Fumarase - Revision history

Michal Harel at 07:46, 7 July 2025

2025-07-07T07:46:37Z

← Older revision		Revision as of 07:46, 7 July 2025
Line 44:		Line 44:
	**[[3gtd]] – FUM II – ''Rickettsia prowazekii''<br />		**[[3gtd]] – FUM II – ''Rickettsia prowazekii''<br />
	**[[2isb]] – FUM I – ''Archaeoglobus fulgidus''<br />		**[[2isb]] – FUM I – ''Archaeoglobus fulgidus''<br />
	**[[1kq7]], [[1yfe]], [[6os7]] - EcFUM II (mutant) – ''Escherichia coli''<br />		**[[1kq7]], [[1yfe]], [[6os7]], [[8sbs]] - EcFUM II (mutant) – ''Escherichia coli''<br />
	**[[4hgv]] – FUM II – ''Sinorhizobium meliloti''<br />		**[[4hgv]] – FUM II – ''Sinorhizobium meliloti''<br />
	**[[3tv2]] – FUM II – ''Burkholderia pseudomallei''<br />		**[[3tv2]] – FUM II – ''Burkholderia pseudomallei''<br />
Line 53:		Line 53:
	**[[7c1c]] – MsFUM II – ''Mannheimia succiniciproducens''<br />		**[[7c1c]] – MsFUM II – ''Mannheimia succiniciproducens''<br />
	**[[6unz]] – LmFUM II – ''Leishmania major''<br />		**[[6unz]] – LmFUM II – ''Leishmania major''<br />
			**[[9bpw]] – FUM C – ''Staphylococcus aureus''<br />

	*Fumarase binary complexes		*Fumarase binary complexes

			**[[7lub]] - hFUM II + phosphono-propionate<br />
	**[[1fur]] - EcFUM II (mutant) + malate<br />		**[[1fur]] - EcFUM II (mutant) + malate<br />
	**[[6nz9]] - EcFUM II + citrate<br />		**[[6nz9]] - EcFUM II + citrate<br />
Line 69:		Line 71:
	**[[6up9]] – LmFUM II (mutant) + malonate <br />		**[[6up9]] – LmFUM II (mutant) + malonate <br />
	**[[6uoj]] – LmFUM II + succinate <br />		**[[6uoj]] – LmFUM II + succinate <br />
			**[[7t93]] – FUM II + malate – ''Mycobacterium ulcerans''<br />

	*Fumarase ternary complexes		*Fumarase ternary complexes

Michal Harel at 09:01, 11 January 2023

2023-01-11T09:01:22Z

← Older revision		Revision as of 09:01, 11 January 2023
Line 10:		Line 10:
	*[[Krebs cycle step 7]]		*[[Krebs cycle step 7]]
	*[[Fumarase 2]]		*[[Fumarase 2]]
			*[[Glyoxylate cycle]]

	==Other interesting information==		==Other interesting information==

Alexander Berchansky at 12:59, 13 September 2022

2022-09-13T12:59:54Z

← Older revision		Revision as of 12:59, 13 September 2022
Line 2:		Line 2:
	== Function ==		== Function ==

	'''Fumarase''' or '''fumarase hydratase''' is used in the citric acid cycle to conduct a transition step in the production of energy to make NADH. It metabolizes fumarate in the cytosol, which becomes a byproduct of the urea cycle and amino acid catabolism. It catalyzes the addition of water to fumarate to make S-malate. This is a reversible reaction<ref>PMID:16204892</ref>. See also:<br />		'''Fumarase''' or '''fumarase hydratase''' is used in the citric acid cycle to conduct a transition step in the production of energy to make NADH. It metabolizes fumarate in the cytosol, which becomes a byproduct of the urea cycle and amino acid catabolism. It catalyzes the addition of water to fumarate to make ''L''-malate. This is a reversible reaction<ref>PMID:16204892</ref>. See also:<br />
	*[[Krebs cycle carbons]]		*[[Krebs cycle carbons]]
	*[[Krebs cycle importance]]		*[[Krebs cycle importance]]

