Netropsin - Revision history

Alexander Berchansky at 15:54, 22 February 2023

2023-02-22T15:54:59Z

← Older revision		Revision as of 15:54, 22 February 2023
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	Netropsin (also termed congocidine or sinanomycin) is a polyamide with antibiotic and antiviral activity. It belongs to the class of pyrrole-amidine antibiotics. See also [https://en.wikipedia.org/wiki/Netropsin].		Netropsin (also termed congocidine or sinanomycin) is a polyamide with antibiotic and antiviral activity. It belongs to the class of pyrrole-amidine antibiotics. See also [https://en.wikipedia.org/wiki/Netropsin].

	Netropsin binds to the minor groove of AT-rich sequences of double stranded DNA. In contrast, netropsin does not bind single stranded DNA or double stranded RNA. Crystallographic structures of DNA-bound Netropsin have been obtained and elucidate details of how the drug binds in the minor groove. In the bound structure, the drug makes hydrogen bonding interactions with ~~four~~ subsequent base pairs of the DNA duplex, locally displacing the water molecules of the spine of hydration.		Netropsin binds to the minor groove of AT-rich sequences of double stranded DNA. In contrast, netropsin does not bind single stranded DNA or double stranded RNA. Crystallographic structures of DNA-bound Netropsin have been obtained and elucidate details of how the drug binds in the minor groove. <scene name='95/953835/Cv/3'>In the bound structure, the drug makes hydrogen bonding interactions with several subsequent base pairs of the DNA duplex</scene>, locally displacing the water molecules of the spine of hydration.

	~~<scene name='95/953835/Cv/2'>TextToBeDisplayed</scene>~~
	</StructureSection>		</StructureSection>
	== References ==		== References ==
	<references/>		<references/>

Alexander Berchansky at 15:38, 22 February 2023

2023-02-22T15:38:46Z

← Older revision		Revision as of 15:38, 22 February 2023
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	Netropsin (also termed congocidine or sinanomycin) is a polyamide with antibiotic and antiviral activity. It belongs to the class of pyrrole-amidine antibiotics. See also [https://en.wikipedia.org/wiki/Netropsin].		Netropsin (also termed congocidine or sinanomycin) is a polyamide with antibiotic and antiviral activity. It belongs to the class of pyrrole-amidine antibiotics. See also [https://en.wikipedia.org/wiki/Netropsin].

	Netropsin binds to the minor groove of AT-rich sequences of double stranded DNA.~~[3]~~ In contrast, netropsin does not bind single stranded DNA or double stranded RNA. Crystallographic structures of DNA-bound Netropsin have been obtained and elucidate details of how the drug binds in the minor groove. In the bound structure, the drug makes hydrogen bonding interactions with four subsequent base pairs of the DNA duplex, locally displacing the water molecules of the spine of hydration.		Netropsin binds to the minor groove of AT-rich sequences of double stranded DNA. In contrast, netropsin does not bind single stranded DNA or double stranded RNA. Crystallographic structures of DNA-bound Netropsin have been obtained and elucidate details of how the drug binds in the minor groove. In the bound structure, the drug makes hydrogen bonding interactions with four subsequent base pairs of the DNA duplex, locally displacing the water molecules of the spine of hydration.

	<scene name='95/953835/Cv/2'>TextToBeDisplayed</scene>		<scene name='95/953835/Cv/2'>TextToBeDisplayed</scene>

Alexander Berchansky at 14:06, 22 February 2023

2023-02-22T14:06:06Z

← Older revision		Revision as of 14:06, 22 February 2023
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	<StructureSection load='101d' size='350' side='right' caption='NETROPSIN BOUND TO DNA' scene='95/953835/Cv/1'>		<StructureSection load='101d' size='350' side='right' caption='NETROPSIN BOUND TO DNA' scene='95/953835/Cv/1'>
	Netropsin (also termed congocidine or sinanomycin) is a polyamide with antibiotic and antiviral activity. It belongs to the class of pyrrole-amidine antibiotics. See also [[https://en.wikipedia.org/wiki/Netropsin]].		Netropsin (also termed congocidine or sinanomycin) is a polyamide with antibiotic and antiviral activity. It belongs to the class of pyrrole-amidine antibiotics. See also [https://en.wikipedia.org/wiki/Netropsin].

	Netropsin binds to the minor groove of AT-rich sequences of double stranded DNA.[3] In contrast, netropsin does not bind single stranded DNA or double stranded RNA. Crystallographic structures of DNA-bound Netropsin have been obtained and elucidate details of how the drug binds in the minor groove. In the bound structure, the drug makes hydrogen bonding interactions with four subsequent base pairs of the DNA duplex, locally displacing the water molecules of the spine of hydration.		Netropsin binds to the minor groove of AT-rich sequences of double stranded DNA.[3] In contrast, netropsin does not bind single stranded DNA or double stranded RNA. Crystallographic structures of DNA-bound Netropsin have been obtained and elucidate details of how the drug binds in the minor groove. In the bound structure, the drug makes hydrogen bonding interactions with four subsequent base pairs of the DNA duplex, locally displacing the water molecules of the spine of hydration.

