 (mutant) + peptide<br />
	**[[4y2e]] – hDUSP 7 catalytic domain (mutant) <br />		**[[4y2e]] – hDUSP 7 catalytic domain (mutant) <br />
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	*Cdc25		*Cdc25

			**[[8roz]] – hCdc25A catalytic domain + CDK2 + cyclin A2 – Cryo EM<br />
	**[[1qb0]], [[1cwr]], [[1cws]], [[1cwt]], [[1ym9]], [[1ymd]], [[1ymk]], [[1yml]], [[1ys0]], [[2uzq]] – hCdc25B catalytic domain <br />		**[[1qb0]], [[1cwr]], [[1cws]], [[1cwt]], [[1ym9]], [[1ymd]], [[1ymk]], [[1yml]], [[1ys0]], [[2uzq]] – hCdc25B catalytic domain <br />
	**[[2a2k]], [[2ifd]], [[2ifv]] – hCdc25B catalytic domain (mutant)<br />		**[[2a2k]], [[2ifd]], [[2ifv]] – hCdc25B catalytic domain (mutant)<br />

Michal Harel at 10:33, 7 February 2023

2023-02-07T10:33:00Z

← Older revision		Revision as of 10:33, 7 February 2023
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	**[[2gwo]], [[2pq5]] – hDUSP 13<br />		**[[2gwo]], [[2pq5]] – hDUSP 13<br />
	**[[5xjv]] – hDUSP 13A (mutant) <br />		**[[5xjv]] – hDUSP 13A (mutant) <br />
			**[[2wgp]] – hDUSP 14<br />
			**[[1yz4]] – hDUSP 15 catalytic domain (mutant) <br />
			**[[2vsw]] – hDUSP 16 rhodanese domain<br />
	**[[2esb]] – hDUSP 18<br />		**[[2esb]] – hDUSP 18<br />
	**[[3s4e]] – hDUSP 19<br />		**[[3s4e]] – hDUSP 19<br />
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	**[[2q05]], [[2rf6]], [[3cm3]] – DUSP – Vaccinia virus<br />		**[[2q05]], [[2rf6]], [[3cm3]] – DUSP – Vaccinia virus<br />
	**[[2p4d]] – DUSP – Variola virus<br />		**[[2p4d]] – DUSP – Variola virus<br />
			**[[7ncy]] – DUSP – Sulfolobales beppu filamentous virus<br />

	*Slingshot phosphatase (SSH)		*Slingshot phosphatase (SSH)
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	**[[1qb0]], [[1cwr]], [[1cws]], [[1cwt]], [[1ym9]], [[1ymd]], [[1ymk]], [[1yml]], [[1ys0]], [[2uzq]] – hCdc25B catalytic domain <br />		**[[1qb0]], [[1cwr]], [[1cws]], [[1cwt]], [[1ym9]], [[1ymd]], [[1ymk]], [[1yml]], [[1ys0]], [[2uzq]] – hCdc25B catalytic domain <br />
	**[[2a2k]], [[2ifd]], [[2ifv]] – hCdc25B catalytic domain (mutant)<br />		**[[2a2k]], [[2ifd]], [[2ifv]] – hCdc25B catalytic domain (mutant)<br />
			**[[4wh7]] – hCdc25B catalytic domain (mutant) + ligand<br />
			**[[4wh9]] – hCdc25B catalytic domain (mutant) + inhibitor<br />
			**[[3op3]] – hCdc25C <br />
	**[[1t3k]] – Cdc25 – ''Arabidopsis thaliana'' - NMR<br />		**[[1t3k]] – Cdc25 – ''Arabidopsis thaliana'' - NMR<br />

Michal Harel at 09:04, 11 July 2021

2021-07-11T09:04:34Z

← Older revision		Revision as of 09:04, 11 July 2021
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	**[[4y2e]] – hDUSP 7 catalytic domain (mutant) <br />		**[[4y2e]] – hDUSP 7 catalytic domain (mutant) <br />
	**[[2hxp]] – hDUSP 9<br />		**[[2hxp]] – hDUSP 9<br />
			**[[4jmj]], [[4mbb]], [[4nyh]] – hDUSP 11 (mutant) or RNA/RNP complex-1 interacting phosphatase<br />
	**[[4jnb]], [[4ki9]] – hDUSP 12<br />		**[[4jnb]], [[4ki9]] – hDUSP 12<br />
	**[[2gwo]], [[2pq5]] – hDUSP 13<br />		**[[2gwo]], [[2pq5]] – hDUSP 13<br />

