Importin 3D structures - Revision history

Michal Harel at 09:22, 18 September 2025

2025-09-18T09:22:47Z

← Older revision		Revision as of 09:22, 18 September 2025
Line 45:		Line 45:
	*''IPO-α 1 complex with NLS peptide''		*''IPO-α 1 complex with NLS peptide''

	**[[4b18]] – hIPO NLS-binding domain + telomerase reverse transcriptase<br />		**[[2jdq]], [[4b18]] – hIPO NLS-binding domain + telomerase reverse transcriptase<br />
	**[[4wv6]] – hIPO NLS-binding domain + TFIID<br />		**[[4wv6]] – hIPO NLS-binding domain + TFIID<br />
	**[[6bw0]] – hIPO NLS-binding domain + Nipa virus peptide<br />		**[[6bw0]] – hIPO NLS-binding domain + Nipa virus peptide<br />
Line 55:		Line 55:
	**[[7n8j]] – hIPO NLS-binding domain + BIMAX peptide<br />		**[[7n8j]] – hIPO NLS-binding domain + BIMAX peptide<br />
	**[[5h43]] – hIPO NLS-binding domain + histone acetyltransferase KAT8<br />		**[[5h43]] – hIPO NLS-binding domain + histone acetyltransferase KAT8<br />
			**[[8gcn]] – hIPO NLS-binding domain + IPO-beta 1 peptide – Cryo EM<br />
	**[[8gai]] – IPO NLS-binding domain + BIMAX peptide – guinea pig<br />		**[[8gai]] – IPO NLS-binding domain + BIMAX peptide – guinea pig<br />
	**[[4mz5]], [[4mz6]] – mIPO NLS-binding domain 70-528 + dUTPase<br />		**[[4mz5]], [[4mz6]] – mIPO NLS-binding domain 70-528 + dUTPase<br />
Line 90:		Line 91:
	**[[7rg4]], [[7rg5]] – mIPO NLS-binding domain + p50 peptide <br />		**[[7rg4]], [[7rg5]] – mIPO NLS-binding domain + p50 peptide <br />
	**[[6wx7]] – mIPO NLS-binding domain + SOX2 peptide <br />		**[[6wx7]] – mIPO NLS-binding domain + SOX2 peptide <br />
			**[[8g8q]] – mIPO NLS-binding domain + monopartite p52 NLS + peptide<br />
			**[[8g8s]] – mIPO NLS-binding domain + bipartite p52 NLS peptide<br />
			**[[9cl8]], [[9cle]], [[9clf]], [[9clg]] – mIPO NLS-binding domain + zero net charge NLS peptide<br />
			**[[9y0r]] – mIPO NLS-binding domain + ATF2 peptide<br />
			**[[5fc8]], [[5hhg]], [[8vpr]], [[8vpu]] – mIPO NLS-binding domain + dengue virus peptide<br />
	**[[4b8o]] – rIPO NLS-binding domain + SV40<br />		**[[4b8o]] – rIPO NLS-binding domain + SV40<br />
	**[[4b8p]] – rIPO NLS-binding domain + A89<br />		**[[4b8p]] – rIPO NLS-binding domain + A89<br />
Line 101:		Line 107:
	**[[2jdq]] – hIPO NLS-binding domain + telomerase reverse transcriptase peptide<br />		**[[2jdq]] – hIPO NLS-binding domain + telomerase reverse transcriptase peptide<br />
	**[[4uaf]] – mIPO NLS-binding domain + influenza RNA polymerase<br />		**[[4uaf]] – mIPO NLS-binding domain + influenza RNA polymerase<br />
			**[[8sg7]], [[9cft]] – mIPO NLS-binding domain + adeno-associated virus VP1<br />

	*IPO-α 2		*IPO-α 2
Line 126:		Line 133:
	**[[3ve6]] – mIPO NLS-binding domain + Venezuelan equine encephalitis virus<br />		**[[3ve6]] – mIPO NLS-binding domain + Venezuelan equine encephalitis virus<br />
	**[[8f2q]] – mIPO NLS-binding domain + parvovirus<br />		**[[8f2q]] – mIPO NLS-binding domain + parvovirus<br />
			**[[8q8k]], [[8sud]], [[8tuq]], [[8tur]], [[8tus]], [[8tut]], [[8tuu]], [[8tuv]] – mIPO NLS-binding domain + polyomavirus peptide<br />
			**[[8sv0]], [[8u36]] – mIPO NLS-binding domain + siadenovirus peptide<br />
			**[[8g8r]] – mIPO NLS-binding domain + RELB peptide<br />
	**[[3uvu]] – mIPO NLS-binding domain + flap endonuclease<br />		**[[3uvu]] – mIPO NLS-binding domain + flap endonuclease<br />
	**[[3ukw]], [[3ukx]] – mIPO NLS-binding domain + BIMAX<br />		**[[3ukw]], [[3ukx]] – mIPO NLS-binding domain + BIMAX<br />
Line 145:		Line 155:
	**[[6bvz]] – hIPO NLS-binding domain <br />		**[[6bvz]] – hIPO NLS-binding domain <br />
	**[[4uae]] – hIPO NLS-binding domain + influenza RNA polymerase<br />		**[[4uae]] – hIPO NLS-binding domain + influenza RNA polymerase<br />
			**[[8qxx]] – hIPO NLS-binding domain + Herpes DNA polymerase processivity factor peptide<br />
			**[[8qxw]] – hIPO NLS-binding domain + cytomegalovirus DNA polymerase processivity factor peptide<br />
	**[[6bw9]], [[6bwa]], [[6bwb]] – hIPO NLS-binding domain + Hendra virus peptide<br />		**[[6bw9]], [[6bwa]], [[6bwb]] – hIPO NLS-binding domain + Hendra virus peptide<br />
	**[[6bvv]] – hIPO NLS-binding domain + Nipa virus peptide<br />		**[[6bvv]] – hIPO NLS-binding domain + Nipa virus peptide<br />
Line 186:		Line 198:
	**[[1ibr]] – hIPO + GTPase Ran<br />		**[[1ibr]] – hIPO + GTPase Ran<br />
	**[[6n88]], [[6n89]] – hIPO + H1.0 – Cryo EM<br />		**[[6n88]], [[6n89]] – hIPO + H1.0 – Cryo EM<br />
			**[[9b4y]] – hIPO + IPO beta 1 peptide – Cryo EM<br />
	**[[1f59]], [[1o6p]], [[1o6o]] – hIPO + FXFG nucleoporin repeats<br />		**[[1f59]], [[1o6p]], [[1o6o]] – hIPO + FXFG nucleoporin repeats<br />
	**[[1m5n]] – hIPO HEAT repeats 1-11 + parathyroid hormone-related protein NLS peptide<br />		**[[1m5n]] – hIPO HEAT repeats 1-11 + parathyroid hormone-related protein NLS peptide<br />
Line 209:		Line 222:
	**[[5tqc]] – hIPO + RPL4 peptide<br />		**[[5tqc]] – hIPO + RPL4 peptide<br />
	**[[5j3v]] – hIPO + histone H3 peptide<br />		**[[5j3v]] – hIPO + histone H3 peptide<br />
			**[[8sgh]] – hIPO NLS-binding domain + HNRNPH2 <br />

