Integrin - Revision history

Michal Harel at 10:25, 29 August 2019

2019-08-29T10:25:04Z

Michal Harel at 10:23, 29 August 2019

2019-08-29T10:23:53Z

← Older revision		Revision as of 10:23, 29 August 2019
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	<scene name='51/516472/Cv/4'>Mg/Cl coordination site</scene>. Water molecules shown as red spheres.		<scene name='51/516472/Cv/4'>Mg/Cl coordination site</scene>. Water molecules shown as red spheres.

			==3D structures of integrin==
			[[Integrin 3D structures]]
	</StructureSection>		</StructureSection>

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	**[[1dzi]], [[4bj3]] - hIG I domain + collagen peptide<br />		**[[1dzi]], [[4bj3]] - hIG I domain + collagen peptide<br />
	**[[1v7p]] - hIG I domain (mutant) + EMS16 + Mn<br />		**[[1v7p]] - hIG I domain (mutant) + EMS16 + Mn<br />
	**[[5thp]] - hIG residues 170-366 + rhodocetin <br />		**[[5thp]], [[6nd8]], [[6nd9]], [[6nda]], [[6ndb]], [[6ndc]], [[6ndd]], [[6nde]], [[6ndf]], [[6ndg]], [[6ndh]] - hIG residues 170-366 + rhodocetin <br />

	*IG α-2b		*IG α-2b
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	**[[2lke]], [[2lkj]] – hIG cytoplasmic domain – NMR<BR />		**[[2lke]], [[2lkj]] – hIG cytoplasmic domain – NMR<BR />
	**[[4xw2]] – hIG + simvastatin<br />		**[[4xw2]] – hIG + simvastatin<br />

			*IG α-V β-8

			**[[6djp]] – hIG + antibody – Cryo EM<br />

	*IG α-X		*IG α-X
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	**[[2p26]], [[2p28]], [[5e6w]] – hIG phe2 + phe3 domains<br />		**[[2p26]], [[2p28]], [[5e6w]] – hIG phe2 + phe3 domains<br />
	**[[1yuk]] – hIG chain A PSI domain + chain B I-EGF domain<br />		**[[1yuk]] – hIG chain A PSI domain + chain B I-EGF domain<br />
			**[[5zaz]] – hIG transmembrane domain - NMR<br />

	*IG β-3 (CD61)		*IG β-3 (CD61)
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	**[[2mtp]] – hIG cytoplasmic tail (mutant) + hIG α-2 β peptide+ filamin rod domain<br />		**[[2mtp]] – hIG cytoplasmic tail (mutant) + hIG α-2 β peptide+ filamin rod domain<br />

	*IG β-4 (CD104)		*IG β-4 (CD104; Gp150)

	**[[2f7q]], [[3f7r]], [[1qg3]], [[3f7q]], [[4wtw]], [[4wtx]] - hIG fibronectin type III domain<br />		**[[2f7q]], [[3f7r]], [[1qg3]], [[3f7q]], [[4wtw]], [[4wtx]] - hIG fibronectin type III domain<br />
	**[[2yrz]] – hIG fibronectin type III domain – NMR<BR />		**[[2yrz]] – hIG fibronectin type III domain – NMR<BR />
	**[[3f7p]], [[4q58]] - hIG fibronectin type III domain + plectin-1 <br />		**[[3f7p]], [[4q58]] - hIG fibronectin type III domain + plectin-1 <br />
	**[[3fq4]], [[3fso]], [[3h6a]] – hIG Calx-β domain		**[[6gvl]] - hIG fibronectin type III domain + dystonin<br />
			**[[6gvk]] - hIG fibronectin type III domain (mutant) + dystonin<br />
			**[[3fq4]], [[3fso]], [[3h6a]] – hIG Calx-β domain<br />
			**[[6hyf]] - rIG fibronectin type III domain <br />

	*IG β-7		*IG β-7

Alexander Berchansky at 13:02, 29 May 2019

2019-05-29T13:02:27Z

← Older revision		Revision as of 13:02, 29 May 2019
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	The interactions of integrin with ligands are dependent on the presence of divalent ions<ref>PMID:10961914</ref>.		The interactions of integrin with ligands are dependent on the presence of divalent ions<ref>PMID:10961914</ref>.

