Interleukin 3D structures - Revision history

Michal Harel at 07:13, 5 October 2025

2025-10-05T07:13:27Z

Michal Harel at 07:11, 5 October 2025

2025-10-05T07:11:40Z

Show changes

Michal Harel at 10:05, 4 June 2023

2023-06-04T10:05:41Z

← Older revision		Revision as of 10:05, 4 June 2023
Line 21:		Line 21:
	**[[3o4o]] - hIL-1 β + IL-1 receptor 2 + IL-1 receptor accessory protein<BR />		**[[3o4o]] - hIL-1 β + IL-1 receptor 2 + IL-1 receptor accessory protein<BR />
	**[[4dep]] - hIL-1 β + IL-1 receptor 1 + IL-1 receptor accessory protein<BR />		**[[4dep]] - hIL-1 β + IL-1 receptor 1 + IL-1 receptor accessory protein<BR />
	**[[4g6j]], [[4g6m]], [[5bvp]], [[7chy]], [[7chz]] - hIL-1 β + antibody<br />		**[[4g6j]], [[4g6m]], [[5bvp]], [[7chy]], [[7chz]], 7z4t]] - hIL-1 β + antibody<br />
	**[[2kh2]] - hIL-1 β + SCFV - NMR<BR />		**[[2kh2]] - hIL-1 β + SCFV - NMR<BR />
	**[[1md6]] – mIL-1F5 – mouse<BR />		**[[1md6]] – mIL-1F5 – mouse<BR />
Line 31:		Line 31:

	**[[1m47]], [[1m4c]], [[3ink]] – hIL-2<BR />		**[[1m47]], [[1m4c]], [[3ink]] – hIL-2<BR />
	**[[3qb1]], [[7m2g]] - hIL-2 (mutant)<br />		**[[3qb1]], [[7m2g]], [[7ra9]], [[7raa]] - hIL-2 (mutant)<br />
	**[[1irl]] – hIL-2 (mutant) - NMR<BR />		**[[1irl]] – hIL-2 (mutant) - NMR<BR />
	**[[5m5e]] - hIL-2 + IL-2 receptor β + cytokine receptor common γ<BR />		**[[5m5e]] - hIL-2 + IL-2 receptor β + cytokine receptor common γ<BR />
Line 41:		Line 41:
	**[[4nej]], [[4nem]] – hIL-2 + methylfuran carboxylate derivative<BR />		**[[4nej]], [[4nem]] – hIL-2 + methylfuran carboxylate derivative<BR />
	**[[5lqb]], [[6ye3]], [[7dr4]] - hIL-2 + antibody<br />		**[[5lqb]], [[6ye3]], [[7dr4]] - hIL-2 + antibody<br />
			**[[7zmz]] - hIL-2 + CD25<br />
	**[[4yue]] - mIL-2 + antibody<br />		**[[4yue]] - mIL-2 + antibody<br />
	**[[4yqx]] - IL-2 + antibody - rat<br />		**[[4yqx]] - IL-2 + antibody - rat<br />
	**[[4zf7]] – hIL-2 - ferret<BR />		**[[4zf7]] – hIL-2 - ferret<BR />
			**[[7cjn]], [[7d9m]] – IL-2 – grass carp<BR />

	*IL-3		*IL-3
Line 77:		Line 79:
	**[[1il6]], [[2il6]] – hIL-6 - NMR<BR />		**[[1il6]], [[2il6]] – hIL-6 - NMR<BR />
	**[[1p9m]] - hIL-6 + IL-6 receptor α and β<br />		**[[1p9m]] - hIL-6 + IL-6 receptor α and β<br />
			**[[8d82]] - hIL-6 + IL-6 receptor α and β – Cryo EM<br />
	**[[5fuc]] - hIL-6 + IL-6 receptor α + VHH6<br />		**[[5fuc]] - hIL-6 + IL-6 receptor α + VHH6<br />
	**[[4j4l]] – hIL-6 + internalin B<BR />		**[[4j4l]] – hIL-6 + internalin B<BR />
Line 100:		Line 103:
	**[[6wzm]] – hIL-8 + antibody<BR />		**[[6wzm]] – hIL-8 + antibody<BR />
	**[[6lfm]], [[6lfo]]– hIL-8 in G-protein coupled receptor – Cryo EM<br />		**[[6lfm]], [[6lfo]]– hIL-8 in G-protein coupled receptor – Cryo EM<br />

			*IL-9

			**[[7ox6]] – hIL-9 - NMR<BR />
			**[[7ox5]] - hIL-9 + IL—9 receptor a<br />
			**[[7ox1]], [[7ox2]], [[7ox3]] - hIL-9 + antibody<br />
			**[[7xcb]] – mIL-9 <BR />
			**[[7ox4]] – mIL-9 + antibody<BR />