	*IPO-β 3 (Karyopherin β 3)		*IPO-β 3 (Karyopherin β 3)
Line 224:		Line 238:

	**[[6aho]] – yIPO <br />		**[[6aho]] – yIPO <br />
			**[[8h5b]] – yIPO + TATA box – Cryo EM<br />
			**[[8f0x]] – yIPO + histone H2A.2 + H2B.2 – Cryo EM<br />
			**[[8f19]] – yIPO + RANGTP – Cryo EM<br />

	*IPO-4		*IPO-4
Line 238:		Line 255:

	**[[6xte]], [[6xu2]] – hIPO + antipain peptide <br />		**[[6xte]], [[6xu2]] – hIPO + antipain peptide <br />
			**[[9im6]] – mIPO NLS-binding domain + RanBP5 peptide – Cryo EM<br />

	*IPO-7		*IPO-7
Line 246:		Line 264:

	**[[6n1z]] – hIPO + histone H2A + histone H2B <br />		**[[6n1z]] – hIPO + histone H2A + histone H2B <br />
			**[[8f7a]] – hIPO NLS-binding domain + RanGTP – Cryo EM<br />

	*IPO-12 (Transportin-3)		*IPO-12 (Transportin-3)
Line 253:		Line 272:
	**[[4c0q]], [[4ol0]] – hIPO + GTPase Ran<br />		**[[4c0q]], [[4ol0]] – hIPO + GTPase Ran<br />
	**[[6gx9]] – hIPO + CPSF 68<br />		**[[6gx9]] – hIPO + CPSF 68<br />
			**[[8cmk]] – hIPO + CIRBP<br />

	*IPO-13 (karyopherin 13)		*IPO-13 (karyopherin 13)

Michal Harel at 10:19, 2 July 2024

2024-07-02T10:19:08Z

← Older revision		Revision as of 10:19, 2 July 2024
Line 259:		Line 259:
	**[[2xwu]] – hIPO + UBC9<br />		**[[2xwu]] – hIPO + UBC9<br />
	**[[3zjy]] – hIPO + GTPase Ran + EIF-1A<br />		**[[3zjy]] – hIPO + GTPase Ran + EIF-1A<br />
			}}

	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 10:18, 2 July 2024

2024-07-02T10:18:04Z

← Older revision		Revision as of 10:18, 2 July 2024
Line 259:		Line 259:
	**[[2xwu]] – hIPO + UBC9<br />		**[[2xwu]] – hIPO + UBC9<br />
	**[[3zjy]] – hIPO + GTPase Ran + EIF-1A<br />		**[[3zjy]] – hIPO + GTPase Ran + EIF-1A<br />

	*IPO-90

	**[[6n89]] – hIPO-90 + histone H1.0 – Cryo EM <br />
	}}

	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 09:50, 2 July 2024

2024-07-02T09:50:38Z

← Older revision		Revision as of 09:50, 2 July 2024
Line 155:		Line 155:
	**[[7lf4]] – hIPO + p50 NLS + p65 NLS<br />		**[[7lf4]] – hIPO + p50 NLS + p65 NLS<br />
	**[[8fub]] – hIPO NLS-binding domain + Hendra virus peptide<br />		**[[8fub]] – hIPO NLS-binding domain + Hendra virus peptide<br />
			**[[7jjl]] – hIPO + LSD1 peptide <br />
	**[[8fzm]] – mIPO NLS-binding domain + BIMAX<br />		**[[8fzm]] – mIPO NLS-binding domain + BIMAX<br />
	**[[7let]] – mIPO + p50 NLS + p65 NLS<br />		**[[7let]] – mIPO + p50 NLS + p65 NLS<br />
Line 223:		Line 224:

	**[[6aho]] – yIPO <br />		**[[6aho]] – yIPO <br />

	*IPO-3

	**[[7jjl]] – hIPO + LSD1 peptide <br />

	*IPO-4		*IPO-4

Michal Harel at 07:10, 29 May 2023

2023-05-29T07:10:28Z

← Older revision		Revision as of 07:10, 29 May 2023
Line 7:		Line 7:

	**[[1ial]] – mIPO NLS-binding domain – mouse<br />		**[[1ial]] – mIPO NLS-binding domain – mouse<br />
			**[[6d7m]] – mIPO (mutant)<br />
			**[[4tnm]] – IPO armadillo repeat domain – ''Arabidopsis thaliana''<br />
	**[[1bk5]] – yIPO NLS-binding domain - yeast<br />		**[[1bk5]] – yIPO NLS-binding domain - yeast<br />
	**[[~~4tnm~~]] – ~~IPO armadillo repeat~~ domain – ''~~Arabidopsis thaliana~~''<br />		**[[7vps]] – NgIPO ARM domain 75-516 – ''Nakaceomyces glabratus''<br />