	<scene name='51/516472/Cv/3'>Mg/Cl coordination site</scene>. Water molecules shown as red spheres.		<scene name='51/516472/Cv/4'>Mg/Cl coordination site</scene>. Water molecules shown as red spheres.
	</StructureSection>		</StructureSection>

Michal Harel at 09:49, 22 July 2018

2018-07-22T09:49:43Z

← Older revision		Revision as of 09:49, 22 July 2018
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	**[[3vi4]] - hIG headpiece + antibody + peptide + Mg<br />		**[[3vi4]] - hIG headpiece + antibody + peptide + Mg<br />

	*IG α-5 (CD49e) β-3 (CD61)		*IG α-5 (CD49e) β-3 (CD61) ectodomain

	**[[3ije]] ~~– hIG + Ca<br />~~		**[[3ije]], [[1m1x]], [[4g1e]], [[4g1m]], [[1u8c]] – hIG + cation<br />
	**[[1m1x]] - hIG ~~extracellular domain~~ + Mn<br />		**[[4mmx]], [[4mmy]], [[4mmz]] - hIG + Mn + fibronectin domain 10<br />
	**[[4mmx]], [[4mmy]], [[4mmz]] - hIG ~~extracellular domain~~ + Mn + fibronectin domain 10<br />		**[[4o02]], [[6avu]], [[6avr]], [[6avq]] - hIG + antibody<br />
	**[[4o02]], [[6avu]], [[6avr]], [[6avq]] - hIG ~~extracellular domain~~ + antibody~~<br />~~		**[[1jv2]] - hIG + platelet membrane glycoprotein IIIA + Ca<br />
	**[[1u8c]] – hIG psi domain + Ca<br />		**[[1l5g]] - hIG + tripeptide + Mn<br />
	**[[1jv2]] - hIG ~~I domain~~ + platelet membrane glycoprotein IIIA + Ca<br />
	**[[1l5g]] - hIG ~~I domain~~ + tripeptide + Mn<br />

	*IG α-5 β-6		*IG α-5 β-6
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	**[[3k6s]], [[3k71]], [[3k72]], [[5es4]] – hIG + Mg<br />		**[[3k6s]], [[3k71]], [[3k72]], [[5es4]] – hIG + Mg<br />
	**[[4neh]], [[4nen]] – hIG (mutant) + Mg<br />		**[[4neh]], [[4nen]] – hIG (mutant) + Mg<br />

	*IG α-V β-3

	**[[4g1e]], [[4g1m]] – hIG + Ni<br />

	*IG β-1D		*IG β-1D

Michal Harel at 09:39, 22 July 2018

2018-07-22T09:39:08Z

← Older revision		Revision as of 09:39, 22 July 2018
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	**[[1dzi]], [[4bj3]] - hIG I domain + collagen peptide<br />		**[[1dzi]], [[4bj3]] - hIG I domain + collagen peptide<br />
	**[[1v7p]] - hIG I domain (mutant) + EMS16 + Mn<br />		**[[1v7p]] - hIG I domain (mutant) + EMS16 + Mn<br />
			**[[5thp]] - hIG residues 170-366 + rhodocetin <br />

	*IG α-2b		*IG α-2b
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	*IG α-2 (CD49b) β		*IG α-2 (CD49b) β

			**[[5hj2]] - hIG I domain<br />
	**[[1aox]] - hIG I domain (mutant) + Mg<br />		**[[1aox]] - hIG I domain (mutant) + Mg<br />
	**[[~~1s4w]], [[1dpk]] - hIG cytoplasmic domain - NMR<BR />~~		**[[2k1a]] - hIG transmembrane domain – NMR<br />
	**[[1dpq]] - hIG ~~cytoplasmic~~ domain ~~(mutant)~~ – NMR<br />

