FKBP 3D structures - Revision history

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← Older revision		Revision as of 08:17, 29 July 2020
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	See [[Peptidyl-prolyl cis-trans isomerase]]		See [[Peptidyl-prolyl cis-trans isomerase]]
	}}		}}
			[[Category: Topic Page]]

Michal Harel: New page: == 3D Structures of FKBP == Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *FKBP **1fkr, 1fks, 1fkt ...

2020-07-29T08:16:03Z

New page: == 3D Structures of FKBP == Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *FKBP **1fkr, 1fks, 1fkt ...

New page

== 3D Structures of FKBP ==

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|

*FKBP

**[[1fkr]], [[1fks]], [[1fkt]] – hFKBP - human - NMR 
**[[1bl4]] – hFKBP (mutant)+inhibitor 
**[[1bkf]] – hFKBP (mutant)+FK-506 
**[[1fkf]] - hFKBP+FK-506 
**[[1fks]], [[1fkr]], [[1fkt]] – EcFKBP – ''Escherichia coli'' 
**[[1q6h]], [[1q6u]] – EcFKBP 
**[[1q6i]] – EcFKBP+FK-506 
**[[1ix5]] – FKBP – ''Methanothermococcus thermolithotrophicus'' – NMR 

*FKBP1

**[[4n19]] - hFKBP-1A (mutant) 
**[[3mdy]] – hFKBP-1A + BMPR1B 
**[[3h9r]], [[6i1s]] - hFKBP-1A+ activin receptor type I 
**[[1j4r]] – hFKBP-1+FKB-001 
**[[4dh0]] - hFKBP-1A+ rapamycin 
**[[6oqa]] - hFKBP-1A+ CEP250 
**[[4iq2]], [[4iqc]] - hFKBP-1B (mutant) 
**[[4c02]] - hFKBP-1B+ activin receptor type I 

*FKBP3

**[[3kz7]] – hFKBP FK506-binding domain + immunosuppressant - human

*FKBP4; Domains – FK1 or FK506-binding 1-148

**[[1q1c]], [[4lav]], [[4law]] – hFKBP 
**[[1n1a]] – hFKBP N terminal 
**[[1p5q]] - hFKBP C terminal 
**[[6rcy]] – hFKBP FK1 domain 
**[[1qz2]] – hFKBP + Hsp90 peptide 
**[[4drj]] – hFKBP FK1 + serine/threonine-protein kinase FRB domain + Immunospressant 

*FKBP5

**[[3o5d]], [[3o5e]], [[3o5f]], [[5omp]], [[5obk]] – hFKBP 
**[[3o5g]], [[3o5i]], [[3o5j]], [[3o5k]] - hFKBP FK1 domain 
**[[3o5l]], [[3o5m]], [[3o5o]], [[3o5p]], [[3o5q]] - hFKBP FK1 domain (mutant) 
**[[6tx4]] – hFKBP FK1 domain + pyridone 
**[[6tx6]] – hFKBP FK1 domain + nicotinamide 
**[[6tx5]], [[6tx8]] – hFKBP FK1 domain (mutant) + imidazole derivative 
**[[6tx7]] – hFKBP FK1 domain (mutant) + piperidone derivative 
**[[6tx9]] – hFKBP FK1 domain (mutant) + hydantoin derivative 
**[[6saf]], [[6txx]] – hFKBP FK1 domain (mutant) + ligand 
**[[4lax]] – hFKBP + FK506 
**[[4lay]] – hFKBP + I63 
**[[3o5r]] - hFKBP FK1 domain (mutant) + immunosuppressant 
**[[4drq]] – hFKBP + pipecolate sulfonamide 
**[[4drk]], [[4drm]], [[4drn]], [[4dro]], [[4drp]] – hFKBP FK1 domain + FK506 analog 
**[[5njx]] – hFKBP + Hsp90 peptide 

*FKBP8

**[[2f2d]], [[3ey6]], [[2awg]] - hFKBP FK506-binding domain 
**[[2d9f]] – hFKBP – NMR 
**[[2mf9]] – hFKBP N terminal 58-206 – NMR 

*FKBP12

**[[1fkk]], [[2ppp]], [[2ppn]], [[2dg3]], [[1d6o]] – hFKBP 
**[[1eym]], [[2ppo]], [[4ipx]] – hFKBP (mutant) 
**[[2gaq]], [[2pnu]] – hFKBP - NMR 
**[[3uqi]] – ymFKBP – yellowfever mosquito 
**[[2lpv]] – ymFKBP - NMR 
**[[5ht1]] – CgFKBP – ''Candida glabrata'' 
**[[5htg]], [[5hw6]], [[5hw7]] – CaFKBP – ''Candida albicans'' 
**[[5i98]] – CaFKBP (mutant) 
**[[5hwb]] – NfFKBP – ''Neosartorya fumigata'' 
**[[5j6e]] – NfFKBP (mutant) 