Michal Harel at 06:51, 1 August 2021

2021-08-01T06:51:50Z

← Older revision		Revision as of 06:51, 1 August 2021
Line 35:		Line 35:
	**[[6ebt]] – hFUM (mutant) – human<br />		**[[6ebt]] – hFUM (mutant) – human<br />
	**[[3e04]], [[5d6b]], [[5upp]] – hFUM residues 44-510 - human<br />		**[[3e04]], [[5d6b]], [[5upp]] – hFUM residues 44-510 - human<br />
	**[[6ebt]] – hFUM (mutant)<br />		**[[6ebt]], [[6v8f]], [[6vbe]] – hFUM (mutant)<br />
	**[[1yfm]] – FUM (mutant) – yeast<br />		**[[1yfm]], [[6ku6]] – FUM (mutant) – yeast<br />
	**[[3qbp]] – FUM – ''Mycobacterium marinum''<br />		**[[3qbp]] – FUM – ''Mycobacterium marinum''<br />
	**[[3no9]] – MtFUM II – ''Mycobacterium tuberculosis''<br />		**[[3no9]] – MtFUM II – ''Mycobacterium tuberculosis''<br />
Line 43:		Line 43:
	**[[3gtd]] – FUM II – ''Rickettsia prowazekii''<br />		**[[3gtd]] – FUM II – ''Rickettsia prowazekii''<br />
	**[[2isb]] – FUM I – ''Archaeoglobus fulgidus''<br />		**[[2isb]] – FUM I – ''Archaeoglobus fulgidus''<br />
	**[[1kq7]], [[1yfe]] - EcFUM II (mutant) – ''Escherichia coli''<br />		**[[1kq7]], [[1yfe]], [[6os7]] - EcFUM II (mutant) – ''Escherichia coli''<br />
	**[[4hgv]] – FUM II – ''Sinorhizobium meliloti''<br />		**[[4hgv]] – FUM II – ''Sinorhizobium meliloti''<br />
	**[[3tv2]] – FUM II – ''Burkholderia pseudomallei''<br />		**[[3tv2]] – FUM II – ''Burkholderia pseudomallei''<br />
	**[[1vdk]] – FUM II (mutant) – ''Thermus thermophilus''<br />		**[[1vdk]] – FUM II (mutant) – ''Thermus thermophilus''<br />
	**[[6n1m]] – FUM II – ''Legionella pneumophila''<br />		**[[6n1m]] – FUM II – ''Legionella pneumophila''<br />
			**[[7miw]] – FUM II – ''Elizabethakingia anophelis''<br />
			**[[6u4o]] – FUM II – ''Schistosoma mansoni''<br />
			**[[7c1c]] – MsFUM II – ''Mannheimia succiniciproducens''<br />
			**[[6unz]] – LmFUM II – ''Leishmania major''<br />

	*Fumarase binary complexes		*Fumarase binary complexes
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	**[[4apb]] - MtFUM II (mutant) + fumarate<br />		**[[4apb]] - MtFUM II (mutant) + fumarate<br />
	**[[5f92]] – MtFUM II + formate<br />		**[[5f92]] – MtFUM II + formate<br />
			**[[7c1a]] – MsFUM II + malate <br />
			**[[7c18]] – MsFUM II + fumarate <br />
			**[[6uo0]], [[6upm]], [[6upo]], [[6uq9]], [[6uql]], [[6uqm]] – LmFUM II (mutant) + malate <br />
			**[[6uoi]] – LmFUM II + malonate <br />
			**[[6up9]] – LmFUM II (mutant) + malonate <br />
			**[[6uoj]] – LmFUM II + succinate <br />

	*Fumarase ternary complexes		*Fumarase ternary complexes
Line 65:		Line 75:
	**[[1fuo]] - EcFUM II + citrate + malate<br />		**[[1fuo]] - EcFUM II + citrate + malate<br />
	**[[5f91]], [[6s43]], [[6s7k]], [[6s7s]], [[6s7u]], [[6s7w]], [[6s7z]], [[6s88]] – MtFUM II + modulator + formate<br />		**[[5f91]], [[6s43]], [[6s7k]], [[6s7s]], [[6s7u]], [[6s7w]], [[6s7z]], [[6s88]] – MtFUM II + modulator + formate<br />
			**[[6uqn]] – LmFUM II (mutant) + malate + fumarate <br />
			**[[6uq8]], [[6uqb]] – LmFUM II (mutant) + malate + malonate <br />