	*IL-10		*IL-10
Line 132:		Line 143:
	**[[3qwr]] - hIL-12 β + hIL- 23 α + adnectin<br />		**[[3qwr]] - hIL-12 β + hIL- 23 α + adnectin<br />
	**[[6uib]] - hIL-12 β + hIL- 23 α + peptide<br />		**[[6uib]] - hIL-12 β + hIL- 23 α + peptide<br />
	**[[6sff]], [[6smc]], [[6sp3]] - mIL-12 β <br />		**[[6sff]], [[6smc]], [[6sp3]], [[7pur]], [[7r3n]] - mIL-12 β <br />

	*IL-13		*IL-13
Line 141:		Line 152:
	**[[3lb6]] - hIL-13 + IL-13 receptor α2<BR />		**[[3lb6]] - hIL-13 + IL-13 receptor α2<BR />
	**[[3bpo]], [[5e4e]] - hIL-13 residues 20-145 + IL-4 receptor α + IL-13 receptor α<br />		**[[3bpo]], [[5e4e]] - hIL-13 residues 20-145 + IL-4 receptor α + IL-13 receptor α<br />
	**[[5l6y]] - hIL-13 + antibody<br />		**[[5l6y]], [[7rew]] - hIL-13 + antibody<br />

	*IL-15		*IL-15
Line 158:		Line 169:
	**[[4hr9]] - hIL-17A (mutant)<br />		**[[4hr9]] - hIL-17A (mutant)<br />
	**[[5n92]] - hIL-17A + hIL-17F <br />		**[[5n92]] - hIL-17A + hIL-17F <br />
			**[[7uwm]] - hIL-17A + IL-17A receptor α – Cryo EM<br />
	**[[4hsa]] - hIL-17A (mutant) + IL-17A receptor α <br />		**[[4hsa]] - hIL-17A (mutant) + IL-17A receptor α <br />
	**[[5nan]] - hIL-17A + hIL-17F + IL-17A receptor α <br />		**[[5nan]] - hIL-17A + hIL-17F + IL-17A receptor α <br />
	**[[2vxs]], [[4qhu]], [[6wio]], [[6wir]] - hIL-17A + antibody<BR />		**[[7uwn]] - hIL-17A + IL-17A receptor α + IL-17A receptor gamma<br />
			**[[7zan]] - hIL-17A (mutant) + IL-17A receptor α + IL-17A receptor gamma<br />
			**[[2vxs]], [[4qhu]], [[6wio]], [[6wir]], [[7wkx]], [[7z2m]] - hIL-17A + antibody<BR />
			**[[8b7w]], [[8dy1]], [[8dy5]] - hIL-17A + scFv<BR />
			**[[8dyf]], [[8dyg]], [[8dyh]], [[8dyi]] - hIL-17A + inhibitor<BR />
	**[[5vb9]] - hIL-17A + peptide inhibitor<BR />		**[[5vb9]] - hIL-17A + peptide inhibitor<BR />
			**[[7ama]], [[7amg]] - hIL-17A + modulator<br />
	**[[5hi5]], [[5hi4]], [[5hi3]], [[5hhx]], [[5hhv]] - hIL-17A + peptide inhibitor + antibody<BR />		**[[5hi5]], [[5hi4]], [[5hi3]], [[5hhx]], [[5hhv]] - hIL-17A + peptide inhibitor + antibody<BR />
	**[[1jpy]], [[6hgo]] – hIL-17F<BR />		**[[1jpy]], [[6hgo]] – hIL-17F<BR />
Line 212:		Line 229:
	**[[6gg1]] - hIL-24<br />		**[[6gg1]] - hIL-24<br />
	**[[6df3]] - hIL-24 + IL—22 receptor α1 + IL-20 receptor β<br />		**[[6df3]] - hIL-24 + IL—22 receptor α1 + IL-20 receptor β<br />

			*IL-25

			**[[7uwj]], [[7uwk]] - hIL-25 + IL—17 receptor b – Cryo EM<br />
			**[[7uwl]] - hIL-25 + IL—17 receptor a + IL—17 receptor b – Cryo EM<br />

			*IL-27

			**[[7u7n]], [[8d85]] - hIL-27 + IL—27 receptor a + IL-6 receptor b – Cryo EM<br />
			**[[7zxk]] - hIL-27 + antibody<br />
			**[[7zg0]] - mIL-27 + IL—27 receptor a <br />
			**[[7z0l]] - mIL-27 + IL—27 receptor a + IL-6 receptor b – Cryo EM<br />

	*IL-28		*IL-28

Michal Harel at 10:43, 1 December 2022

2022-12-01T10:43:25Z

← Older revision		Revision as of 10:43, 1 December 2022
Line 99:		Line 99:
	**[[1ilp]], [[1ilq]] - hIL-8 + IL-8 receptor peptide<br />		**[[1ilp]], [[1ilq]] - hIL-8 + IL-8 receptor peptide<br />
	**[[6wzm]] – hIL-8 + antibody<BR />		**[[6wzm]] – hIL-8 + antibody<BR />
			**[[6lfm]], [[6lfo]]– hIL-8 in G-protein coupled receptor – Cryo EM<br />

