MDM2 3D structures - Revision history

Michal Harel at 11:24, 15 December 2025

2025-12-15T11:24:21Z

Michal Harel at 09:25, 27 June 2023

2023-06-27T09:25:45Z

← Older revision		Revision as of 09:25, 27 June 2023
Line 36:		Line 36:
	**[[3jzs]] - hMDM2 p53-binding domain + pDIQ peptide<br />		**[[3jzs]] - hMDM2 p53-binding domain + pDIQ peptide<br />
	**[[3tpx]] - hMDM2 p53-binding domain + D-peptide inhibitor<br />		**[[3tpx]] - hMDM2 p53-binding domain + D-peptide inhibitor<br />
	**[[2axi]], [[2gv2]], [[3eqs]], [[3g03]], [[3iux]], [[3lnj]], [[3lnz]], [[3iwy]], [[~~5uml~~]], [[~~5umm]], ]]~~6hfa]], [[7kjm]], [[8f0z]], [[8f10]], [[8f12]], [[8f13]] - hMDM2 p53-binding domain + peptide inhibitor<br />		**[[2axi]], [[2gv2]], [[3eqs]], [[3g03]], [[3iux]], [[3lnj]], [[3lnz]], [[3iwy]], [[5umm]], [[6hfa]], [[7kjm]], [[8f0z]], [[8f10]], [[8f12]], [[8f13]] - hMDM2 p53-binding domain + peptide inhibitor<br />
	**[[5vk0]], [[6kzu]], [[6aaw]] - hMDM2 p53-binding domain + stapled peptide<br />		**[[5vk0]], [[6kzu]], [[6aaw]] - hMDM2 p53-binding domain + stapled peptide<br />
	**[[4ud7]], [[4ue1]], [[4umn]], [[5afg]], [[5xxk]], [[6h22]], [[6t2d]], [[6t2e]], [[6t2f]], [[6y4q]] - hMDM2 p53-binding domain (mutant) + stapled peptide<br />		**[[4ud7]], [[4ue1]], [[4umn]], [[5afg]], [[5xxk]], [[6h22]], [[6t2d]], [[6t2e]], [[6t2f]], [[6y4q]] - hMDM2 p53-binding domain (mutant) + stapled peptide<br />

Michal Harel at 09:20, 27 June 2023

2023-06-27T09:20:51Z

Michal Harel at 10:17, 28 October 2021

2021-10-28T10:17:13Z

Michal Harel at 08:01, 6 September 2020

2020-09-06T08:01:30Z

← Older revision		Revision as of 08:01, 6 September 2020
Line 4:		Line 4:
	{{#tree:id=OrganizedByTopic\|openlevels=0\|		{{#tree:id=OrganizedByTopic\|openlevels=0\|

	*'''MDM2'''		*'''MDM2''' ); Domains – p53-binding 24-220; ring – 383-446; C4 zinc-finger 429-491

	**[[2ruh]] - hMDM2 p53-binding domain ~~residues 24-110~~ - human<br />		**[[2ruh]] - hMDM2 p53-binding domain - human<br />
	**[[1z1m]] – hMDM2 p53-binding domain - NMR<br />		**[[1z1m]] – hMDM2 p53-binding domain - NMR<br />
	**[[2c6a]], [[2c6b]] – hMDM2 C4 Zinc-finger domain ~~residues 290-335~~ - NMR<br />		**[[2c6a]], [[2c6b]] – hMDM2 C4 Zinc-finger domain - NMR<br />
	**[[2hdp]] - hMDM2 C4 ring-finger domain ~~residues 429~~-~~491~~ - ~~NMR~~<br />		**[[2hdp]] - hMDM2 C4 ring-finger domain - NMR<br />
			**[[6sqp]] - cMDM2 C4 ring-finger domain – cat<br />
	**[[4ipf]], [[4j74]] – fMDM2 p53-binding domain (mutant) - frog<br />		**[[4ipf]], [[4j74]] – fMDM2 p53-binding domain (mutant) - frog<br />

	*MDM2 complex with small molecule		*MDM2 p53-binding domain complex with small molecule