*FKBP12 complex

**[[1fkd]], [[1fkj]], [[2fke]], [[1qpf]], [[1qpl]] – hFKBP + immunosuppressant 
**[[1j4h]], [[1j4i]] – hFKBP + inhibitor 
**[[1b6c]] – hFKBP + TGF-B superfamily receptor I 
**[[3fap]] – hFKBP + FKBP12-rapamycin associated protein 
**[[4fap]] - hFKBP + FKBP12-rapamycin associated protein + immunosuppressant 
**[[2dg4]], [[1fkb]], [[1c9h]], [[4dh0]] - hFKBP+rapamycin 
**[[2dg9]] - hFKBP (mutant)+rapamycin 
**[[2fap]], [[1nsg]], [[1fap]] - hFKBP+rapamycin+FRB 
**[[1f40]] – hFKBP +GPI-1046 
**[[1a7x]] – hFKBP +FK-1012 
**[[1d7h]], [[1d7i]], [[1d7j]], [[1fkg]], [[1fkh]], [[1fki]] – hFKBP +ligand 
**[[2rse]] – hFKBP + serine/threonine protein kinase MTOR peptide + rapamycin - NMR 
**[[1tco]] - bFKBP + Ser/Thr phosphatase B2 + immunosuppressant - bovine 
**[[1fkl]] – bFKBP +rapamycin 
**[[1yat]] – FKBP + antagonist – yeast 
**[[5hua]] – CgFKBP + FK506 
**[[5hw8]] – CaFKBP (mutant) + FK506 
**[[6tz6]] – CaFKBP + FK506 + calcineurin B + serine/threonine protein phosphatase 
**[[5hwc]] – NfFKBP (mutant) + FK506 
**[[6tz7]] – NfFKBP + FK506 + calcineurin B + serine/threonine protein phosphatase 
**[[6tz8]] – FKBP + FK506 + calcineurin B + serine/threonine protein phosphatase – ''Cryptococcus neoformans'' 

*FKBP12.6

**[[5hkg]] – hFKBP 

*FKBP13

**[[2pbc]] – hFKBP 
**[[4nnr]] – hFKBP + FK506 
**[[1y0o]], [[1u79]] – AtFKBP - ''Arabidopsis thaliana''

*FKBP14

**[[4dip]], [[4msp]] – hFKBP 

*FKBP22

**[[3b09]] – FKBP N terminal - ''Shewanella'' 

*FKBP25

**[[2mph]] – hFKBP 
**[[2kfv]] – hFKBP N terminal 20-92 
**[[1pbk]] – hFKBP C terminal 
**[[5d75]] – hFKBP + FK506 
**[[5gpg]] – hFKBP FK1 domain + rapamycin + MTOR 

*FKBP26

**[[3pr9]], [[3pra]], [[3prb]], [[3prd]] – FKBP – ''Methanocaldococcus jannaschii''

*FKBP35

**[[2vn1]] – PfFKBP FK1 domain+FK506 
**[[4j4n]] – PfFKBP FK1 domain + antimalarial drug 

*FKBP36

**[[3b7x]] – hFKBP 
**[[5mgx]] – hFKBP + Hsp90 C-terminal 

*FKBP38

**[[2mf9]] - hFKBP N terminal - NMR

*FKBP39

**[[4ca9]] - FKBP N terminal – ''Drosophila melanogaster'' – NMR 

*FKBP42

**[[2f4e]] – AtFKBP N-terminal 
**[[2if4]] – AtFKBP 

*FKBP51

**[[1kt0]], [[1kt1]] – hFKBP 
**[[4r0x]] – hFKBP FK1 domain (mutant) 
**[[4drq]] – hFKBP FK1 domain + pipecolate sulfonamide 
**[[4jfi]], [[4jfj]], [[4jfk]], [[4jfl]], [[4jfm]], [[4tw6]], [[4tw7]], [[4tx0]], [[4w9o]], [[4w9p]], [[4w9q]], [[5dit]], [[5diu]], [[5div]] – hFKBP FK1 domain (mutant) + inhibitor 
**[[5bxj]] – hFKBP FK1 domain (mutant) + nitrophenol 
**[[4tw8]] – hFKBP FK1+FK2 domains (mutant) + inhibitor 
**[[4drk]], [[4drm]], [[4drn]], [[4dro]], [[4drp]] – hFKBP FK1 domain + FK506 analog 
**[[4drh]], [[4dri]] – hFKBP FK1 domain + serine/threonine protein kinase MTOR peptide + rapamycin 