	*IL-10		*IL-10

Michal Harel at 07:32, 6 October 2021

2021-10-06T07:32:05Z

← Older revision		Revision as of 07:32, 6 October 2021
Line 21:		Line 21:
	**[[3o4o]] - hIL-1 β + IL-1 receptor 2 + IL-1 receptor accessory protein<BR />		**[[3o4o]] - hIL-1 β + IL-1 receptor 2 + IL-1 receptor accessory protein<BR />
	**[[4dep]] - hIL-1 β + IL-1 receptor 1 + IL-1 receptor accessory protein<BR />		**[[4dep]] - hIL-1 β + IL-1 receptor 1 + IL-1 receptor accessory protein<BR />
	**[[4g6j]], [[4g6m]], [[5bvp]] - hIL-1 β + antibody<br />		**[[4g6j]], [[4g6m]], [[5bvp]], [[7chy]], [[7chz]] - hIL-1 β + antibody<br />
	**[[2kh2]] - hIL-1 β + SCFV - NMR<BR />		**[[2kh2]] - hIL-1 β + SCFV - NMR<BR />
	**[[1md6]] – mIL-1F5 – mouse<BR />		**[[1md6]] – mIL-1F5 – mouse<BR />
Line 31:		Line 31:

	**[[1m47]], [[1m4c]], [[3ink]] – hIL-2<BR />		**[[1m47]], [[1m4c]], [[3ink]] – hIL-2<BR />
	**[[3qb1]] - hIL-2 (mutant)<br />		**[[3qb1]], [[7m2g]] - hIL-2 (mutant)<br />
	**[[1irl]] – hIL-2 (mutant) - NMR<BR />		**[[1irl]] – hIL-2 (mutant) - NMR<BR />
	**[[5m5e]] - hIL-2 + IL-2 receptor β + cytokine receptor common γ<BR />		**[[5m5e]] - hIL-2 + IL-2 receptor β + cytokine receptor common γ<BR />
Line 40:		Line 40:
	**[[1pw6]], [[1py2]], [[1m48]], [[1m49]] – hIL-2 + inhibitor<BR />		**[[1pw6]], [[1py2]], [[1m48]], [[1m49]] – hIL-2 + inhibitor<BR />
	**[[4nej]], [[4nem]] – hIL-2 + methylfuran carboxylate derivative<BR />		**[[4nej]], [[4nem]] – hIL-2 + methylfuran carboxylate derivative<BR />
	**[[5lqb]] - hIL-2 + antibody<br />		**[[5lqb]], [[6ye3]], [[7dr4]] - hIL-2 + antibody<br />
	**[[4yue]] - mIL-2 + antibody<br />		**[[4yue]] - mIL-2 + antibody<br />
	**[[4yqx]] - IL-2 + antibody - rat<br />		**[[4yqx]] - IL-2 + antibody - rat<br />
Line 74:		Line 74:
	*IL-6		*IL-6

	**[[1alu]] – hIL-6<BR />		**[[1alu]], [[7nxz]] – hIL-6<BR />
	**[[1il6]], [[2il6]] – hIL-6 - NMR<BR />		**[[1il6]], [[2il6]] – hIL-6 - NMR<BR />
	**[[1p9m]] - hIL-6 + IL-6 receptor α and β<br />		**[[1p9m]] - hIL-6 + IL-6 receptor α and β<br />
Line 95:		Line 95:
	**[[1ikl]], [[1ikm]] - hIL-8 (mutant) - NMR<BR />		**[[1ikl]], [[1ikm]] - hIL-8 (mutant) - NMR<BR />
	**[[3il8]], [[5d14]], [[4xdx]] – hIL-8 residues 28-99<BR />		**[[3il8]], [[5d14]], [[4xdx]] – hIL-8 residues 28-99<BR />
			**[[6xmn]] – hIL-8 residues 28-93 + CXCR1 N-terminal - NMR<BR />
	**[[1rod]] - hIL-8/melanoma growth stimulating protein – NMR<br />		**[[1rod]] - hIL-8/melanoma growth stimulating protein – NMR<br />
	**[[1ilp]], [[1ilq]] - hIL-8 + IL-8 receptor peptide		**[[1ilp]], [[1ilq]] - hIL-8 + IL-8 receptor peptide<br />
			**[[6wzm]] – hIL-8 + antibody<BR />

