Lipase 3D Structures - Revision history

Michal Harel at 09:13, 27 October 2025

2025-10-27T09:13:39Z

← Older revision		Revision as of 09:13, 27 October 2025
Line 9:		Line 9:
	**[[1jmy]] – hBSSL <br />		**[[1jmy]] – hBSSL <br />
	**[[1hpl]] – hLip – horse <br />		**[[1hpl]] – hLip – horse <br />
	**[[~~1akn~~]] – ~~bBSSL~~ – bovine <br />		**[[9nrn]] – bLip – bovine - Cryo EM<br />
	**[[2bce]] - bBSSL (mutant) <br />		**[[2bce]] - bBSSL (mutant) <br />
	**[[1f6w]] - bBSSL – catalytic domain<br />		**[[1f6w]] - bBSSL – catalytic domain<br />
Line 18:		Line 18:
	**[[6a0w]] – Lip catalytic domain – bread mold<br />		**[[6a0w]] – Lip catalytic domain – bread mold<br />
	**[[4zrd]], [[4zre]] – Lip1 (mutant) – dandruff fungus<br />		**[[4zrd]], [[4zre]] – Lip1 (mutant) – dandruff fungus<br />
			**[[1tic]], [[9jca]] – fLip – fungus<br />
			**[[9jc9]] – fLip (mutant) <br />

	*Prokaryote lipase:		*Prokaryote lipase:
Line 35:		Line 37:
	**[[1jfr]] – Lip – ''Streptomyces exfoliates''<br />		**[[1jfr]] – Lip – ''Streptomyces exfoliates''<br />
	**[[5mal]] – Lip – ''Streptomyces rimosus''<br />		**[[5mal]] – Lip – ''Streptomyces rimosus''<br />
	**[[2lip]] – BcLip – open state<br />		**[[2lip]] – BcLip open state<br />
			**[[8xy5]] – Lip open state – ''Burkholderia stagnalis''<br />
	**[[1cvl]] – Lip – ''Chromobacterium viscosum''<br />		**[[1cvl]] – Lip – ''Chromobacterium viscosum''<br />
	**[[1tic]] - Lip – ''Rhizopus oryzae''<br />		**[[1tic]] - Lip – ''Rhizopus oryzae''<br />
Line 65:		Line 68:
	**[[6khk]], [[6khl]] – CuaLip closed form <br />		**[[6khk]], [[6khl]] – CuaLip closed form <br />
	**[[6nkc]], [[6nkd]], [[6nkf]], [[6nkg]] – Lip – goat metagenome<br />		**[[6nkc]], [[6nkd]], [[6nkf]], [[6nkg]] – Lip – goat metagenome<br />
	**[[7q4h]] – TtLip – Thermoanaerobacter thermohydrosulfuricus<br />		**[[7q4h]] – TtLip – ''Thermoanaerobacter thermohydrosulfuricus''<br />
			**[[8yqj]], [[8yqp]] – Lip – ''Paracoccus kondratievae''<br />
			**[[8yzn]] – Lip – ''Pseudomonas lcaligenes''<br />
			**[[8oim]] – SpLip - ''Sphingomonas''<br />
			**[[9jcb]] – Lip – ''Kalmanozyma brasiliensis''<br />
			**[[8yzo]] – Lip – ''Aquipseudomonas alcaligenes''<br />

	*Bacterial lipase A		*Bacterial lipase A
Line 82:		Line 89:

	**[[4zv7]], [[3w9b]], [[5a6v]], [[5a71]], [[4k6g]], [[1tca]], [[1tcb]], [[1tcc]], [[1lbs]], [[1lbt]] – CaLipB <br />		**[[4zv7]], [[3w9b]], [[5a6v]], [[5a71]], [[4k6g]], [[1tca]], [[1tcb]], [[1tcc]], [[1lbs]], [[1lbt]] – CaLipB <br />
	**[[3icv]], [[4k5q]], [[5k6h]], [[5k6k]] – CaLipB (mutant) <br />		**[[3icv]], [[4k5q]], [[5k6h]], [[5k6k]], [[9evi]] – CaLipB (mutant) <br />
	**[[5gv5]] - CaLipB + phosphonate<br />		**[[5gv5]] - CaLipB + phosphonate<br />
	**[[4k6h]] – CaLipB (mutant) <br />		**[[4k6h]] – CaLipB (mutant) <br />
Line 93:		Line 100:
	**[[7v6d]] - LipB - ''Lasiodiplodia theobromae''<br />		**[[7v6d]] - LipB - ''Lasiodiplodia theobromae''<br />
	**[[7wol]] - LipB - ''Thermomicrobium roseum''<br />		**[[7wol]] - LipB - ''Thermomicrobium roseum''<br />
			**[[9fde]] - LipB + Lys – ''Moesziomyces antarcticus'' <br />

	*Bacterial lipase C		*Bacterial lipase C
Line 105:		Line 113:
	*Hormone-sensitive-lipases (LIPE) hydrolyze the first fatty acid of the triacylglycerol substrate		*Hormone-sensitive-lipases (LIPE) hydrolyze the first fatty acid of the triacylglycerol substrate

			**[[8zvq]] – hHSL – Cryo EM<br />
	**[[3k6k]] – EstE7(LIPE) – metagenome library<br />		**[[3k6k]] – EstE7(LIPE) – metagenome library<br />
	**[[3fak]], [[3dnm]] – EstE5(LIPE) – metagenome library<br />		**[[3fak]], [[3dnm]] – EstE5(LIPE) – metagenome library<br />
Line 135:		Line 144:
	**[[4s0x]] – TlLip + lauric acid<br />		**[[4s0x]] – TlLip + lauric acid<br />
	**[[4gxn]] – PmLip + inhibitor<br />		**[[4gxn]] – PmLip + inhibitor<br />
			**[[8p7e]] – SpLip + inhibitor <br />

	*Lipase conjugated with analogs to its reaction intermediates		*Lipase conjugated with analogs to its reaction intermediates
Line 147:		Line 157:
	**[[6h0t]] – hBAL (mutant) <br />		**[[6h0t]] – hBAL (mutant) <br />
	**[[6h0v]], [[6h18]], [[6h19]], [[6h1a]] – hBAL (mutant) + nerve agent<br />		**[[6h0v]], [[6h18]], [[6h19]], [[6h1a]] – hBAL (mutant) + nerve agent<br />
	**[[1aql]] – bBAL+taurocholate ~~- bovine~~<br />		**[[1akn]] – bBAL<br />
			**[[1f6w]] - bBAL catalytic domain
			**[[1aql]] – bBAL+taurocholate <br />