	**[[1rv1]], [[1t4e]], [[3lbk]], [[4dij]], [[3vzv]], [[3w69]], [[3lkb]], [[4lwt]], [[4lwu]], [[4lwv]], [[4oq3]], [[5hmh]], [[5hmi]], [[5hmk]] – hMDM2 (mutant) ~~p53-binding domain~~ + inhibitor<br />		**[[1rv1]], [[1t4e]], [[3lbk]], [[4dij]], [[3vzv]], [[3w69]], [[3lkb]], [[4lwt]], [[4lwu]], [[4lwv]], [[4oq3]], [[5hmh]], [[5hmi]], [[5hmk]] – hMDM2 (mutant) + inhibitor<br />
	**[[3jzk]], [[3lbl]], [[3tu1]], [[4ere]], [[4erf]], [[3tj2]], [[4hbm]], [[4jv7]], [[4jv9]], [[4jve]], [[4jvr]], [[4jwr]], [[4mdn]], [[4mdq]], [[4oas]], [[4oba]], [[4occ]], [[4ode]], [[4odf]], [[4ogn]], [[4ogt]], [[4ogv]], [[4qo4]], [[4hg7]], [[4wt2]], [[4qoc]], [[4wt2]], [[4zfi]], [[4zgk]], [[4zyf]], [[4zyi]], [[5j7f]], [[5j7g]], [[5lav]], [[5law]], [[5lay]], [[5laz]], [[5ln2]], [[5trf]], [[6q96]], [[6q9h]], [[6q9l]], [[6q9o]], [[6i3s]], [[6ggn]], [[5oc8]], [[5oai]] - hMDM2 ~~p53-binding domain~~ + inhibitor<br />		**[[3jzk]], [[3lbl]], [[3tu1]], [[4ere]], [[4erf]], [[3tj2]], [[4hbm]], [[4jv7]], [[4jv9]], [[4jve]], [[4jvr]], [[4jwr]], [[4mdn]], [[4mdq]], [[4oas]], [[4oba]], [[4occ]], [[4ode]], [[4odf]], [[4ogn]], [[4ogt]], [[4ogv]], [[4qo4]], [[4hg7]], [[4wt2]], [[4qoc]], [[4wt2]], [[4zfi]], [[4zgk]], [[4zyf]], [[4zyi]], [[5j7f]], [[5j7g]], [[5lav]], [[5law]], [[5lay]], [[5laz]], [[5ln2]], [[5trf]], [[6q96]], [[6q9h]], [[6q9l]], [[6q9o]], [[6i3s]], [[6ggn]], [[5oc8]], [[5oai]], [[6i29]] - hMDM2 + inhibitor<br />
	**[[5z02]], [[5zxf]] - hMDM2 ~~p53-binding domain~~ + nutlin<br />		**[[5z02]], [[5zxf]] - hMDM2 + nutlin<br />
	**[[2lzg]] - hMDM2 ~~p53-binding domain~~ + inhibitor – NMR<br />		**[[2lzg]] - hMDM2 + inhibitor – NMR<br />
	**[[3vbg]] - hMDM2 ~~p53-binding domain~~ + indolyl hydantoin<br />		**[[3vbg]] - hMDM2 + indolyl hydantoin<br />
	**[[5c5a]] - hMDM2 (mutant) ~~p53-binding domain~~ + inhibitor – NMR<br />		**[[5c5a]] - hMDM2 (mutant) + inhibitor – NMR<br />
	**[[1ttv]] - fMDM2 (mutant) ~~p53-binding domain~~ + inhibitor – NMR<br />		**[[1ttv]] - fMDM2 (mutant) + inhibitor – NMR<br />
	**[[4j3e]], [[4j7d]], [[4j7e]], [[4jrg]], [[4jsc]], [[4zyc]], [[4lwt]], [[4lwu]], [[4lwv]] - fMDM2 ~~p53-binding domain~~ (mutant) + inhibitor<br />		**[[4j3e]], [[4j7d]], [[4j7e]], [[4jrg]], [[4jsc]], [[4zyc]], [[4lwt]], [[4lwu]], [[4lwv]] - fMDM2 (mutant) + inhibitor<br />