	*IL-10		*IL-10
Line 124:		Line 126:
	**[[5mj3]], [[5mj4]], [[5njd]] - hIL-12 β + hIL-23 α + antibody<br />		**[[5mj3]], [[5mj4]], [[5njd]] - hIL-12 β + hIL-23 α + antibody<br />
	**[[5mzv]] - hIL-12 β + hIL-23 α + hIL-23 receptor + antibody<br />		**[[5mzv]] - hIL-12 β + hIL-23 α + hIL-23 receptor + antibody<br />
			**[[6wdq]] - hIL-12 β + hIL-23 α + hIL-12 receptor + hIL-23 receptor <br />
	**[[5mxa]] - hIL-12 β + hIL- 23 α<br />		**[[5mxa]] - hIL-12 β + hIL- 23 α<br />
	**[[5mj3]], [[5mj4]] - hIL-12 β + hIL-23 α + alphabody MB3<br />		**[[5mj3]], [[5mj4]] - hIL-12 β + hIL-23 α + alphabody MB3<br />
	**[[3qwr]] - hIL-12 β + hIL- 23 α + adnectin<br />		**[[3qwr]] - hIL-12 β + hIL- 23 α + adnectin<br />
	**[[6uib]] - hIL-12 β + hIL- 23 α + peptide<br />		**[[6uib]] - hIL-12 β + hIL- 23 α + peptide<br />
	**[[6sff]] - mIL-12 β <br />		**[[6sff]], [[6smc]], [[6sp3]] - mIL-12 β <br />

	*IL-13		*IL-13
Line 156:		Line 159:
	**[[4hsa]] - hIL-17A (mutant) + IL-17A receptor α <br />		**[[4hsa]] - hIL-17A (mutant) + IL-17A receptor α <br />
	**[[5nan]] - hIL-17A + hIL-17F + IL-17A receptor α <br />		**[[5nan]] - hIL-17A + hIL-17F + IL-17A receptor α <br />
	**[[2vxs]], [[4qhu]] - hIL-17A + antibody<BR />		**[[2vxs]], [[4qhu]], [[6wio]], [[6wir]] - hIL-17A + antibody<BR />
	**[[5vb9]] - hIL-17A + peptide inhibitor<BR />		**[[5vb9]] - hIL-17A + peptide inhibitor<BR />
	**[[5hi5]], [[5hi4]], [[5hi3]], [[5hhx]], [[5hhv]] - hIL-17A + peptide inhibitor + antibody<BR />		**[[5hi5]], [[5hi4]], [[5hi3]], [[5hhx]], [[5hhv]] - hIL-17A + peptide inhibitor + antibody<BR />
Line 194:		Line 197:
	**[[3dlq]], [[3dgc]] - hIL-22 residues 29-179 (mutant) + IL-22 receptor α1<br />		**[[3dlq]], [[3dgc]] - hIL-22 residues 29-179 (mutant) + IL-22 receptor α1<br />
	**[[3q1s]] - hIL-22 residues 29-179 (mutant) + antibody<br />		**[[3q1s]] - hIL-22 residues 29-179 (mutant) + antibody<br />
			**[[6weo]] - hIL-22 + IL-22 receptor + IL-10 receptor <br />
	**[[4o6k]] – IL-22 – zebra fish<BR />		**[[4o6k]] – IL-22 – zebra fish<BR />

Line 220:		Line 224:

	**[[2kll]] - hIL-33 residues 110-270 - NMR<BR />		**[[2kll]] - hIL-33 residues 110-270 - NMR<BR />
			**[[4kc3]] - hIL-33 + IL—1 receptor-like 1<br />
			**[[5iv4]] - mIL-33 + IL—1 receptor-like 1 + IL-1 receptor accessory protein<br />

	*IL-34		*IL-34

Michal Harel at 07:27, 26 August 2020

2020-08-26T07:27:32Z

← Older revision		Revision as of 07:27, 26 August 2020
Line 17:		Line 17:
	**[[3ltq]] - hIL-1 β residues 117-269 <BR />		**[[3ltq]] - hIL-1 β residues 117-269 <BR />
	**[[3pok]] - hIL-1 β residues 117-269 (mutant) <BR />		**[[3pok]] - hIL-1 β residues 117-269 (mutant) <BR />
			**[[6y8i]], [[6y8m]] - hIL-1 β residues 117-269 + pyridine derivative<BR />
	**[[1itb]] - hIL-1 β + IL-1 receptor 1 extracellular domain<BR />		**[[1itb]] - hIL-1 β + IL-1 receptor 1 extracellular domain<BR />
	**[[3o4o]] - hIL-1 β + IL-1 receptor 2 + IL-1 receptor accessory protein<BR />		**[[3o4o]] - hIL-1 β + IL-1 receptor 2 + IL-1 receptor accessory protein<BR />
Line 47:		Line 48:

	**[[1jli]] – hIL-3 (mutant) – NMR<BR />		**[[1jli]] – hIL-3 (mutant) – NMR<BR />
			**[[6nmy]] – hIL-3 + IL-3 receptor α + cytokine receptor common subunit β<BR />
	**[[5uv8]], [[5uwc]] – hIL-3 (mutant) + IL-3 receptor α<BR />		**[[5uv8]], [[5uwc]] – hIL-3 (mutant) + IL-3 receptor α<BR />
	**[[2l3o]] – mIL-3 residues 33-156 (mutant) - NMR		**[[2l3o]] – mIL-3 residues 33-156 (mutant) - NMR
Line 88:		Line 90:
	*IL-8		*IL-8

	**[[~~3il8]], [[5d14]], [[4xdx~~]] – hIL-8 ~~residues 28-99~~<BR />		**[[6n2u]] – hIL-8 <BR />
	**[[1il8]], [[2il8]], [[5wdz]] – hIL-8 - NMR<BR />		**[[1il8]], [[2il8]], [[5wdz]] – hIL-8 - NMR<BR />
	**[[1qe6]], [[1icw]] – hIL-8 (mutant) <BR />		**[[1qe6]], [[1icw]] – hIL-8 (mutant) <BR />
	**[[1ikl]], [[1ikm]] - hIL-8 (mutant) - NMR<BR />		**[[1ikl]], [[1ikm]] - hIL-8 (mutant) - NMR<BR />
			**[[3il8]], [[5d14]], [[4xdx]] – hIL-8 residues 28-99<BR />
	**[[1rod]] - hIL-8/melanoma growth stimulating protein – NMR<br />		**[[1rod]] - hIL-8/melanoma growth stimulating protein – NMR<br />
	**[[1ilp]], [[1ilq]] - hIL-8 + IL-8 receptor peptide		**[[1ilp]], [[1ilq]] - hIL-8 + IL-8 receptor peptide
Line 123:		Line 126:
	**[[5mxa]] - hIL-12 β + hIL- 23 α<br />		**[[5mxa]] - hIL-12 β + hIL- 23 α<br />
	**[[5mj3]], [[5mj4]] - hIL-12 β + hIL-23 α + alphabody MB3<br />		**[[5mj3]], [[5mj4]] - hIL-12 β + hIL-23 α + alphabody MB3<br />
	**[[3qwr]] - hIL-12 β + hIL- 23 α + adnectin		**[[3qwr]] - hIL-12 β + hIL- 23 α + adnectin<br />
			**[[6uib]] - hIL-12 β + hIL- 23 α + peptide<br />
			**[[6sff]] - mIL-12 β <br />

	*IL-13		*IL-13
Line 154:		Line 159:
	**[[5vb9]] - hIL-17A + peptide inhibitor<BR />		**[[5vb9]] - hIL-17A + peptide inhibitor<BR />
	**[[5hi5]], [[5hi4]], [[5hi3]], [[5hhx]], [[5hhv]] - hIL-17A + peptide inhibitor + antibody<BR />		**[[5hi5]], [[5hi4]], [[5hi3]], [[5hhx]], [[5hhv]] - hIL-17A + peptide inhibitor + antibody<BR />
	**[[1jpy]] – hIL-17F<BR />		**[[1jpy]], [[6hgo]] – hIL-17F<BR />
	**[[3jvf]] - hIL-17F + IL-17 receptor α		**[[6ppg]] – hIL-17F + antibody<BR />
			**[[3jvf]], [[6hg4]], [[6hg9]] - hIL-17F + IL-17 receptor α

	*IL-18 (Interferon-γ inducing factor)		*IL-18 (Interferon-γ inducing factor)
Line 225:		Line 231:
	*IL-36		*IL-36

			**[[6hpi]] - hIL-36 α - NMR<br />
	**[[4ize]] - hIL-36 γ<br />		**[[4ize]] - hIL-36 γ<br />
	**[[6p9e]] - hIL-36 g + antagonist<br />		**[[6p9e]] - hIL-36 γ + antagonist<br />

	*IL-37		*IL-37

Joel L. Sussman at 08:38, 10 October 2019

2019-10-10T08:38:14Z

← Older revision		Revision as of 08:38, 10 October 2019
Line 119:		Line 119:
	**[[1f42]] - hIL-12 β P40 domain<BR />		**[[1f42]] - hIL-12 β P40 domain<BR />
	**[[3hmx]] - hIL-12 α and β+ antibody<br />		**[[3hmx]] - hIL-12 α and β+ antibody<br />
	**[[~~4oe8~~]], [[~~4og9~~]], [[5njd]] - hIL-12 β + hIL-23 α + antibody<br />		**[[5mj3]], [[5mj4]], [[5njd]] - hIL-12 β + hIL-23 α + antibody<br />
	**[[5mzv]] - hIL-12 β + hIL-23 α + hIL-23 receptor + antibody<br />		**[[5mzv]] - hIL-12 β + hIL-23 α + hIL-23 receptor + antibody<br />
	**[[5mxa]] - hIL-12 β + hIL- 23 α<br />		**[[5mxa]] - hIL-12 β + hIL- 23 α<br />

Michal Harel: New page: ==3D structures of interleukin== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *IL-1 α **2ila - hIL-1 α - ...