	*Monoacylglycerol lipase		*Monoacylglycerol lipase

	**[[3hju]], [[3jw8]], [[7ots]] - hMAGL <BR />		**[[3hju]], [[3jw8]], [[7ots]] - hMAGL <BR />
	**[[3jwe]], [[3pe6~~]], [[4uuq~~]], [[6ax1]], [[6bq0]], [[7l4t]], [[7l4u]], [[7l4w]], [[7l50]], [[7prm]], [[7zpg]] – hMAGL + inhibitor<br />		**[[3jwe]], [[3pe6]], [[6ax1]], [[6bq0]], [[7l4t]], [[7l4u]], [[7l4w]], [[7l50]], [[7prm]], [[7zpg]], [[8aqf]], [[8ptr]], [[8rvf]], [[9f8a]], [[9f8b]], [[9f8c]], [[9f8d]], [[9fy5]], [[9g4m]] – hMAGL + inhibitor<br />
			**[[8ptc]], [[8ptq]] – hMAGL (mutant) + inhibitor<br />
	**[[4uuq]] - hMAGLip + SAR <br />		**[[4uuq]] - hMAGLip + SAR <br />
	**[[5zun]] – hMAGL (mutant) + inhibitor<br />		**[[5zun]] – hMAGL (mutant) + inhibitor<br />
Line 159:		Line 172:
	**[[6eic]], [[6k34]] – MtMAGLip – ''Mycobacterium tuberculosis''<br />		**[[6eic]], [[6k34]] – MtMAGLip – ''Mycobacterium tuberculosis''<br />
	**[[7ozm]], [[7p0y]] – MtMAGL (mutant) <br />		**[[7ozm]], [[7p0y]] – MtMAGL (mutant) <br />
			**[[9rhw]] – MtMAGL + inhibitor<br />
			**[[9rf2]], [[8rf5]] – MtMAGL (mutant) + inhibitor<br />
	**[[5xk2]] – MAGLip – ''Aespergillus oryzae''<br />		**[[5xk2]] – MAGLip – ''Aespergillus oryzae''<br />
	**[[6qe2]] – MAGLip – ''Plaeococcus ferrophilus''<br />		**[[6qe2]] – MAGLip – ''Plaeococcus ferrophilus''<br />
Line 167:		Line 182:
	**[[7q4j]] – TtLip + monoacylglycerol intermediate<br />		**[[7q4j]] – TtLip + monoacylglycerol intermediate<br />
	**[[7e04]] – Lip – ''Cytobacillus oceanisediminis''<br />		**[[7e04]] – Lip – ''Cytobacillus oceanisediminis''<br />
			**[[8yye]] – Lip – ''Caldibacillus thermomylovorans''<br />

	*Triacylglycerol lipase		*Triacylglycerol lipase
Line 173:		Line 189:
	**[[3tgl]], [[4tgl]], [[1tgl]], [[6qpp]] – RmLip – ''Rhyzomucor miehei''<br />		**[[3tgl]], [[4tgl]], [[1tgl]], [[6qpp]] – RmLip – ''Rhyzomucor miehei''<br />
	**[[6qpr]] – RmLip (mutant)<br />		**[[6qpr]] – RmLip (mutant)<br />
			**[[8ze9]] – Lip (mutant) + phthalate – ''Sulfobacillus acidophilus''<br />
			**[[8spk]] – Lip1 – ''Moraxella'' <br />

	*Lipase with substrate bound at active site		*Lipase with substrate bound at active site
Line 205:		Line 223:
	**[[4jei]] – Lip2 – ''Yarrowia lipolytica''<br />		**[[4jei]] – Lip2 – ''Yarrowia lipolytica''<br />
	**[[1thg]] – Lip2 – ''Geotrichum candidum''<br />		**[[1thg]] – Lip2 – ''Geotrichum candidum''<br />
	**[[6ksi]] – SaLip2 – ''Staphylococcus aureus''<br />		**[[6ksi]], [[8s9r]] – SaLip2 – Staphylococcus aureus<br />
	**[[6ksl]] – SaLip2 (mutant)<br />		**[[6ksl]], [[8k7p]] – SaLip2 (mutant)<br />
	**[[6ksm]] – SaLip2 + drug<br />		**[[6ksm]], [[9l3c]], [[9l3s]] – SaLip2 + drug<br />
			**[[8yib]] – SaLip2 + petroselinic acid<br />
			**[[8k7q]] – SaLip2 (mutant) + petroselinic acid<br /

	*Lipoprotein lipase		*Lipoprotein lipase
Line 214:		Line 234:
	**[[6u7m]], [[8erl]] – bLPL – Cryo EM<br />		**[[6u7m]], [[8erl]] – bLPL – Cryo EM<br />
	}}		}}


	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 08:50, 18 June 2023

2023-06-18T08:50:48Z

← Older revision		Revision as of 08:50, 18 June 2023
Line 21:		Line 21:
	*Prokaryote lipase:		*Prokaryote lipase:

	**[[1llf]] – Lip – ''Candida cylindracea''<br />		**[[1lpm]], [[1lps]] – CrLip closed state – ''Candida rugosa'' <br />
			**[[1crl]], [[1trh]] – CrLip open state<br />
			*[[1llf]] – Lip – ''Candida cylindracea''<br />
	**[[3g7n]] – Lip - ''Penicillium expansum''<br />		**[[3g7n]] – Lip - ''Penicillium expansum''<br />
	**[[1tia]] - Lip – ''Penicillium camemberti''<br />		**[[1tia]] - Lip – ''Penicillium camemberti''<br />
Line 60:		Line 62:
	**[[5ah0]] – Lip – ''Pelosinus fermentans''<br />		**[[5ah0]] – Lip – ''Pelosinus fermentans''<br />
	**[[5ah1]] – Lip – ''Clostridium botulinum''<br />		**[[5ah1]] – Lip – ''Clostridium botulinum''<br />
	**[[6khm]] – ~~Lip~~ – ''Cutibacterium acnes''<br />		**[[6khm]] – CuaLip open form – ''Cutibacterium acnes''<br />
			**[[6khk]], [[6khl]] – CuaLip closed form <br />
			**[[6nkc]], [[6nkd]], [[6nkf]], [[6nkg]] – Lip – goat metagenome<br />
			**[[7q4h]] – TtLip – Thermoanaerobacter thermohydrosulfuricus<br />