	}}		}}

Michal Harel at 07:39, 30 July 2020

2020-07-30T07:39:44Z

← Older revision		Revision as of 07:39, 30 July 2020
Line 33:		Line 33:
	*Fumarase		*Fumarase

			**[[6ebt]] – hFUM (mutant) – human<br />
			**[[3e04]], [[5d6b]], [[5upp]] – hFUM residues 44-510 - human<br />
			**[[6ebt]] – hFUM (mutant)<br />
			**[[1yfm]] – FUM (mutant) – yeast<br />
	**[[3qbp]] – FUM – ''Mycobacterium marinum''<br />		**[[3qbp]] – FUM – ''Mycobacterium marinum''<br />
	**[[3no9]] – MtFUM II – ''Mycobacterium tuberculosis''<br />		**[[3no9]] – MtFUM II – ''Mycobacterium tuberculosis''<br />
Line 38:		Line 42:
	**[[3rd8]] – FUM II – ''Mycobacterium smegmatis''<br />		**[[3rd8]] – FUM II – ''Mycobacterium smegmatis''<br />
	**[[3gtd]] – FUM II – ''Rickettsia prowazekii''<br />		**[[3gtd]] – FUM II – ''Rickettsia prowazekii''<br />
	**[[3e04]], [[5d6b]], [[5upp]] – FUM residues 44-510 – human<br />
	**[[2isb]] – FUM I – ''Archaeoglobus fulgidus''<br />		**[[2isb]] – FUM I – ''Archaeoglobus fulgidus''<br />
	**[[1kq7]], [[1yfe]] - EcFUM II (mutant) – ''Escherichia coli''<br />		**[[1kq7]], [[1yfe]] - EcFUM II (mutant) – ''Escherichia coli''<br />
	**[[4hgv]] – FUM II – ''Sinorhizobium meliloti''<br />		**[[4hgv]] – FUM II – ''Sinorhizobium meliloti''<br />
	**[[3tv2]] – FUM II – ''Burkholderia pseudomallei''<br />		**[[3tv2]] – FUM II – ''Burkholderia pseudomallei''<br />
	**[[1yfm]] – FUM (mutant) – yeast<br />
	**[[1vdk]] – FUM II (mutant) – ''Thermus thermophilus''<br />		**[[1vdk]] – FUM II (mutant) – ''Thermus thermophilus''<br />
			**[[6n1m]] – FUM II – ''Legionella pneumophila''<br />

	*Fumarase binary complexes		*Fumarase binary complexes

	**[[1fur]] - EcFUM II (mutant) + malate<br />		**[[1fur]] - EcFUM II (mutant) + malate<br />
	**[[2fus]] - EcFUM II (mutant) + citrate<br />		**[[6nz9]] - EcFUM II + citrate<br />
			**[[2fus]], [[6nza]], [[6nzb]], [[6nzc]], [[6os7]], [[6p3c]] - EcFUM II (mutant) + citrate<br />
	**[[4adl]] - MtFUM II + malate<br />		**[[4adl]] - MtFUM II + malate<br />
	**[[4adm]] - MtFUM II + tartrate<br />		**[[4adm]] - MtFUM II + tartrate<br />
Line 60:		Line 64:
	**[[1fuq]] - EcFUM II + pyromellitic acid + citrate<br />		**[[1fuq]] - EcFUM II + pyromellitic acid + citrate<br />
	**[[1fuo]] - EcFUM II + citrate + malate<br />		**[[1fuo]] - EcFUM II + citrate + malate<br />
	**[[5f91]] – MtFUM II + ~~phthalazin derivative~~ + formate<br />		**[[5f91]], [[6s43]], [[6s7k]], [[6s7s]], [[6s7u]], [[6s7w]], [[6s7z]], [[6s88]] – MtFUM II + modulator + formate<br />

	}}		}}

Michal Harel at 07:20, 30 July 2020

2020-07-30T07:20:31Z

← Older revision		Revision as of 07:20, 30 July 2020
Line 2:		Line 2:
	== Function ==		== Function ==