2019-09-03T09:03:33Z

New page: ==3D structures of interleukin== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *IL-1 α **2ila - hIL-1 α - ...

New page

==3D structures of interleukin==

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|

*IL-1 α

**[[2ila]] - hIL-1 α - human 
**[[2kki]] - hIL-1 α residues 121-271 
**[[2l5x]] – hIL-1 α residues 121-271 + calcium-binding protein A13 – NMR 

*IL-1 β

**[[2nvh]], [[9ilb]], [[1iob]], [[5i1b]], [[2i1b]], [[4i1b]], [[1i1b]] - hIL-1 β 
**[[1tp0]], [[1t4q]], [[1too]], [[1twe]], [[1twm]], [[1s0l]], [[1l2h]], [[1hib]], [[21bi]], [[31bi]], [[41bi]] - hIL-1 β (mutant) 
**[[6i1b]], [[7i1b]] - hIL-1 β - NMR 
**[[3ltq]] - hIL-1 β residues 117-269 
**[[3pok]] - hIL-1 β residues 117-269 (mutant) 
**[[1itb]] - hIL-1 β + IL-1 receptor 1 extracellular domain 
**[[3o4o]] - hIL-1 β + IL-1 receptor 2 + IL-1 receptor accessory protein 
**[[4dep]] - hIL-1 β + IL-1 receptor 1 + IL-1 receptor accessory protein 
**[[4g6j]], [[4g6m]], [[5bvp]] - hIL-1 β + antibody 
**[[2kh2]] - hIL-1 β + SCFV - NMR 
**[[1md6]] – mIL-1F5 – mouse 
**[[2mib]], [[8i1b]] - mIL-1 β 
**[[2wry]] - cIL-1 β – chicken 
**[[3nj5]], [[4x3a]], [[4x39]], [[4x38]], [[4x37]] – cIL-1 β (mutant) 

*IL-2 (T-cell growth factor)

**[[1m47]], [[1m4c]], [[3ink]] – hIL-2 
**[[3qb1]] - hIL-2 (mutant) 
**[[1irl]] – hIL-2 (mutant) - NMR 
**[[5m5e]] - hIL-2 + IL-2 receptor β + cytokine receptor common γ 
**[[2erj]], [[2b5i]] - hIL-2 + IL-2 receptor α and β + cytokine receptor common γ 
**[[1z92]] - hIL-2 + IL-2 receptor α 
**[[3qaz]] - hIL-2 + IL-2 receptor β and γ 
**[[1qvn]], [[1nbp]], [[1m4a]], [[1m4b]] – hIL-2 (mutant) + inhibitor 
**[[1pw6]], [[1py2]], [[1m48]], [[1m49]] – hIL-2 + inhibitor 
**[[4nej]], [[4nem]] – hIL-2 + methylfuran carboxylate derivative 
**[[5lqb]] - hIL-2 + antibody 
**[[4yue]] - mIL-2 + antibody 
**[[4yqx]] - IL-2 + antibody - rat 
**[[4zf7]] – hIL-2 - ferret 

*IL-3

**[[1jli]] – hIL-3 (mutant) – NMR 
**[[5uv8]], [[5uwc]] – hIL-3 (mutant) + IL-3 receptor α 
**[[2l3o]] – mIL-3 residues 33-156 (mutant) - NMR

*IL-4

**[[2b8u]], [[1hik]], [[2int]], [[1rcb]] – hIL-4 
**[[2cyk]], [[1cyl]], [[1itm]], [[1bbn]], [[1bcn]], [[1iti]], [[1itl]] – hIL-4 - NMR 
**[[2b8x]], [[2b8y]], [[2b8z]], [[2b90]], [[2b91]], [[2d48]], [[1hzi]], [[1hij]] - hIL-4 (mutant) 
**[[5fhx]] - hIL-4 + antibody 
**[[1iar]] - hIL-4 + IL-4 receptor α (mutant) 
**[[3bpl]] - hIL-4 + IL-4 receptor α + cytokine receptor common γ 
**[[6oel]] - hIL-4 + IL-4 receptor α + cytokine receptor common γ + antibody 
**[[3qb7]] - hIL-4 + cytokine receptor common γ 
**[[4ydy]] – hIL-4 + darpin 
**[[3bpn]] - hIL-4 + IL-4 receptor α + IL-13 receptor α

*IL-5

**[[1hul]] – hIL-5 
**[[3qt2]] - hIL-5 + IL-5 receptor α (mutant) 
**[[3va2]] - hIL-5 + IL-5 receptor α 
**[[3b5k]] – mIL-5 