	*Bacterial lipase A		*Bacterial lipase A
Line 71:		Line 77:
	**[[1r4z]] – BsLipA+Rc-IPG-phosphonate<br />		**[[1r4z]] – BsLipA+Rc-IPG-phosphonate<br />
	**[[1r50]] – BsLipA +Sc-IPG-phosphonate<br />		**[[1r50]] – BsLipA +Sc-IPG-phosphonate<br />
			**[[7r1k]], [[7r25]] – LipA – ''Bacillus pumilus''<br />

	*Bacterial lipase B		*Bacterial lipase B
Line 77:		Line 84:
	**[[3icv]], [[4k5q]], [[5k6h]], [[5k6k]] – CaLipB (mutant) <br />		**[[3icv]], [[4k5q]], [[5k6h]], [[5k6k]] – CaLipB (mutant) <br />
	**[[5gv5]] - CaLipB + phosphonate<br />		**[[5gv5]] - CaLipB + phosphonate<br />
			**[[4k6h]] – CaLipB (mutant) <br />
	**[[3icw]] – CaLipB (mutant) + phosphonate<br />		**[[3icw]] – CaLipB (mutant) + phosphonate<br />
	**[[5x7k]] – SmLipB NBD <br />		**[[5x7k]] – SmLipB NBD <br />
Line 84:		Line 92:
	**[[6idy]] - AfLipB - ''Aspergillus fumigatus''<br />		**[[6idy]] - AfLipB - ''Aspergillus fumigatus''<br />
	**[[7v6d]] - LipB - ''Lasiodiplodia theobromae''<br />		**[[7v6d]] - LipB - ''Lasiodiplodia theobromae''<br />
			**[[7wol]] - LipB - ''Thermomicrobium roseum''<br />

	*Bacterial lipase C		*Bacterial lipase C
Line 100:		Line 109:
	**[[1evq]] – AaEst2(LIPE) – ''Alicyclobacillus acidocaldarius''<br />		**[[1evq]] – AaEst2(LIPE) – ''Alicyclobacillus acidocaldarius''<br />
	**[[1u4n]] – AaEst2(LIPE) (mutant) <br />		**[[1u4n]] – AaEst2(LIPE) (mutant) <br />
	**[[6keu]], [[7ci0]], [[7cip]] – ElEstE53(HSL) – ''Erythrobacter longus''<br />		**[[6keu]], [[7ci0]], [[7cip]], [[7w8n]] – ElEstE53(HSL) – ''Erythrobacter longus''<br />
	**[[6kf1]], [[6kf5]], [[6kf7]], [[7cih]] – ElEstE53(HSL) (mutant)<br />		**[[6kf1]], [[6kf5]], [[6kf7]], [[7cih]] – ElEstE53(HSL) (mutant)<br />

	*Putative lipases; Proteins with unknown function but structural similarity to lipase obtained in structural genomics projects.

	**[[2rau]] - Lip – ''Sulfolobus solfataricus''<br />
	**[[3bxp]], [[3d3n]] - Lip – ''Lactobacillus plantarum''<br />
	**[[3e0x]] - Lip – ''Clostridium acetobutylicum''<br />
	**[[1z8h]] – Lip – ''Nostoc sp.'' PCC 712<br />
	**[[1vj3]] - Lip – ''Nostoc sp.'' <br />
	**[[3bzw]] – Lip - ''Bacteroides thetaiotaomicron''<br />
	**[[2pbl]] – Lip - ''Silicibacter''

	*Lipase + inhibitors		*Lipase + inhibitors
Line 135:		Line 134:
	**[[4n8s]] - TlLip + nitrobenzaldehyde + ethylacetoacetate<br />		**[[4n8s]] - TlLip + nitrobenzaldehyde + ethylacetoacetate<br />
	**[[4s0x]] – TlLip + lauric acid<br />		**[[4s0x]] – TlLip + lauric acid<br />
			**[[4gxn]] – PmLip + inhibitor<br />

	*Lipase conjugated with analogs to its reaction intermediates		*Lipase conjugated with analogs to its reaction intermediates

			**[[1lpn]] – CrLip+ dodecanesulfonate <br />
			**[[1lpo]], [[1lpp]] – CrLip+ hexadecanesulfonate<br />
			**[[3rar]] – CrLip + phosphonate derivative<br />
	**[[1qz3]] – EaEst2(mutant) (LIPE)+hexadecanesulfonate <br />		**[[1qz3]] – EaEst2(mutant) (LIPE)+hexadecanesulfonate <br />

Line 149:		Line 152:

	**[[3hju]], [[3jw8]], [[7ots]] - hMAGL <BR />		**[[3hju]], [[3jw8]], [[7ots]] - hMAGL <BR />
	**[[3jwe]], [[3pe6]], [[4uuq]], [[6ax1]], [[6bq0]], [[7l4t]], [[7l4u]], [[7l4w]], [[7l50]] – hMAGL + inhibitor<br />		**[[3jwe]], [[3pe6]], [[4uuq]], [[6ax1]], [[6bq0]], [[7l4t]], [[7l4u]], [[7l4w]], [[7l50]], [[7prm]], [[7zpg]] – hMAGL + inhibitor<br />
	**[[4uuq]] - hMAGLip + SAR <br />		**[[4uuq]] - hMAGLip + SAR <br />
	**[[5zun]] – hMAGL (mutant) + inhibitor<br />		**[[5zun]] – hMAGL (mutant) + inhibitor<br />
Line 162:		Line 165:
	**[[4ke7]], [[4ke8]], [[4ke9]] – BaMAGL + ligand<br />		**[[4ke7]], [[4ke8]], [[4ke9]] – BaMAGL + ligand<br />
	**[[4ke6]], [[4kea]] – BaMAGL (mutant) + ligand<br />		**[[4ke6]], [[4kea]] – BaMAGL (mutant) + ligand<br />
			**[[7q4j]] – TtLip + monoacylglycerol intermediate<br />
			**[[7e04]] – Lip – ''Cytobacillus oceanisediminis''<br />