	'''Fumarase''' is used in the citric acid cycle to conduct a transition step in the production of energy to make NADH. It metabolizes fumarate in the cytosol, which becomes a byproduct of the urea cycle and amino acid catabolism. It catalyzes the addition of water to make S-malate. This is a reversible reaction<ref>PMID:16204892</ref>. See also:<br />		'''Fumarase''' or '''fumarase hydratase''' is used in the citric acid cycle to conduct a transition step in the production of energy to make NADH. It metabolizes fumarate in the cytosol, which becomes a byproduct of the urea cycle and amino acid catabolism. It catalyzes the addition of water to fumarate to make S-malate. This is a reversible reaction<ref>PMID:16204892</ref>. See also:<br />
	*[[Krebs cycle carbons]]		*[[Krebs cycle carbons]]
	*[[Krebs cycle importance]]		*[[Krebs cycle importance]]

Michal Harel at 10:24, 22 January 2019

2019-01-22T10:24:03Z

← Older revision		Revision as of 10:24, 22 January 2019
Line 7:		Line 7:
	*[[Krebs cycle overview]]		*[[Krebs cycle overview]]
	*[[Krebs cycle reactions]]		*[[Krebs cycle reactions]]
			*[[Citric Acid Cycle]]
	*[[Krebs cycle step 7]]		*[[Krebs cycle step 7]]
	*[[Fumarase 2]]		*[[Fumarase 2]]

Michal Harel at 08:40, 21 January 2019

2019-01-21T08:40:43Z

← Older revision		Revision as of 08:40, 21 January 2019
Line 6:		Line 6:
	*[[Krebs cycle importance]]		*[[Krebs cycle importance]]
	*[[Krebs cycle overview]]		*[[Krebs cycle overview]]
			*[[Krebs cycle reactions]]
	*[[Krebs cycle step 7]]		*[[Krebs cycle step 7]]
	*[[Fumarase 2]]		*[[Fumarase 2]]

Michal Harel at 07:47, 16 January 2019

2019-01-16T07:47:16Z

← Older revision		Revision as of 07:47, 16 January 2019
Line 7:		Line 7:
	*[[Krebs cycle overview]]		*[[Krebs cycle overview]]
	*[[Krebs cycle step 7]]		*[[Krebs cycle step 7]]
			*[[Fumarase 2]]

	==Other interesting information==		==Other interesting information==

Michal Harel at 09:49, 28 May 2018

2018-05-28T09:49:13Z

← Older revision		Revision as of 09:49, 28 May 2018
Line 35:		Line 35:
	**[[3rd8]] – FUM II – ''Mycobacterium smegmatis''<br />		**[[3rd8]] – FUM II – ''Mycobacterium smegmatis''<br />
	**[[3gtd]] – FUM II – ''Rickettsia prowazekii''<br />		**[[3gtd]] – FUM II – ''Rickettsia prowazekii''<br />
	**[[3e04]] – FUM residues 44-510 – human<br />		**[[3e04]], [[5d6b]], [[5upp]] – FUM residues 44-510 – human<br />
	**[[2isb]] – FUM I – ''Archaeoglobus fulgidus''<br />		**[[2isb]] – FUM I – ''Archaeoglobus fulgidus''<br />
	**[[1kq7]], [[1yfe]] - EcFUM II (mutant) – ''Escherichia coli''<br />		**[[1kq7]], [[1yfe]] - EcFUM II (mutant) – ''Escherichia coli''<br />
Line 49:		Line 49:
	**[[4adl]] - MtFUM II + malate<br />		**[[4adl]] - MtFUM II + malate<br />
	**[[4adm]] - MtFUM II + tartrate<br />		**[[4adm]] - MtFUM II + tartrate<br />
	**[[4apb]] - MtFUM II (mutant) + fumarate		**[[4apb]] - MtFUM II (mutant) + fumarate<br />
			**[[5f92]] – MtFUM II + formate<br />

	*Fumarase ternary complexes		*Fumarase ternary complexes
Line 55:		Line 56:
	**[[1fup]] - EcFUM II + pyromellitic acid + malate<br />		**[[1fup]] - EcFUM II + pyromellitic acid + malate<br />
	**[[1fuq]] - EcFUM II + pyromellitic acid + citrate<br />		**[[1fuq]] - EcFUM II + pyromellitic acid + citrate<br />
	**[[1fuo]] - EcFUM II + citrate + malate		**[[1fuo]] - EcFUM II + citrate + malate<br />
			**[[5f91]] – MtFUM II + phthalazin derivative + formate<br />

	}}		}}