Index.php/Sandbox Reserved 337 - Revision history

Andrea Gorrell at 19:30, 4 April 2011

2011-04-04T19:30:55Z

← Older revision		Revision as of 19:30, 4 April 2011
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	=Structure=		=Structure=
	This protein is in a unique form containing four subunits, and forming a homotetramer.<ref name= "pizza"> PMID:15095868</ref> The protein also contains a unique <scene name='Index.php/Sandbox_Reserved_337/Aroc2/1'>β-α-β sandwich fold</scene>.<ref name = "pizza"/>		This protein is in a unique form containing four subunits, and forming a homotetramer.<ref name= "pizza"> PMID:15095868</ref> The protein also contains a unique <scene name='Index.php/Sandbox_Reserved_337/Aroc2/1'>β-α-β sandwich fold</scene>.<ref name = "pizza"/>
	<structure load= 1um0 size=250 frame =’1’ align=’left’ caption= 'Fig. 1. Chorismate synthase complexed with FMN, from PDB 1um0' ~~scene=~~ />		<structure load= 1um0 size=250 frame =’1’ align=’left’ caption= 'Fig. 1. Chorismate synthase complexed with FMN, from PDB [[1um0]]'/>
	The protein also has a cofactor bound within each monomer of the protein. This cofactor is FMN which is located within the <scene name='Index.php/Sandbox_Reserved_337/Fmn_cofactor1/1'>active site</scene> of the protein.<ref name = "pizza"/> Each of these cofactors are bound non-covalently within the protein in the reduced form.<ref name = "pizza"/>		The protein also has a cofactor bound within each monomer of the protein. This cofactor is FMN which is located within the <scene name='Index.php/Sandbox_Reserved_337/Fmn_cofactor1/1'>active site</scene> of the protein.<ref name = "pizza"/> Each of these cofactors are bound non-covalently within the protein in the reduced form.<ref name = "pizza"/>

Craig Murray at 20:01, 3 April 2011

2011-04-03T20:01:26Z

← Older revision		Revision as of 20:01, 3 April 2011
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	This protein is in a unique form containing four subunits, and forming a homotetramer.<ref name= "pizza"> PMID:15095868</ref> The protein also contains a unique <scene name='Index.php/Sandbox_Reserved_337/Aroc2/1'>β-α-β sandwich fold</scene>.<ref name = "pizza"/>		This protein is in a unique form containing four subunits, and forming a homotetramer.<ref name= "pizza"> PMID:15095868</ref> The protein also contains a unique <scene name='Index.php/Sandbox_Reserved_337/Aroc2/1'>β-α-β sandwich fold</scene>.<ref name = "pizza"/>
	<structure load= 1um0 size=250 frame =’1’ align=’left’ caption= 'Fig. 1. Chorismate synthase complexed with FMN, from PDB 1um0' scene= />		<structure load= 1um0 size=250 frame =’1’ align=’left’ caption= 'Fig. 1. Chorismate synthase complexed with FMN, from PDB 1um0' scene= />
	The protein also has a cofactor bound within each monomer of the protein. This cofactor is FMN which is located within the active site of the protein.<ref name = "pizza"/> Each of these cofactors are bound non-covalently within the protein in the reduced form.<ref name = "pizza"/>		The protein also has a cofactor bound within each monomer of the protein. This cofactor is FMN which is located within the <scene name='Index.php/Sandbox_Reserved_337/Fmn_cofactor1/1'>active site</scene> of the protein.<ref name = "pizza"/> Each of these cofactors are bound non-covalently within the protein in the reduced form.<ref name = "pizza"/>

