Met repressor - Revision history

Alexander Berchansky at 10:30, 10 July 2019

2019-07-10T10:30:49Z

← Older revision		Revision as of 10:30, 10 July 2019
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	== Structural highlights ==		== Structural highlights ==
	<scene name='53/536702/Cv/2'>EcMR (mutant) with corepressor SAM, Ca+2 ion and DNA</scene>. <scene name='53/536702/Cv/6'>SAM binds to MR in a hydrophobic pocket between 2 monomers</scene><ref>PMID:10986458</ref>. Water molecules shown as red spheres.		<scene name='53/536702/Cv/7'>EcMR (mutant) with corepressor SAM, Ca+2 ion and DNA</scene>. <scene name='53/536702/Cv/8'>SAM binds to MR in a hydrophobic pocket between 2 monomers</scene><ref>PMID:10986458</ref>. Water molecules are shown as red spheres.
	</StructureSection>		</StructureSection>
	== 3D Structures of Met repressor ==		== 3D Structures of Met repressor ==

Alexander Berchansky at 09:20, 26 April 2016

2016-04-26T09:20:21Z

← Older revision		Revision as of 09:20, 26 April 2016
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	== Structural highlights ==		== Structural highlights ==
	<scene name='53/536702/Cv/2'>EcMR (mutant) with corepressor SAM, Ca+2 ion and DNA</scene>. <scene name='53/536702/Cv/6'>SAM binds to MR in a hydrophobic pocket between 2 monomers</scene><ref>PMID:10986458</ref>.		<scene name='53/536702/Cv/2'>EcMR (mutant) with corepressor SAM, Ca+2 ion and DNA</scene>. <scene name='53/536702/Cv/6'>SAM binds to MR in a hydrophobic pocket between 2 monomers</scene><ref>PMID:10986458</ref>. Water molecules shown as red spheres.
	</StructureSection>		</StructureSection>
	== 3D Structures of Met repressor ==		== 3D Structures of Met repressor ==

Alexander Berchansky at 08:32, 26 April 2016

2016-04-26T08:32:12Z

← Older revision		Revision as of 08:32, 26 April 2016
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	== Structural highlights ==		== Structural highlights ==
	<scene name='53/536702/Cv/2'>EcMR (mutant) with corepressor SAM, Ca+2 ion and DNA</scene>. SAM binds to MR in a hydrophobic pocket between 2 monomers<ref>PMID:10986458</ref>.		<scene name='53/536702/Cv/2'>EcMR (mutant) with corepressor SAM, Ca+2 ion and DNA</scene>. <scene name='53/536702/Cv/6'>SAM binds to MR in a hydrophobic pocket between 2 monomers</scene><ref>PMID:10986458</ref>.
	</StructureSection>		</StructureSection>
	== 3D Structures of Met repressor ==		== 3D Structures of Met repressor ==

Alexander Berchansky at 07:57, 26 April 2016

2016-04-26T07:57:36Z

← Older revision		Revision as of 07:57, 26 April 2016
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	== Structural highlights ==		== Structural highlights ==
	SAM binds to MR in a hydrophobic pocket between 2 monomers<ref>PMID:10986458</ref>.		<scene name='53/536702/Cv/2'>EcMR (mutant) with corepressor SAM, Ca+2 ion and DNA</scene>. SAM binds to MR in a hydrophobic pocket between 2 monomers<ref>PMID:10986458</ref>.
	</StructureSection>		</StructureSection>
	== 3D Structures of Met repressor ==		== 3D Structures of Met repressor ==

Alexander Berchansky at 07:43, 26 April 2016

2016-04-26T07:43:22Z

← Older revision		Revision as of 07:43, 26 April 2016
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	<StructureSection load='1mjo' size='450' side='right' scene='' caption='EcMR (mutant) complex with corepressor SAM, Ca+2 ion (green) and DNA [[1mjo]]'>		<StructureSection load='1mjo' size='450' side='right' scene='53/536702/Cv/1' caption='EcMR (mutant) complex with corepressor SAM, Ca+2 ion (green) and DNA [[1mjo]]'>

	== Function ==		== Function ==

Alexander Berchansky at 07:36, 26 April 2016

2016-04-26T07:36:44Z

← Older revision		Revision as of 07:36, 26 April 2016
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			<StructureSection load='1mjo' size='450' side='right' scene='' caption='EcMR (mutant) complex with corepressor SAM, Ca+2 ion (green) and DNA [[1mjo]]'>
	~~{{STRUCTURE_1mjo\| PDB~~=1mjo ~~\| SIZE~~=~~400\| SCENE~~= \|right~~\|CAPTION~~=EcMR (mutant) complex with corepressor SAM Ca+2 ion (green) and DNA [[1mjo]] }}
	== Function ==		== Function ==
	'''Met repressor''' (MR) interacts with the DNA operator (Met box) repressing methionine synthesis. The co-repressor of MR is S-adenosyl methionine (SAM) which is a product of methionine synthesis. Binding of SAM to MR increases the repressor affinity to the DNA thus halting methionine synthesis<ref>PMID:8092669</ref>. For additional details see<br />		'''Met repressor''' (MR) interacts with the DNA operator (Met box) repressing methionine synthesis. The co-repressor of MR is S-adenosyl methionine (SAM) which is a product of methionine synthesis. Binding of SAM to MR increases the repressor affinity to the DNA thus halting methionine synthesis<ref>PMID:8092669</ref>. For additional details see<br />
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	== Structural highlights ==		== Structural highlights ==
	SAM binds to MR in a hydrophobic pocket between 2 monomers<ref>PMID:10986458</ref>.		SAM binds to MR in a hydrophobic pocket between 2 monomers<ref>PMID:10986458</ref>.
			</StructureSection>
	== 3D Structures of Met repressor ==		== 3D Structures of Met repressor ==

