Glyceraldehyde-3-Phosphate Dehydrogenase - Revision history

Alexander Berchansky at 13:46, 4 January 2023

2023-01-04T13:46:06Z

← Older revision		Revision as of 13:46, 4 January 2023
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	== Function ==		== Function ==

	'''Glyceraldehyde-3-phosphate dehydrogenase''' (GAPDH) is a very important enzyme in the production of energy and in photosynthesis. In the production of energy this enzyme catalyzes the sixth step in the process of breaking down glucose, also known as [[glycolysis]] which occurs in organisms of all phyla. The sixth step consists of of the oxidation of GAP by [[NAD]] and an inorganic phosphate to yield 1,3 bisphosphoglycerate. In photosynthesis, which is carried out by plants and algae, this enzyme uses '''NADPH''' in the reverse reaction in a step in the [[Calvin ~~Cycle~~]], which fixes gaseous CO<sub>2</sub> into carbohydrate. Though these are its main functions, GAPDH has been shown to perform other functions including transcription activation, initiation of apoptosis, and ER to Golgi apparatus vesicle transportation <ref>PMID: 22851451</ref>. However, this page will focus on GAPDH’s role in glycolysis. See [[2pkq]] for the plant Calvin Cycle enzyme. See [[Glycolysis Enzymes]] and [[Carbon Fixation]].		'''Glyceraldehyde-3-phosphate dehydrogenase''' (GAPDH) is a very important enzyme in the production of energy and in photosynthesis. In the production of energy this enzyme catalyzes the sixth step in the process of breaking down glucose, also known as [[glycolysis]] which occurs in organisms of all phyla. The sixth step consists of of the oxidation of GAP by [[NAD]] and an inorganic phosphate to yield 1,3 bisphosphoglycerate. In photosynthesis, which is carried out by plants and algae, this enzyme uses '''NADPH''' in the reverse reaction in a step in the [[Calvin cycle]], which fixes gaseous CO<sub>2</sub> into carbohydrate. Though these are its main functions, GAPDH has been shown to perform other functions including transcription activation, initiation of apoptosis, and ER to Golgi apparatus vesicle transportation <ref>PMID: 22851451</ref>. However, this page will focus on GAPDH’s role in glycolysis. See [[2pkq]] for the plant Calvin Cycle enzyme. See [[Glycolysis Enzymes]] and [[Carbon Fixation]].

	== Structure ==		== Structure ==

	GAPDH most commonly exists as what looks to be a dimer. Interesting though, the two monomers of the enzyme are not exactly the same. While one side consists only of parallel and antiparallel beta-sheets, the other monomer is made up of both <scene name='Nathan_Line_sandbox_3/Secondary_structure/1'>beta-sheets and alpha helixes</scene>. Though each monomer does not have to exact same sequence, each does contain replicate active sites and function. This is consistent with the following SCOP information:		GAPDH most commonly exists as what looks to be a dimer. Interesting though, the two monomers of the enzyme are not exactly the same. While one side consists only of parallel and antiparallel beta-sheets, the other monomer is made up of both <scene name='Nathan_Line_sandbox_3/Secondary_structure/1'>beta-sheets and alpha helixes</scene>. Though each monomer does not have to exact same sequence, each does contain replicate active sites and function. This is consistent with the following SCOP information:

	Class: Alpha and beta proteins (a/b)		Class: Alpha and beta proteins (a/b)

Alexander Berchansky at 10:51, 2 January 2023

2023-01-02T10:51:47Z

← Older revision		Revision as of 10:51, 2 January 2023
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	== Function ==		== Function ==

