Polycomb complex protein - Revision history

Michal Harel at 08:47, 9 January 2023

2023-01-09T08:47:47Z

@@ Line 99: / Line 99: @@
 ==Polycomb complex protein 3D structures==
 [[Polycomb complex proteins 3D structures]]
 == References ==

Michal Harel at 08:47, 9 January 2023

2023-01-09T08:47:05Z

← Older revision		Revision as of 08:47, 9 January 2023
Line 98:		Line 98:

	==Polycomb complex protein 3D structures==		==Polycomb complex protein 3D structures==
			[[Polycomb complex proteins 3D structures]]

	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

Jaime Prilusky: B-cell-specific Moloney leukemia virus insertion site 1 (BMI1) moved to Polycomb complex protein: requested by Editor

2023-01-08T10:41:59Z

B-cell-specific Moloney leukemia virus insertion site 1 (BMI1) moved to Polycomb complex protein: requested by Editor

← Older revision	Revision as of 10:41, 8 January 2023
(No difference)

Michal Harel at 09:08, 8 January 2023

2023-01-08T09:08:07Z

← Older revision		Revision as of 09:08, 8 January 2023
Line 2:		Line 2:

	== Function ==		== Function ==

			'''Polycomb group ring finger protein 1''' (Pcgf1) is a link between Polycomb function and pluripotency <ref>PMID:26687479</ref>.<br />
			'''Polycomb group ring finger protein 4''' (Pcgf4) or (BMI1) see below <ref>PMID:23523425</ref>.<br />
			'''Polycomb group ring finger protein 5''' (Pcgf5) is regulator of gene expression and development <ref>PMID:29765032</ref>.<br />
			'''Polycomb group ring finger protein 6''' (Pcgf6) has a role in safeguarding lineage decisions and in preventing aberrant expression of germ cell-related gens <ref>PMID:32482889</ref>.<br />

	'''B-cell-specific Moloney leukemia virus insertion site 1''' (BMI1) is a ring finger protein that is component of a <scene name='78/787701/2h0d/2'>Polycomb group (PcG) multiprotein PRC1 complex</scene>, which epigenetically repress regulatory genes related to embryonic development and self-renewal of somatic stem-cells. The name come from the original identification of BMI1 as an oncogene cooperating with a myc gene in lymphomagenesis <ref>DOI: 10.1038/16476</ref> . It became clear that the Bmi1 protein is part of an E3 ubiquitin ligase complex (PRC1) <ref>DOI: 10.1038/nature02985</ref> and that this complex has an important role in gene regulation during development.		'''B-cell-specific Moloney leukemia virus insertion site 1''' (BMI1) is a ring finger protein that is component of a <scene name='78/787701/2h0d/2'>Polycomb group (PcG) multiprotein PRC1 complex</scene>, which epigenetically repress regulatory genes related to embryonic development and self-renewal of somatic stem-cells. The name come from the original identification of BMI1 as an oncogene cooperating with a myc gene in lymphomagenesis <ref>DOI: 10.1038/16476</ref> . It became clear that the Bmi1 protein is part of an E3 ubiquitin ligase complex (PRC1) <ref>DOI: 10.1038/nature02985</ref> and that this complex has an important role in gene regulation during development.

Michal Harel at 08:49, 8 January 2023

2023-01-08T08:49:44Z

← Older revision		Revision as of 08:49, 8 January 2023
Line 1:		Line 1:
	<StructureSection load='' size='350' side='right' caption='Structure of a Bmi1 protein' scene='78/787701/Bmi1_isolada_da_2h0d/3'>		<StructureSection load='' size='350' side='right' caption='Structure of a Bmi1 protein complex with ubiquitin ligase protein RING2 (PDB id [[2h0d]])' scene='78/787701/Bmi1_isolada_da_2h0d/3'>

	== Function ==		== Function ==

Michal Harel at 08:29, 8 January 2023

2023-01-08T08:29:17Z

← Older revision		Revision as of 08:29, 8 January 2023
Line 92:		Line 92:
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

	==Polycomb complex protein==		==Polycomb complex protein 3D structures==

	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

Michal Harel at 08:25, 8 January 2023

2023-01-08T08:25:34Z

← Older revision		Revision as of 08:25, 8 January 2023
Line 1:		Line 1:
	<StructureSection load='' size='350' side='right' caption='Structure of a Bmi1 protein' scene='78/787701/Bmi1_isolada_da_2h0d/3'>		<StructureSection load='' size='350' side='right' caption='Structure of a Bmi1 protein' scene='78/787701/Bmi1_isolada_da_2h0d/3'>


	== Function ==		== Function ==
Line 11:		Line 10:

	PcG PRC1 is responsible for chromatin remodeling and histone modification, mediating monoubiquitination of histone H2A at Lysine 119, rendering chromatin heritably changed in its expressibility. BMI1 regulates the E3 ubiquitin-protein ligase activity of RING1b, which is also a protein component of the PcG PRC1 complex.		PcG PRC1 is responsible for chromatin remodeling and histone modification, mediating monoubiquitination of histone H2A at Lysine 119, rendering chromatin heritably changed in its expressibility. BMI1 regulates the E3 ubiquitin-protein ligase activity of RING1b, which is also a protein component of the PcG PRC1 complex.