Michal Harel at 06:59, 21 April 2016

2016-04-21T06:59:15Z

← Older revision		Revision as of 06:59, 21 April 2016
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	[[Taylor met repressor]]<br />		[[Taylor met repressor]]<br />
	[[Joe Granger Methionine Repressor: Escherichia coli]].		[[Joe Granger Methionine Repressor: Escherichia coli]].

			== Structural highlights ==
			SAM binds to MR in a hydrophobic pocket between 2 monomers<ref>PMID:10986458</ref>.

	== 3D Structures of Met repressor ==		== 3D Structures of Met repressor ==

Michal Harel at 10:58, 20 April 2016

2016-04-20T10:58:15Z

← Older revision		Revision as of 10:58, 20 April 2016
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	{{STRUCTURE_1mjo\| PDB=1mjo \| SIZE=400\| SCENE= \|right\|CAPTION=EcMR (mutant) complex with corepressor SAM Ca+2 ion (green) and DNA [[1mjo]] }}		{{STRUCTURE_1mjo\| PDB=1mjo \| SIZE=400\| SCENE= \|right\|CAPTION=EcMR (mutant) complex with corepressor SAM Ca+2 ion (green) and DNA [[1mjo]] }}
	== Function ==		== Function ==
	'''Met repressor''' (MR) interacts with the DNA operator (Met box) repressing methionine synthesis. The ~~coreppressor~~ of MR is S-adenosyl methionine (SAM) which is a product of methionine synthesis. Binding of SAM to MR increases the repressor affinity to the DNA thus halting methionine synthesis<ref>PMID:~~11696548~~</ref>. For additional details see<br />		'''Met repressor''' (MR) interacts with the DNA operator (Met box) repressing methionine synthesis. The co-repressor of MR is S-adenosyl methionine (SAM) which is a product of methionine synthesis. Binding of SAM to MR increases the repressor affinity to the DNA thus halting methionine synthesis<ref>PMID:8092669</ref>. For additional details see<br />
	[[Taylor met repressor]]<br />		[[Taylor met repressor]]<br />
	[[Joe Granger Methionine Repressor: Escherichia coli]].		[[Joe Granger Methionine Repressor: Escherichia coli]].

Michal Harel at 10:37, 20 April 2016

2016-04-20T10:37:23Z

@@ Line 1: / Line 1: @@
 {{STRUCTURE_1mjo|  PDB=1mjo  | SIZE=400| SCENE= |right|CAPTION=EcMR (mutant) complex with corepressor SAM Ca+2 ion (green) and DNA [[1mjo]] }}
+== Function ==
+'''Met repressor''' (MR) interacts with the DNA operator (Met box) repressing methionine synthesis.  The coreppressor of MR is S-adenosyl methionine (SAM) which is a product of methionine synthesis.  Binding of SAM to MR increases the repressor affinity to the DNA thus halting methionine synthesis<ref>PMID:11696548</ref>.  For additional details see<br />
 [[Taylor met repressor]]<br />
 [[Joe Granger Methionine Repressor: Escherichia coli]].
@@ Line 40: / Line 17: @@
 [[1mjl]], [[1mjp]] – EcMR (mutant) + SAM<br />
 [[1mj2]], [[1mjo]], [[1mjq]] – EcMR (mutant) + SAM + DNA<br />
 [[Category:Topic Page]]

Michal Harel at 07:12, 11 January 2016

2016-01-11T07:12:52Z

← Older revision		Revision as of 07:12, 11 January 2016
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	'''Met repressor''' (MR) interacts with the DNA operator (Met box) repressing methionine synthesis. The corepressor of MR is S-adenosyl methionine (SAM) which is a product of methionine synthesis. Binding of SAM to MR increases the repressor affinity to the DNA thus halting methionine synthesis. For additional details see<br />		'''Met repressor''' (MR) interacts with the DNA operator (Met box) repressing methionine synthesis. The corepressor of MR is S-adenosyl methionine (SAM) which is a product of methionine synthesis. Binding of SAM to MR increases the repressor affinity to the DNA thus halting methionine synthesis. For additional details see<br />
	[[Taylor met ~~rpressor~~]]<br />		[[Taylor met repressor]]<br />
	[[Joe Granger Methionine Repressor: Escherichia coli]].		[[Joe Granger Methionine Repressor: Escherichia coli]].