	'''Glyceraldehyde-3-phosphate dehydrogenase''' (GAPDH) is a very important enzyme in the production of energy and in photosynthesis. In the production of energy this enzyme catalyzes the sixth step in the process of breaking down glucose, also known as [[glycolysis]] which occurs in organisms of all phyla. The sixth step consists of of the oxidation of GAP by [[NAD]] and an inorganic phosphate to yield 1,3 bisphosphoglycerate. In photosynthesis, which is carried out by plants and algae, this enzyme uses '''NADPH''' in the reverse reaction in a step in the Calvin Cycle, which fixes gaseous CO<sub>2</sub> into carbohydrate. Though these are its main functions, GAPDH has been shown to perform other functions including transcription activation, initiation of apoptosis, and ER to Golgi apparatus vesicle transportation <ref>PMID: 22851451</ref>. However, this page will focus on GAPDH’s role in glycolysis. See [[2pkq]] for the plant Calvin Cycle enzyme. See [[Glycolysis Enzymes]] and [[Carbon Fixation]].		'''Glyceraldehyde-3-phosphate dehydrogenase''' (GAPDH) is a very important enzyme in the production of energy and in photosynthesis. In the production of energy this enzyme catalyzes the sixth step in the process of breaking down glucose, also known as [[glycolysis]] which occurs in organisms of all phyla. The sixth step consists of of the oxidation of GAP by [[NAD]] and an inorganic phosphate to yield 1,3 bisphosphoglycerate. In photosynthesis, which is carried out by plants and algae, this enzyme uses '''NADPH''' in the reverse reaction in a step in the [[Calvin Cycle]], which fixes gaseous CO<sub>2</sub> into carbohydrate. Though these are its main functions, GAPDH has been shown to perform other functions including transcription activation, initiation of apoptosis, and ER to Golgi apparatus vesicle transportation <ref>PMID: 22851451</ref>. However, this page will focus on GAPDH’s role in glycolysis. See [[2pkq]] for the plant Calvin Cycle enzyme. See [[Glycolysis Enzymes]] and [[Carbon Fixation]].

	== Structure ==		== Structure ==

Alexander Berchansky at 11:57, 1 January 2023

2023-01-01T11:57:35Z

← Older revision		Revision as of 11:57, 1 January 2023
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	== Function ==		== Function ==

	'''Glyceraldehyde-3-phosphate dehydrogenase''' (GAPDH) is a very important enzyme in the production of energy and in photosynthesis. In the production of energy this enzyme catalyzes the sixth step in the process of breaking down glucose, also known as [[glycolysis]] which occurs in organisms of all phyla. The sixth step consists of of the oxidation of GAP by [[NAD]] and an inorganic phosphate to yield 1,3 bisphosphoglycerate. In photosynthesis, which is carried out by plants and algae, this enzyme uses '''NADPH''' in the reverse reaction in a step in the Calvin Cycle, which fixes gaseous CO<sub>2</sub> into carbohydrate. Though these are its main functions, GAPDH has been shown to perform other functions including transcription activation, initiation of apoptosis, and ER to Golgi apparatus vesicle transportation <ref>PMID: 22851451</ref>. However, this page will focus on GAPDH’s role in glycolysis. See [[2pkq]] for the plant Calvin Cycle enzyme. See [[Glycolysis Enzymes]].		'''Glyceraldehyde-3-phosphate dehydrogenase''' (GAPDH) is a very important enzyme in the production of energy and in photosynthesis. In the production of energy this enzyme catalyzes the sixth step in the process of breaking down glucose, also known as [[glycolysis]] which occurs in organisms of all phyla. The sixth step consists of of the oxidation of GAP by [[NAD]] and an inorganic phosphate to yield 1,3 bisphosphoglycerate. In photosynthesis, which is carried out by plants and algae, this enzyme uses '''NADPH''' in the reverse reaction in a step in the Calvin Cycle, which fixes gaseous CO<sub>2</sub> into carbohydrate. Though these are its main functions, GAPDH has been shown to perform other functions including transcription activation, initiation of apoptosis, and ER to Golgi apparatus vesicle transportation <ref>PMID: 22851451</ref>. However, this page will focus on GAPDH’s role in glycolysis. See [[2pkq]] for the plant Calvin Cycle enzyme. See [[Glycolysis Enzymes]] and [[Carbon Fixation]].