Michal Harel at 08:56, 11 July 2021

2021-07-11T08:56:58Z

← Older revision		Revision as of 08:56, 11 July 2021
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	{{#tree:id=OrganizedByTopic\|openlevels=0\|		{{#tree:id=OrganizedByTopic\|openlevels=0\|

	*Dual specificity phosphatase		* Dual specificity phosphatase

	**[[4y2e]] – hDUSP 7 catalytic domain (mutant) ~~- human~~<br />		**[[6d66]], [[6d67]] – hDUSP 1 (mutant)/MBP - human<br />
			**[[6apx]] – hDUSP 1 (mutant)/MBP + monobody<br />
			**[[6d65]] – hDUSP 1 (mutant)/MBP + off7<br />
			**[[3f81]] – hDUSP 3 + inhibitor <br />
			**[[1j4x]] – hDUSP 3 (mutant) + peptide<br />
			**[[4y2e]] – hDUSP 7 catalytic domain (mutant) <br />
			**[[2hxp]] – hDUSP 9<br />
			**[[4jnb]], [[4ki9]] – hDUSP 12<br />
			**[[2gwo]], [[2pq5]] – hDUSP 13<br />
	**[[5xjv]] – hDUSP 13A (mutant) <br />		**[[5xjv]] – hDUSP 13A (mutant) <br />
	**[[~~4yr8~~]] – hDUSP ~~16 residues 156-301 + MAPK 8~~<br />		**[[2esb]] – hDUSP 18<br />
			**[[3s4e]] – hDUSP 19<br />
			**[[4d3p]], [[4d3q]], [[4d3r]] – hDUSP 19 (mutant)<br />
			**[[1wrm]], [[6lvq]] – hDUSP 22<br />
			**[[6l1s]], [[6lmy]], [[6lot]], [[6lou]], [[7c8s]] – hDUSP 22 (mutant) <br />
	**[[4woh]] – hDUSP 22 (mutant) + nitrophenolphosphate<br />		**[[4woh]] – hDUSP 22 (mutant) + nitrophenolphosphate<br />
	**[[5gtj]] – hDUSP 26 (mutant) <br />		**[[4erc]] – hDUSP 23 + metavanadate<br />
			**[[2img]] – hDUSP 23 + malate<br />
			**[[2e0t]], [[4hrf]] – hDUSP 26<br />
			**[[4b04]], [[5gtj]] – hDUSP 26 (mutant) <br />
			**[[2y96]] – hDUSP 27<br />
	**[[5y15]], [[5y16]] – hDUSP 28 (mutant) <br />		**[[5y15]], [[5y16]] – hDUSP 28 (mutant) <br />

			* hDUSP 5 see [[MAP kinase phosphatase]] MKP-3<br />
			* hDUSP 10 see [[MAP kinase phosphatase]] MKP-5<br />
			* hDUSP 14 see [[MAP kinase phosphatase]] MKP-6<br />
			* hDUSP 16 see [[MAP kinase phosphatase]] MKP-7<br />

			* Viral dual specificity phosphatase

			**[[2q05]], [[2rf6]], [[3cm3]] – DUSP – Vaccinia virus<br />
			**[[2p4d]] – DUSP – Variola virus<br />

	*Slingshot phosphatase (SSH)		*Slingshot phosphatase (SSH)
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	**[[1xm2]] – hPRL-1 (mutant)<br />		**[[1xm2]] – hPRL-1 (mutant)<br />
	**[[5bx1]] – hPRL-1 + inhibitor<br />		**[[5bx1]] – hPRL-1 + inhibitor<br />
			**[[5k25]], [[5k23]] – hPRL-2 + magnesium transporter<br />
			**[[5k22]], [[6wur]] – hPRL-2 (mutant) + magnesium transporter<br />
			**[[1r6h]], [[1v3a]], [[2mbc]] – hPRL-3 - NMR<br />
			**[[5tsr]] – hPRL-3 + magnesium transporter<br />
	**[[1zck]], [[1x24]] – rPRL-1 - rat<br />		**[[1zck]], [[1x24]] – rPRL-1 - rat<br />
	**[[1zcl]] – rPRL-1 (mutant)<br />		**[[1zcl]] – rPRL-1 (mutant)<br />
	**[[3rz2]] – rPRL-1 + peptide<br />		**[[3rz2]] – rPRL-1 + peptide<br />
	**[[5mmz]], [[5lxq~~]] – mPRL-1 + magnesium transporter - mouse<br />~~		**[[5mmz]], [[5lxq]], [[6wus]] – mPRL-1 + magnesium transporter - mouse<br />
	**[[5k25]], [[~~5k23~~]] – ~~hPRL~~-2 + magnesium transporter~~<br />~~
	**[[5k22]] – hPRL-~~2 (mutant) + magnesium transporter~~<br />
	**[[5k24]] – mPRL-2 + magnesium transporter<br />		**[[5k24]] – mPRL-2 + magnesium transporter<br />
	**[[1r6h]], [[1v3a]], [[2mbc]] – hPRL-3 - NMR<br />
	**[[5tsr]] – hPRL-3 + magnesium transporter<br />