*FKBP52

**[[4drj]] – hFKBP FK1 domain + serine/threonine protein kinase MTOR peptide + rapamycin 

*FKBP59

**[[1rot]], [[1rou]] – FKBP N terminal – NMR – rabbit

**[[2lgo]] – FKBP – NMR –'' Giardia lamblia''

*FKBP73

**[[3jym]], [[3jxv]] - FKBP - wheat

*SlyD

See [[Peptidyl-prolyl cis-trans isomerase]]
}}

← Older revision		Revision as of 11:33, 5 March 2023
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	**[[1bkf]] – hFKBP (mutant)+FK-506<br />		**[[1bkf]] – hFKBP (mutant)+FK-506<br />
	**[[1fkf]] - hFKBP+FK-506<br />		**[[1fkf]] - hFKBP+FK-506<br />
			**[[7dki]] – FKBP - silk worm<br />
	**[[1fks]], [[1fkr]], [[1fkt]] – EcFKBP – ''Escherichia coli''<br />		**[[1fks]], [[1fkr]], [[1fkt]] – EcFKBP – ''Escherichia coli''<br />
	**[[1q6h]], [[1q6u]] – EcFKBP<br />		**[[1q6h]], [[1q6u]] – EcFKBP<br />
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	**[[4fap]] - hFKBP + FKBP12-rapamycin associated protein + immunosuppressant<br />		**[[4fap]] - hFKBP + FKBP12-rapamycin associated protein + immunosuppressant<br />
	**[[2dg4]], [[1fkb]], [[1c9h]], [[4dh0]] - hFKBP+rapamycin<br />		**[[2dg4]], [[1fkb]], [[1c9h]], [[4dh0]] - hFKBP+rapamycin<br />
	**[[2dg9]] - hFKBP (mutant)+rapamycin<br />		**[[2dg9]], [[7u8d]] - hFKBP (mutant)+rapamycin<br />
	**[[2fap]], [[1nsg]], [[1fap]] - hFKBP+rapamycin+FRB<br />		**[[2fap]], [[1nsg]], [[1fap]] - hFKBP+rapamycin+FRB<br />
	**[[1f40]] – hFKBP +GPI-1046<br />		**[[1f40]] – hFKBP +GPI-1046<br />
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	**[[1d7h]], [[1d7i]], [[1d7j]], [[1fkg]], [[1fkh]], [[1fki]] – hFKBP +ligand<br />		**[[1d7h]], [[1d7i]], [[1d7j]], [[1fkg]], [[1fkh]], [[1fki]] – hFKBP +ligand<br />
	**[[6vcu]], [[6yf0]], [[6yf1]], [[6yf2]], [[6yf3]] – hFKBP + drug<br />		**[[6vcu]], [[6yf0]], [[6yf1]], [[6yf2]], [[6yf3]] – hFKBP + drug<br />
			**[[8er6]], [[8er7]] – hFKBP + serine/threonine protein kinase 224-317 + inhibitor<br />
	**[[6m4u]] – hFKBP + serine/threonine protein kinase MTOR peptide <br />		**[[6m4u]] – hFKBP + serine/threonine protein kinase MTOR peptide <br />
	**[[2rse]] – hFKBP + serine/threonine protein kinase MTOR peptide + rapamycin - NMR<br />		**[[2rse]] – hFKBP + serine/threonine protein kinase MTOR peptide + rapamycin - NMR<br />
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	**[[1j4r]] – hFKBP + FKB-001<br />		**[[1j4r]] – hFKBP + FKB-001<br />
	**[[6oqa]] - hFKBP+ CEP250<br />		**[[6oqa]] - hFKBP+ CEP250<br />
			**[[7m6a]], [[7m6l]], [[7vmm]], [[7vmn]], [[7vml]], [[7vmo]], [[7vmp]], [[7vmq]], [[7vmr]], [[7vms]], [[7u0s]], [[7u8d]], [[7u9q]], [[7u9r]], [[7u9t]], [[7u9x]], [[7u9z]], [[7ua1]], [[7ua3]], [[7ua4]], [[7ua5]], [[7ua9]] - hFKBP + ryanodine receptor type 2 – Cryo EM<br />
	**[[1tco]] - bFKBP + Ser/Thr phosphatase B2 + immunosuppressant - bovine<br />		**[[1tco]] - bFKBP + Ser/Thr phosphatase B2 + immunosuppressant - bovine<br />
	**[[1fkl]] – bFKBP +rapamycin <br />		**[[1fkl]] – bFKBP +rapamycin <br />
Line 82:		Line 85:

	**[[5hkg]] – hFKBP <br />		**[[5hkg]] – hFKBP <br />
			**[[7t64]], [[7t65]], [[7tzc]] - rFKBP + ryanodine receptor type 1 – Cryo EM<br />