	== Structure ==		== Structure ==

Alexander Berchansky at 12:27, 8 September 2022

2022-09-08T12:27:30Z

← Older revision		Revision as of 12:27, 8 September 2022
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	== Function ==		== Function ==

	'''Glyceraldehyde-3-phosphate dehydrogenase''' (GAPDH) is a very important enzyme in the production of energy and in photosynthesis. In the production of energy this enzyme catalyzes the sixth step in the process of breaking down glucose, also known as glycolysis which occurs in organisms of all phyla. The sixth step consists of of the oxidation of GAP by [[NAD]] and an inorganic phosphate to yield 1,3 bisphosphoglycerate. In photosynthesis, which is carried out by plants and algae, this enzyme uses '''NADPH''' in the reverse reaction in a step in the Calvin Cycle, which fixes gaseous CO<sub>2</sub> into carbohydrate. Though these are its main functions, GAPDH has been shown to perform other functions including transcription activation, initiation of apoptosis, and ER to Golgi apparatus vesicle transportation <ref>PMID: 22851451</ref>. However, this page will focus on GAPDH’s role in glycolysis. See [[2pkq]] for the plant Calvin Cycle enzyme. See [[Glycolysis Enzymes]].		'''Glyceraldehyde-3-phosphate dehydrogenase''' (GAPDH) is a very important enzyme in the production of energy and in photosynthesis. In the production of energy this enzyme catalyzes the sixth step in the process of breaking down glucose, also known as [[glycolysis]] which occurs in organisms of all phyla. The sixth step consists of of the oxidation of GAP by [[NAD]] and an inorganic phosphate to yield 1,3 bisphosphoglycerate. In photosynthesis, which is carried out by plants and algae, this enzyme uses '''NADPH''' in the reverse reaction in a step in the Calvin Cycle, which fixes gaseous CO<sub>2</sub> into carbohydrate. Though these are its main functions, GAPDH has been shown to perform other functions including transcription activation, initiation of apoptosis, and ER to Golgi apparatus vesicle transportation <ref>PMID: 22851451</ref>. However, this page will focus on GAPDH’s role in glycolysis. See [[2pkq]] for the plant Calvin Cycle enzyme. See [[Glycolysis Enzymes]].

	== Structure ==		== Structure ==

Michal Harel at 10:27, 14 July 2019

2019-07-14T10:27:42Z

Show changes

Michal Harel at 10:26, 14 July 2019

2019-07-14T10:26:25Z

Show changes

Michal Harel at 08:56, 3 June 2018

2018-06-03T08:56:21Z

← Older revision		Revision as of 08:56, 3 June 2018
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	**[[1vsu]] – CpGAPDH – ''Cryptosporidium parvum''<br />		**[[1vsu]] – CpGAPDH – ''Cryptosporidium parvum''<br />
	**[[1dc5]], [[1s7c]] - EcGAPDH – ''Escherichia coli''<br />		**[[1dc5]], [[1s7c]], [[5o0v]] - EcGAPDH – ''Escherichia coli''<br />
	**[[1euh]], [[1qi6]] - SmGAPDH – ''Streptococcus mutans''<br />		**[[1euh]], [[1qi6]] - SmGAPDH – ''Streptococcus mutans''<br />
	**[[5m6d]] - GAPDH – ''Streptococcus pneumoniae''<br />		**[[5m6d]] - GAPDH – ''Streptococcus pneumoniae''<br />
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	**[[1obf]] – GAPDH – ''Achromobacter xylosoxidans''<br />		**[[1obf]] – GAPDH – ''Achromobacter xylosoxidans''<br />
	**[[1b7g]] - GAPDH – ''Sulfolobus solfataricus''<br />		**[[1b7g]] - GAPDH – ''Sulfolobus solfataricus''<br />
			**[[5v8y]], [[5v8x]] - SagGAPDH (mutant) – ''Streptococcus agalactiae''<br />