	*Triacylglycerol lipase		*Triacylglycerol lipase
Line 207:		Line 212:

	**[[6oau]], [[6e7k]], [[6oaz]], [[6ob0]] – hLPL + GPIHBP1<br />		**[[6oau]], [[6e7k]], [[6oaz]], [[6ob0]] – hLPL + GPIHBP1<br />
	**[[6u7m]] – bLPL – Cryo EM<br />		**[[6u7m]], [[8erl]] – bLPL – Cryo EM<br />
	}}		}}


	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 08:05, 18 October 2021

2021-10-18T08:05:51Z

← Older revision		Revision as of 08:05, 18 October 2021
Line 24:		Line 24:
	**[[3g7n]] – Lip - ''Penicillium expansum''<br />		**[[3g7n]] – Lip - ''Penicillium expansum''<br />
	**[[1tia]] - Lip – ''Penicillium camemberti''<br />		**[[1tia]] - Lip – ''Penicillium camemberti''<br />
			**[[5ch8]] – Lip (mutant) – ''Penicillium cyclopium''<br />
			**[[6l7n]] – Lip – ''Penicillium roqueforti''<br />
	**[[2hih]] – Lip – ''Staphylococcus hyicus''<br />		**[[2hih]] – Lip – ''Staphylococcus hyicus''<br />
	**[[2fx5]] – Lip – ''Pseudomonas mendocina''<br />		**[[2fx5]] – Lip – ''Pseudomonas mendocina''<br />
	**[[1yzf]] – Lip – ''Enterococcus faecalis''<br />		**[[1yzf]] – Lip – ''Enterococcus faecalis''<br />
	**[[1dt3]], [[1dt5]], [[1dte]], [[1du4]], [[1ein]], [[1tib]], [[4dyh]], [[4ea6]], [[4flf]], [[4gbg]], [[4gwl]], [[4zgb]], [[6hw1]] - TlLip - ''Thermomyces lanuginose''<br />		**[[1dt3]], [[1dt5]], [[1dte]], [[1du4]], [[1ein]], [[1tib]], [[4dyh]], [[4ea6]], [[4flf]], [[4gbg]], [[4gwl]], [[4zgb]], [[6hw1]], [[6xok]], [[6xrv]], [[6xs3]], [[7apn]], [[7app]] - TlLip - ''Thermomyces lanuginose''<br />
	**[[5ap9]] – TlLip (mutant)<br />		**[[5ap9]] – TlLip (mutant)<br />
	**[[1jfr]] – Lip – ''Streptomyces exfoliates''<br />		**[[1jfr]] – Lip – ''Streptomyces exfoliates''<br />
Line 48:		Line 50:
	**[[2ory]] – Lip – ''Photobacterium lypoliticum''<br />		**[[2ory]] – Lip – ''Photobacterium lypoliticum''<br />
	**[[2z5g]], [[2dsn]] – GzLip T1 – ''Geobacillus zalihae''<br />		**[[2z5g]], [[2dsn]] – GzLip T1 – ''Geobacillus zalihae''<br />
	**[[3umj]] – GzLip (mutant)<br />		**[[3umj]], [[7buk]] – GzLip (mutant)<br />
	**[[3p94]] – Lip – ''Parabacteroides distasonis''<br />		**[[3p94]] – Lip – ''Parabacteroides distasonis''<br />
	**[[3ngm]] – Lip – ''Gibberella zeae''<br />		**[[3ngm]] – Lip – ''Gibberella zeae''<br />
	**[[3auk]] - Lip – ''Geobacillus''<br />		**[[3auk]] - Lip – ''Geobacillus''<br />
	**[[3uue]], [[3uuf]] – Lip – ''Malassezia globosa''<br />		**[[3uue]], [[3uuf]] – Lip – ''Malassezia globosa''<br />
	**[[4hs9]] – ~~Lip~~ – ''Proteus mirabilis''<br />		**[[4hs9]] – PmLip – ''Proteus mirabilis''<br />
			**[[6jd9]] – PmLip (mutant) <br />
	**[[4opm]] – Lip – ''Acinetobacter baumannii''<br />		**[[4opm]] – Lip – ''Acinetobacter baumannii''<br />
	**[[5ah0]] – Lip – ''Pelosinus fermentans''<br />		**[[5ah0]] – Lip – ''Pelosinus fermentans''<br />
	**[[5ah1]] – Lip – ''Clostridium botulinum''<br />		**[[5ah1]] – Lip – ''Clostridium botulinum''<br />
	**[[~~5ch8~~]] – Lip ~~(mutant)~~ – ''~~Penicillium cyclopium~~''<br />		**[[6khm]] – Lip – ''Cutibacterium acnes''<br />

	*Bacterial lipase A		*Bacterial lipase A
Line 80:		Line 83:
	**[[6tp8]] – PaLipB + substrate<br />		**[[6tp8]] – PaLipB + substrate<br />
	**[[6idy]] - AfLipB - ''Aspergillus fumigatus''<br />		**[[6idy]] - AfLipB - ''Aspergillus fumigatus''<br />
			**[[7v6d]] - LipB - ''Lasiodiplodia theobromae''<br />

	*Bacterial lipase C		*Bacterial lipase C
Line 96:		Line 100:
	**[[1evq]] – AaEst2(LIPE) – ''Alicyclobacillus acidocaldarius''<br />		**[[1evq]] – AaEst2(LIPE) – ''Alicyclobacillus acidocaldarius''<br />
	**[[1u4n]] – AaEst2(LIPE) (mutant) <br />		**[[1u4n]] – AaEst2(LIPE) (mutant) <br />
	**[[6keu]] – ElEstE53(HSL) – ''Erythrobacter longus''<br />		**[[6keu]], [[7ci0]], [[7cip]] – ElEstE53(HSL) – ''Erythrobacter longus''<br />
	**[[6kf1]], [[6kf5]], [[6kf7]] – ElEstE53(HSL) (mutant)<br />		**[[6kf1]], [[6kf5]], [[6kf7]], [[7cih]] – ElEstE53(HSL) (mutant)<br />