	*FKBP13		*FKBP13
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	**[[1kt0]] – hFKBP (mutant)<br />		**[[1kt0]] – hFKBP (mutant)<br />
	**[[5njx]] – hFKBP + Hsp90 peptide<br />		**[[5njx]] – hFKBP + Hsp90 peptide<br />
			**[[7l7i]] – hFKBP + Hsp90 + P23 – Cryo EM<br />
	**[[3o5d]] – hFKBP FK1+FK2 domains <br />		**[[3o5d]] – hFKBP FK1+FK2 domains <br />
	**[[3o5e]], [[3o5f]], [[3o5g]], [[3o5i]], [[3o5j]], [[3o5k]] - hFKBP FK1 domain<br />		**[[3o5e]], [[3o5f]], [[3o5g]], [[3o5i]], [[3o5j]], [[3o5k]] - hFKBP FK1 domain<br />
	**[[3o5l]], [[3o5m]], [[3o5o]], [[3o5p]], [[3o5q]], [[4r0x]] - hFKBP FK1 domain (mutant)<br />		**[[3o5l]], [[3o5m]], [[3o5o]], [[3o5p]], [[3o5q]], [[4r0x]] - hFKBP FK1 domain (mutant)<br />
	**[[4drq]], [[5obk]] - hFKBP FK1 domain + inhibitor<br />
	**[[4lax]] – hFKBP FK1+FK2 domains + FK506<br />		**[[4lax]] – hFKBP FK1+FK2 domains + FK506<br />
	**[[4lay]] – hFKBP FK1+FK2 domains + I63<br />		**[[4lay]] – hFKBP FK1+FK2 domains + I63<br />
	**[[3o5r]] - hFKBP FK1 domain (mutant) + immunosuppressant<br />		**[[3o5r]] - hFKBP FK1 domain (mutant) + immunosuppressant<br />
	**[[4drk]], [[4drm]], [[4drn]], [[4dro]], [[4drp]] – hFKBP FK1 domain + FK506 analog<br />		**[[4drk]], [[4drm]], [[4drn]], [[4dro]], [[4drp]] – hFKBP FK1 domain + FK506 analog<br />
	**[[7a6w]], [[7a6x]], [[7aot]], [[7aou]], [[7awf]], [[7awx]], [[7b9y]], [[7b9z]], [[7ba0]] – hFKBP FK1 domain + inhibitor<br />		[[4drq]], [[5obk]], [[7a6w]], [[7a6x]], [[7aot]], [[7aou]], [[7apq]], [[7aps]], [[7apt]], [[7apw]], [[7awf]], [[7awx]], [[7b9y]], [[7b9z]], [[7ba0]] – hFKBP FK1 domain + inhibitor<br /[[7a6w]], [[7a6x]], [[7aot]], [[7aou]], [[7awf]], [[7awx]], [[7b9y]], [[7b9z]], [[7ba0]] – hFKBP FK1 domain + inhibitor<br />
	**[[4jfi]], [[4jfj]], [[4jfk]], [[4jfl]], [[4jfm]], [[4tw6]], [[4tw7]], [[4tx0]], [[4w9o]], [[4w9p]], [[4w9q]], [[5dit]], [[5diu]], [[5div]] – hFKBP FK1 domain (mutant) + inhibitor<br />		**[[4jfi]], [[4jfj]], [[4jfk]], [[4jfl]], [[4jfm]], [[4tw6]], [[4tw7]], [[4tx0]], [[4w9o]], [[4w9p]], [[4w9q]], [[5dit]], [[5diu]], [[5div]], [[7r0l]], [[8ba6]], [[8baj]] – hFKBP FK1 domain (mutant) + inhibitor<br />
			**[[7ett]], [[7etu]], [[7etv]] – hFKBP FK1 domain (mutant) + peptide inhibitor<br />
	**[[5bxj]] – hFKBP FK1 domain (mutant) + nitrophenol<br />		**[[5bxj]] – hFKBP FK1 domain (mutant) + nitrophenol<br />
	**[[4tw8]] – hFKBP FK1+FK2 domains (mutant) + inhibitor<br />		**[[4tw8]] – hFKBP FK1+FK2 domains (mutant) + inhibitor<br />
	**[[4drk]], [[4drm]], [[4drn]], [[4dro]], [[4drp]] – hFKBP FK1 domain + FK506 analog<br />		**[[4drk]], [[4drm]], [[4drn]], [[4dro]], [[4drp]] – hFKBP FK1 domain + FK506 analog<br />
			**[[8era]] – hFKBP FK1 domain + serine/threonine protein kinase MTOR + TORC + raptor – Cryo EM <br />
	**[[4drh]], [[4dri]] – hFKBP FK1 domain + serine/threonine protein kinase MTOR peptide + rapamycin <br />		**[[4drh]], [[4dri]] – hFKBP FK1 domain + serine/threonine protein kinase MTOR peptide + rapamycin <br />
	**[[6tx4]] – hFKBP FK1 domain + pyridone<br />		**[[6tx4]] – hFKBP FK1 domain + pyridone<br />