	*NAD-dependent GAPDH with cofactor NAD		*NAD-dependent GAPDH with cofactor NAD
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	**[[3sth]] - GAPDH + NAD – ''Toxoplasma gondii''<br />		**[[3sth]] - GAPDH + NAD – ''Toxoplasma gondii''<br />
	**[[3pym]] - yGAPDH + NAD – yeast<br />		**[[3pym]] - yGAPDH + NAD – yeast<br />
	**[[~~5mvt~~]] - GAPDH + NAD – ''Neisseria gonorrhoeae''<br />		**[[5vmt]] - GAPDH + NAD – ''Neisseria gonorrhoeae''<br />
	**[[5jy6]], [[5jye]], [[5jyf]], [[4qx6]] - SagGAPDH + NAD – ''Streptococcus agalactiae''<br />		**[[5jy6]], [[5jye]], [[5jyf]], [[4qx6]], [[5y37]] - SagGAPDH + NAD – ''Streptococcus agalactiae''<br />
	**[[5jya]] - SagGAPDH (mutant) + NAD<br />		**[[5jya]], [[5utm]], [[5utl]] - SagGAPDH (mutant) + NAD<br />
	**[[5ddi]] - pGAPDH + NAD – pig<br />		**[[5ddi]] - pGAPDH + NAD – pig<br />
	**[[4o63]], [[4o59]] - bGAPDH + NAD – bovine<br />		**[[4o63]], [[4o59]] - bGAPDH + NAD – bovine<br />
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	**[[3doc]] - GAPDH + NAD – ''Brucella melitensis''<br />		**[[3doc]] - GAPDH + NAD – ''Brucella melitensis''<br />
	**[[1vc2]] - GAPDH + NAD – ''Thermos thermophilus''<br />		**[[1vc2]] - GAPDH + NAD – ''Thermos thermophilus''<br />
			**[[5ur0]] - GAPDH + NAD – amoeba<br />
			**[[5ld5]] - GAPDH + NAD – ''Atopobium vaginae''<br />
			**[[4lsm]] - TcGAPDH + NAD – ''Trypanosoma cruzi''<br />
			**[[1ihx]] – scsGAPDH + NAD derivative – South China Sea lobster<br />

	*NAD-dependent GAPDH ternary complexes containing glyceraldehyde-3-phosphate (G3P)		*NAD-dependent GAPDH ternary complexes containing glyceraldehyde-3-phosphate (G3P)
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	**[[5tso]] - pGAPDH + NAD + phenanthroline <br />		**[[5tso]] - pGAPDH + NAD + phenanthroline <br />
	**[[1i33]], [[1i32]] - LmGAPDH + inhibitor<br />		**[[1i33]], [[1i32]] - LmGAPDH + inhibitor<br />
			**[[1ihy]] – scsGAPDH + ADP-ribose <br />
			**[[5za0]] – EcGAPDH-A + trehalose<br />

	*NADP-dependent GAPDH		*NADP-dependent GAPDH
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	*Other NADP-dependent GAPDH ternary complexes		*Other NADP-dependent GAPDH ternary complexes

	**[[1k3t]] - TcGAPDH + coumarin derivative ~~– ''Trypanosoma cruzi''~~<br />		**[[1k3t]] - TcGAPDH + coumarin derivative <br />
	**[[1uxv]] - TtGAPDH + NADP + AMP<br />		**[[1uxv]] - TtGAPDH + NADP + AMP<br />
	**[[1ml3]] - TtGAPDH + NAD + inhibitor<br />		**[[1ml3]] - TtGAPDH + NAD + inhibitor<br />