	*''IPO-α complex with NLS peptide''		*''IPO-α complex with NLS peptide''
Line 25:		Line 27:
	**[[4rxh]] – NcIPO NLS-binding domain + SV40 large T antigen – ''Neurospora crassa''<br />		**[[4rxh]] – NcIPO NLS-binding domain + SV40 large T antigen – ''Neurospora crassa''<br />
	**[[5vqi]] – NcIPO NLS-binding domain + NIT2<br />		**[[5vqi]] – NcIPO NLS-binding domain + NIT2<br />
			**[[7vpt]] – NgIPO ARM domain + Upc2<br />

	*''IPO-α complex with protein''		*''IPO-α complex with protein''
Line 34:		Line 37:
	*IPO-α 1		*IPO-α 1

	**[[3wpt]] – hIPO NLS-binding domain - human<br />		**[[3wpt]], [[8fzk]] – hIPO NLS-binding domain - human<br />
	**[[4b8j]] – rIPO <br />		**[[4b8j]] – rIPO <br />
	**[[6bvt]] – mIPO NLS-binding domain <br />		**[[6bvt]] – mIPO NLS-binding domain <br />
Line 47:		Line 50:
	**[[6bw1]] – hIPO NLS-binding domain + Hendra virus peptide<br />		**[[6bw1]] – hIPO NLS-binding domain + Hendra virus peptide<br />
	**[[5w4e]], [[5w4f]], [[5w4g]] – hIPO NLS-binding domain + polymerase peptide<br />		**[[5w4e]], [[5w4f]], [[5w4g]] – hIPO NLS-binding domain + polymerase peptide<br />
			**[[7n9h]] – hIPO NLS-binding domain + TDP-43 peptide<br />
			**[[7cru]] – hIPO NLS-binding domain + hnRNPK peptide<br />
			**[[8he3]] – hIPO NLS-binding domain + HIF-1 peptide<br />
	**[[7n8j]] – hIPO NLS-binding domain + BIMAX peptide<br />		**[[7n8j]] – hIPO NLS-binding domain + BIMAX peptide<br />
	**[[5h43]] – hIPO NLS-binding domain + histone acetyltransferase KAT8<br />		**[[5h43]] – hIPO NLS-binding domain + histone acetyltransferase KAT8<br />
			**[[8gai]] – IPO NLS-binding domain + BIMAX peptide – guinea pig<br />
	**[[4mz5]], [[4mz6]] – mIPO NLS-binding domain 70-528 + dUTPase<br />		**[[4mz5]], [[4mz6]] – mIPO NLS-binding domain 70-528 + dUTPase<br />
	**[[4oih]] – mIPO NLS-binding domain + guanine nucleotide exchange factor SRM1<br />		**[[4oih]] – mIPO NLS-binding domain + guanine nucleotide exchange factor SRM1<br />
Line 58:		Line 65:
	**[[5ekg]], [[5ekf]], [[5e6q]] – mIPO NLS-binding domain + XPG2<br />		**[[5ekg]], [[5ekf]], [[5e6q]] – mIPO NLS-binding domain + XPG2<br />
	**[[5d5k]] – mIPO NLS-binding domain + PARP 2<br />		**[[5d5k]] – mIPO NLS-binding domain + PARP 2<br />
	**[[7l04]] – mIPO NLS-binding domain + adeno-associated virus<br />		**[[7l04]], [[8fk3]] – mIPO NLS-binding domain + adeno-associated virus<br />
	**[[5ctt]] – mIPO NLS-binding domain + SART3/TIP110<br />		**[[5ctt]] – mIPO NLS-binding domain + SART3/TIP110<br />
	**[[5b56]] – mIPO NLS-binding domain + HIV-1 VPR<br />		**[[5b56]] – mIPO NLS-binding domain + HIV-1 VPR<br />
Line 67:		Line 74:
	**[[6iu7]], [[6iua]] – mIPO NLS-binding domain + TP53-binding protein <br />		**[[6iu7]], [[6iua]] – mIPO NLS-binding domain + TP53-binding protein <br />
	**[[5w41]] – mIPO NLS-binding domain + Zika virus peptide <br />		**[[5w41]] – mIPO NLS-binding domain + Zika virus peptide <br />
			**[[8fua]], [[8fuc]] – mIPO NLS-binding domain + Hendra virus peptide<br />
			**[[8ech]] – mIPO NLS-binding domain + tick-bourne encephalitis virus<br />
	**[[5v5o]], [[5v5p]] – mIPO NLS-binding domain + influenza virus peptide <br />		**[[5v5o]], [[5v5p]] – mIPO NLS-binding domain + influenza virus peptide <br />
	**[[5umz]] – mIPO NLS-binding domain + TNRC6A peptide <br />		**[[5umz]] – mIPO NLS-binding domain + TNRC6A peptide <br />
Line 78:		Line 87:
	**[[7jjm]], [[7jk7]] – mIPO NLS-binding domain + LSD1 peptide <br />		**[[7jjm]], [[7jk7]] – mIPO NLS-binding domain + LSD1 peptide <br />
	**[[7jvo]] – mIPO NLS-binding domain + ACE2 peptide <br />		**[[7jvo]] – mIPO NLS-binding domain + ACE2 peptide <br />
			**[[8he0]] – mIPO NLS-binding domain + HIF-1 peptide<br />
	**[[7rg4]], [[7rg5]] – mIPO NLS-binding domain + p50 peptide <br />		**[[7rg4]], [[7rg5]] – mIPO NLS-binding domain + p50 peptide <br />
	**[[6wx7]] – mIPO NLS-binding domain + SOX2 peptide <br />		**[[6wx7]] – mIPO NLS-binding domain + SOX2 peptide <br />
Line 105:		Line 115:
	**[[1y2a]], [[3q5u]] – mIPO NLS-binding domain + phospholipid scramblase <br />		**[[1y2a]], [[3q5u]] – mIPO NLS-binding domain + phospholipid scramblase <br />
	**[[2c1m]] – mIPO NLS-binding domain + Nup50<br />		**[[2c1m]] – mIPO NLS-binding domain + Nup50<br />
			**[[7leq]] – mIPO NLS-binding domain + p50<br />
			**[[7leu]] – mIPO NLS-binding domain + p65<br />
	**[[3btr]] – mIPO NLS-binding domain + androgen receptor<br />		**[[3btr]] – mIPO NLS-binding domain + androgen receptor<br />
	**[[3knd]] – mIPO NLS-binding domain + targeting protein for KXLP2<br />		**[[3knd]] – mIPO NLS-binding domain + targeting protein for KXLP2<br />
Line 113:		Line 125:
	**[[3tpm]] – mIPO NLS-binding domain + MAL<br />		**[[3tpm]] – mIPO NLS-binding domain + MAL<br />
	**[[3ve6]] – mIPO NLS-binding domain + Venezuelan equine encephalitis virus<br />		**[[3ve6]] – mIPO NLS-binding domain + Venezuelan equine encephalitis virus<br />
			**[[8f2q]] – mIPO NLS-binding domain + parvovirus<br />
	**[[3uvu]] – mIPO NLS-binding domain + flap endonuclease<br />		**[[3uvu]] – mIPO NLS-binding domain + flap endonuclease<br />
	**[[3ukw]], [[3ukx]] – mIPO NLS-binding domain + BIMAX<br />		**[[3ukw]], [[3ukx]] – mIPO NLS-binding domain + BIMAX<br />
Line 135:		Line 148:
	**[[6bvv]] – hIPO NLS-binding domain + Nipa virus peptide<br />		**[[6bvv]] – hIPO NLS-binding domain + Nipa virus peptide<br />
	**[[5xzx]] – hIPO NLS-binding domain + RAN-binding protein peptide<br />		**[[5xzx]] – hIPO NLS-binding domain + RAN-binding protein peptide<br />
			**[[8hkw]] – hIPO NLS-binding domain + 53BP1 peptide<br />
	**[[5tbk]] – hIPO NLS-binding domain + regulator of chromosome condensation <br />		**[[5tbk]] – hIPO NLS-binding domain + regulator of chromosome condensation <br />
	**[[7rfy]] – hIPO + ORF4b<br />		**[[7rfy]] – hIPO + ORF4b<br />
	**[[6wx8]] – hIPO + SOX2<br />		**[[6wx8]] – hIPO + SOX2<br />
			**[[7lfc]] – hIPO + p50 NLS<br />
			**[[7lf4]] – hIPO + p50 NLS + p65 NLS<br />
			**[[8fub]] – hIPO NLS-binding domain + Hendra virus peptide<br />
			**[[8fzm]] – mIPO NLS-binding domain + BIMAX<br />
			**[[7let]] – mIPO + p50 NLS + p65 NLS<br />

