Merlin - Revision history

Michal Harel at 10:03, 31 October 2021

2021-10-31T10:03:10Z

← Older revision		Revision as of 10:03, 31 October 2021
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	[[6cds]] – hMer (mutant) <br />		[[6cds]] – hMer (mutant) <br />
	[[4zrj]] – hMer + C-terminal domain (mutant) <br />		[[4zrj]] – hMer + C-terminal domain (mutant) <br />
			[[7lwh]] – hMer + Lats1 peptide <br />
	[[4zri]] – hMer + Lats2 peptide <br />		[[4zri]] – hMer + Lats2 peptide <br />
	[[1isn]] – mMer - mouse<br />		[[1isn]] – mMer - mouse<br />
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	[[4p7i]] – mMer + HIV-1 Vpr-binding protein residues 998-1058 <br />		[[4p7i]] – mMer + HIV-1 Vpr-binding protein residues 998-1058 <br />
	[[4zrk]] – mMer + Lats1 peptide <br />		[[4zrk]] – mMer + Lats1 peptide <br />
			[[7edr]] – Mer + C-terminal domain 510-635 – ''Drosophila melanogaster'' <br />

	== References ==		== References ==

Michal Harel at 09:08, 6 September 2020

2020-09-06T09:08:46Z

← Older revision		Revision as of 09:08, 6 September 2020
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	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

	Merlin FERM domain 1-320		'''Merlin FERM domain 1-320'''

	[[3u8z]], [[1h4r]] – hMer – human <br />		[[3u8z]], [[1h4r]] – hMer – human <br />

Michal Harel at 09:08, 6 September 2020

2020-09-06T09:08:13Z

← Older revision		Revision as of 09:08, 6 September 2020
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	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

	[[3u8z]], [[1h4r]] – hMer ~~FERM domain~~ – human <br />		Merlin FERM domain 1-320
	[[6cds]] – hMer ~~FERM domain~~ (mutant) <br />
	[[4zrj]] – hMer ~~FERM~~ + C-terminal domain (mutant) <br />		[[3u8z]], [[1h4r]] – hMer – human <br />
	[[1isn]] – mMer ~~FERM domain~~ - mouse<br />		[[6cds]] – hMer (mutant) <br />
	[[3wa0]] – mMer ~~FERM domain~~ + HIV-1 Vpr-binding protein residues 1417-1506 <br />		[[4zrj]] – hMer + C-terminal domain (mutant) <br />
	[[4p7i]] – mMer ~~FERM domain~~ + HIV-1 Vpr-binding protein residues 998-1058 <br />		[[4zri]] – hMer + Lats2 peptide <br />
	[[4zrk]] – mMer ~~FERM domain~~ + Lats1 peptide <br />		[[1isn]] – mMer - mouse<br />
	~~[[4zri]] – hMer FERM domain + Lats2 peptide <br />~~		[[3wa0]] – mMer + HIV-1 Vpr-binding protein residues 1417-1506 <br />
			[[4p7i]] – mMer + HIV-1 Vpr-binding protein residues 998-1058 <br />
			[[4zrk]] – mMer + Lats1 peptide <br />

	== References ==		== References ==
	<references/>		<references/>

	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 09:32, 6 August 2018

2018-08-06T09:32:31Z

← Older revision		Revision as of 09:32, 6 August 2018
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	[[3u8z]], [[1h4r]] – hMer FERM domain – human <br />		[[3u8z]], [[1h4r]] – hMer FERM domain – human <br />
			[[6cds]] – hMer FERM domain (mutant) <br />
	[[4zrj]] – hMer FERM + C-terminal domain (mutant) <br />		[[4zrj]] – hMer FERM + C-terminal domain (mutant) <br />
	[[1isn]] – mMer FERM domain - mouse<br />		[[1isn]] – mMer FERM domain - mouse<br />

Michal Harel at 07:14, 26 December 2017

2017-12-26T07:14:45Z

← Older revision		Revision as of 07:14, 26 December 2017
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	== Function ==		== Function ==

	'''Merlin''' (Mer) or Moesin-exrin-radixin-like protein is a unique tumor suppressor that inhibits mitogenic signaling at the membrane-cytoskeleton interface<ref>PMID:21167305</ref>. The FERM domain of Mer regulates cell proliferation in response to adhesive signaling<ref>PMID:24726726</ref>.		'''Merlin''' (Mer) or '''Moesin-exrin-radixin-like protein''' is a unique tumor suppressor that inhibits mitogenic signaling at the membrane-cytoskeleton interface<ref>PMID:21167305</ref>. The FERM domain of Mer regulates cell proliferation in response to adhesive signaling<ref>PMID:24726726</ref>.