Michal Harel at 08:14, 1 June 2017

2017-06-01T08:14:39Z

← Older revision		Revision as of 08:14, 1 June 2017
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	**[[1vsu]] – CpGAPDH – ''Cryptosporidium parvum''<br />		**[[1vsu]] – CpGAPDH – ''Cryptosporidium parvum''<br />
	**[[1dc5]] - EcGAPDH – ''Escherichia coli''<br />		**[[1dc5]], [[1s7c]] - EcGAPDH – ''Escherichia coli''<br />
	**[[1euh]], [[1qi6]] - SmGAPDH – ''Streptococcus mutans''<br />		**[[1euh]], [[1qi6]] - SmGAPDH – ''Streptococcus mutans''<br />
			**[[5m6d]] - GAPDH – ''Streptococcus pneumoniae''<br />
	**[[2hki]] – sGAPDH – spinach<br />		**[[2hki]] – sGAPDH – spinach<br />
	**[[3e6a]] – RiGAPDH ligand binding domain – rice<br />		**[[3e6a]] – RiGAPDH ligand binding domain – rice<br />
	**[[3lc7]] - SaGAPDH – ''Staphylococcus aureus''<br />		**[[3lc7]], [[5t73]] - SaGAPDH – ''Staphylococcus aureus''<br />
	**[[3pqa]] – MjGAPDH – ''Methanocaldococcus jannaschii''<br />		**[[3pqa]] – MjGAPDH – ''Methanocaldococcus jannaschii''<br />
	**[[3prl]] – BhGAPDH – ''Bacillus halodurans''<br />		**[[3prl]] – BhGAPDH – ''Bacillus halodurans''<br />
			**[[5c7i]] - mGAPDH – mouse<br />
			**[[5c7l]] - hGAPDH – human<br />
			**[[4iq8]] - GAPDH – yeast<br />
			**[[4gpd]], [[1crw]] – AlGAPDH – American lobster<br />
			**[[4dib]] – GAPDH – ''Bacillus anthracis''<br />
			**[[2gd1]] – GsGAPDH – ''Geobacillus stearothermophilus''<br />
			**[[1obf]] – GAPDH – ''Achromobacter xylosoxidans''<br />
			**[[1b7g]] - GAPDH – ''Sulfolobus solfataricus''<br />

