Fibronectin - Revision history

Michal Harel at 08:14, 1 July 2019

2019-07-01T08:14:27Z

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 </StructureSection>
 == References ==
 <references/>
 [[Category:Topic Page]]

Michal Harel at 08:13, 1 July 2019

2019-07-01T08:13:19Z

← Older revision		Revision as of 08:13, 1 July 2019
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	<scene name='43/430871/Cv/3'>Fn is a dimer of homologous monomers</scene> linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., FnI<sub>6</sub>-FnII<sub>1-2</sub>-FnI<sub>7-9</sub> is the gelatin binding domain (GBD).		<scene name='43/430871/Cv/3'>Fn is a dimer of homologous monomers</scene> linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., FnI<sub>6</sub>-FnII<sub>1-2</sub>-FnI<sub>7-9</sub> is the gelatin binding domain (GBD).

			== 3D Structures of Fibronectin ==
			[[Fibronectin 3D structures]]

	</StructureSection>		</StructureSection>

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	**[[1fnf]] – hFnIII<sub>7-10</sub><br />		**[[1fnf]] – hFnIII<sub>7-10</sub><br />
	**[[5dft]] - hFn FnIII<sub>11</sub> <br />		**[[5dft]] - hFn FnIII<sub>11</sub> <br />
			**[[6hnf]] - hFn 14FnIII - NMR <br />
	**[[5m0a]] - hFn 15FnIII - NMR <br />		**[[5m0a]] - hFn 15FnIII - NMR <br />
	**[[2fnb]] – hFn FnIII ed-b domain – NMR<br />		**[[2fnb]] – hFn FnIII ed-b domain – NMR<br />

Michal Harel at 07:04, 27 May 2018

2018-05-27T07:04:06Z

← Older revision		Revision as of 07:04, 27 May 2018
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	**[[2crm]] - hFnIII<sub>4</sub> – NMR<br />		**[[2crm]] - hFnIII<sub>4</sub> – NMR<br />
	**[[2crz]] - hFnIII<sub>5</sub> – NMR<br />		**[[2crz]] - hFnIII<sub>5</sub> – NMR<br />
			**[[4lxo]] - hFn 9-10FnIII <br />
	**[[1fna]], [[1ttf]], [[1ttg]] – hFnIII<sub>10</sub><br />		**[[1fna]], [[1ttf]], [[1ttg]] – hFnIII<sub>10</sub><br />
	**[[4mmx]] - hFnIII<sub>10</sub> + integrin α V + integrin β 3<br />		**[[4mmx]] - hFnIII<sub>10</sub> + integrin α V + integrin β 3<br />
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	**[[1fnf]] – hFnIII<sub>7-10</sub><br />		**[[1fnf]] – hFnIII<sub>7-10</sub><br />
	**[[5dft]] - hFn FnIII<sub>11</sub> <br />		**[[5dft]] - hFn FnIII<sub>11</sub> <br />
			**[[5m0a]] - hFn 15FnIII - NMR <br />
	**[[2fnb]] – hFn FnIII ed-b domain – NMR<br />		**[[2fnb]] – hFn FnIII ed-b domain – NMR<br />
	**[[1mfn]], [[2mfn]] – FnIII<sub>9-10</sub> – mouse - NMR<br />		**[[1mfn]], [[2mfn]] – FnIII<sub>9-10</sub> – mouse - NMR<br />
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	**[[3mql]] – hFnI<sub>6</sub>+FnII<sub>2</sub>+FnI<sub>7</sub>		**[[3mql]] – hFnI<sub>6</sub>+FnII<sub>2</sub>+FnI<sub>7</sub>

			*Fn

			**[[5n48]], [[5n47]] – hFn residues 1266-1357 + NGAL<br />
			**[[5dc0]] - hFn residues 1-93 + Abl1 <br />

	}}		}}
	== References ==		== References ==

Michal Harel at 08:41, 16 May 2017

2017-05-16T08:41:47Z

← Older revision		Revision as of 08:41, 16 May 2017
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	**[[2ocf]] - hFnIII<sub>10</sub>+estrogen receptor ligand-binding domain<br />		**[[2ocf]] - hFnIII<sub>10</sub>+estrogen receptor ligand-binding domain<br />
	**[[1fnf]] – hFnIII<sub>7-10</sub><br />		**[[1fnf]] – hFnIII<sub>7-10</sub><br />
			**[[5dft]] - hFn FnIII<sub>11</sub> <br />
	**[[2fnb]] – hFn FnIII ed-b domain – NMR<br />		**[[2fnb]] – hFn FnIII ed-b domain – NMR<br />
	**[[1mfn]], [[2mfn]] – FnIII<sub>9-10</sub> – mouse - NMR<br />		**[[1mfn]], [[2mfn]] – FnIII<sub>9-10</sub> – mouse - NMR<br />

Michal Harel at 08:32, 16 May 2017

2017-05-16T08:32:49Z

← Older revision		Revision as of 08:32, 16 May 2017
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	== Disease ==		== Disease ==

	Overexpression of Fn1 is associated with lung cancer.		Overexpression of Fn1 is associated with lung cancer<ref>PMID:16397245</ref>.