	*IG α-2b β-3 (CD61)		*IG α-2b β-3 (CD61)
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	**[[1m1x]] - hIG extracellular domain + Mn<br />		**[[1m1x]] - hIG extracellular domain + Mn<br />
	**[[4mmx]], [[4mmy]], [[4mmz]] - hIG extracellular domain + Mn + fibronectin domain 10<br />		**[[4mmx]], [[4mmy]], [[4mmz]] - hIG extracellular domain + Mn + fibronectin domain 10<br />
	**[[4o02]] - hIG extracellular domain ~~+ Mn~~ + antibody<br />		**[[4o02]], [[6avu]], [[6avr]], [[6avq]] - hIG extracellular domain + antibody<br />
	**[[1u8c]] – hIG psi domain + Ca<br />		**[[1u8c]] – hIG psi domain + Ca<br />
	**[[1jv2]] - hIG I domain + platelet membrane glycoprotein IIIA + Ca<br />		**[[1jv2]] - hIG I domain + platelet membrane glycoprotein IIIA + Ca<br />
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	**[[5ffg]] – hIG headpiece + Ca<br />		**[[5ffg]] – hIG headpiece + Ca<br />
	**[[4um9]] – hIG headpiece (mutant) + Mg + transforming growth factor β 3<br />		**[[4um9]] – hIG headpiece (mutant) + Mg + transforming growth factor β 3<br />
			**[[5neu]], [[5net]], [[5ner]], [[5nem]] – hIG headpiece + foot-and-mouth virus – Cryo EM<br />
			**[[5ffo]] – hIG headpiece + TGF-beta-1<br />

	*IG α-L		*IG α-L
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	*IG β-2 (CD18)		*IG β-2 (CD18)

	**[[2p26]], [[2p28]] – hIG phe2 + phe3 domains<br />		**[[2p26]], [[2p28]], [[5e6w]] – hIG phe2 + phe3 domains<br />
	**[[1yuk]] – hIG chain A PSI domain + chain B I-EGF domain<br />		**[[1yuk]] – hIG chain A PSI domain + chain B I-EGF domain<br />

Michal Harel at 10:24, 19 June 2017

2017-06-19T10:24:19Z

← Older revision		Revision as of 10:24, 19 June 2017
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	**[[4a0q]] - hIG I domain (mutant) + Mg<br />		**[[4a0q]] - hIG I domain (mutant) + Mg<br />
	**[[2l8s]] - hIG transmembrane domain – NMR<BR />		**[[2l8s]] - hIG transmembrane domain – NMR<BR />
			**[[5hgj]] - hIG VWFA domain<br />
	**[[1mhp]] - rIG I domain (mutant) + antibody + Mn<br />		**[[1mhp]] - rIG I domain (mutant) + antibody + Mn<br />
	**[[2b2x]] - rIG I domain (mutant) + antibody + Mg<br />		**[[2b2x]] - rIG I domain (mutant) + antibody + Mg<br />
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	*IG α-2 (CD49b)		*IG α-2 (CD49b)