	== Structure ==		== Structure ==
Line 122:		Line 120:
	**[[2djb]] – hPcgf6 ring domain - NMR<br />		**[[2djb]] – hPcgf6 ring domain - NMR<br />
	}}		}}

	~~</StructureSection>~~

	== References ==		== References ==
Line 132:		Line 128:
	*[http://www.uniprot.org/uniprot/P35226#structure Aggregated information about BMI1 protein in UniProt database]		*[http://www.uniprot.org/uniprot/P35226#structure Aggregated information about BMI1 protein in UniProt database]
	*[https://www.genecards.org/cgi-bin/carddisp.pl?gene=BMI1 Aggregated information about BMI1 gene in GeneCards database]		*[https://www.genecards.org/cgi-bin/carddisp.pl?gene=BMI1 Aggregated information about BMI1 gene in GeneCards database]

			</StructureSection>

	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 08:23, 8 January 2023

2023-01-08T08:23:01Z

@@ Line 56: / Line 56: @@
 Proposed architecture of the PRC1 complex oligomer.
 == Disease ==
@@ Line 71: / Line 69: @@
 BMI1 also inhibits the CDKN1A gene, an important inhibitor of the cellular cycle, promoting the cellular proliferation. The inhibition of CDKN1A gene is promoted when a lncRNA, FALEC (focally amplified long non-coding RNA on chromosome 1 gene), stabilizes BMI1.
 == Conservation ==
@@ Line 98: / Line 94: @@
 <div style="background-color:#fffaf0;">
 </StructureSection>
@@ Line 104: / Line 127: @@
 == References ==
 <references/>
 == External resources==
@@ Line 111: / Line 132: @@
 *[http://www.uniprot.org/uniprot/P35226#structure Aggregated information about BMI1 protein in UniProt database]
 *[https://www.genecards.org/cgi-bin/carddisp.pl?gene=BMI1 Aggregated information about BMI1 gene in GeneCards database]

Michal Harel at 10:32, 5 January 2023

2023-01-05T10:32:59Z

← Older revision		Revision as of 10:32, 5 January 2023
Line 4:		Line 4:
	== Function ==		== Function ==

	B-cell-specific Moloney leukemia virus insertion site 1 (BMI1) is a ring finger protein that is component of a <scene name='78/787701/2h0d/2'>Polycomb group (PcG) multiprotein PRC1 complex</scene>, which epigenetically repress regulatory genes related to embryonic development and self-renewal of somatic stem-cells. The name come from the original identification of BMI1 as an oncogene cooperating with a myc gene in lymphomagenesis <ref>DOI: 10.1038/16476</ref> . It became clear that the Bmi1 protein is part of an E3 ubiquitin ligase complex (PRC1) <ref>DOI: 10.1038/nature02985</ref> and that this complex has an important role in gene regulation during development.		'''B-cell-specific Moloney leukemia virus insertion site 1''' (BMI1) is a ring finger protein that is component of a <scene name='78/787701/2h0d/2'>Polycomb group (PcG) multiprotein PRC1 complex</scene>, which epigenetically repress regulatory genes related to embryonic development and self-renewal of somatic stem-cells. The name come from the original identification of BMI1 as an oncogene cooperating with a myc gene in lymphomagenesis <ref>DOI: 10.1038/16476</ref> . It became clear that the Bmi1 protein is part of an E3 ubiquitin ligase complex (PRC1) <ref>DOI: 10.1038/nature02985</ref> and that this complex has an important role in gene regulation during development.

	Monoubiquitinated H2A is enriched on the inactive human female X-chromosome. The inactivation of one of the X-chromosome is responsible for “dosing” the X-chromosome expression, which leads to the physiological X expression levels in females similar to the X expression levels in males (which has only one X).		Monoubiquitinated H2A is enriched on the inactive human female X-chromosome. The inactivation of one of the X-chromosome is responsible for “dosing” the X-chromosome expression, which leads to the physiological X expression levels in females similar to the X expression levels in males (which has only one X).

Ricardo Alberto Chiong Zevallos: BMI1 moved to B-cell-specific Moloney leukemia virus insertion site 1 (BMI1)

2019-03-01T13:29:31Z

BMI1 moved to B-cell-specific Moloney leukemia virus insertion site 1 (BMI1)

← Older revision	Revision as of 13:29, 1 March 2019
(No difference)