HMG-CoA Reductase - Revision history

Michal Harel at 08:34, 16 January 2023

2023-01-16T08:34:16Z

← Older revision		Revision as of 08:34, 16 January 2023
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	[[Ephrin Type-A Receptor]]<br />		[[Ephrin Type-A Receptor]]<br />
	[[Neurodevelopmental Disorders]]<br />		[[Neurodevelopmental Disorders]]<br />
			[[Mevalonate pathway]]<br />
	[[Biosynthesis of cholesterol]].		[[Biosynthesis of cholesterol]].
	[[Image: HMG-CoA_reductase_pathway.png\|350px\|left\|thumb\| Mevalonate Pathway. Note the early stage at which the statins interfere in the pathway]]		[[Image: HMG-CoA_reductase_pathway.png\|350px\|left\|thumb\| Mevalonate Pathway. Note the early stage at which the statins interfere in the pathway]]

Michal Harel at 09:48, 8 January 2023

2023-01-08T09:48:50Z

← Older revision		Revision as of 09:48, 8 January 2023
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	[[HMG-CoA Reductase]] (or '''3-hydroxy-3-methyl-glutaryl-CoA reductase''' or '''HMGR''') is the rate-controlling enzyme of the mevalonate pathway, responsible for cholesterol and other isoprenoid biosynthesis. HMGR is a transmembrane protein, containing 8 domains, that is anchored in the membrane of the endoplasmic reticulum.<ref name="Roitelman">PMID:1374417</ref> It is the major target of the '''Statins''' the best selling pharmaceutical drugs in the world and [[Vytorin]] - cholesterol lowering drug class . See also		[[HMG-CoA Reductase]] (or '''3-hydroxy-3-methyl-glutaryl-CoA reductase''' or '''HMGR''') is the rate-controlling enzyme of the mevalonate pathway, responsible for cholesterol and other isoprenoid biosynthesis. HMGR is a transmembrane protein, containing 8 domains, that is anchored in the membrane of the endoplasmic reticulum.<ref name="Roitelman">PMID:1374417</ref> It is the major target of the '''Statins''' the best selling pharmaceutical drugs in the world and [[Vytorin]] - cholesterol lowering drug class . See also
	[[Ephrin Type-A Receptor]]<br />		[[Ephrin Type-A Receptor]]<br />
	[[Neurodevelopmental Disorders]]		[[Neurodevelopmental Disorders]]<br />
	[[Biosynthesis of cholesterol]].		[[Biosynthesis of cholesterol]].
	[[Image: HMG-CoA_reductase_pathway.png\|350px\|left\|thumb\| Mevalonate Pathway. Note the early stage at which the statins interfere in the pathway]]		[[Image: HMG-CoA_reductase_pathway.png\|350px\|left\|thumb\| Mevalonate Pathway. Note the early stage at which the statins interfere in the pathway]]

Michal Harel at 09:48, 8 January 2023

2023-01-08T09:48:34Z

← Older revision		Revision as of 09:48, 8 January 2023
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	[[HMG-CoA Reductase]] (or '''3-hydroxy-3-methyl-glutaryl-CoA reductase''' or '''HMGR''') is the rate-controlling enzyme of the mevalonate pathway, responsible for cholesterol and other isoprenoid biosynthesis. HMGR is a transmembrane protein, containing 8 domains, that is anchored in the membrane of the endoplasmic reticulum.<ref name="Roitelman">PMID:1374417</ref> It is the major target of the '''Statins''' the best selling pharmaceutical drugs in the world and [[Vytorin]] - cholesterol lowering drug class . See also		[[HMG-CoA Reductase]] (or '''3-hydroxy-3-methyl-glutaryl-CoA reductase''' or '''HMGR''') is the rate-controlling enzyme of the mevalonate pathway, responsible for cholesterol and other isoprenoid biosynthesis. HMGR is a transmembrane protein, containing 8 domains, that is anchored in the membrane of the endoplasmic reticulum.<ref name="Roitelman">PMID:1374417</ref> It is the major target of the '''Statins''' the best selling pharmaceutical drugs in the world and [[Vytorin]] - cholesterol lowering drug class . See also
	[[Ephrin Type-A Receptor]]		[[Ephrin Type-A Receptor]]<br />
	[[Neurodevelopmental Disorders]]		[[Neurodevelopmental Disorders]]
	[[Biosynthesis of cholesterol]].		[[Biosynthesis of cholesterol]].