			**[[4bj3]], [[5e6x]], [[5e6v]] - hIG I domain<br />
	**[[1dzi]], [[4bj3]] - hIG I domain + collagen peptide<br />		**[[1dzi]], [[4bj3]] - hIG I domain + collagen peptide<br />
	**[[1v7p]] - hIG I domain (mutant) + EMS16 + Mn<br />		**[[1v7p]] - hIG I domain (mutant) + EMS16 + Mn<br />
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	**[[1tye]], [[3fcu]], [[3fcs]] – hIG + Mg<br />		**[[1tye]], [[3fcu]], [[3fcs]] – hIG + Mg<br />
	**[[3fc3]] – hIG (mutant) + Mg<br />		**[[3fc3]] – hIG (mutant) + Mg<br />
	**[[2vc2]], [[2vdk]], [[2vdl]], [[3nid]], [[3nif]], [[3nig]], [[3zdx]], [[3zdy]], [[3zdz]], [[3ze0]], [[3ze1]], [[3ze2]] – hIG headpiece + antibody + Mg<br />		**[[2vc2]], [[2vdk]], [[2vdl]], [[3nid]], [[3nif]], [[3nig]], [[3zdx]], [[3zdy]], [[3zdz]], [[3ze0]], [[3ze1]], [[3ze2]], [[5hdb]] – hIG headpiece + antibody + Mg<br />
			**[[4z7q]], [[4z7o]], [[4z7n]] – hIG headpiece + antibody + Mg + tetrapeptide<br />
	**[[2vdm]], [[2vdn]], [[3t3m]], [[3t3p]] – hIG headpiece + antibody + antagonist + Mg<br />		**[[2vdm]], [[2vdn]], [[3t3m]], [[3t3p]] – hIG headpiece + antibody + antagonist + Mg<br />
	**[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hIG headpiece + antibody + fibrinogen peptide + Mg<br />		**[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hIG headpiece + antibody + fibrinogen peptide + Mg<br />
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	**[[4um8]] – hIG headpiece (mutant) + Ni<br />		**[[4um8]] – hIG headpiece (mutant) + Ni<br />
			**[[5ffg]] – hIG headpiece + Ca<br />
	**[[4um9]] – hIG headpiece (mutant) + Mg + transforming growth factor β 3<br />		**[[4um9]] – hIG headpiece (mutant) + Mg + transforming growth factor β 3<br />

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	**[[4ixd]] – hIG I domain<br />		**[[4ixd]] – hIG I domain<br />
			**[[5e6s]], [[5e6r]] – hIG AI, headpiece,pocket domains + Mg<br />
	**[[2m3e]] – hIG transmembrane domain - NMR<br />		**[[2m3e]] – hIG transmembrane domain - NMR<br />

			*IG α-L β-2

			**[[5e6u]] – hIG headpiece (mutant) + Ni<br />

	*IG α-M		*IG α-M
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	**[[4m76]] – hIG + complement C3<br />		**[[4m76]] – hIG + complement C3<br />
	**[[2lke]], [[2lkj]] – hIG cytoplasmic domain – NMR<BR />		**[[2lke]], [[2lkj]] – hIG cytoplasmic domain – NMR<BR />
			**[[4xw2]] – hIG + simvastatin<br />

	*IG α-X		*IG α-X
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	*IG α-X β-2 (CD18)		*IG α-X β-2 (CD18)

	**[[3k6s]], [[3k71]], [[3k72]] – hIG + Mg<br />		**[[3k6s]], [[3k71]], [[3k72]], [[5es4]] – hIG + Mg<br />
	**[[4neh]], [[4nen]] – hIG (mutant) + Mg<br />		**[[4neh]], [[4nen]] – hIG (mutant) + Mg<br />

Alexander Berchansky at 11:42, 5 April 2016

2016-04-05T11:42:09Z

← Older revision		Revision as of 11:42, 5 April 2016
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	== Structural highlights ==		== Structural highlights ==
	The interactions of integrin with ligands are dependent on the presence of divalent ions<ref>PMID:10961914</ref>.		The interactions of integrin with ligands are dependent on the presence of divalent ions<ref>PMID:10961914</ref>.