	==Function==		==Function==

Craig Murray at 19:41, 3 April 2011

2011-04-03T19:41:36Z

← Older revision		Revision as of 19:41, 3 April 2011
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	=Structure=		=Structure=
	This protein is in a unique form containing four subunits, and forming a homotetramer.<ref name= "pizza"> PMID:15095868</ref> The protein also contains a unique β-α-β sandwich fold.<ref name = "pizza"/>		This protein is in a unique form containing four subunits, and forming a homotetramer.<ref name= "pizza"> PMID:15095868</ref> The protein also contains a unique <scene name='Index.php/Sandbox_Reserved_337/Aroc2/1'>β-α-β sandwich fold</scene>.<ref name = "pizza"/>
	<structure load= 1um0 size=250 frame =’1’ align=’left’ caption= 'Fig. 1. Chorismate synthase complexed with FMN, from PDB 1um0' scene= />		<structure load= 1um0 size=250 frame =’1’ align=’left’ caption= 'Fig. 1. Chorismate synthase complexed with FMN, from PDB 1um0' scene= />
	The protein also has a cofactor bound within each monomer of the protein. This cofactor is FMN which is located within the active site of the protein.<ref name = "pizza"/> Each of these cofactors are bound non-covalently within the protein in the reduced form.<ref name = "pizza"/>		The protein also has a cofactor bound within each monomer of the protein. This cofactor is FMN which is located within the active site of the protein.<ref name = "pizza"/> Each of these cofactors are bound non-covalently within the protein in the reduced form.<ref name = "pizza"/>

Craig Murray at 05:32, 3 April 2011

2011-04-03T05:32:14Z

← Older revision		Revision as of 05:32, 3 April 2011
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	{{STRUCTURE_1ztb \| PDB=1ztb \| SCENE=Index.php/Sandbox_Reserved_337/Aroc/1 }}		{{STRUCTURE_1ztb \| PDB=1ztb \| SCENE=Index.php/Sandbox_Reserved_337/Aroc/1 }}
	__TOC__		__TOC__
	Chorismate Synthase is the last enzyme present in the shikimate pathway<ref name= "planta"> PMID:9951731</ref>, a process which converts phosphoenolpyruvate, and erythrose 4-phosphate to chorismate in a series of seven steps.<ref name= ~~“review”~~> PMID:15012217</ref> The shikimate pathway is essential in the production of the amino acids phenylalanine, tryptophan and tyrosine, all essential amino acids.<ref name= "main"> PMID:16459102</ref>		Chorismate Synthase is the last enzyme present in the shikimate pathway<ref name= "planta"> PMID:9951731</ref>, a process which converts phosphoenolpyruvate, and erythrose 4-phosphate to chorismate in a series of seven steps.<ref name= "review"> PMID:15012217</ref> The shikimate pathway is essential in the production of the amino acids phenylalanine, tryptophan and tyrosine, all essential amino acids.<ref name= "main"> PMID:16459102</ref>

	=Structure=		=Structure=
	<structure load= 1um0 size=~~500~~ frame =’1’ align=’left’ caption= 'Fig. 1. Chorismate synthase complexed with FMN, from PDB 1um0' scene= /><ref name= "~~fuck~~"> ~~PMID:15095868~~</~~ref~~>		This protein is in a unique form containing four subunits, and forming a homotetramer.<ref name= "pizza"> PMID:15095868</ref> The protein also contains a unique β-α-β sandwich fold.<ref name = "pizza"/>
			<structure load= 1um0 size=250 frame =’1’ align=’left’ caption= 'Fig. 1. Chorismate synthase complexed with FMN, from PDB 1um0' scene= />
			The protein also has a cofactor bound within each monomer of the protein. This cofactor is FMN which is located within the active site of the protein.<ref name = "pizza"/> Each of these cofactors are bound non-covalently within the protein in the reduced form.<ref name = "pizza"/>

	==Function==		==Function==
			The purpose of chorismate synthase is to convert 5-enolpyruvylshikimate 3-phosphate to chorismate, an essential step in the formation of indole rings used in the essential amino acids phenylalanine, tyrosine, and tryptophan.<ref name = "planta" /> The reduced flavin is believed to have one of a couple functions. It either has a structural role helping with formation of the structure, or reduces a sulfhydryl group in the protein residue, either aiding with binding or with having a catalytic effect.<ref name ="planta" /> The enzyme is monofunctional, requiring another enzyme to reduce the flavin cofactor, or addition of extra reduced flavin to add to the enzyme.<ref name = "review" />
	=Mechanism=		=Mechanism=
			In this reaction the 5-enolpyruvylshikimate 3-phosphate, is reduced forming a second double bond in the benzene ring attached to the phosphate.<ref name = "review" /> It appears that the phosphate group is reduced allowing the benzene ring to have a free electron pair to form a double bond with.<ref name = "review" /> As well the double bond which originally existed, experiences a hydrogen shift and the second double bond occurs to form resonance.<ref name = "review" />
	=References=		=References=
	<references />		<references />