	*NAD-dependent GAPDH with cofactor NAD		*NAD-dependent GAPDH with cofactor NAD

	**[[1vsv]] – CpGAPDH + NAD<br />		**[[1vsv]], [[3cps]] – CpGAPDH + NAD<br />
	**[[1gpd]] – ~~GAPDH~~ + NAD – American lobster<br />		**[[1gpd]], [[1szj]], [[1dss]] – AlGAPDH + NAD – American lobster<br />
	**[[3gpd]], [[1znq]], [[1u8f]] - GAPDH + NAD ~~– human~~<br />		**[[3gpd]], [[1znq]], [[1u8f]], [[5c7o]], [[4wnc]], [[3pfw]] - GAPDH + NAD <br />
			**[[4wni]] - hGAPDH (mutant) + NAD<br />
	**[[2vyn]], [[2vyv]] - GAPDH + NAD - rat<br />		**[[2vyn]], [[2vyv]] - GAPDH + NAD - rat<br />
	**[[1gd1]], [[3cmc]] – GsGAPDH + NAD – ''Geobacillus stearothermophilus''<br />		**[[1gd1]], [[3cmc]] – GsGAPDH + NAD – ''Geobacillus stearothermophilus''<br />
	**[[1dbv]], [[3dbv]] - GsGAPDH (mutant) + NAD<br />		**[[1dbv]], [[3dbv]], [[1nq5]], [[1npt]] - GsGAPDH (mutant) + NAD<br />
	**[[1hdg]] - GAPDH + NAD – ''Thermotoga maritima''<br />		**[[1hdg]] - GAPDH + NAD – ''Thermotoga maritima''<br />
	**[[1gyp]], [[1a7k]] - ~~GAPDH~~ + NAD – ''Leishmania mexicana''<br />		**[[1gyp]], [[1a7k]] - LmGAPDH + NAD – ''Leishmania mexicana''<br />
	**[[1gyq]] - LmGAPDH + benzyl-NAD<br />		**[[1gyq]] - LmGAPDH + benzyl-NAD<br />
	**[[1cer]], [[2g82]] - GAPDH + NAD – ''Thermus aquaticus''<br />		**[[1cer]], [[2g82]] - GAPDH + NAD – ''Thermus aquaticus''<br />
	**[[1gad]], [[1dc6]] - EcGAPDH + NAD<br />		**[[1gad]], [[1dc6]], [[4mvj]] - EcGAPDH + NAD<br />
	**[[1gae]] - EcGAPDH (mutant) + NAD<br />		**[[1gae]] - EcGAPDH (mutant) + NAD<br />
	**[[2ep7]] – GAPDH + NAD – ''Aquifex aeolicus''<br />		**[[2ep7]] – GAPDH + NAD – ''Aquifex aeolicus''<br />
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	**[[3gnq]] - GAPDH + NAD – ''Burkholderia pseudomallei''<br />		**[[3gnq]] - GAPDH + NAD – ''Burkholderia pseudomallei''<br />
	**[[3hja]] - GAPDH + NAD – ''Borrelia burgdorferi''<br />		**[[3hja]] - GAPDH + NAD – ''Borrelia burgdorferi''<br />
	**[[3e5r]] - RiGAPDH + NAD<br />		**[[3e5r]], [[3v1y]] - RiGAPDH + NAD<br />
	**[[2x0n]] – ~~GAPDH~~ + NAD – ''Trypanosoma brucei'' – Laue<br />		**[[2x0n]] – TbGAPDH + NAD – ''Trypanosoma brucei'' – Laue<br />
	**[[3k2b]] - GAPDH + NAD – ''Arabidopsis thaliana''<br />		**[[4p8r]] - TbGAPDH + NAD<br />
	**[[3hq4]], [[3k9q]], [[3ksd]], [[3lc1]] - SaGAPDH (mutant) + NAD<br />		**[[3k2b]], [[4z0h]], [[3rvd]] - GAPDH + NAD – ''Arabidopsis thaliana''<br />
	**[[3lvf]] - SaGAPDH + NAD<br />		**[[3hq4]], [[3k9q]], [[3ksd]], [[3lc1]], [[3kv3]] - SaGAPDH (mutant) + NAD<br />
			**[[3lvf]], [[3vaz]] - SaGAPDH + NAD<br />
	**[[3pfw]] - hGAPDH + NAD – human<br />		**[[3pfw]] - hGAPDH + NAD – human<br />
	**[[3sth]] - GAPDH + NAD – ''Toxoplasma gondii''<br />		**[[3sth]] - GAPDH + NAD – ''Toxoplasma gondii''<br />
	**[[3pym]] - GAPDH + NAD – ~~yeast~~<br />		**[[3pym]] - yGAPDH + NAD – yeast<br />
			**[[5mvt]] - GAPDH + NAD – ''Neisseria gonorrhoeae''<br />
			**[[5jy6]], [[5jye]], [[5jyf]], [[4qx6]] - SagGAPDH + NAD – ''Streptococcus agalactiae''<br />
			**[[5jya]] - SagGAPDH (mutant) + NAD<br />
			**[[5ddi]] - pGAPDH + NAD – pig<br />
			**[[4o63]], [[4o59]] - bGAPDH + NAD – bovine<br />
			**[[4k9d]] - GAPDH + NAD – ''Brugia malayi''<br />
			**[[4boy]], [[3zcx]], [[3b20]] - SeGAPDH + NAD – ''Synechococcus elongatus''<br />
			**[[3l0d]] - GAPDH + NAD – ''Bartonella henselae''<br />
			**[[3doc]] - GAPDH + NAD – ''Brucella melitensis''<br />
			**[[1vc2]] - GAPDH + NAD – ''Thermos thermophilus''<br />

	*NAD-dependent GAPDH ternary complexes containing glyceraldehyde-3-phosphate (G3P)		*NAD-dependent GAPDH ternary complexes containing glyceraldehyde-3-phosphate (G3P)
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	**[[3cif]] - CpGAPDH (mutant) + NAD + G3P<br />		**[[3cif]] - CpGAPDH (mutant) + NAD + G3P<br />
	**[[3ksz]], [[3l4s]] - SaGAPDH (mutant) + NAD + G3P<br />		**[[3ksz]], [[3l4s]] - SaGAPDH (mutant) + NAD + G3P<br />
			**[[1nqo]], [[1nqa]] - GsGAPDH (mutant) + NAD + G3P<br />
			**[[1dc4]], [[1dc3]] - EcGAPDH + G3P<br />