			<scene name='51/516472/Cv/3'>Mg/Cl coordination site</scene>. Water molecules shown as red spheres.
	</StructureSection>		</StructureSection>

Alexander Berchansky at 11:28, 5 April 2016

2016-04-05T11:28:38Z

← Older revision		Revision as of 11:28, 5 April 2016
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	<StructureSection load='1zoo' size='400' side='right' caption='Structure of human integrin CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions (PDB entry [[1zoo]])' scene=''>		<StructureSection load='1zoo' size='400' side='right' caption='Structure of human integrin CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions (PDB entry [[1zoo]])' scene='51/516472/Cv/1'>
	== Function ==		== Function ==
	'''Integrins''' (IG) are receptors which mediate the attachment between cells and between cells and the extracellular matrix. They are involved in cellular signaling and cell cycle<ref>PMID:10961914</ref>. IGs contain α and β chain. IG subunits span the cell membrane. Both subunits bind divalent cations some of which bind the ligands which interact with IG. Some IGs contain an insertion domain named I domain. For more details see [[Molecular Playground/IntegrinBeta1]].		'''Integrins''' (IG) are receptors which mediate the attachment between cells and between cells and the extracellular matrix. They are involved in cellular signaling and cell cycle<ref>PMID:10961914</ref>. IGs contain α and β chain. IG subunits span the cell membrane. Both subunits bind divalent cations some of which bind the ligands which interact with IG. Some IGs contain an insertion domain named I domain. For more details see [[Molecular Playground/IntegrinBeta1]].

Michal Harel at 10:21, 29 March 2016

2016-03-29T10:21:55Z

← Older revision		Revision as of 10:21, 29 March 2016
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	==Disease ==		==Disease ==
	Defective integrin is the cause of the skin disease epidermolysis bullosa, of congenital muscular dystrophy. Overexpression of integrin is correlated with some types of cancer and enhanced bone resorption in osteoporosis<ref>PMID:8976799</ref>. Defective integrin is involved in periodontal diseases<ref>PMID:24662197</ref>.		Defective integrin is the cause of the skin disease epidermolysis bullosa, of congenital muscular dystrophy. Overexpression of integrin is correlated with some types of cancer and enhanced bone resorption in osteoporosis<ref>PMID:8976799</ref>. Defective integrin is involved in periodontal diseases<ref>PMID:24662197</ref>.

			== Structural highlights ==
			The interactions of integrin with ligands are dependent on the presence of divalent ions<ref>PMID:10961914</ref>.
	</StructureSection>		</StructureSection>

Michal Harel at 10:03, 29 March 2016

2016-03-29T10:03:35Z

← Older revision		Revision as of 10:03, 29 March 2016
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	<StructureSection load='1zoo' size='400' side='right' caption='Structure of human ~~integrein~~ CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions (PDB entry [[1zoo]])' scene=''>		<StructureSection load='1zoo' size='400' side='right' caption='Structure of human integrin CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions (PDB entry [[1zoo]])' scene=''>
			== Function ==
	'''Integrins''' (IG) are receptors which mediate the attachment between cells ~~or to~~ extracellular matrix. They are involved in cellular signaling and cell cycle. IGs contain α and β chain. IG subunits span the cell membrane. Both subunits bind divalent cations some of which bind the ligands which interact with IG. Some IGs contain an insertion domain named I domain. For more details see [[Molecular Playground/IntegrinBeta1]].		'''Integrins''' (IG) are receptors which mediate the attachment between cells and between cells and the extracellular matrix. They are involved in cellular signaling and cell cycle<ref>PMID:10961914</ref>. IGs contain α and β chain. IG subunits span the cell membrane. Both subunits bind divalent cations some of which bind the ligands which interact with IG. Some IGs contain an insertion domain named I domain. For more details see [[Molecular Playground/IntegrinBeta1]].

	For some details on the interaction of a targeting peptide with integrin see [[Molecular Playground/Targeting Peptide]].		For some details on the interaction of a targeting peptide with integrin see [[Molecular Playground/Targeting Peptide]].

			==Disease ==
			Defective integrin is the cause of the skin disease epidermolysis bullosa, of congenital muscular dystrophy. Overexpression of integrin is correlated with some types of cancer and enhanced bone resorption in osteoporosis<ref>PMID:8976799</ref>. Defective integrin is involved in periodontal diseases<ref>PMID:24662197</ref>.
	</StructureSection>		</StructureSection>

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	}}		}}
			== References ==
			<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]