	*Putative lipases; Proteins with unknown function but structural similarity to lipase obtained in structural genomics projects.		*Putative lipases; Proteins with unknown function but structural similarity to lipase obtained in structural genomics projects.
Line 144:		Line 148:
	*Monoacylglycerol lipase		*Monoacylglycerol lipase

	**[[3hju]], [[3jw8]] - hMAGL <BR />		**[[3hju]], [[3jw8]], [[7ots]] - hMAGL <BR />
	**[[3jwe]], [[3pe6]], [[4uuq]], [[6ax1]], [[6bq0]] – hMAGL + inhibitor<br />		**[[3jwe]], [[3pe6]], [[4uuq]], [[6ax1]], [[6bq0]], [[7l4t]], [[7l4u]], [[7l4w]], [[7l50]] – hMAGL + inhibitor<br />
	**[[4uuq]] - hMAGLip + SAR <br />		**[[4uuq]] - hMAGLip + SAR <br />
	**[[5zun]] – hMAGL (mutant) + inhibitor<br />		**[[5zun]] – hMAGL (mutant) + inhibitor<br />
			**[[4zwn]] – yMAGL – yeast<br />
			**[[4zxf]] – yMAGLip + substrate analog<br />
			**[[6eic]], [[6k34]] – MtMAGLip – ''Mycobacterium tuberculosis''<br />
			**[[7ozm]], [[7p0y]] – MtMAGL (mutant) <br />
			**[[5xk2]] – MAGLip – ''Aespergillus oryzae''<br />
			**[[6qe2]] – MAGLip – ''Plaeococcus ferrophilus''<br />
	**[[3rm3]], [[4lhe]], [[5xks]] - BaMAGL – ''Bacillus'' <BR />		**[[3rm3]], [[4lhe]], [[5xks]] - BaMAGL – ''Bacillus'' <BR />
	**[[3rli]] – BaMAGL + PMSF<br />		**[[3rli]] – BaMAGL + PMSF<br />
	**[[4ke7]], [[4ke8]], [[4ke9]] – BaMAGL + ligand<br />		**[[4ke7]], [[4ke8]], [[4ke9]] – BaMAGL + ligand<br />
	**[[4ke6]], [[4kea]] – BaMAGL (mutant) + ligand<br />		**[[4ke6]], [[4kea]] – BaMAGL (mutant) + ligand<br />
	**[[4zwn]] – yMAGL – yeast<br />
	**[[4zxf]] – yMAGLip + substrate analog<br />
	**[[6eic]], [[6k34]] – MAGLip – ''Mycobacterium tuberculosis''<br />
	**[[5xk2]] – MAGLip – ''Aespergillus oryzae''<br />
	**[[6qe2]] – MAGLip – ''Plaeococcus ferrophilus''<br />

	*Triacylglycerol lipase		*Triacylglycerol lipase

Joel L. Sussman at 06:31, 11 September 2020

2020-09-11T06:31:54Z

← Older revision		Revision as of 06:31, 11 September 2020
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	**[[1gpl]] – Lip – Guinea pig<br />		**[[1gpl]] – Lip – Guinea pig<br />
	**[[3zpx]] – Lip – ''Ustilago maydis''<br />		**[[3zpx]] – Lip – ''Ustilago maydis''<br />
	**[[6a0w~~]], [[4l3w~~]] – Lip catalytic domain – bread mold<br />		**[[6a0w]] – Lip catalytic domain – bread mold<br />
	**[[4zrd]], [[4zre]] – Lip1 (mutant) – dandruff fungus<br />		**[[4zrd]], [[4zre]] – Lip1 (mutant) – dandruff fungus<br />

Michal Harel at 07:55, 1 September 2020

2020-09-01T07:55:50Z

← Older revision		Revision as of 07:55, 1 September 2020
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	== 3D Structures of Lipase ==		== 3D Structures of Lipase ==

Line 7:		Line 6:
	*Eukaryote lipase:		*Eukaryote lipase:

	**[[1hpl]] – hLip – horse <br />
	**[[1hlg]] – hLip – human - gastric<br />		**[[1hlg]] – hLip – human - gastric<br />
	**[[1jmy]] – hBSSL <br />		**[[1jmy]] – hBSSL <br />
	**[[1akn]] – ~~cBSSL~~ – ~~cattle~~ <br />		**[[1hpl]] – hLip – horse <br />
	**[[2bce]] - ~~cBSSL~~ (mutant) <br />		**[[1akn]] – bBSSL – bovine <br />
	**[[1f6w]] - ~~cBSSL~~ – catalytic domain<br />		**[[2bce]] - bBSSL (mutant) <br />
			**[[1f6w]] - bBSSL – catalytic domain<br />
	**[[3o0d]] – Lip – ''Yarrowia lipolytica''<br />		**[[3o0d]] – Lip – ''Yarrowia lipolytica''<br />
	**[[4jei]] – YlLip (mutant)<br />		**[[4jei]] – YlLip (mutant)<br />
	**[[1gpl]] – Lip – Guinea pig<br />		**[[1gpl]] – Lip – Guinea pig<br />
	**[[3zpx]] – Lip – ''Ustilago maydis''<br />		**[[3zpx]] – Lip – ''Ustilago maydis''<br />
	**[[6a0w]] – Lip catalytic domain – bread mold<br />		**[[6a0w]], [[4l3w]] – Lip catalytic domain – bread mold<br />
	**[[4zrd]], [[4zre]] – Lip1 (mutant) – dandruff fungus<br />		**[[4zrd]], [[4zre]] – Lip1 (mutant) – dandruff fungus<br />