	*IPO-α 5		*IPO-α 5
Line 149:		Line 168:
	*IPO-α 7		*IPO-α 7

			**[[7rht]] – hIPO <br />
	**[[4uad]] – hIPO NLS-binding domain + influenza RNA polymerase<br />		**[[4uad]] – hIPO NLS-binding domain + influenza RNA polymerase<br />

	*IPO-β		*IPO-β

	**[[4xrk]] – IPO – ''Chaetomium thermophilum'' <br />		**[[4xri]], [[4xrk]] – IPO – ''Chaetomium thermophilum'' <br />

	*IPO-β 1 (karyopherin β 1)		*IPO-β 1 (karyopherin β 1)
Line 207:		Line 227:

	**[[7jjl]] – hIPO + LSD1 peptide <br />		**[[7jjl]] – hIPO + LSD1 peptide <br />

			*IPO-4

			**[[8dyo]] – hIPO + RanGTP – Cryo EM<br />
			**[[7unk]] – hIPO + H3 + H4 + ASF1 – Cryo EM<br />

	*IPO-4B		*IPO-4B
Line 230:		Line 255:
	**[[4c0o]] – hIPO + serine/arginine-rich splicing factor<br />		**[[4c0o]] – hIPO + serine/arginine-rich splicing factor<br />
	**[[4c0q]], [[4ol0]] – hIPO + GTPase Ran<br />		**[[4c0q]], [[4ol0]] – hIPO + GTPase Ran<br />
			**[[6gx9]] – hIPO + CPSF 68<br />

	*IPO-13 (karyopherin 13)		*IPO-13 (karyopherin 13)

Joel L. Sussman at 21:21, 22 February 2023

2023-02-22T21:21:49Z

← Older revision		Revision as of 21:21, 22 February 2023
Line 38:		Line 38:
	**[[6bvt]] – mIPO NLS-binding domain <br />		**[[6bvt]] – mIPO NLS-binding domain <br />
	**[[4u5v]], [[4u5u]], [[4u5s]], [[4u5o]], [[4u5n]], [[4u5l]], [[4u58]], [[4u54]] – mIPO NLS-binding domain + inhibitor<br />		**[[4u5v]], [[4u5u]], [[4u5s]], [[4u5o]], [[4u5n]], [[4u5l]], [[4u58]], [[4u54]] – mIPO NLS-binding domain + inhibitor<br />
	**[[~~7s1e~~]] – IPO – guinea pig<br />		**[[8g4j]] – IPO – guinea pig<br />

	*''IPO-α 1 complex with NLS peptide''		*''IPO-α 1 complex with NLS peptide''

Michal Harel at 07:38, 3 October 2021

2021-10-03T07:38:35Z

← Older revision		Revision as of 07:38, 3 October 2021
Line 38:		Line 38:
	**[[6bvt]] – mIPO NLS-binding domain <br />		**[[6bvt]] – mIPO NLS-binding domain <br />
	**[[4u5v]], [[4u5u]], [[4u5s]], [[4u5o]], [[4u5n]], [[4u5l]], [[4u58]], [[4u54]] – mIPO NLS-binding domain + inhibitor<br />		**[[4u5v]], [[4u5u]], [[4u5s]], [[4u5o]], [[4u5n]], [[4u5l]], [[4u58]], [[4u54]] – mIPO NLS-binding domain + inhibitor<br />
			**[[7s1e]] – IPO – guinea pig<br />