	*MDM2 complex with peptide		*MDM2 complex with peptide

	**[[1ycq]], [[1ycr]] – fMDM2 + p53 peptide <br />
	**[[1t4f]], [[4hfz]] - hMDM2 (mutant) p53-binding domain + p53 peptide<br />		**[[1t4f]], [[4hfz]] - hMDM2 (mutant) p53-binding domain + p53 peptide<br />
	**[[3v3b]] - hMDM2 p53-binding domain + p53 peptide<br />		**[[3v3b]] - hMDM2 p53-binding domain + p53 peptide<br />
Line 33:		Line 33:
	**[[3jzs]] - hMDM2 p53-binding domain + pDIQ peptide<br />		**[[3jzs]] - hMDM2 p53-binding domain + pDIQ peptide<br />
	**[[3tpx]] - hMDM2 p53-binding domain + D-peptide inhibitor<br />		**[[3tpx]] - hMDM2 p53-binding domain + D-peptide inhibitor<br />
	**[[2axi]], [[2gv2]], [[3eqs]], [[3g03]], [[3iux]], [[3lnj]], [[3lnz]], [[3iwy]], [[5umm]] - hMDM2 p53-binding domain + peptide<br />		**[[2axi]], [[2gv2]], [[3eqs]], [[3g03]], [[3iux]], [[3lnj]], [[3lnz]], [[3iwy]], [[5umm]], ]]6hfa]] - hMDM2 p53-binding domain + peptide<br />
	**[[5vk0]], [[6kzu]], [[6aaw]] - hMDM2 p53-binding domain + stapled peptide<br />		**[[5vk0]], [[6kzu]], [[6aaw]] - hMDM2 p53-binding domain + stapled peptide<br />
	**[[4ud7]], [[4ue1]], [[4umn]], [[5afg]], [[5xxk]], [[6h22]] - hMDM2 p53-binding domain (mutant) + stapled peptide<br />		**[[4ud7]], [[4ue1]], [[4umn]], [[5afg]], [[5xxk]], [[6h22]], [[6t2d]], [[6t2e]], [[6t2f]], [[6y4q]] - hMDM2 p53-binding domain (mutant) + stapled peptide<br />
	**[[2m86]] - hMDM2 p53-binding domain + cyclotide - NMR<br />		**[[2m86]] - hMDM2 p53-binding domain + cyclotide - NMR<br />
	**[[2vje]], [[2vjf]] - hMDM2 ring domain + MDM4 peptide<br />		**[[2vje]], [[2vjf]] - hMDM2 ring domain + MDM4 peptide<br />
			**[[1ycq]], [[1ycr]] – fMDM2 p53-binding domain + p53 peptide <br />

	*MDM2 complex with protein		*MDM2 complex with protein

	**[[5mnj]] - hMDM2 ~~residues 428~~-~~491~~ + MDM4 + polyubiquitin + ubiquitin-conjugating enzyme E2<br />		**[[5mnj]] - hMDM2 C4 zinc-finger domain + MDM4 + polyubiquitin + ubiquitin-conjugating enzyme E2<br />
	**[[5wts]] - hMDM2 p53-binding domain + GFP-linked peptide<br />		**[[5wts]] - hMDM2 p53-binding domain + GFP-linked peptide<br />
	**[[5swk]] - hMDM2 p53-binding domain + cysteine protease inhibitor<br />		**[[5swk]] - hMDM2 p53-binding domain + cysteine protease inhibitor<br />
	**[[6im9]] - hMDM2 p53-binding domain + copper reflux oxidase<br />		**[[6im9]] - hMDM2 p53-binding domain + copper reflux oxidase<br />
			**[[6sqo]] - hMDM2 ring domain + ubiquitin-conjugating enzyme E2 + S27A<br />
			**[[6sqr]], [[6sqs]] - cMDM2 ring domain + ubiquitin-conjugating enzyme E2 + S27A<br />

	}}		}}

	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 09:52, 29 October 2019

2019-10-29T09:52:54Z

← Older revision		Revision as of 09:52, 29 October 2019
Line 8:		Line 8:
	**[[2ruh]] - hMDM2 p53-binding domain residues 24-110 - human<br />		**[[2ruh]] - hMDM2 p53-binding domain residues 24-110 - human<br />
	**[[1z1m]] – hMDM2 p53-binding domain - NMR<br />		**[[1z1m]] – hMDM2 p53-binding domain - NMR<br />
	**[[2c6a]], [[2c6b~~]], [[2cr8~~]] – hMDM2 C4 Zinc-finger domain residues ~~300~~-~~339~~ - NMR<br />		**[[2c6a]], [[2c6b]] – hMDM2 C4 Zinc-finger domain residues 290-335 - NMR<br />
	**[[2hdp]] - hMDM2 C4 ring-finger domain residues 429-491 - NMR<br />		**[[2hdp]] - hMDM2 C4 ring-finger domain residues 429-491 - NMR<br />
	**[[4ipf]], [[4j74]] – fMDM2 p53-binding domain (mutant) - frog<br />		**[[4ipf]], [[4j74]] – fMDM2 p53-binding domain (mutant) - frog<br />

Michal Harel: New page: ==3D structures of MDM2== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *'''MDM2''' **2ruh - hMDM2 p53-bindi...

2019-10-29T09:40:40Z

New page: ==3D structures of MDM2== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *'''MDM2''' **2ruh - hMDM2 p53-bindi...