*IL-6

**[[1alu]] – hIL-6 
**[[1il6]], [[2il6]] – hIL-6 - NMR 
**[[1p9m]] - hIL-6 + IL-6 receptor α and β 
**[[5fuc]] - hIL-6 + IL-6 receptor α + VHH6 
**[[4j4l]] – hIL-6 + internalin B 
**[[4ni7]], [[4ni9]] – hIL-6 + nucleotide aptamer 
**[[4cni]], [[4o9h]], [[4zs7]] – hIL-6 + antibody 
**[[2l3y]] - mIL-6 residues 27-211 - NMR 
**[[1i16]] – IL-6 + IL-6 receptor β - Herpesvirus 8 

*IL-7

**[[3di2]], [[3di3]] - hIL-7 residues 26-177 + IL-7 receptor α ectodomain

*IL-8

**[[3il8]], [[5d14]], [[4xdx]] – hIL-8 residues 28-99 
**[[1il8]], [[2il8]], [[5wdz]] – hIL-8 - NMR 
**[[1qe6]], [[1icw]] – hIL-8 (mutant) 
**[[1ikl]], [[1ikm]] - hIL-8 (mutant) - NMR 
**[[1rod]] - hIL-8/melanoma growth stimulating protein – NMR 
**[[1ilp]], [[1ilq]] - hIL-8 + IL-8 receptor peptide

*IL-10

**[[2h24]], [[1inr]], [[2ilk]], [[1ilk]] – hIL-10 
**[[1j7v]] – hIL-10 + IL-10 receptor α (mutant) 
**[[1y6k]] - hIL-10 residues 19-178 + IL-10 receptor α 
**[[4x51]] – mIL-10 

*IL-10 viral

**[[1vlk]] - hvIL-10 residues 26-170 - human herpesvirus 4 
**[[1y6m]] - hvIL-10 residues 26-170 + IL-10 receptor α 
**[[1y6n]] - hvIL-10 residues 26-170 (mutant) + IL-10 receptor α 
**[[1lqs]] - hvIL-10 residues 20-176 + IL-10 receptor α - human herpesvirus 5 
**[[1lk3]] - hvIL-10 residues 26-175 + antibody

*IL-11

**[[4mhl]] - hIL-11 

*IL-12

**[[1f45]] - hIL-12 α and β (mutant) 
**[[1f42]] - hIL-12 β P40 domain 
**[[3hmx]] - hIL-12 α and β+ antibody 
**[[4oe8]], [[4og9]], [[5njd]] - hIL-12 β + hIL-23 α + antibody 
**[[5mzv]] - hIL-12 β + hIL-23 α + hIL-23 receptor + antibody 
**[[5mxa]] - hIL-12 β + hIL- 23 α 
**[[5mj3]], [[5mj4]] - hIL-12 β + hIL-23 α + alphabody MB3 
**[[3qwr]] - hIL-12 β + hIL- 23 α + adnectin

*IL-13

**[[1ijz]], [[1ik0]] – hIL-13 – NMR 
**[[1ga3]] - hIL-13 residues 21-132 - NMR 
**[[3l5w]], [[3l5x]], [[3g6d]], [[4i77]], [[4ps4]] - hIL-13 residues 35-146 + antibody 
**[[3lb6]] - hIL-13 + IL-13 receptor α2 
**[[3bpo]], [[5e4e]] - hIL-13 residues 20-145 + IL-4 receptor α + IL-13 receptor α 
**[[5l6y]] - hIL-13 + antibody 

*IL-15

**[[2xqb]] – hIL-15 + antibody 
**[[2psm]], [[2z3q]], [[2z3r]] - hIL-15 + IL-15 receptor α 
**[[4gs7]] - hIL-15 + IL-15 receptor α + IL-2 receptor β,γ 

*IL-16

**[[1i16]] – hIL-16 - NMR 
**[[1x6d]] – hIL-16 PDZ domain – NMR 

*IL-17

**[[4hr9]] - hIL-17A (mutant) 
**[[5n92]] - hIL-17A + hIL-17F 
**[[4hsa]] - hIL-17A (mutant) + IL-17A receptor α 
**[[5nan]] - hIL-17A + hIL-17F + IL-17A receptor α 
**[[2vxs]], [[4qhu]] - hIL-17A + antibody 
**[[5vb9]] - hIL-17A + peptide inhibitor 
**[[5hi5]], [[5hi4]], [[5hi3]], [[5hhx]], [[5hhv]] - hIL-17A + peptide inhibitor + antibody 
**[[1jpy]] – hIL-17F 
**[[3jvf]] - hIL-17F + IL-17 receptor α

*IL-18 (Interferon-γ inducing factor)

**[[3wo2]] – hIL-18 
**[[4xfu]], [[4xft]], [[4xfs]] - hIL-18 (mutant) 
**[[1j0s]] – hIL-18 - NMR 
**[[4hjj]] - hIL-18 + antibody 
**[[2vxt]] - hIL-18 (mutant) + antibody 
**[[3f62]] - hIL-18 residues 37-193 (mutant) + IL-18 binding protein 
**[[4eee]], [[4ekx]] - hIL-18 (mutant) + 14L protein 
**[[3wo3]], [[4r6u]] - hIL-18 + IL-18 receptor 
**[[3wo4]] - hIL-18 + IL-18 receptor + IL-18 receptor accessory protein 