	*''IPO-α 1 complex with NLS peptide''		*''IPO-α 1 complex with NLS peptide''
Line 46:		Line 47:
	**[[6bw1]] – hIPO NLS-binding domain + Hendra virus peptide<br />		**[[6bw1]] – hIPO NLS-binding domain + Hendra virus peptide<br />
	**[[5w4e]], [[5w4f]], [[5w4g]] – hIPO NLS-binding domain + polymerase peptide<br />		**[[5w4e]], [[5w4f]], [[5w4g]] – hIPO NLS-binding domain + polymerase peptide<br />
			**[[7n8j]] – hIPO NLS-binding domain + BIMAX peptide<br />
	**[[5h43]] – hIPO NLS-binding domain + histone acetyltransferase KAT8<br />		**[[5h43]] – hIPO NLS-binding domain + histone acetyltransferase KAT8<br />
	**[[4mz5]], [[4mz6]] – mIPO NLS-binding domain 70-528 + dUTPase<br />		**[[4mz5]], [[4mz6]] – mIPO NLS-binding domain 70-528 + dUTPase<br />
Line 56:		Line 58:
	**[[5ekg]], [[5ekf]], [[5e6q]] – mIPO NLS-binding domain + XPG2<br />		**[[5ekg]], [[5ekf]], [[5e6q]] – mIPO NLS-binding domain + XPG2<br />
	**[[5d5k]] – mIPO NLS-binding domain + PARP 2<br />		**[[5d5k]] – mIPO NLS-binding domain + PARP 2<br />
			**[[7l04]] – mIPO NLS-binding domain + adeno-associated virus<br />
	**[[5ctt]] – mIPO NLS-binding domain + SART3/TIP110<br />		**[[5ctt]] – mIPO NLS-binding domain + SART3/TIP110<br />
	**[[5b56]] – mIPO NLS-binding domain + HIV-1 VPR<br />		**[[5b56]] – mIPO NLS-binding domain + HIV-1 VPR<br />
Line 66:		Line 69:
	**[[5v5o]], [[5v5p]] – mIPO NLS-binding domain + influenza virus peptide <br />		**[[5v5o]], [[5v5p]] – mIPO NLS-binding domain + influenza virus peptide <br />
	**[[5umz]] – mIPO NLS-binding domain + TNRC6A peptide <br />		**[[5umz]] – mIPO NLS-binding domain + TNRC6A peptide <br />
	**[[5u5p]], [[5u5r]] – mIPO NLS-binding domain + MLH1 peptide <br />		**[[5u5p]], [[5u5r]], [[6wba]], [[6wbb]], [[6wbc]], [[7m60]] – mIPO NLS-binding domain + MLH1 peptide <br />
	**[[5gxw]] – mIPO NLS-binding domain + NUMA peptide <br />		**[[5gxw]] – mIPO NLS-binding domain + NUMA peptide <br />
	**[[6iw8]], [[6iwa]] – mIPO NLS-binding domain + GM130 peptide <br />		**[[6iw8]], [[6iwa]] – mIPO NLS-binding domain + GM130 peptide <br />
Line 73:		Line 76:
	**[[6p6a]] – mIPO NLS-binding domain + NIT-2 peptide <br />		**[[6p6a]] – mIPO NLS-binding domain + NIT-2 peptide <br />
	**[[6p6e]] – mIPO NLS-binding domain + PAC3 peptide <br />		**[[6p6e]] – mIPO NLS-binding domain + PAC3 peptide <br />
	**[[7jk7]] – mIPO NLS-binding domain + LSD1 peptide <br />		**[[7jjm]], [[7jk7]] – mIPO NLS-binding domain + LSD1 peptide <br />
			**[[7jvo]] – mIPO NLS-binding domain + ACE2 peptide <br />
			**[[7rg4]], [[7rg5]] – mIPO NLS-binding domain + p50 peptide <br />
			**[[6wx7]] – mIPO NLS-binding domain + SOX2 peptide <br />
	**[[4b8o]] – rIPO NLS-binding domain + SV40<br />		**[[4b8o]] – rIPO NLS-binding domain + SV40<br />
	**[[4b8p]] – rIPO NLS-binding domain + A89<br />		**[[4b8p]] – rIPO NLS-binding domain + A89<br />
Line 120:		Line 126:

	**[[3fex]], [[3fey]] – mIPO NLS-binding domain + nuclear CAP-binding protein<br />		**[[3fex]], [[3fey]] – mIPO NLS-binding domain + nuclear CAP-binding protein<br />
			**[[7rfx]], [[7rfz]], [[7rg0]], [[7rg1]], [[7rg2]], [[7rg3]], [[7rg6]] – mIPO + ORF4b<br />

	*IPO-α 3		*IPO-α 3
Line 129:		Line 136:
	**[[5xzx]] – hIPO NLS-binding domain + RAN-binding protein peptide<br />		**[[5xzx]] – hIPO NLS-binding domain + RAN-binding protein peptide<br />
	**[[5tbk]] – hIPO NLS-binding domain + regulator of chromosome condensation <br />		**[[5tbk]] – hIPO NLS-binding domain + regulator of chromosome condensation <br />
			**[[7rfy]] – hIPO + ORF4b<br />
			**[[6wx8]] – hIPO + SOX2<br />