	*Other NAD-dependent GAPDH ternary complexes		*Other NAD-dependent GAPDH ternary complexes
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	**[[3k73]], [[3l6o]] - SaGAPDH + NAD + phosphate<br />		**[[3k73]], [[3l6o]] - SaGAPDH + NAD + phosphate<br />
	**[[1uxt]] - TtGAPDH (mutant) + NAD + G1P<br />		**[[1uxt]] - TtGAPDH (mutant) + NAD + G1P<br />
	**[[3b1j]], [[3b1k]] - ~~GAPDH~~ + NAD + CP12 ~~– ''Synechococcus elongatus''~~<br />		**[[3b1j]], [[3b1k]], [[3zdf]] - SeGAPDH + NAD + CP12 <br />
			**[[3qv1]] - AtGAPDH + NAD + CP12 <br />
			**[[5tso]] - pGAPDH + NAD + phenanthroline <br />
			**[[1i33]], [[1i32]] - LmGAPDH + inhibitor<br />

			*NADP-dependent GAPDH

			**[[2duu]], [[2d2i]] - SeGAPDH <br />

	*NADP-dependent GAPDH with cofactor NADP		*NADP-dependent GAPDH with cofactor NADP
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	**[[1k3t]] - TcGAPDH + coumarin derivative – ''Trypanosoma cruzi''<br />		**[[1k3t]] - TcGAPDH + coumarin derivative – ''Trypanosoma cruzi''<br />
	**[[1uxv]] - TtGAPDH + NADP + AMP<br />		**[[1uxv]] - TtGAPDH + NADP + AMP<br />
			**[[1ml3]] - TtGAPDH + NAD + inhibitor<br />
	**[[1uxp]] - TtGAPDH (mutant) + NADP + ADP<br />		**[[1uxp]] - TtGAPDH (mutant) + NADP + ADP<br />
			**[[1qxs]] - TtGAPDH + NAD + bisphosphono-glycerate<br />
	**[[1uxq]] - TtGAPDH (mutant) + NADP + G1P<br />		**[[1uxq]] - TtGAPDH (mutant) + NADP + G1P<br />
	**[[1uxr]] - TtGAPDH (mutant) + NADP + F6P<br />		**[[1uxr]] - TtGAPDH (mutant) + NADP + F6P<br />
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	==References==		==References==

	1) Voet, D, Voet, J, & Pratt, C. (2008)~~. Fundamentals of biochemistry, third edition. Hoboken, NJ: Wiley & Sons, Inc.~~		1) Voet, D, Voet, J, & Pratt, C. (2008)

	2)Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain. Retrieved from: http://scop.mrc-lmb.cam.ac.uk/scop/data/scop.b.d.c.b.d.html		2)Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain. Retrieved from: http://scop.mrc-lmb.cam.ac.uk/scop/data/scop.b.d.c.b.d.html

Michal Harel at 10:22, 30 May 2017

2017-05-30T10:22:36Z

← Older revision		Revision as of 10:22, 30 May 2017
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	<StructureSection load='3gpd' size='340' side='right' caption='Human glyceraldehyde-3-phosphate dehydrogenase complex with NAD and sulfate, [[3gpd]]' scene=''>		<StructureSection load='3gpd' size='340' side='right' caption='Human glyceraldehyde-3-phosphate dehydrogenase complex with NAD and sulfate, [[3gpd]]' scene=''>
	== Function ==		== Function ==

Michal Harel at 08:56, 30 May 2017

2017-05-30T08:56:57Z

← Older revision		Revision as of 08:56, 30 May 2017
Line 1:		Line 1:
	~~{{STRUCTURE_3gpd\| PDB=3gpd \| SIZE=400\| SCENE= \|right\|CAPTION=Human glyceraldehyde-3-phosphate dehydrogenase complex with NAD and sulfate, [[3gpd]] }}~~

			<StructureSection load='3gpd' size='340' side='right' caption='Human glyceraldehyde-3-phosphate dehydrogenase complex with NAD and sulfate, [[3gpd]]' scene=''>
	== Function ==		== Function ==

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	For additional information, see: [[Carbohydrate Metabolism]]		For additional information, see: [[Carbohydrate Metabolism]]
	<br />		<br />
			</StructureSection>

	==3D structures of glyceraldehyde-3-phosphate dehydrogenase==		==3D structures of glyceraldehyde-3-phosphate dehydrogenase==