*IL-19

**[[1n1f]] – hIL-19

*IL-20

**[[4doh]] - hIL-20 + IL-20 receptor α,β 

*IL-21

**[[2oqp]]– hIL-21 – NMR 
**[[3tgx]] - hIL-21 + IL-21 receptor α (mutant) 

*IL-22

**[[1ykb]], [[1m4r]] – hIL-22 
**[[3g9v]] - hIL-22 residues 29-179 + IL-22 receptor α2 
**[[3dlq]], [[3dgc]] - hIL-22 residues 29-179 (mutant) + IL-22 receptor α1 
**[[3q1s]] - hIL-22 residues 29-179 (mutant) + antibody 
**[[4o6k]] – IL-22 – zebra fish 

*IL-23

**[[3d87]] - hIL-23 α 
**[[3d85]] - hIL-23 α + antibody 
**[[4grw]] - hIL-23 α + + hIL-12 β + nanobody 
**[[3duh]] - hIL-23 α + hIL-12 β

*IL-24

**[[6gg1]] - hIL-24 
**[[6df3]] - hIL-24 + IL—22 receptor α1 + IL-20 receptor β 

*IL-28

**[[3hhc]] – hIL-28B 
**[[5t5w]] - hIL-28B + IL—10 receptor β + IL-28 receptor α 

*IL-29

**[[3og4]], [[3og6]] – hIL-29 + IL-28 receptor α

*IL-33

**[[2kll]] - hIL-33 residues 110-270 - NMR 

*IL-34

**[[4dkc]] - hIL-34 
**[[4dkd]] - hIL-34 active core + macrophage colony-stimulating factor 1 receptor 
**[[4dke]], [[4dkf]] - hIL-34 active core + antibody 
**[[4exn]] - mIL-34 
**[[4exp]] - mIL-34 active core + macrophage colony-stimulating factor 1 receptor 

*IL-36

**[[4ize]] - hIL-36 γ 
**[[6p9e]] - hIL-36 g + antagonist 

*IL-37

**[[6ncu]], [[5hn1]] - hIL-37 
}}

[[Category: Topic Page]]

← Older revision		Revision as of 07:13, 5 October 2025
Line 55:		Line 55:

	*IL-4		*IL-4


	**[[1hik]], [[1rcb]], [[2b8u]], [[2int]] – hIL-4<BR />		**[[1hik]], [[1rcb]], [[2b8u]], [[2int]] – hIL-4<BR />
Line 154:		Line 153:
	**[[8oe4]] - hIL-12 β + hIL-23 α + hIL-12 receptor + hIL-23 receptor – Cryo EM <br />		**[[8oe4]] - hIL-12 β + hIL-23 α + hIL-12 receptor + hIL-23 receptor – Cryo EM <br />
	**[[5mxa]], [[8cr8]] - hIL-12 β + hIL- 23 α<br />		**[[5mxa]], [[8cr8]] - hIL-12 β + hIL- 23 α<br />
	[[3qwr]] - hIL-12 β + hIL- 23 α + adnectin<br />		**[[3qwr]] - hIL-12 β + hIL- 23 α + adnectin<br />
	**[[6uib]], [[8uui]] - hIL-12 β + hIL- 23 α + peptide<br />		**[[6uib]], [[8uui]] - hIL-12 β + hIL- 23 α + peptide<br />
	**[[8cr6]] - mIL-12 alpha + beta subunits <br />		**[[8cr6]] - mIL-12 alpha + beta subunits <br />
Line 198:		Line 197:
	**[[7ama]], [[7amg]] - hIL-17A + modulator<br />		**[[7ama]], [[7amg]] - hIL-17A + modulator<br />
	**[[5hi5]], [[5hi4]], [[5hi3]], [[5hhx]], [[5hhv]] - hIL-17A + peptide inhibitor + antibody<BR />		**[[5hi5]], [[5hi4]], [[5hi3]], [[5hhx]], [[5hhv]] - hIL-17A + peptide inhibitor + antibody<BR />
	[[1jpy]], [[6hgo]] – hIL-17F<BR />		**[[1jpy]], [[6hgo]] – hIL-17F<BR />
	**[[6ppg]], [[8ruu]] – hIL-17F + antibody<BR />		**[[6ppg]], [[8ruu]] – hIL-17F + antibody<BR />
	[[3jvf]], [[6hg4]], [[6hg9]] - hIL-17F + IL-17 receptor α		**[[3jvf]], [[6hg4]], [[6hg9]] - hIL-17F + IL-17 receptor α

	*IL-18 (Interferon-γ inducing factor)		*IL-18 (Interferon-γ inducing factor)