			*IPO-α 5

			**[[6wx9]] – hIPO + SOX2<br />

	*IPO-α 6		*IPO-α 6
Line 151:		Line 164:
	**[[1qgx]], [[1qgk]] – hIPO + IPO-α 2 IBB domain<br />		**[[1qgx]], [[1qgk]] – hIPO + IPO-α 2 IBB domain<br />
	**[[1ibr]] – hIPO + GTPase Ran<br />		**[[1ibr]] – hIPO + GTPase Ran<br />
	**[[~~2bku~~]], [[~~3ea5~~]] – ~~yIPO~~ + ~~GTPase Ran~~<br />		**[[6n88]], [[6n89]] – hIPO + H1.0 – Cryo EM<br />
	**[[1f59]], [[1o6p]], [[1o6o]] – hIPO + FXFG nucleoporin repeats<br />		**[[1f59]], [[1o6p]], [[1o6o]] – hIPO + FXFG nucleoporin repeats<br />
	**[[1m5n]] – hIPO HEAT repeats 1-11 + parathyroid hormone-related protein NLS peptide<br />		**[[1m5n]] – hIPO HEAT repeats 1-11 + parathyroid hormone-related protein NLS peptide<br />
	**[[2p8q]], [[2q5d]], [[2qna]], [[3lww]] – hIPO + RNA U transporter N terminal<br />		**[[2p8q]], [[2q5d]], [[2qna]], [[3lww]] – hIPO + RNA U transporter N terminal<br />
	**[[1qgr]], [[3w5k]] – hIPO + zinc finger protein SNAI1<br />		**[[1qgr]], [[3w5k]] – hIPO + zinc finger protein SNAI1<br />
			**[[1ukl]] – mIPO + SREBP-2<br />
			**[[2bku]], [[3ea5]] – yIPO + GTPase Ran<br />
	**[[5owu]] – yIPO + Nup1<br />		**[[5owu]] – yIPO + Nup1<br />
	**[[1ukl]] – mIPO + SREBP-2<br />

	*IPO-β 2 (Transportin 1)		*IPO-β 2 (Transportin 1)

Michal Harel at 10:14, 23 August 2020

2020-08-23T10:14:08Z

← Older revision		Revision as of 10:14, 23 August 2020
Line 37:		Line 37:
	**[[4b8j]] – rIPO <br />		**[[4b8j]] – rIPO <br />
	**[[6bvt]] – mIPO NLS-binding domain <br />		**[[6bvt]] – mIPO NLS-binding domain <br />
			**[[4u5v]], [[4u5u]], [[4u5s]], [[4u5o]], [[4u5n]], [[4u5l]], [[4u58]], [[4u54]] – mIPO NLS-binding domain + inhibitor<br />

	*''IPO-α 1 complex with NLS peptide''		*''IPO-α 1 complex with NLS peptide''
Line 46:		Line 47:
	**[[5w4e]], [[5w4f]], [[5w4g]] – hIPO NLS-binding domain + polymerase peptide<br />		**[[5w4e]], [[5w4f]], [[5w4g]] – hIPO NLS-binding domain + polymerase peptide<br />
	**[[5h43]] – hIPO NLS-binding domain + histone acetyltransferase KAT8<br />		**[[5h43]] – hIPO NLS-binding domain + histone acetyltransferase KAT8<br />
	**[[4mz5]], [[4mz6]] – mIPO NLS-binding domain + dUTPase<br />		**[[4mz5]], [[4mz6]] – mIPO NLS-binding domain 70-528 + dUTPase<br />
	**[[4oih]] – mIPO NLS-binding domain + guanine nucleotide exchange factor SRM1<br />		**[[4oih]] – mIPO NLS-binding domain + guanine nucleotide exchange factor SRM1<br />
	**[[5svz]] – mIPO NLS-binding domain + TAT NLS motif<br />		**[[5svz]] – mIPO NLS-binding domain + TAT NLS motif<br />
Line 67:		Line 68:
	**[[5u5p]], [[5u5r]] – mIPO NLS-binding domain + MLH1 peptide <br />		**[[5u5p]], [[5u5r]] – mIPO NLS-binding domain + MLH1 peptide <br />
	**[[5gxw]] – mIPO NLS-binding domain + NUMA peptide <br />		**[[5gxw]] – mIPO NLS-binding domain + NUMA peptide <br />
			**[[6iw8]], [[6iwa]] – mIPO NLS-binding domain + GM130 peptide <br />
			**[[6k06]] – mIPO NLS-binding domain (mutant) + GM130 peptide <br />
			**[[6mjl]] – mIPO NLS-binding domain + CHREBP peptide <br />
			**[[6p6a]] – mIPO NLS-binding domain + NIT-2 peptide <br />
			**[[6p6e]] – mIPO NLS-binding domain + PAC3 peptide <br />
			**[[7jk7]] – mIPO NLS-binding domain + LSD1 peptide <br />
	**[[4b8o]] – rIPO NLS-binding domain + SV40<br />		**[[4b8o]] – rIPO NLS-binding domain + SV40<br />
	**[[4b8p]] – rIPO NLS-binding domain + A89<br />		**[[4b8p]] – rIPO NLS-binding domain + A89<br />
Line 108:		Line 115:
	**[[3zio]], [[3zip]], [[3ziq]], [[3zir]] – mIPO NLS-binding domain + minor site-specific NLS <br />		**[[3zio]], [[3zip]], [[3ziq]], [[3zir]] – mIPO NLS-binding domain + minor site-specific NLS <br />
	**[[3zin]] – mIPO NLS-binding domain + nucleolar RNA helicase<br />		**[[3zin]] – mIPO NLS-binding domain + nucleolar RNA helicase<br />
			**[[7jjm]] – mIPO + LSD1 peptide <br />

	*''IPO-α 2 complex with protein''		*''IPO-α 2 complex with protein''
Line 177:		Line 185:
	**[[5h2v]] – yIPO + ubiquitin-like specific protease<br />		**[[5h2v]] – yIPO + ubiquitin-like specific protease<br />
	**[[4zj7]] – yIPO + CDC14<br />		**[[4zj7]] – yIPO + CDC14<br />

			*IPO-β 5 (Karyopherin β 5)

			**[[6aho]] – yIPO <br />

			*IPO-3

			**[[7jjl]] – hIPO + LSD1 peptide <br />

	*IPO-4B		*IPO-4B
Line 182:		Line 198:
	**[[5xah]] – hIPO residues 668-1081 <br />		**[[5xah]] – hIPO residues 668-1081 <br />
	**[[5xbk]] – hIPO residues 668-1081 + histone H3 peptide <br />		**[[5xbk]] – hIPO residues 668-1081 + histone H3 peptide <br />

			*IPO-5

			**[[6xte]], [[6xu2]] – hIPO + antipain peptide <br />

	*IPO-7		*IPO-7

Michal Harel: New page: ==3D structures of importin== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *IPO-α **1ial – mIPO NLS-bind...