New page

==3D structures of MDM2==

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|

*'''MDM2'''

**[[2ruh]] - hMDM2 p53-binding domain residues 24-110 - human 
**[[1z1m]] – hMDM2 p53-binding domain - NMR 
**[[2c6a]], [[2c6b]], [[2cr8]] – hMDM2 C4 Zinc-finger domain residues 300-339 - NMR 
**[[2hdp]] - hMDM2 C4 ring-finger domain residues 429-491 - NMR 
**[[4ipf]], [[4j74]] – fMDM2 p53-binding domain (mutant) - frog 

*MDM2 complex with small molecule

**[[1rv1]], [[1t4e]], [[3lbk]], [[4dij]], [[3vzv]], [[3w69]], [[3lkb]], [[4lwt]], [[4lwu]], [[4lwv]], [[4oq3]], [[5hmh]], [[5hmi]], [[5hmk]] – hMDM2 (mutant) p53-binding domain + inhibitor 
**[[3jzk]], [[3lbl]], [[3tu1]], [[4ere]], [[4erf]], [[3tj2]], [[4hbm]], [[4jv7]], [[4jv9]], [[4jve]], [[4jvr]], [[4jwr]], [[4mdn]], [[4mdq]], [[4oas]], [[4oba]], [[4occ]], [[4ode]], [[4odf]], [[4ogn]], [[4ogt]], [[4ogv]], [[4qo4]], [[4hg7]], [[4wt2]], [[4qoc]], [[4wt2]], [[4zfi]], [[4zgk]], [[4zyf]], [[4zyi]], [[5j7f]], [[5j7g]], [[5lav]], [[5law]], [[5lay]], [[5laz]], [[5ln2]], [[5trf]], [[6q96]], [[6q9h]], [[6q9l]], [[6q9o]], [[6i3s]], [[6ggn]], [[5oc8]], [[5oai]] - hMDM2 p53-binding domain + inhibitor 
**[[5z02]], [[5zxf]] - hMDM2 p53-binding domain + nutlin 
**[[2lzg]] - hMDM2 p53-binding domain + inhibitor – NMR 
**[[3vbg]] - hMDM2 p53-binding domain + indolyl hydantoin 
**[[5c5a]] - hMDM2 (mutant) p53-binding domain + inhibitor – NMR 
**[[1ttv]] - fMDM2 (mutant) p53-binding domain + inhibitor – NMR 
**[[4j3e]], [[4j7d]], [[4j7e]], [[4jrg]], [[4jsc]], [[4zyc]], [[4lwt]], [[4lwu]], [[4lwv]] - fMDM2 p53-binding domain (mutant) + inhibitor 

*MDM2 complex with peptide

**[[1ycq]], [[1ycr]] – fMDM2 + p53 peptide 
**[[1t4f]], [[4hfz]] - hMDM2 (mutant) p53-binding domain + p53 peptide 
**[[3v3b]] - hMDM2 p53-binding domain + p53 peptide 
**[[2mps]] - hMDM2 p53-binding domain + p73 peptide 
**[[3jzr]] - hMDM2 p53-binding domain + pDI6W peptide 
**[[4umn]] - hMDM2 p53-binding domain + M06 peptide 
**[[3jzs]] - hMDM2 p53-binding domain + pDIQ peptide 
**[[3tpx]] - hMDM2 p53-binding domain + D-peptide inhibitor 
**[[2axi]], [[2gv2]], [[3eqs]], [[3g03]], [[3iux]], [[3lnj]], [[3lnz]], [[3iwy]], [[5umm]] - hMDM2 p53-binding domain + peptide 
**[[5vk0]], [[6kzu]], [[6aaw]] - hMDM2 p53-binding domain + stapled peptide 
**[[4ud7]], [[4ue1]], [[4umn]], [[5afg]], [[5xxk]], [[6h22]] - hMDM2 p53-binding domain (mutant) + stapled peptide 
**[[2m86]] - hMDM2 p53-binding domain + cyclotide - NMR 
**[[2vje]], [[2vjf]] - hMDM2 ring domain + MDM4 peptide 

*MDM2 complex with protein

**[[5mnj]] - hMDM2 residues 428-491 + MDM4 + polyubiquitin + ubiquitin-conjugating enzyme E2 
**[[5wts]] - hMDM2 p53-binding domain + GFP-linked peptide 
**[[5swk]] - hMDM2 p53-binding domain + cysteine protease inhibitor 
**[[6im9]] - hMDM2 p53-binding domain + copper reflux oxidase 

}}

[[Category:Topic Page]]