	== Structural insights ==		== Structural insights ==

Alexander Berchansky at 10:43, 21 February 2016

2016-02-21T10:43:16Z

← Older revision		Revision as of 10:43, 21 February 2016
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	== Structural insights ==		== Structural insights ==

	Fn is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., FnI<sub>6</sub>-FnII<sub>1-2</sub>-FnI<sub>7-9</sub> is the gelatin binding domain (GBD).		<scene name='43/430871/Cv/3'>Fn is a dimer of homologous monomers</scene> linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., FnI<sub>6</sub>-FnII<sub>1-2</sub>-FnI<sub>7-9</sub> is the gelatin binding domain (GBD).
	</StructureSection>		</StructureSection>

Alexander Berchansky at 10:33, 21 February 2016

2016-02-21T10:33:08Z

← Older revision		Revision as of 10:33, 21 February 2016
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	<StructureSection load='3m7p' size='350' side='right' scene='' caption='Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) (PDB code [[3m7p]]) '>		<StructureSection load='3m7p' size='350' side='right' scene='43/430871/Cv/2' caption='Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) (PDB code [[3m7p]]) '>

	== Function ==		== Function ==

Alexander Berchansky at 10:26, 21 February 2016

2016-02-21T10:26:15Z

← Older revision		Revision as of 10:26, 21 February 2016
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	~~[[Image:1fbr.png\|left\|200px\|thumb\|Crystal Structure of Fibronectin FnI<sub>4-5</sub> fragment [[1fbr]]]]~~

	<StructureSection load='3m7p' size='350' side='right' scene='' caption='Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) (PDB code [[3m7p]]) '>		<StructureSection load='3m7p' size='350' side='right' scene='' caption='Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) (PDB code [[3m7p]]) '>

Michal Harel at 14:28, 22 January 2016

2016-01-22T14:28:16Z

← Older revision		Revision as of 14:28, 22 January 2016
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	**[[3m7p]] – hFn GBD – human<br />		**[[3m7p]] – hFn GBD – human<br />
	**[[1e8b]], [[1e88]], [[1qo6]] - hFn GBD – NMR<br />		**[[1e8b]], [[1e88]], [[1qo6]] - hFn GBD – NMR<br />
	**[[3gxe]], [[3ejh]] – ~~hFn~~ 8-~~9FnI~~+collagen alpha-1<br />		**[[3gxe]], [[3ejh]] – hFnI<sub>8-9</sub> +collagen alpha-1<br />
	**[[1fbr]] - ~~hFn~~ 4-~~5FnI~~ - NMR<br />		**[[1fbr]] - hFnI<sub>4-5</sub> - NMR<br />
	**[[2rky]], [[2rl0]] – ~~hFn~~ 4-~~5FnI~~+Fn binding peptide<br />		**[[2rky]], [[2rl0]] – hFnI<sub>4-5</sub>+Fn binding peptide<br />
	**[[2rkz]], [[3cal]], [[3zrz]] - hFn 2-~~3FnI~~+Fn binding peptide<br />		**[[2rkz]], [[3cal]], [[3zrz]] - hFn<sub>2-3</sub> +Fn binding peptide<br />
	**[[2cg6]], [[2cg7]] - ~~hFn~~ 2-~~3FnI~~<br />		**[[2cg6]], [[2cg7]] - hFnI<sub>2-3</sub><br />
	**[[2cku]] - ~~hFn~~ 2-~~3FnI~~ – NMR<br />		**[[2cku]] - hFnI<sub>2-3</sub> – NMR<br />
	**[[1o9a]] - ~~hFn~~ 1-~~2FnI~~+B3 from FNBB – NMR<br />		**[[1o9a]] - hFnI<sub>1-2</sub>+B3 from FNBB – NMR<br />
	**[[2ec3]] – ~~hFn 11FnI~~ – NMR<br />		**[[2ec3]] – hFnI<sub>11</sub> – NMR<br />
	**[[3r8q]] – ~~hFn~~ 12-~~14FnI~~<br />		**[[3r8q]] – hFnI<sub>12-14</sub><br />
	**[[1qgb]] – hFn FnI N-terminal - NMR<br />		**[[1qgb]] – hFn FnI N-terminal - NMR<br />
	**[[2ck2]] – hFn (mutant) core swapped<br />		**[[2ck2]] – hFn (mutant) core swapped<br />
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	* Fn module FnII		* Fn module FnII