Alexander Berchansky at 14:05, 22 February 2023

2023-02-22T14:05:45Z

← Older revision		Revision as of 14:05, 22 February 2023
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	<StructureSection load='101d' size='350' side='right' caption='NETROPSIN BOUND TO DNA' scene='95/953835/Cv/1'>		<StructureSection load='101d' size='350' side='right' caption='NETROPSIN BOUND TO DNA' scene='95/953835/Cv/1'>
	Netropsin (also termed congocidine or sinanomycin) is a polyamide with antibiotic and antiviral activity. It belongs to the class of pyrrole-amidine antibiotics.		Netropsin (also termed congocidine or sinanomycin) is a polyamide with antibiotic and antiviral activity. It belongs to the class of pyrrole-amidine antibiotics. See also [[https://en.wikipedia.org/wiki/Netropsin]].

			Netropsin binds to the minor groove of AT-rich sequences of double stranded DNA.[3] In contrast, netropsin does not bind single stranded DNA or double stranded RNA. Crystallographic structures of DNA-bound Netropsin have been obtained and elucidate details of how the drug binds in the minor groove. In the bound structure, the drug makes hydrogen bonding interactions with four subsequent base pairs of the DNA duplex, locally displacing the water molecules of the spine of hydration.

	<scene name='95/953835/Cv/2'>TextToBeDisplayed</scene>		<scene name='95/953835/Cv/2'>TextToBeDisplayed</scene>

Alexander Berchansky at 14:03, 22 February 2023

2023-02-22T14:03:35Z

← Older revision		Revision as of 14:03, 22 February 2023
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	<StructureSection load='101d' size='350' side='right' caption='NETROPSIN BOUND TO DNA' scene='95/953835/Cv/1'>		<StructureSection load='101d' size='350' side='right' caption='NETROPSIN BOUND TO DNA' scene='95/953835/Cv/1'>
	Netropsin (also termed congocidine or sinanomycin) is a polyamide with antibiotic and antiviral activity. It belongs to the class of pyrrole-amidine antibiotics.		Netropsin (also termed congocidine or sinanomycin) is a polyamide with antibiotic and antiviral activity. It belongs to the class of pyrrole-amidine antibiotics.

			<scene name='95/953835/Cv/2'>TextToBeDisplayed</scene>
	</StructureSection>		</StructureSection>
	== References ==		== References ==
	<references/>		<references/>

Alexander Berchansky at 13:57, 22 February 2023

2023-02-22T13:57:22Z

← Older revision		Revision as of 13:57, 22 February 2023
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	<StructureSection load='101d' size='350' side='right' caption='~~Caption for this structure~~' scene='95/953835/Cv/1'>		<StructureSection load='101d' size='350' side='right' caption='NETROPSIN BOUND TO DNA' scene='95/953835/Cv/1'>
	Netropsin (also termed congocidine or sinanomycin) is a polyamide with antibiotic and antiviral activity. It belongs to the class of pyrrole-amidine antibiotics.		Netropsin (also termed congocidine or sinanomycin) is a polyamide with antibiotic and antiviral activity. It belongs to the class of pyrrole-amidine antibiotics.
	</StructureSection>		</StructureSection>
	== References ==		== References ==
	<references/>		<references/>

Alexander Berchansky at 13:56, 22 February 2023

2023-02-22T13:56:54Z

← Older revision		Revision as of 13:56, 22 February 2023
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	<StructureSection load='101d' size='~~340~~' side='right' caption='Caption for this structure' scene=''>		<StructureSection load='101d' size='350' side='right' caption='Caption for this structure' scene='95/953835/Cv/1'>
	Netropsin (also termed congocidine or sinanomycin) is a polyamide with antibiotic and antiviral activity. It belongs to the class of pyrrole-amidine antibiotics.		Netropsin (also termed congocidine or sinanomycin) is a polyamide with antibiotic and antiviral activity. It belongs to the class of pyrrole-amidine antibiotics.
	</StructureSection>		</StructureSection>
	== References ==		== References ==
	<references/>		<references/>

Alexander Berchansky: New page: Netropsin (also termed congocidine or sinanomycin) is a polyamide with antibiotic and a...

2023-02-22T13:53:50Z

New page: <StructureSection load='101d' size='340' side='right' caption='Caption for this structure' scene=''> Netropsin (also termed congocidine or sinanomycin) is a polyamide with antibiotic and a...

New page

<StructureSection load='101d' size='340' side='right' caption='Caption for this structure' scene=''>
Netropsin (also termed congocidine or sinanomycin) is a polyamide with antibiotic and antiviral activity. It belongs to the class of pyrrole-amidine antibiotics.
</StructureSection>
== References ==
<references/>