← Older revision		Revision as of 11:24, 15 December 2025
Line 21:		Line 21:
	**[[3jzk]], [[3lbl]], [[3tu1]], [[4ere]], [[4erf]], [[3tj2]], [[4hbm]], [[4jv7]], [[4jv9]], [[4jve]], [[4jvr]], [[4jwr]], [[4mdn]], [[4mdq]], [[4oas]], [[4oba]], [[4occ]], [[4ode]], [[4odf]], [[4ogn]], [[4ogt]], [[4ogv]], [[4qo4]], [[4hg7]], [[4wt2]], [[4qoc]], [[4wt2]], [[4zfi]], [[4zgk]], [[4zyf]], [[4zyi]], [[5j7f]], [[5j7g]], [[5lav]], [[5law]], [[5lay]], [[5laz]], [[5ln2]], [[5trf]], [[6q96]], [[6q9h]], [[6q9l]], [[6q9o]], [[6i3s]], [[6ggn]], [[5oc8]], [[5oai]], [[6i29]], [[7bir]], [[7bit]], [[7biv]], [[7bj0]], [[7bj6]], [[7bmg]], [[7na1]], [[7na2]], [[7na3]], [[7na4]], [[7qdq]], [[8aeu]] - hMDM2 + inhibitor<br />		**[[3jzk]], [[3lbl]], [[3tu1]], [[4ere]], [[4erf]], [[3tj2]], [[4hbm]], [[4jv7]], [[4jv9]], [[4jve]], [[4jvr]], [[4jwr]], [[4mdn]], [[4mdq]], [[4oas]], [[4oba]], [[4occ]], [[4ode]], [[4odf]], [[4ogn]], [[4ogt]], [[4ogv]], [[4qo4]], [[4hg7]], [[4wt2]], [[4qoc]], [[4wt2]], [[4zfi]], [[4zgk]], [[4zyf]], [[4zyi]], [[5j7f]], [[5j7g]], [[5lav]], [[5law]], [[5lay]], [[5laz]], [[5ln2]], [[5trf]], [[6q96]], [[6q9h]], [[6q9l]], [[6q9o]], [[6i3s]], [[6ggn]], [[5oc8]], [[5oai]], [[6i29]], [[7bir]], [[7bit]], [[7biv]], [[7bj0]], [[7bj6]], [[7bmg]], [[7na1]], [[7na2]], [[7na3]], [[7na4]], [[7qdq]], [[8aeu]] - hMDM2 + inhibitor<br />
	**[[5z02]], [[5zxf]] - hMDM2 + nutlin<br />		**[[5z02]], [[5zxf]] - hMDM2 + nutlin<br />
			**[[8pwc]] - hMDM2 + brigimadlin<br />
	**[[2lzg]] - hMDM2 + inhibitor – NMR<br />		**[[2lzg]] - hMDM2 + inhibitor – NMR<br />
	**[[3vbg]] - hMDM2 + indolyl hydantoin<br />		**[[3vbg]] - hMDM2 + indolyl hydantoin<br />
Line 36:		Line 37:
	**[[3jzs]] - hMDM2 p53-binding domain + pDIQ peptide<br />		**[[3jzs]] - hMDM2 p53-binding domain + pDIQ peptide<br />
	**[[3tpx]] - hMDM2 p53-binding domain + D-peptide inhibitor<br />		**[[3tpx]] - hMDM2 p53-binding domain + D-peptide inhibitor<br />
	**[[2axi]], [[2gv2]], [[3eqs]], [[3g03]], [[3iux]], [[3lnj]], [[3lnz]], [[3iwy]], [[5umm]], [[6hfa]], [[7kjm]], [[8f0z]], [[8f10]], [[8f12]], [[8f13]] - hMDM2 p53-binding domain + peptide inhibitor<br />		**[[2axi]], [[2gv2]], [[3eqs]], [[3g03]], [[3iux]], [[3lnj]], [[3lnz]], [[3iwy]], [[5umm]], [[6hfa]], [[7kjm]], [[8f0z]], [[8f10]], [[8f12]], [[8f13]], [[8gcg]], [[8j81]], [[9cdz]], [[9fql]] - hMDM2 p53-binding domain + peptide inhibitor<br />
	**[[5vk0]], [[6kzu]], [[6aaw]] - hMDM2 p53-binding domain + stapled peptide<br />		**[[5vk0]], [[6kzu]], [[6aaw]], [[9gfc]], [[9gfk]] - hMDM2 p53-binding domain + stapled peptide<br />
	**[[4ud7]], [[4ue1]], [[4umn]], [[5afg]], [[5xxk]], [[6h22]], [[6t2d]], [[6t2e]], [[6t2f]], [[6y4q]] - hMDM2 p53-binding domain (mutant) + stapled peptide<br />		**[[4ud7]], [[4ue1]], [[4umn]], [[5afg]], [[5xxk]], [[6h22]], [[6t2d]], [[6t2e]], [[6t2f]], [[6y4q]] - hMDM2 p53-binding domain (mutant) + stapled peptide<br />
			**[[5wts]] - hMDM2 p53-binding domain + GFP-linked peptide<br />
	**[[2m86]] - hMDM2 p53-binding domain + cyclotide - NMR<br />		**[[2m86]] - hMDM2 p53-binding domain + cyclotide - NMR<br />
	**[[2vje]], [[2vjf]] - hMDM2 ring domain + MDM4 peptide<br />		**[[2vje]], [[2vjf]] - hMDM2 ring domain + MDM4 peptide<br />
Line 46:		Line 48:

	**[[5mnj]] - hMDM2 C4 zinc-finger domain + MDM4 + polyubiquitin + ubiquitin-conjugating enzyme E2<br />		**[[5mnj]] - hMDM2 C4 zinc-finger domain + MDM4 + polyubiquitin + ubiquitin-conjugating enzyme E2<br />
	**[[5wts]] - hMDM2 p53-binding domain + GFP-linked peptide<br />
	**[[5swk]] - hMDM2 p53-binding domain + cysteine protease inhibitor<br />		**[[5swk]] - hMDM2 p53-binding domain + cysteine protease inhibitor<br />
	**[[6im9]] - hMDM2 p53-binding domain + copper reflux oxidase<br />		**[[6im9]] - hMDM2 p53-binding domain + copper reflux oxidase<br />
	**[[7aye]] - hMDM2 p53-binding domain + DsbD<br />		**[[7aye]] - hMDM2 p53-binding domain + DsbD<br />
			**[[8ei9]], [[8eia]], [[8eib]], [[8eic]] - hMDM2 p53-binding domain + catenin + helicon peptide<br />
	**[[6sqo]] - hMDM2 ring domain + ubiquitin-conjugating enzyme E2 + S27A<br />		**[[6sqo]] - hMDM2 ring domain + ubiquitin-conjugating enzyme E2 + S27A<br />
	**[[6sqr]], [[6sqs]] - cMDM2 ring domain + ubiquitin-conjugating enzyme E2 + S27A<br />		**[[6sqr]], [[6sqs]] - cMDM2 ring domain + ubiquitin-conjugating enzyme E2 + S27A<br />

← Older revision		Revision as of 09:20, 27 June 2023
Line 6:		Line 6:
	*'''MDM2''' ); Domains – p53-binding 24-220; ring – 383-446; C4 zinc-finger 429-491		*'''MDM2''' ); Domains – p53-binding 24-220; ring – 383-446; C4 zinc-finger 429-491

	**[[2ruh]] - hMDM2 p53-binding domain ~~- human~~<br />		**[[8bgu]] - hMDM2 + RNA - human<br />
			**[[2ruh]] - hMDM2 p53-binding domain <br />
	**[[1z1m]] – hMDM2 p53-binding domain - NMR<br />		**[[1z1m]] – hMDM2 p53-binding domain - NMR<br />
	**[[2c6a]], [[2c6b]] – hMDM2 C4 Zinc-finger domain - NMR<br />		**[[2c6a]], [[2c6b]] – hMDM2 C4 Zinc-finger domain - NMR<br />
Line 18:		Line 19:

	**[[1rv1]], [[1t4e]], [[3lbk]], [[4dij]], [[3vzv]], [[3w69]], [[3lkb]], [[4lwt]], [[4lwu]], [[4lwv]], [[4oq3]], [[5hmh]], [[5hmi]], [[5hmk]] – hMDM2 (mutant) + inhibitor<br />		**[[1rv1]], [[1t4e]], [[3lbk]], [[4dij]], [[3vzv]], [[3w69]], [[3lkb]], [[4lwt]], [[4lwu]], [[4lwv]], [[4oq3]], [[5hmh]], [[5hmi]], [[5hmk]] – hMDM2 (mutant) + inhibitor<br />
	**[[3jzk]], [[3lbl]], [[3tu1]], [[4ere]], [[4erf]], [[3tj2]], [[4hbm]], [[4jv7]], [[4jv9]], [[4jve]], [[4jvr]], [[4jwr]], [[4mdn]], [[4mdq]], [[4oas]], [[4oba]], [[4occ]], [[4ode]], [[4odf]], [[4ogn]], [[4ogt]], [[4ogv]], [[4qo4]], [[4hg7]], [[4wt2]], [[4qoc]], [[4wt2]], [[4zfi]], [[4zgk]], [[4zyf]], [[4zyi]], [[5j7f]], [[5j7g]], [[5lav]], [[5law]], [[5lay]], [[5laz]], [[5ln2]], [[5trf]], [[6q96]], [[6q9h]], [[6q9l]], [[6q9o]], [[6i3s]], [[6ggn]], [[5oc8]], [[5oai]], [[6i29]], [[7bir]], [[7bit]], [[7biv]], [[7bj0]], [[7bj6]], [[7bmg]] - hMDM2 + inhibitor<br />		**[[3jzk]], [[3lbl]], [[3tu1]], [[4ere]], [[4erf]], [[3tj2]], [[4hbm]], [[4jv7]], [[4jv9]], [[4jve]], [[4jvr]], [[4jwr]], [[4mdn]], [[4mdq]], [[4oas]], [[4oba]], [[4occ]], [[4ode]], [[4odf]], [[4ogn]], [[4ogt]], [[4ogv]], [[4qo4]], [[4hg7]], [[4wt2]], [[4qoc]], [[4wt2]], [[4zfi]], [[4zgk]], [[4zyf]], [[4zyi]], [[5j7f]], [[5j7g]], [[5lav]], [[5law]], [[5lay]], [[5laz]], [[5ln2]], [[5trf]], [[6q96]], [[6q9h]], [[6q9l]], [[6q9o]], [[6i3s]], [[6ggn]], [[5oc8]], [[5oai]], [[6i29]], [[7bir]], [[7bit]], [[7biv]], [[7bj0]], [[7bj6]], [[7bmg]], [[7na1]], [[7na2]], [[7na3]], [[7na4]], [[7qdq]], [[8aeu]] - hMDM2 + inhibitor<br />
	**[[5z02]], [[5zxf]] - hMDM2 + nutlin<br />		**[[5z02]], [[5zxf]] - hMDM2 + nutlin<br />
	**[[2lzg]] - hMDM2 + inhibitor – NMR<br />		**[[2lzg]] - hMDM2 + inhibitor – NMR<br />
Line 35:		Line 36:
	**[[3jzs]] - hMDM2 p53-binding domain + pDIQ peptide<br />		**[[3jzs]] - hMDM2 p53-binding domain + pDIQ peptide<br />
	**[[3tpx]] - hMDM2 p53-binding domain + D-peptide inhibitor<br />		**[[3tpx]] - hMDM2 p53-binding domain + D-peptide inhibitor<br />
	**[[2axi]], [[2gv2]], [[3eqs]], [[3g03]], [[3iux]], [[3lnj]], [[3lnz]], [[3iwy]], [[5umm]], ]]6hfa]] - hMDM2 p53-binding domain + peptide<br />		**[[2axi]], [[2gv2]], [[3eqs]], [[3g03]], [[3iux]], [[3lnj]], [[3lnz]], [[3iwy]], [[5uml]], [[5umm]], ]]6hfa]], [[7kjm]], [[8f0z]], [[8f10]], [[8f12]], [[8f13]] - hMDM2 p53-binding domain + peptide inhibitor<br />
	**[[5vk0]], [[6kzu]], [[6aaw]] - hMDM2 p53-binding domain + stapled peptide<br />		**[[5vk0]], [[6kzu]], [[6aaw]] - hMDM2 p53-binding domain + stapled peptide<br />
	**[[4ud7]], [[4ue1]], [[4umn]], [[5afg]], [[5xxk]], [[6h22]], [[6t2d]], [[6t2e]], [[6t2f]], [[6y4q]] - hMDM2 p53-binding domain (mutant) + stapled peptide<br />		**[[4ud7]], [[4ue1]], [[4umn]], [[5afg]], [[5xxk]], [[6h22]], [[6t2d]], [[6t2e]], [[6t2f]], [[6y4q]] - hMDM2 p53-binding domain (mutant) + stapled peptide<br />

← Older revision		Revision as of 10:17, 28 October 2021
Line 12:		Line 12:
	**[[6sqp]] - cMDM2 C4 ring-finger domain – cat<br />		**[[6sqp]] - cMDM2 C4 ring-finger domain – cat<br />
	**[[4ipf]], [[4j74]] – fMDM2 p53-binding domain (mutant) - frog<br />		**[[4ipf]], [[4j74]] – fMDM2 p53-binding domain (mutant) - frog<br />
			**[[7ahy]] - fMDM2 RING domain <br />
			**[[7ah2]] - MDM2 RING domain – zebrafish<br />

	*MDM2 p53-binding domain complex with small molecule		*MDM2 p53-binding domain complex with small molecule