	*Cdc14		*Cdc14

Michal Harel at 10:21, 19 July 2020

2020-07-19T10:21:11Z

← Older revision		Revision as of 10:21, 19 July 2020
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	**[[3rz2]] – rPRL-1 + peptide<br />		**[[3rz2]] – rPRL-1 + peptide<br />
	**[[5mmz]], [[5lxq]] – mPRL-1 + magnesium transporter - mouse<br />		**[[5mmz]], [[5lxq]] – mPRL-1 + magnesium transporter - mouse<br />
	**[[5k24]] – mPRL-2 + magnesium transporter<br />
	**[[5k25]], [[5k23]] – hPRL-2 + magnesium transporter<br />		**[[5k25]], [[5k23]] – hPRL-2 + magnesium transporter<br />
	**[[5k22]] – hPRL-2 (mutant) + magnesium transporter<br />		**[[5k22]] – hPRL-2 (mutant) + magnesium transporter<br />
			**[[5k24]] – mPRL-2 + magnesium transporter<br />
	**[[1r6h]], [[1v3a]], [[2mbc]] – hPRL-3 - NMR<br />		**[[1r6h]], [[1v3a]], [[2mbc]] – hPRL-3 - NMR<br />
	**[[5tsr]] – hPRL-3 + magnesium transporter<br />		**[[5tsr]] – hPRL-3 + magnesium transporter<br />

Michal Harel at 07:43, 18 June 2019

2019-06-18T07:43:47Z

← Older revision		Revision as of 07:43, 18 June 2019
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	**[[2nt2]] – hSSH-2L catalytic domain - human<br />		**[[2nt2]] – hSSH-2L catalytic domain - human<br />

	*Phosphatase of regenerating liver (PRL)		*Phosphatase of regenerating liver (PRL) or protein tyrosine phosphatase type IVA

			**[[1rxd]] – hPRL-1 <br />
	**[[1xm2]] – hPRL-1 (mutant)<br />		**[[1xm2]] – hPRL-1 (mutant)<br />
			**[[5bx1]] – hPRL-1 + inhibitor<br />
	**[[1zck]], [[1x24]] – rPRL-1 - rat<br />		**[[1zck]], [[1x24]] – rPRL-1 - rat<br />
	**[[1zcl]] – rPRL-1 (mutant)<br />		**[[1zcl]] – rPRL-1 (mutant)<br />
			**[[3rz2]] – rPRL-1 + peptide<br />
			**[[5mmz]], [[5lxq]] – mPRL-1 + magnesium transporter - mouse<br />
			**[[5k24]] – mPRL-2 + magnesium transporter<br />
			**[[5k25]], [[5k23]] – hPRL-2 + magnesium transporter<br />
			**[[5k22]] – hPRL-2 (mutant) + magnesium transporter<br />
	**[[1r6h]], [[1v3a]], [[2mbc]] – hPRL-3 - NMR<br />		**[[1r6h]], [[1v3a]], [[2mbc]] – hPRL-3 - NMR<br />
			**[[5tsr]] – hPRL-3 + magnesium transporter<br />

	*Cdc14		*Cdc14
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	**[[1ohc]], [[1ohd]] – hCdc14B2 core domain <br />		**[[1ohc]], [[1ohd]] – hCdc14B2 core domain <br />
	**[[1ohe]] – hCdc14B2 core domain + peptide<br />		**[[1ohe]] – hCdc14B2 core domain + peptide<br />
			**[[6g86]] – hCdc14 + SIC1 peptide<br />
			**[[6g85]], [[6g84]] – hCdc14 + CBK1 peptide<br />
			**[[5xw5]] – hCdc14 + SWI6P peptide<br />
			**[[5xw4]] – yCdc14 - yeast<br />
			**[[4zj7]] – yCdc14 C-terminal + importin<br />