	**[[2fn2]] – ~~hFn 2FnII~~ – NMR		**[[2fn2]] – hFnII<sub>2</sub> – NMR

	* Fn module FnIII		* Fn module FnIII

	**[[1q38]], [[1x3d]], [[1x4x]], [[1x5x]] - hFn FnIII – NMR<br />		**[[1q38]], [[1x3d]], [[1x4x]], [[1x5x]] - hFn FnIII – NMR<br />
	**[[2h41]], [[2h45]] – ~~hFn 2FnIII~~ – NMR<br />		**[[2h41]], [[2h45]] – hFnIII<sub>2</sub> – NMR<br />
	**[[1oww]] - ~~hFn 1FnIII~~ – NMR<br />		**[[1oww]] - hFnIII<sub>1</sub> – NMR<br />
	**[[2ha1]] - ~~hFn~~ 1-~~2FnIII~~ – NMR<br />		**[[2ha1]] - hFnIII<sub>1-2</sub> – NMR<br />
	**[[2crm]] - ~~hFn 4FnIII~~ – NMR<br />		**[[2crm]] - hFnIII<sub>4</sub> – NMR<br />
	**[[2crz]] - ~~hFn 5FnIII~~ – NMR<br />		**[[2crz]] - hFnIII<sub>5</sub> – NMR<br />
	**[[1fna]], [[1ttf]], [[1ttg]] – ~~hFn 10FnIII~~<br />		**[[1fna]], [[1ttf]], [[1ttg]] – hFnIII<sub>10</sub><br />
	**[[4mmx]] - ~~hFn 10FnIII~~ + integrin α V + integrin β 3<br />		**[[4mmx]] - hFnIII<sub>10</sub> + integrin α V + integrin β 3<br />
	**[[4mmy]], [[4mmz]] - ~~hFn 10FnIII~~ (mutant) + integrin α V + integrin β 3<br />		**[[4mmy]], [[4mmz]] - hFnIII<sub>10</sub> (mutant) + integrin α V + integrin β 3<br />
	**[[2ocf]] - ~~hFn 10FnIII~~+estrogen receptor ligand-binding domain<br />		**[[2ocf]] - hFnIII<sub>10</sub>+estrogen receptor ligand-binding domain<br />
	**[[1fnf]] – ~~hFn~~ 7-~~10FnIII~~<br />		**[[1fnf]] – hFnIII<sub>7-10</sub><br />
	**[[2fnb]] – hFn FnIII ed-b domain – NMR<br />		**[[2fnb]] – hFn FnIII ed-b domain – NMR<br />
	**[[1mfn]], [[2mfn]] – Fn 9-~~10FnIII~~ – mouse - NMR<br />		**[[1mfn]], [[2mfn]] – FnIII<sub>9-10</sub> – mouse - NMR<br />
	**[[2vmg]], [[2vmi]] - Fn FnIII carbohydrate-binding domain – ''Clostridium perfringens''		**[[2vmg]], [[2vmi]] - Fn FnIII carbohydrate-binding domain – ''Clostridium perfringens''

	* Fn module FnI+FnII		* Fn module FnI+FnII

	**[[3mql]] – ~~hFn 6FnI~~+~~2FnII~~+~~7FnI~~		**[[3mql]] – hFnI<sub>6</sub>+FnII<sub>2</sub>+FnI<sub>7</sub>
	}}		}}
	== References ==		== References ==

Michal Harel at 14:06, 22 January 2016

2016-01-22T14:06:24Z

← Older revision		Revision as of 14:06, 22 January 2016
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	[[Image:1fbr.png\|left\|200px\|thumb\|Crystal Structure of Fibronectin ~~4-5FnI~~<sub>4-5</sub> fragment [[1fbr]]]]		[[Image:1fbr.png\|left\|200px\|thumb\|Crystal Structure of Fibronectin FnI<sub>4-5</sub> fragment [[1fbr]]]]

	<StructureSection load='3m7p' size='350' side='right' scene='' caption='Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) (PDB code [[3m7p]]) '>		<StructureSection load='3m7p' size='350' side='right' scene='' caption='Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) (PDB code [[3m7p]]) '>