2019-08-27T10:29:15Z

New page: ==3D structures of importin== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *IPO-α **1ial – mIPO NLS-bind...

New page

==3D structures of importin==

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|

*IPO-α

**[[1ial]] – mIPO NLS-binding domain – mouse 
**[[1bk5]] – yIPO NLS-binding domain - yeast 
**[[4tnm]] – IPO armadillo repeat domain – ''Arabidopsis thaliana'' 

*''IPO-α complex with NLS peptide''

**[[1ejl]] – mIPO NLS-binding domain + SV40 large T antigen 
**[[1ejy]] – mIPO NLS-binding domain + nucleoplasmin 
**[[2ynr]] – mIPO NLS-binding domain + B54NLS 
**[[2yns]] – rIPO NLS-binding domain + B54NLS - rice 
**[[1bk6]] – yIPO NLS-binding domain + SV40 large T antigen 
**[[1ee4]] – yIPO NLS-binding domain (mutant) + c-Myc 
**[[1ee5]] – yIPO NLS-binding domain (mutant) + nucleoplasmin 
**[[1un0]], [[2c1t]] – yIPO NLS-binding domain (mutant) + Nup2 
**[[5h2x]], [[5h2w]] – yIPO NLS-binding domain + ubiquitin-like specific protease 
**[[4xzr]] – yIPO NLS-binding domain + HEH1 
**[[4pvz]] – yIPO NLS-binding domain + HEH2 
**[[4rxh]] – NcIPO NLS-binding domain + SV40 large T antigen – ''Neurospora crassa'' 
**[[5vqi]] – NcIPO NLS-binding domain + NIT2 

*''IPO-α complex with protein''

**[[1wa5]] – yIPO NLS-binding domain + GTPase Ran + IPO-α re-exporter 
**[[5t94]] – yIPO NLS-binding domain + guanine nucleotide exchange factor 
**[[5mfm]] – yIPO NLS-binding domain + YIIIM6AII 

*IPO-α 1

**[[3wpt]] – hIPO NLS-binding domain - human 
**[[4b8j]] – rIPO 
**[[6bvt]] – mIPO NLS-binding domain 

*''IPO-α 1 complex with NLS peptide''

**[[4b18]] – hIPO NLS-binding domain + telomerase reverse transcriptase 
**[[4wv6]] – hIPO NLS-binding domain + TFIID 
**[[6bw0]] – hIPO NLS-binding domain + Nipa virus peptide 
**[[6bw1]] – hIPO NLS-binding domain + Hendra virus peptide 
**[[5w4e]], [[5w4f]], [[5w4g]] – hIPO NLS-binding domain + polymerase peptide 
**[[5h43]] – hIPO NLS-binding domain + histone acetyltransferase KAT8 
**[[4mz5]], [[4mz6]] – mIPO NLS-binding domain + dUTPase 
**[[4oih]] – mIPO NLS-binding domain + guanine nucleotide exchange factor SRM1 
**[[5svz]] – mIPO NLS-binding domain + TAT NLS motif 
**[[5wum]], [[5wun]], [[5x8n]] – mIPO NLS-binding domain + Epstein Barr antigen 
**[[5huw]] – mIPO NLS-binding domain + HSVI large terminase 
**[[5huy]] – mIPO NLS-binding domain + HSMV small terminase 
**[[5hhg]], [[5fc8]] – mIPO NLS-binding domain + dengue 2 NS5 
**[[5ekg]], [[5ekf]], [[5e6q]] – mIPO NLS-binding domain + XPG2 
**[[5d5k]] – mIPO NLS-binding domain + PARP 2 
**[[5ctt]] – mIPO NLS-binding domain + SART3/TIP110 
**[[5b56]] – mIPO NLS-binding domain + HIV-1 VPR 
**[[4zdu]] – mIPO NLS-binding domain + influenza nucleoprotein 
**[[4yi0]] – mIPO NLS-binding domain + Nup121 
**[[5klr]], [[5klt]] – mIPO NLS-binding domain + NLS 
**[[5k9s]] – mIPO NLS-binding domain + HNF-b 
**[[6iu7]], [[6iua]] – mIPO NLS-binding domain + TP53-binding protein 
**[[5w41]] – mIPO NLS-binding domain + Zika virus peptide 
**[[5v5o]], [[5v5p]] – mIPO NLS-binding domain + influenza virus peptide 
**[[5umz]] – mIPO NLS-binding domain + TNRC6A peptide 
**[[5u5p]], [[5u5r]] – mIPO NLS-binding domain + MLH1 peptide 
**[[5gxw]] – mIPO NLS-binding domain + NUMA peptide 
**[[4b8o]] – rIPO NLS-binding domain + SV40 
**[[4b8p]] – rIPO NLS-binding domain + A89 
**[[4bpl]] – rIPO NLS-binding domain + nucleoplasmin 
**[[4bqk]] – rIPO NLS-binding domain + VirD2 

*''IPO-α 1 complex with protein''

**[[2jdq]] – hIPO NLS-binding domain + polymerase basic protein 2 C terminal 
**[[3tj3]] – hIPO NLS-binding domain + Nup50 N terminal 
**[[2jdq]] – hIPO NLS-binding domain + telomerase reverse transcriptase peptide 
**[[4uaf]] – mIPO NLS-binding domain + influenza RNA polymerase 

*IPO-α 2

**[[3tpo]] – mIPO 
**[[1iq1]] – mIPO NLS-binding + autoinhibitory peptide domains 
**[[4e4v]] – hIPO NLS-binding domain (mutant) 

*''IPO-α 2 complex with NLS peptide''