	*Cdc25		*Cdc25
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	**[[1qb0]], [[1cwr]], [[1cws]], [[1cwt]], [[1ym9]], [[1ymd]], [[1ymk]], [[1yml]], [[1ys0]], [[2uzq]] – hCdc25B catalytic domain <br />		**[[1qb0]], [[1cwr]], [[1cws]], [[1cwt]], [[1ym9]], [[1ymd]], [[1ymk]], [[1yml]], [[1ys0]], [[2uzq]] – hCdc25B catalytic domain <br />
	**[[2a2k]], [[2ifd]], [[2ifv]] – hCdc25B catalytic domain (mutant)<br />		**[[2a2k]], [[2ifd]], [[2ifv]] – hCdc25B catalytic domain (mutant)<br />
			**[[1t3k]] – Cdc25 – ''Arabidopsis thaliana'' - NMR<br />

	*Phosphoinositide phosphatase PTEN		*Phosphoinositide phosphatase PTEN

	**[[1d5r]], [[5bzz]], [[5bzx]], [[5bug]] – hPTEN (mutant)<br />		**[[1d5r]], [[5bzz]], [[5bzx]], [[5bug]] – hPTEN (mutant)<br />

			*Phosphoinositide phosphatase Sac1

			**[[3lwt]] – ySac1<br />
			**[[4tu3]] – ySac1 + VPS74<br />

			*Phosphoinositide phosphatase Sac2

			**[[4xuu]] – hSac2 residues 169-563<br />

	*Myotubularin-related protein (MTMR)		*Myotubularin-related protein (MTMR)
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	**[[1m7r]], [[1lw3]] - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphate<br />		**[[1m7r]], [[1lw3]] - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphate<br />
	**[[2yf0]] – hMTMR6<br />		**[[2yf0]] – hMTMR6<br />

			*Myotubularin-related protein 15 (MTMR15) or Fanconi-associated nuclease 1

			**[[4rid]], [[4ry3]] – hMTMR15 residues 370-1009<br />
			**[[4rec]], [[4ri8]], [[4ri9]], [[4ria]], [[4rib]], [[4ric]], [[4reb]], [[4rea]] – hMTMR15 (mutant) + DNA<br />

	*MAPK phosphatase see [[MAP kinase phosphatase]]		*MAPK phosphatase see [[MAP kinase phosphatase]]

Michal Harel: New page: ==3D structures of dual specificity phosphatase== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *Dual specificity...

2019-06-17T09:12:18Z

New page: ==3D structures of dual specificity phosphatase== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *Dual specificity...

New page

==3D structures of dual specificity phosphatase==

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|

*Dual specificity phosphatase

**[[4y2e]] – hDUSP 7 catalytic domain (mutant) - human 
**[[5xjv]] – hDUSP 13A (mutant) 
**[[4yr8]] – hDUSP 16 residues 156-301 + MAPK 8 
**[[4woh]] – hDUSP 22 (mutant) + nitrophenolphosphate 
**[[5gtj]] – hDUSP 26 (mutant) 
**[[5y15]], [[5y16]] – hDUSP 28 (mutant) 

*Slingshot phosphatase (SSH)

**[[2nt2]] – hSSH-2L catalytic domain - human 

*Phosphatase of regenerating liver (PRL)

**[[1xm2]] – hPRL-1 (mutant) 
**[[1zck]], [[1x24]] – rPRL-1 - rat 
**[[1zcl]] – rPRL-1 (mutant) 
**[[1r6h]], [[1v3a]], [[2mbc]] – hPRL-3 - NMR 

*Cdc14

**[[1ohc]], [[1ohd]] – hCdc14B2 core domain 
**[[1ohe]] – hCdc14B2 core domain + peptide 

*Cdc25

**[[1qb0]], [[1cwr]], [[1cws]], [[1cwt]], [[1ym9]], [[1ymd]], [[1ymk]], [[1yml]], [[1ys0]], [[2uzq]] – hCdc25B catalytic domain 
**[[2a2k]], [[2ifd]], [[2ifv]] – hCdc25B catalytic domain (mutant) 

*Phosphoinositide phosphatase PTEN

**[[1d5r]], [[5bzz]], [[5bzx]], [[5bug]] – hPTEN (mutant) 

*Myotubularin-related protein (MTMR)

**[[1zvr]] – hMTMR2 PH-gram and phosphatase domains (mutant) 
**[[1zsq]] - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphatidylinositol 3-phosphate 
**[[1m7r]], [[1lw3]] - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphate 
**[[2yf0]] – hMTMR6 

*MAPK phosphatase see [[MAP kinase phosphatase]]
}}

[[Category:Topic Page]]