Line 35:		Line 34:
	**[[1cvl]] – Lip – ''Chromobacterium viscosum''<br />		**[[1cvl]] – Lip – ''Chromobacterium viscosum''<br />
	**[[1tic]] - Lip – ''Rhizopus oryzae''<br />		**[[1tic]] - Lip – ''Rhizopus oryzae''<br />
	**[[3tgl]], [[4tgl]], [[1tgl]], [[6qpp]] – RmLip – ''Rhyzomucor miehei''<br />
	**[[6qpr]] – RmLip (mutant)<br />
	**[[2zvd]] – PsLip - ''Pseudomonas sp.'' – open state<br />		**[[2zvd]] – PsLip - ''Pseudomonas sp.'' – open state<br />
	**[[2z8x]] - PsLip – extracellular<br />		**[[2z8x]] - PsLip – extracellular<br />
Line 79:		Line 76:
	**[[3icw]] – CaLipB (mutant) + phosphonate<br />		**[[3icw]] – CaLipB (mutant) + phosphonate<br />
	**[[5x7k]] – SmLipB NBD <br />		**[[5x7k]] – SmLipB NBD <br />
	**[[6isp]], [[6isq]], [[6isr]] – ~~LipB~~ (mutant) – ''Pseudozyma antarctica''<br />		**[[6isp]], [[6isq]], [[6isr]], [[6j1p]], [[6j1q]], [[6j1r]], [[6j1s]] – PaLipB (mutant) – ''Pseudozyma antarctica''<br />
			**[[6j1t]] – PaLipB (mutant) + product analog<br />
			**[[6tp8]] – PaLipB + substrate<br />
	**[[6idy]] - AfLipB - ''Aspergillus fumigatus''<br />		**[[6idy]] - AfLipB - ''Aspergillus fumigatus''<br />

Line 97:		Line 96:
	**[[1evq]] – AaEst2(LIPE) – ''Alicyclobacillus acidocaldarius''<br />		**[[1evq]] – AaEst2(LIPE) – ''Alicyclobacillus acidocaldarius''<br />
	**[[1u4n]] – AaEst2(LIPE) (mutant) <br />		**[[1u4n]] – AaEst2(LIPE) (mutant) <br />
			**[[6keu]] – ElEstE53(HSL) – ''Erythrobacter longus''<br />
			**[[6kf1]], [[6kf5]], [[6kf7]] – ElEstE53(HSL) (mutant)<br />

	*Putative lipases; Proteins with unknown function but structural similarity to lipase obtained in structural genomics projects.		*Putative lipases; Proteins with unknown function but structural similarity to lipase obtained in structural genomics projects.
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	**[[4zwn]] – yMAGL – yeast<br />		**[[4zwn]] – yMAGL – yeast<br />
	**[[4zxf]] – yMAGLip + substrate analog<br />		**[[4zxf]] – yMAGLip + substrate analog<br />
	**[[6eic]] – MAGLip – ''Mycobacterium tuberculosis''<br />		**[[6eic]], [[6k34]] – MAGLip – ''Mycobacterium tuberculosis''<br />
	**[[5xk2]] – MAGLip – ''Aespergillus oryzae''<br />		**[[5xk2]] – MAGLip – ''Aespergillus oryzae''<br />
			**[[6qe2]] – MAGLip – ''Plaeococcus ferrophilus''<br />

			*Triacylglycerol lipase

			**[[6or3]] –TlTAGLip + palmitate<br />
			**[[3tgl]], [[4tgl]], [[1tgl]], [[6qpp]] – RmLip – ''Rhyzomucor miehei''<br />
			**[[6qpr]] – RmLip (mutant)<br />

	*Lipase with substrate bound at active site		*Lipase with substrate bound at active site
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	*Lipase 2 or esterase/lipase		*Lipase 2 or esterase/lipase

	**[[3v9a]],[[3g9t]], [[3g9u]], [[3g9z]], [[3h19]], [[3h1a]], [[3h1b]], [[3l1h]], [[3l1i]], [[3l1j]], [[3fak]], [[3h17]], [[3h18]], [[3dnm]], [[3k6k]] - E/L - uncultured bacteria<br />		**[[3v9a]],[[3g9t]], [[3g9u]], [[3g9z]], [[3h19]], [[3h1a]], [[3h1b]], [[3l1h]], [[3l1i]], [[3l1j]], [[3fak]], [[3h17]], [[3h18]], [[3dnm]], [[3k6k]], [[6cl4]] - E/L - uncultured bacteria<br />
	**[[3w9b]] - CaE/L <br />		**[[3w9b]] - CaE/L <br />
	**[[4v2i]] - E/L - ''Thalassospira''<br />		**[[4v2i]] - E/L - ''Thalassospira''<br />
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	**[[4bzz]], [[4bzw]] - LpE/L <br />		**[[4bzz]], [[4bzw]] - LpE/L <br />
	**[[6gup]] - AfE/L <br />		**[[6gup]] - AfE/L <br />
			**[[6unv]] - E/L – ''Rasamsonia emersonii'' <br />
	**[[1lgy]] – Lip2 – ''Rhizopus niveus''<br />		**[[1lgy]] – Lip2 – ''Rhizopus niveus''<br />
	**[[1gz7]] - CrLip2 <br />		**[[1gz7]] - CrLip2 <br />
	**[[4jei]] – Lip2 – ''Yarrowia lipolytica''<br />		**[[4jei]] – Lip2 – ''Yarrowia lipolytica''<br />
	**[[1thg]] – Lip2 – ''Geotrichum candidum''<br />		**[[1thg]] – Lip2 – ''Geotrichum candidum''<br />
			**[[6ksi]] – SaLip2 – ''Staphylococcus aureus''<br />
			**[[6ksl]] – SaLip2 (mutant)<br />
			**[[6ksm]] – SaLip2 + drug<br />

			*Lipoprotein lipase

			**[[6oau]], [[6e7k]], [[6oaz]], [[6ob0]] – hLPL + GPIHBP1<br />
			**[[6u7m]] – bLPL – Cryo EM<br />
	}}		}}


	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 09:57, 22 October 2019

2019-10-22T09:57:38Z

← Older revision		Revision as of 09:57, 22 October 2019
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	~~</StructureSection>~~

	== 3D Structures of Lipase ==		== 3D Structures of Lipase ==

Michal Harel: New page: == 3D Structures of Lipase == Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *Eukaryote lipas...

2019-10-22T09:57:16Z

New page: </StructureSection> == 3D Structures of Lipase == Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *Eukaryote lipas...