**[[1pjm]] – mIPO NLS-binding domain + retinoblastoma-associated protein 
**[[1pjn]] – mIPO NLS-binding domain + histone-binding protein N1/N2 
**[[1q1s]], [[1q1t]] – mIPO NLS-binding domain + SV40 large T antigen 
**[[1y2a]], [[3q5u]] – mIPO NLS-binding domain + phospholipid scramblase 
**[[2c1m]] – mIPO NLS-binding domain + Nup50 
**[[3btr]] – mIPO NLS-binding domain + androgen receptor 
**[[3knd]] – mIPO NLS-binding domain + targeting protein for KXLP2 
**[[3l3q]] – mIPO NLS-binding domain + library peptide 
**[[3oqs]] – mIPO NLS-binding domain + CLIC4 
**[[3rz9]] – mIPO NLS-binding domain + KU80 
**[[3rzx]] – mIPO NLS-binding domain + KU70 
**[[3tpm]] – mIPO NLS-binding domain + MAL 
**[[3ve6]] – mIPO NLS-binding domain + Venezuelan equine encephalitis virus 
**[[3uvu]] – mIPO NLS-binding domain + flap endonuclease 
**[[3ukw]], [[3ukx]] – mIPO NLS-binding domain + BIMAX 
**[[3uky]], [[3ukz]], [[3ul0]] – mIPO NLS-binding domain + nuclear CAP-binding protein 
**[[3ul1]] – mIPO NLS-binding domain + nucleoplasmin 
**[[4htv]] – mIPO NLS-binding domain + capsid protein 
**[[4ba3]] – mIPO NLS-binding domain + A89NLS 
**[[3zio]], [[3zip]], [[3ziq]], [[3zir]] – mIPO NLS-binding domain + minor site-specific NLS 
**[[3zin]] – mIPO NLS-binding domain + nucleolar RNA helicase 

*''IPO-α 2 complex with protein''

**[[3fex]], [[3fey]] – mIPO NLS-binding domain + nuclear CAP-binding protein 

*IPO-α 3

**[[6bvz]] – hIPO NLS-binding domain 
**[[4uae]] – hIPO NLS-binding domain + influenza RNA polymerase 
**[[6bw9]], [[6bwa]], [[6bwb]] – hIPO NLS-binding domain + Hendra virus peptide 
**[[6bvv]] – hIPO NLS-binding domain + Nipa virus peptide 
**[[5xzx]] – hIPO NLS-binding domain + RAN-binding protein peptide 
**[[5tbk]] – hIPO NLS-binding domain + regulator of chromosome condensation 

*IPO-α 6

**[[4u2x]] – hIPO C terminal + ebola VP24 

*IPO-α 7

**[[4uad]] – hIPO NLS-binding domain + influenza RNA polymerase 

*IPO-β

**[[4xrk]] – IPO – ''Chaetomium thermophilum'' 

*IPO-β 1 (karyopherin β 1)

**[[3nd2]] – yIPO 
**[[1gcj]] – mIPO N terminal 

*''IPO-β 1 complex with protein''

**[[1qgx]], [[1qgk]] – hIPO + IPO-α 2 IBB domain 
**[[1ibr]] – hIPO + GTPase Ran 
**[[2bku]], [[3ea5]] – yIPO + GTPase Ran 
**[[1f59]], [[1o6p]], [[1o6o]] – hIPO + FXFG nucleoporin repeats 
**[[1m5n]] – hIPO HEAT repeats 1-11 + parathyroid hormone-related protein NLS peptide 
**[[2p8q]], [[2q5d]], [[2qna]], [[3lww]] – hIPO + RNA U transporter N terminal 
**[[1qgr]], [[3w5k]] – hIPO + zinc finger protein SNAI1 
**[[5owu]] – yIPO + Nup1 
**[[1ukl]] – mIPO + SREBP-2 

*IPO-β 2 (Transportin 1)

**[[2z5j]], [[2qmr]] – hIPO 

*''IPO-β 2 complex with protein''

**[[2h4m]], [[2ot8]], [[2z5n]] – hIPO + hnRNP peptide 
**[[2z5k]], [[2z5m]] – hIPO + nuclear RNA export factor peptide 
**[[2z5o]] – hIPO + JKTBP peptide 
**[[4fdd]], [[4jlq]], [[4oo6]] – hIPO + RNA binding protein peptide 
**[[5yvg]], [[5yvh]] – hIPO + FUS 
**[[5vyh]], [[5vyi]] – hIPO + FUS peptide 
**[[4fq3]] – hIPO + FUS peptide 
**[[5tqc]] – hIPO + RPL4 peptide 
**[[5j3v]] – hIPO + histone H3 peptide 

*IPO-β 3 (Karyopherin β 3)

**[[3w3t]] – yIPO 
**[[3w3u]], [[3w3v]] – yIPO (mutant) 
**[[3w3w]] – yIPO + STE12P 
**[[3w3x]] – yIPO + PHO4 
**[[3w3y]] – yIPO + Nup53P 
**[[3w3z]] – yIPO + RANGTP 
**[[5h2v]] – yIPO + ubiquitin-like specific protease 
**[[4zj7]] – yIPO + CDC14 

*IPO-4B

**[[5xah]] – hIPO residues 668-1081 
**[[5xbk]] – hIPO residues 668-1081 + histone H3 peptide 

*IPO-7

**[[6n88]] – IPO + hIPO-90 + histone H1.0 – frog – Cryo EM 

*IPO-9

**[[6n1z]] – hIPO + histone H2A + histone H2B 

*IPO-12 (Transportin-3)

**[[4c0p]] – hIPO 
**[[4c0o]] – hIPO + serine/arginine-rich splicing factor 
**[[4c0q]], [[4ol0]] – hIPO + GTPase Ran 

*IPO-13 (karyopherin 13)

**[[2x19]] – hIPO + GTPase Ran 
**[[2xwu]] – hIPO + UBC9 
**[[3zjy]] – hIPO + GTPase Ran + EIF-1A 

*IPO-90

**[[6n89]] – hIPO-90 + histone H1.0 – Cryo EM 
}}

[[Category:Topic Page]]