Michal Harel at 09:48, 8 January 2023

2023-01-08T09:48:07Z

← Older revision		Revision as of 09:48, 8 January 2023
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	==Function==		==Function==

	[[HMG-CoA Reductase]] (or '''3-hydroxy-3-methyl-glutaryl-CoA reductase''' or '''HMGR''') is the rate-controlling enzyme of the mevalonate pathway, responsible for cholesterol and other isoprenoid biosynthesis. HMGR is a transmembrane protein, containing 8 domains, that is anchored in the membrane of the endoplasmic reticulum.<ref name="Roitelman">PMID:1374417</ref> It is the major target of the '''Statins''' the best selling pharmaceutical drugs in the world and [[Vytorin]] - cholesterol lowering drug class . See also [[Ephrin Type-A Receptor]] ~~and~~ [[Neurodevelopmental Disorders]].		[[HMG-CoA Reductase]] (or '''3-hydroxy-3-methyl-glutaryl-CoA reductase''' or '''HMGR''') is the rate-controlling enzyme of the mevalonate pathway, responsible for cholesterol and other isoprenoid biosynthesis. HMGR is a transmembrane protein, containing 8 domains, that is anchored in the membrane of the endoplasmic reticulum.<ref name="Roitelman">PMID:1374417</ref> It is the major target of the '''Statins''' the best selling pharmaceutical drugs in the world and [[Vytorin]] - cholesterol lowering drug class . See also
			[[Ephrin Type-A Receptor]]
			[[Neurodevelopmental Disorders]]
			[[Biosynthesis of cholesterol]].
	[[Image: HMG-CoA_reductase_pathway.png\|350px\|left\|thumb\| Mevalonate Pathway. Note the early stage at which the statins interfere in the pathway]]		[[Image: HMG-CoA_reductase_pathway.png\|350px\|left\|thumb\| Mevalonate Pathway. Note the early stage at which the statins interfere in the pathway]]
	{{clear}}		{{clear}}

Michal Harel at 08:05, 1 August 2019

2019-08-01T08:05:59Z

← Older revision		Revision as of 08:05, 1 August 2019
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	</StructureSection>		</StructureSection>

	~~==3D Structures of HMG-CoA Reductase==~~

	~~Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}~~
	~~{{#tree:id=OrganizedByTopic\|openlevels=0\|~~

	*HMGCR

	**[[1r7i]], [[4i64]] - PmHMGCR catalytic domain - ''Pseudomonas mevalonii'' <br/>
	**[[3qae]], [[3qau]] - HMGCR (mutant) - ''Streptococcus pneumoniae'' <br/>
	**[[6hr7]] - MtHMGCR – ''Methanothermococcus thermolithotrophicus''<br />
	**[[6eeu]] - DaHMGCR – ''Delftiya acidovorans''<br />

	*HMGCR+statins

	**[[3cct]], [[3ccw]], [[3ccz]], [[3cd0]], [[3cd5]], [[3cd7]], [[3cda]], [[3cdb]], [[2r4f]], [[3bgl]], [[2q1l]], [[2q6b]], [[2q6c]], [[1hw8]], [[1hw9]], [[1hwi]], [[1hwj]], [[1hwk]], [[1hwl]] – hHMGCR catalytic domain + statin derivatives - human <br />
	**[[1t02]] - PmHMGCR catalytic domain + statin derivatives <br />

	*HMGCR+cofactors

	**[[1dq8]] - hHMGCR catalytic domain (mutant) +CoA+HMG<br />
	**[[1dq9]] - hHMGCR catalytic domain (mutant)+HMG-CoA<br />
	**[[1dqa]] - hHMGCR catalytic domain (mutant)+HMG+CoA+NADP<br />
	**[[1r31]] – PmHMGCR catalytic domain +CoA+mevalonate<br />
	**[[1qax]], [[4i4b]] - PmHMGCR catalytic domain +HMG+CoA+NAD+<br />
	**[[4i56]] - PmHMGCR catalytic domain + dithio-HMG+CoA<br />
	**[[4i6a]] - PmHMGCR catalytic domain + HMG+CoA<br />
	**[[4i6w]] - PmHMGCR catalytic domain + thiomevalonate<br />
	**[[4i6y]] - PmHMGCR catalytic domain + mevalonate<br />
	**[[6eev]] - DaHMGCR + mevalonate<br />
	**[[1qay]] - PmHMGCR catalytic domain +mevalonate+NAD+<br />
	**[[5wpk]] - SpHMGCR catalytic domain + HMG-CoA<br />