New page

</StructureSection>

== 3D Structures of Lipase ==

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|

*Eukaryote lipase:

**[[1hpl]] – hLip – horse 
**[[1hlg]] – hLip – human - gastric 
**[[1jmy]] – hBSSL 
**[[1akn]] – cBSSL – cattle 
**[[2bce]] - cBSSL (mutant) 
**[[1f6w]] - cBSSL – catalytic domain 
**[[3o0d]] – Lip – ''Yarrowia lipolytica'' 
**[[4jei]] – YlLip (mutant) 
**[[1gpl]] – Lip – Guinea pig 
**[[3zpx]] – Lip – ''Ustilago maydis'' 
**[[6a0w]] – Lip catalytic domain – bread mold 
**[[4zrd]], [[4zre]] – Lip1 (mutant) – dandruff fungus 

*Prokaryote lipase:

**[[1llf]] – Lip – ''Candida cylindracea'' 
**[[3g7n]] – Lip - ''Penicillium expansum'' 
**[[1tia]] - Lip – ''Penicillium camemberti'' 
**[[2hih]] – Lip – ''Staphylococcus hyicus'' 
**[[2fx5]] – Lip – ''Pseudomonas mendocina'' 
**[[1yzf]] – Lip – ''Enterococcus faecalis'' 
**[[1dt3]], [[1dt5]], [[1dte]], [[1du4]], [[1ein]], [[1tib]], [[4dyh]], [[4ea6]], [[4flf]], [[4gbg]], [[4gwl]], [[4zgb]], [[6hw1]] - TlLip - ''Thermomyces lanuginose'' 
**[[5ap9]] – TlLip (mutant) 
**[[1jfr]] – Lip – ''Streptomyces exfoliates'' 
**[[5mal]] – Lip – ''Streptomyces rimosus'' 
**[[2lip]] – BcLip – open state 
**[[1cvl]] – Lip – ''Chromobacterium viscosum'' 
**[[1tic]] - Lip – ''Rhizopus oryzae'' 
**[[3tgl]], [[4tgl]], [[1tgl]], [[6qpp]] – RmLip – ''Rhyzomucor miehei'' 
**[[6qpr]] – RmLip (mutant) 
**[[2zvd]] – PsLip - ''Pseudomonas sp.'' – open state 
**[[2z8x]] - PsLip – extracellular 
**[[5xpx]] – PsLip residues 1-388 
**[[2zj6]], [[2zj7]] – PsLip (mutant) 
**[[2z8z]] – PsLip(mutant) – closed state 
**[[3lip]], [[3a6z]] - Lip - ''Pseudomonas cepacia'' – open state 
**[[1qge]], [[1tah]] – Lip – ''Pseudomonas glumae'' 
**[[2w22]], [[6a12]] – GtLip – ''Geobacillus thermocatenulatus'' 
**[[5ce5]] – GtLip (mutant) 
**[[1ji3]], [[1ku0]], [[4fmp]], [[4x6u]] – BstLip – ''Bacillus stearothermophilus'' 
**[[4x71]], [[4x7b]], [[4x85]], [[6s3g]], [[6s3j]], [[6s3v]], [[6fz1]], [[6fz7]], [[6fz8]], [[6fz9]], [[6fza]], [[6fzc]], [[6fzd]] – BstLip (mutant) 
**[[1ah7]] - Lip – ''Bacillus cereus'' 
**[[2ory]] – Lip – ''Photobacterium lypoliticum'' 
**[[2z5g]], [[2dsn]] – GzLip T1 – ''Geobacillus zalihae'' 
**[[3umj]] – GzLip (mutant) 
**[[3p94]] – Lip – ''Parabacteroides distasonis'' 
**[[3ngm]] – Lip – ''Gibberella zeae'' 
**[[3auk]] - Lip – ''Geobacillus'' 
**[[3uue]], [[3uuf]] – Lip – ''Malassezia globosa'' 
**[[4hs9]] – Lip – ''Proteus mirabilis'' 
**[[4opm]] – Lip – ''Acinetobacter baumannii'' 
**[[5ah0]] – Lip – ''Pelosinus fermentans'' 
**[[5ah1]] – Lip – ''Clostridium botulinum'' 
**[[5ch8]] – Lip (mutant) – ''Penicillium cyclopium'' 

*Bacterial lipase A

**[[3guu]] – CaLipA – ''Candida Antarctica'' 
**[[2veo]] – CaLipA – closed state 
**[[2qua]], [[2qub]] – SmLipA – ''Serratia marcescens'' 
**[[2qxt]], [[2qxu]], [[1isp]], [[1i6w]], [[5ct4]], [[5ct5]], [[5ct6]], [[5cri]] - BsLipA – ''Bacillus subtilis'' 
**[[3d2a]], [[3d2b]], [[3d2c]], [[1t2n]], [[1t4m]], [[5ct8]], [[5ct9]], [[5cta]], [[5cur]], [[3qzu]], [[3qmm]] - BsLipA (mutant) 
**[[1r4z]] – BsLipA+Rc-IPG-phosphonate 
**[[1r50]] – BsLipA +Sc-IPG-phosphonate 

*Bacterial lipase B

**[[4zv7]], [[3w9b]], [[5a6v]], [[5a71]], [[4k6g]], [[1tca]], [[1tcb]], [[1tcc]], [[1lbs]], [[1lbt]] – CaLipB 
**[[3icv]], [[4k5q]], [[5k6h]], [[5k6k]] – CaLipB (mutant) 
**[[5gv5]] - CaLipB + phosphonate 
**[[3icw]] – CaLipB (mutant) + phosphonate 
**[[5x7k]] – SmLipB NBD 
**[[6isp]], [[6isq]], [[6isr]] – LipB (mutant) – ''Pseudozyma antarctica'' 
**[[6idy]] - AfLipB - ''Aspergillus fumigatus'' 

*Bacterial lipase C

**[[5nen]] – SmLipC residues 1-443 

*Lipase/colipase complexes. The colipase is a co-enzyme whose binding to lipase optimizes the enzymatic activity

**[[1n8s]] – hLip+colipase II 
**[[1eth]], [[1lpa]] - pLip+colipase II - pig 

*Hormone-sensitive-lipases (LIPE) hydrolyze the first fatty acid of the triacylglycerol substrate

**[[3k6k]] – EstE7(LIPE) – metagenome library 
**[[3fak]], [[3dnm]] – EstE5(LIPE) – metagenome library 
**[[1evq]] – AaEst2(LIPE) – ''Alicyclobacillus acidocaldarius'' 
**[[1u4n]] – AaEst2(LIPE) (mutant) 

*Putative lipases; Proteins with unknown function but structural similarity to lipase obtained in structural genomics projects.