Andrea Gorrell at 20:56, 22 March 2011

2011-03-22T20:56:56Z

← Older revision		Revision as of 20:56, 22 March 2011
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	=Structure=		=Structure=
	<structure load= 1um0 size=500 frame =’1’ align=’left’ caption= 'Chorismate synthase complexed with FMN' scene= /><ref name= "fuck"> PMID:15095868</ref>		<structure load= 1um0 size=500 frame =’1’ align=’left’ caption= 'Fig. 1. Chorismate synthase complexed with FMN, from PDB 1um0' scene= /><ref name= "fuck"> PMID:15095868</ref>


	==Function==		==Function==

Craig Murray at 20:29, 17 March 2011

2011-03-17T20:29:20Z

← Older revision		Revision as of 20:29, 17 March 2011
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	=Structure=		=Structure=
			<structure load= 1um0 size=500 frame =’1’ align=’left’ caption= 'Chorismate synthase complexed with FMN' scene= /><ref name= "fuck"> PMID:15095868</ref>


	==Function==		==Function==

Craig Murray at 19:21, 15 March 2011

2011-03-15T19:21:27Z

← Older revision		Revision as of 19:21, 15 March 2011
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	=Structure=		=Structure=

	==Function==		==Function==

	=~~Pathway~~=		=Mechanism=
	=References=		=References=
	<references />		<references />

Craig Murray at 20:59, 14 March 2011

2011-03-14T20:59:53Z

← Older revision		Revision as of 20:59, 14 March 2011
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	~~==This is a placeholder==~~
	~~This is a placeholder text to help you get started in~~
	~~placing a Jmol applet on your page. At any time, click~~
	~~"Show Preview" at the bottom of this page to see how it goes.~~

	~~Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load~~
	~~and display another structure.~~
	=Chorismate synthase=		=Chorismate synthase=
	{{STRUCTURE_1ztb \| PDB=1ztb \| SCENE=Index.php/Sandbox_Reserved_337/Aroc/1 }}		{{STRUCTURE_1ztb \| PDB=1ztb \| SCENE=Index.php/Sandbox_Reserved_337/Aroc/1 }}
	__TOC__		__TOC__
			Chorismate Synthase is the last enzyme present in the shikimate pathway<ref name= "planta"> PMID:9951731</ref>, a process which converts phosphoenolpyruvate, and erythrose 4-phosphate to chorismate in a series of seven steps.<ref name= “review”> PMID:15012217</ref> The shikimate pathway is essential in the production of the amino acids phenylalanine, tryptophan and tyrosine, all essential amino acids.<ref name= "main"> PMID:16459102</ref>

	=Structure=		=Structure=
	==Function==		==Function==

	=Pathway=		=Pathway=
	=References=		=References=
			<references />

Craig Murray at 16:32, 7 March 2011

2011-03-07T16:32:46Z

← Older revision		Revision as of 16:32, 7 March 2011
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	=Structure=		=Structure=
	==Function==		==Function==
			=Pathway=
	=References=		=References=

Craig Murray at 19:44, 4 March 2011

2011-03-04T19:44:16Z

← Older revision		Revision as of 19:44, 4 March 2011
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	=Chorismate synthase=		=Chorismate synthase=
	{{STRUCTURE_1ztb \| PDB=1ztb \| SCENE=Index.php/Sandbox_Reserved_337/Aroc/1 }}		{{STRUCTURE_1ztb \| PDB=1ztb \| SCENE=Index.php/Sandbox_Reserved_337/Aroc/1 }}
			__TOC__
	=Structure=		=Structure=
	==Function==		==Function==
	=References=		=References=