	* HMGCR other complexes

	**[[5wpj]] - SpHMGCR catalytic domain + NADP<br />
	**[[6hr8]] - MtHMGCR + NADP<br />
	**[[6dio]] - DaHMGCR + NAD <br />
	}}

	==Additional Resources==		==Additional Resources==

Michal Harel at 08:04, 1 August 2019

2019-08-01T08:04:52Z

← Older revision		Revision as of 08:04, 1 August 2019
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	[[Treatments:Statin Pharmacokinetics References]]<br />.		[[Treatments:Statin Pharmacokinetics References]]<br />.
	<br />		<br />

			==3D Structures of HMG-CoA Reductase==
			[[HMG-CoA Reductase 3D structures]]

	</StructureSection>		</StructureSection>

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	**[[1r7i]], [[4i64]] - PmHMGCR catalytic domain - ''Pseudomonas mevalonii'' <br/>		**[[1r7i]], [[4i64]] - PmHMGCR catalytic domain - ''Pseudomonas mevalonii'' <br/>
	**[[3qae]], [[3qau]] - HMGCR (mutant) - ''Streptococcus pneumoniae'' <br/>		**[[3qae]], [[3qau]] - HMGCR (mutant) - ''Streptococcus pneumoniae'' <br/>
			**[[6hr7]] - MtHMGCR – ''Methanothermococcus thermolithotrophicus''<br />
			**[[6eeu]] - DaHMGCR – ''Delftiya acidovorans''<br />

	*HMGCR+statins		*HMGCR+statins
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	*HMGCR+cofactors		*HMGCR+cofactors

			**[[1dq8]] - hHMGCR catalytic domain (mutant) +CoA+HMG<br />
			**[[1dq9]] - hHMGCR catalytic domain (mutant)+HMG-CoA<br />
			**[[1dqa]] - hHMGCR catalytic domain (mutant)+HMG+CoA+NADP<br />
	**[[1r31]] – PmHMGCR catalytic domain +CoA+mevalonate<br />		**[[1r31]] – PmHMGCR catalytic domain +CoA+mevalonate<br />
	**[[1qax]], [[4i4b]] - PmHMGCR catalytic domain +HMG+CoA+NAD+<br />		**[[1qax]], [[4i4b]] - PmHMGCR catalytic domain +HMG+CoA+NAD+<br />
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	**[[4i6w]] - PmHMGCR catalytic domain + thiomevalonate<br />		**[[4i6w]] - PmHMGCR catalytic domain + thiomevalonate<br />
	**[[4i6y]] - PmHMGCR catalytic domain + mevalonate<br />		**[[4i6y]] - PmHMGCR catalytic domain + mevalonate<br />
			**[[6eev]] - DaHMGCR + mevalonate<br />
	**[[1qay]] - PmHMGCR catalytic domain +mevalonate+NAD+<br />		**[[1qay]] - PmHMGCR catalytic domain +mevalonate+NAD+<br />
	**[[1dq8]] - hHMGCR catalytic domain (mutant) +CoA+HMG<br />
	**[[1dq9]] - hHMGCR catalytic domain (mutant)+HMG-CoA<br />
	**[[1dqa]] - hHMGCR catalytic domain (mutant)+HMG+CoA+NADP<br />
	**[[5wpk]] - SpHMGCR catalytic domain + HMG-CoA<br />		**[[5wpk]] - SpHMGCR catalytic domain + HMG-CoA<br />

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	**[[5wpj]] - SpHMGCR catalytic domain + NADP<br />		**[[5wpj]] - SpHMGCR catalytic domain + NADP<br />
			**[[6hr8]] - MtHMGCR + NADP<br />
			**[[6dio]] - DaHMGCR + NAD <br />
	}}		}}