**[[2rau]] - Lip – ''Sulfolobus solfataricus'' 
**[[3bxp]], [[3d3n]] - Lip – ''Lactobacillus plantarum'' 
**[[3e0x]] - Lip – ''Clostridium acetobutylicum'' 
**[[1z8h]] – Lip – ''Nostoc sp.'' PCC 712 
**[[1vj3]] - Lip – ''Nostoc sp.'' 
**[[3bzw]] – Lip - ''Bacteroides thetaiotaomicron'' 
**[[2pbl]] – Lip - ''Silicibacter''

*Lipase + inhibitors

**[[3l1h]] – EstE5(LIPE)+FeCl3 – noninvasive inhibitor 
**[[3l1i]], [[3l1j]] - EstE5(LIPE)+CuSO4 – noninvasive inhibitor 
**[[3lij]] - EstE5(LIPE)+ZnSO4– noninvasive inhibitor 
**[[3h18]], [[3h17]] - EstE5 (LIPE)+PMSF 
**[[3h19]], [[3h1b]], [[3h1a]] – EstE5 (LIPE)+methyl alcohol 
**[[3h1a]] – EstE5 SLIPE)+ethyl alcohol 
**[[3h19]] – EstE5 SLIPE)+isopropyl alcohol 
**[[3g9t]], [[3g9u]] - EstE5 (HSLIPE)+p-nitrophenyl butyrate 
**[[3g9z]] - EstE5 (LIPE) +p-nitrophenyl caprylate 
**[[2nw6]] – BcLip+ S inhibitor 
**[[4lip]], [[5lip]], [[1r4z]], [[1r50]] – BcLip+ Rc-(Rp,Sp)-1,2-dioctylcarbamoyl-glycero-3-O-phosphonate 
**[[1k8q]] - Lip+phosphonate – dog 
**[[1ex9]] – Lip+Rc-(Rp,Sp)-1,2-dioctylcarbamoyl-glycero-3-O-phosphonate – ''Pseudomonas aeruginosa'' 
**[[5tgl]] – RmLip+N-hexyl-phosphonate 
**[[1lpb]] – pLip + colipase+C11 alkyl phosphonate 
**[[3a70]] – PsLip+diethyl phosphate 
**[[4glb]] – TlLip + nitrobenzaldehyde 
**[[4kjx]] - TlLip + nitrobenzaldehyde + lauric acid 
**[[4n8s]] - TlLip + nitrobenzaldehyde + ethylacetoacetate 
**[[4s0x]] – TlLip + lauric acid 

*Lipase conjugated with analogs to its reaction intermediates

**[[1qz3]] – EaEst2(mutant) (LIPE)+hexadecanesulfonate 

*Bile-salt activated lipase

**[[6h0t]] – hBAL (mutant) 
**[[6h0v]], [[6h18]], [[6h19]], [[6h1a]] – hBAL (mutant) + nerve agent 
**[[1aql]] – bBAL+taurocholate - bovine 

*Monoacylglycerol lipase

**[[3hju]], [[3jw8]] - hMAGL 
**[[3jwe]], [[3pe6]], [[4uuq]], [[6ax1]], [[6bq0]] – hMAGL + inhibitor 
**[[4uuq]] - hMAGLip + SAR 
**[[5zun]] – hMAGL (mutant) + inhibitor 
**[[3rm3]], [[4lhe]], [[5xks]] - BaMAGL – ''Bacillus'' 
**[[3rli]] – BaMAGL + PMSF 
**[[4ke7]], [[4ke8]], [[4ke9]] – BaMAGL + ligand 
**[[4ke6]], [[4kea]] – BaMAGL (mutant) + ligand 
**[[4zwn]] – yMAGL – yeast 
**[[4zxf]] – yMAGLip + substrate analog 
**[[6eic]] – MAGLip – ''Mycobacterium tuberculosis'' 
**[[5xk2]] – MAGLip – ''Aespergillus oryzae'' 

*Lipase with substrate bound at active site

**[[2zyh]] – AfLip (mutant)+fatty acid – ''Archaeoglobus fulgidus'' 
**[[2zyi]], [[2zyr]], [[2zys]] - AfLip+fatty acid+ ion 
**[[1gt6]], [[4ghw]], [[4gi1]] – TlLip+ fatty acid - lipid ligand 

*Lipase conjugated to transition-state analogs showing the binding mode of the enzyme catalysis

**[[1ys1]] – BhLip+hexylphosphonic acid (R) 2-methyl-3-phenylpropyl ester 
**[[1ys2]] – BhLip+hexylphosphonic acid (S) 2-methyl-3-phenylpropyl ester 
**[[1hqd]] – Lip+1-phenoxy-2-acrtoxy butane – ''Pseudomonas cepacia'' 

*Lipase+lipase chaperone

**[[2es4]] – Lip+lipase chaperone C-terminal - ''Burkholderia glumae''

*Lipase 2 or esterase/lipase

**[[3v9a]],[[3g9t]], [[3g9u]], [[3g9z]], [[3h19]], [[3h1a]], [[3h1b]], [[3l1h]], [[3l1i]], [[3l1j]], [[3fak]], [[3h17]], [[3h18]], [[3dnm]], [[3k6k]] - E/L - uncultured bacteria 
**[[3w9b]] - CaE/L 
**[[4v2i]] - E/L - ''Thalassospira'' 
**[[4n5h]] - LrE/L (mutant) - ''Lactobacillus rhamnosus'' 
**[[4n5i]] - LrE/L + inhibitor 
**[[4ouk]] - LrE/L (mutant) + inhibitor 
**[[4bzz]], [[4bzw]] - LpE/L 
**[[6gup]] - AfE/L 
**[[1lgy]] – Lip2 – ''Rhizopus niveus'' 
**[[1gz7]] - CrLip2 
**[[4jei]] – Lip2 – ''Yarrowia lipolytica'' 
**[[1thg]] – Lip2 – ''Geotrichum candidum'' 
}}

[[Category:Topic Page]]