	== Disease ==		== Disease ==

Joel L. Sussman at 12:30, 24 December 2017

2017-12-24T12:30:22Z

← Older revision		Revision as of 12:30, 24 December 2017
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	<StructureSection load='' size='340' side='right' caption='Mouse merlin FERM domain (grey) complex with HIV-1 Vpr-binding protein C-terminal (gold) (PDB code [[3wa0]])' scene=''>		<StructureSection load='3wa0' size='340' side='right' caption='Mouse merlin FERM domain (grey) complex with HIV-1 Vpr-binding protein C-terminal (gold) (PDB code [[3wa0]])' scene=''>

Joel L. Sussman at 12:30, 24 December 2017

2017-12-24T12:30:08Z

← Older revision		Revision as of 12:30, 24 December 2017
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	<StructureSection load='~~3wa0~~' size='340' side='right' caption='Mouse merlin FERM domain (grey) complex with HIV-1 Vpr-binding protein C-terminal (gold) (PDB code [[3wa0]])' scene=''>		<StructureSection load='' size='340' side='right' caption='Mouse merlin FERM domain (grey) complex with HIV-1 Vpr-binding protein C-terminal (gold) (PDB code [[3wa0]])' scene=''>

Michal Harel at 10:50, 24 December 2017

2017-12-24T10:50:10Z

← Older revision		Revision as of 10:50, 24 December 2017
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	<StructureSection load='3wa0' size='340' side='right' caption='Mouse merlin FERM domain (grey) complex with HIV-1 Vpr-binding protein C-terminal (gold) (PDB code [[3wa0]])' scene=''>		<StructureSection load='3wa0' size='340' side='right' caption='Mouse merlin FERM domain (grey) complex with HIV-1 Vpr-binding protein C-terminal (gold) (PDB code [[3wa0]])' scene=''>

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	== Function ==		== Function ==

	Merlin (Mer) or Moesin-exrin-radixin-like protein is a unique tumor suppressor that inhibits mitogenic signaling at the membrane-cytoskeleton interface<ref>PMID:21167305</ref>. The FERM domain of Mer regulates cell proliferation in response to adhesive signaling<ref>PMID:24726726</ref>.		'''Merlin''' (Mer) or Moesin-exrin-radixin-like protein is a unique tumor suppressor that inhibits mitogenic signaling at the membrane-cytoskeleton interface<ref>PMID:21167305</ref>. The FERM domain of Mer regulates cell proliferation in response to adhesive signaling<ref>PMID:24726726</ref>.

	== Disease ==		== Disease ==

Michal Harel: New page: ==...

2017-12-24T10:48:55Z

New page: <StructureSection load='3wa0' size='340' side='right' caption='Mouse merlin FERM domain (grey) complex with HIV-1 Vpr-binding protein C-terminal (gold) (PDB code 3wa0)' scene=''> ==...

New page

<StructureSection load='3wa0' size='340' side='right' caption='Mouse merlin FERM domain (grey) complex with HIV-1 Vpr-binding protein C-terminal (gold) (PDB code [[3wa0]])' scene=''>

== Function ==

Merlin (Mer) or Moesin-exrin-radixin-like protein is a unique tumor suppressor that inhibits mitogenic signaling at the membrane-cytoskeleton interface<ref>PMID:21167305</ref>. The FERM domain of Mer regulates cell proliferation in response to adhesive signaling<ref>PMID:24726726</ref>.

== Disease ==

Neurofibromatosis type 2, characterized by tumors of the nervous system, is the result of loss of the NF2 gene which encodes Mer<ref>PMID:22750751</ref>.

== Structural highlights ==

The binding of Mer FERM domain to the C-terminal of HIV-1 Vpr-binding protein results in the inhibition of Mer-mediated suppression of tumorigenesis. The interactions between the proteins are formed by the α-helix and a β-sheet of Mer and a mostly β-sheet of HIV-1 Vpr-binding protein<ref>PMID:24912773</ref>.
</StructureSection>
== 3D Structures of merlin ==

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

[[3u8z]], [[1h4r]] – hMer FERM domain – human 
[[4zrj]] – hMer FERM + C-terminal domain (mutant) 
[[1isn]] – mMer FERM domain - mouse 
[[3wa0]] – mMer FERM domain + HIV-1 Vpr-binding protein residues 1417-1506 
[[4p7i]] – mMer FERM domain + HIV-1 Vpr-binding protein residues 998-1058 
[[4zrk]] – mMer FERM domain + Lats1 peptide 
[[4zri]] – hMer FERM domain + Lats2 peptide 
== References ==
<references/>

[[Category:Topic Page]]