Michal Harel at 07:45, 18 July 2018

2018-07-18T07:45:46Z

← Older revision		Revision as of 07:45, 18 July 2018
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	**[[1dq8]] - hHMGCR catalytic domain (mutant) +CoA+HMG<br />		**[[1dq8]] - hHMGCR catalytic domain (mutant) +CoA+HMG<br />
	**[[1dq9]] - hHMGCR catalytic domain (mutant)+HMG-CoA<br />		**[[1dq9]] - hHMGCR catalytic domain (mutant)+HMG-CoA<br />
	**[[1dqa]] - hHMGCR catalytic domain (mutant)+HMG+CoA+NADP+<br />		**[[1dqa]] - hHMGCR catalytic domain (mutant)+HMG+CoA+NADP<br />
			**[[5wpk]] - SpHMGCR catalytic domain + HMG-CoA<br />

			* HMGCR other complexes

			**[[5wpj]] - SpHMGCR catalytic domain + NADP<br />
	}}		}}

Michal Harel at 09:14, 7 January 2018

2018-01-07T09:14:01Z

← Older revision		Revision as of 09:14, 7 January 2018
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	See<br />		See<br />
	[[Statin Pharmacokinetics]]<br />		[[Statin Pharmacokinetics]]<br />
			[[Lovastatin-Mevacor]]<br />
	[[Treatments:Hypercholeseterolemia]]<br />		[[Treatments:Hypercholeseterolemia]]<br />
	[[Treatments:Statin Pharmacokinetics References]]<br />.		[[Treatments:Statin Pharmacokinetics References]]<br />.

Joel L. Sussman at 21:20, 6 January 2018

2018-01-06T21:20:43Z

← Older revision		Revision as of 21:20, 6 January 2018
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	\|BAMBEDDOI=10.1002/bmb.20481		\|BAMBEDDOI=10.1002/bmb.20481
	}}		}}
	<StructureSection load='~~1dq8~~' size='350' side='right' scene='HMG-CoA_Reductase/1dq8_starting_scene/1' caption='Crystal Structure of HMG-CoA, (PDB code [[1dq8]])'>		<StructureSection load='' size='350' side='right' scene='HMG-CoA_Reductase/1dq8_starting_scene/1' caption='Crystal Structure of HMG-CoA, (PDB code [[1dq8]])'>
	==Function==		==Function==

Michal Harel at 11:13, 4 January 2018

2018-01-04T11:13:49Z

← Older revision		Revision as of 11:13, 4 January 2018
Line 7:		Line 7:
	==Function==		==Function==

	[[HMG-CoA Reductase]] (or '''3-hydroxy-3-methyl-glutaryl-CoA reductase''' or '''HMGR''') is the rate-controlling enzyme of the mevalonate pathway, responsible for cholesterol and other isoprenoid biosynthesis. HMGR is a transmembrane protein, containing 8 domains, that is anchored in the membrane of the endoplasmic reticulum.<ref name="Roitelman">PMID:1374417</ref> It is the major target of the Statins~~, a cholesterol lowering drug class and~~ the best selling pharmaceutical drugs in the world. See also [[Ephrin Type-A Receptor]] and [[Neurodevelopmental Disorders]].		[[HMG-CoA Reductase]] (or '''3-hydroxy-3-methyl-glutaryl-CoA reductase''' or '''HMGR''') is the rate-controlling enzyme of the mevalonate pathway, responsible for cholesterol and other isoprenoid biosynthesis. HMGR is a transmembrane protein, containing 8 domains, that is anchored in the membrane of the endoplasmic reticulum.<ref name="Roitelman">PMID:1374417</ref> It is the major target of the '''Statins''' the best selling pharmaceutical drugs in the world and [[Vytorin]] - cholesterol lowering drug class . See also [[Ephrin Type-A Receptor]] and [[Neurodevelopmental Disorders]].
	[[Image: HMG-CoA_reductase_pathway.png\|350px\|left\|thumb\| Mevalonate Pathway. Note the early stage at which the statins interfere in the pathway]]		[[Image: HMG-CoA_reductase_pathway.png\|350px\|left\|thumb\| Mevalonate Pathway. Note the early stage at which the statins interfere in the pathway]]
	{{clear}}		{{clear}}