	**[[1rv1]], [[1t4e]], [[3lbk]], [[4dij]], [[3vzv]], [[3w69]], [[3lkb]], [[4lwt]], [[4lwu]], [[4lwv]], [[4oq3]], [[5hmh]], [[5hmi]], [[5hmk]] – hMDM2 (mutant) + inhibitor<br />		**[[1rv1]], [[1t4e]], [[3lbk]], [[4dij]], [[3vzv]], [[3w69]], [[3lkb]], [[4lwt]], [[4lwu]], [[4lwv]], [[4oq3]], [[5hmh]], [[5hmi]], [[5hmk]] – hMDM2 (mutant) + inhibitor<br />
	**[[3jzk]], [[3lbl]], [[3tu1]], [[4ere]], [[4erf]], [[3tj2]], [[4hbm]], [[4jv7]], [[4jv9]], [[4jve]], [[4jvr]], [[4jwr]], [[4mdn]], [[4mdq]], [[4oas]], [[4oba]], [[4occ]], [[4ode]], [[4odf]], [[4ogn]], [[4ogt]], [[4ogv]], [[4qo4]], [[4hg7]], [[4wt2]], [[4qoc]], [[4wt2]], [[4zfi]], [[4zgk]], [[4zyf]], [[4zyi]], [[5j7f]], [[5j7g]], [[5lav]], [[5law]], [[5lay]], [[5laz]], [[5ln2]], [[5trf]], [[6q96]], [[6q9h]], [[6q9l]], [[6q9o]], [[6i3s]], [[6ggn]], [[5oc8]], [[5oai]], [[6i29]] - hMDM2 + inhibitor<br />		**[[3jzk]], [[3lbl]], [[3tu1]], [[4ere]], [[4erf]], [[3tj2]], [[4hbm]], [[4jv7]], [[4jv9]], [[4jve]], [[4jvr]], [[4jwr]], [[4mdn]], [[4mdq]], [[4oas]], [[4oba]], [[4occ]], [[4ode]], [[4odf]], [[4ogn]], [[4ogt]], [[4ogv]], [[4qo4]], [[4hg7]], [[4wt2]], [[4qoc]], [[4wt2]], [[4zfi]], [[4zgk]], [[4zyf]], [[4zyi]], [[5j7f]], [[5j7g]], [[5lav]], [[5law]], [[5lay]], [[5laz]], [[5ln2]], [[5trf]], [[6q96]], [[6q9h]], [[6q9l]], [[6q9o]], [[6i3s]], [[6ggn]], [[5oc8]], [[5oai]], [[6i29]], [[7bir]], [[7bit]], [[7biv]], [[7bj0]], [[7bj6]], [[7bmg]] - hMDM2 + inhibitor<br />
	**[[5z02]], [[5zxf]] - hMDM2 + nutlin<br />		**[[5z02]], [[5zxf]] - hMDM2 + nutlin<br />
	**[[2lzg]] - hMDM2 + inhibitor – NMR<br />		**[[2lzg]] - hMDM2 + inhibitor – NMR<br />
Line 27:		Line 29:

	**[[1t4f]], [[4hfz]] - hMDM2 (mutant) p53-binding domain + p53 peptide<br />		**[[1t4f]], [[4hfz]] - hMDM2 (mutant) p53-binding domain + p53 peptide<br />
	**[[3v3b]] - hMDM2 p53-binding domain + p53 peptide<br />		**[[3v3b]], [[7ad0]], [[7nus]] - hMDM2 p53-binding domain + p53 peptide<br />
	**[[2mps]] - hMDM2 p53-binding domain + p73 peptide<br />		**[[2mps]] - hMDM2 p53-binding domain + p73 peptide<br />
	**[[3jzr]] - hMDM2 p53-binding domain + pDI6W peptide<br />		**[[3jzr]] - hMDM2 p53-binding domain + pDI6W peptide<br />
Line 46:		Line 48:
	**[[5swk]] - hMDM2 p53-binding domain + cysteine protease inhibitor<br />		**[[5swk]] - hMDM2 p53-binding domain + cysteine protease inhibitor<br />
	**[[6im9]] - hMDM2 p53-binding domain + copper reflux oxidase<br />		**[[6im9]] - hMDM2 p53-binding domain + copper reflux oxidase<br />
			**[[7aye]] - hMDM2 p53-binding domain + DsbD<br />
	**[[6sqo]] - hMDM2 ring domain + ubiquitin-conjugating enzyme E2 + S27A<br />		**[[6sqo]] - hMDM2 ring domain + ubiquitin-conjugating enzyme E2 + S27A<br />
	**[[6sqr]], [[6sqs]] - cMDM2 ring domain + ubiquitin-conjugating enzyme E2 + S27A<br />		**[[6sqr]], [[6sqs]] - cMDM2 ring domain + ubiquitin-conjugating enzyme E2 + S27A<br />
			**[[7ahz]], [[7ai0]], [[7ai1]] - fMDM2 RING domain (mutant) + polyubiquitin + ubiquitin-conjugating enzyme E2<br />

	}}		}}

	[[Category:Topic Page]]		[[Category:Topic Page]]