Selectin - Revision history

Michal Harel at 09:32, 21 January 2020

2020-01-21T09:32:09Z

← Older revision		Revision as of 09:32, 21 January 2020
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	**[[1g1t]] – hCD62E EGF domain + tetrasaccharide<br />		**[[1g1t]] – hCD62E EGF domain + tetrasaccharide<br />
	**[[4c16]] – hCD62 EGF+SCR domains + antagonist <br />		**[[4c16]] – hCD62 EGF+SCR domains + antagonist <br />
	**[[4csy]] – hCD62 EGF+SCR domains + ligand <br />		**[[4csy]], [[6eyi]], [[6eyj]], [[6eyk]] - hCD62 EGF+SCR domains + ligand <br />

	}}		}}

Alexander Berchansky at 13:46, 2 September 2019

2019-09-02T13:46:59Z

← Older revision		Revision as of 13:46, 2 September 2019
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	== Structural insight ==		== Structural insight ==
	The <scene name='55/552185/Cv/2'>tetrasaccharide binding interactions to P-selectin are electrostatic</scene><ref>PMID:11081633</ref>. <scene name='55/552185/Cv/3'>Ca coordination site</scene>.		The <scene name='55/552185/Cv/4'>tetrasaccharide binding interactions to P-selectin are electrostatic</scene><ref>PMID:11081633</ref>. <scene name='55/552185/Cv/5'>Ca coordination site</scene>.
	</StructureSection>		</StructureSection>

Michal Harel at 18:27, 17 September 2018

2018-09-17T18:27:08Z

← Older revision		Revision as of 18:27, 17 September 2018
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	<StructureSection load='1g1r' size='~~450~~' side='right' caption='Structure of P-selectin EGF domain complex with tetrasaccharide and Ca+2 ion (green) (PDB entry [[1g1r]])' scene='55/552185/Cv/1'>		<StructureSection load='1g1r' size='350' side='right' caption='Structure of P-selectin EGF domain complex with tetrasaccharide and Ca+2 ion (green) (PDB entry [[1g1r]])' scene='55/552185/Cv/1'>
	== Function ==		== Function ==
	'''Selectin''' or '''CD62''' are cell adhesion molecules which bind sugar moieties and thus are regarded as lectins. The structure of selectin consists of extracellular calcium-dependent lectin domain, an EGF-like domain and a number of concensus repeat units, a transmembranal domain and a intracellular domain<ref>PMID:7542213</ref>. Three types of selectins are found:<br />		'''Selectin''' or '''CD62''' are cell adhesion molecules which bind sugar moieties and thus are regarded as lectins. The structure of selectin consists of extracellular calcium-dependent lectin domain, an EGF-like domain and a number of concensus repeat units, a transmembranal domain and a intracellular domain<ref>PMID:7542213</ref>. Three types of selectins are found:<br />
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	**[[3cfw]] – hCD62L EGF domain <br />		**[[3cfw]] – hCD62L EGF domain <br />
			**[[5vc1]] – hCD62L EGF domain (mutant)<br />
	**[[2lgf]] – hCD62L calmodulin-binding domain + calmodulin<br />		**[[2lgf]] – hCD62L calmodulin-binding domain + calmodulin<br />

Alexander Berchansky at 11:46, 28 August 2016

2016-08-28T11:46:39Z

← Older revision		Revision as of 11:46, 28 August 2016
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	<StructureSection load='1g1r' size='450' side='right' caption='Structure of P-selectin EGF domain complex with tetrasaccharide ~~(stick model)~~ and Ca+2 ion (green) (PDB entry [[1g1r]])' scene='55/552185/Cv/1'>		<StructureSection load='1g1r' size='450' side='right' caption='Structure of P-selectin EGF domain complex with tetrasaccharide and Ca+2 ion (green) (PDB entry [[1g1r]])' scene='55/552185/Cv/1'>
	== Function ==		== Function ==
	'''Selectin''' or '''CD62''' are cell adhesion molecules which bind sugar moieties and thus are regarded as lectins. The structure of selectin consists of extracellular calcium-dependent lectin domain, an EGF-like domain and a number of concensus repeat units, a transmembranal domain and a intracellular domain<ref>PMID:7542213</ref>. Three types of selectins are found:<br />		'''Selectin''' or '''CD62''' are cell adhesion molecules which bind sugar moieties and thus are regarded as lectins. The structure of selectin consists of extracellular calcium-dependent lectin domain, an EGF-like domain and a number of concensus repeat units, a transmembranal domain and a intracellular domain<ref>PMID:7542213</ref>. Three types of selectins are found:<br />

Alexander Berchansky at 11:46, 28 August 2016

2016-08-28T11:46:14Z

← Older revision		Revision as of 11:46, 28 August 2016
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	== Structural insight ==		== Structural insight ==
	The tetrasaccharide binding interactions to P-selectin are electrostatic<ref>PMID:11081633</ref>.		The <scene name='55/552185/Cv/2'>tetrasaccharide binding interactions to P-selectin are electrostatic</scene><ref>PMID:11081633</ref>. <scene name='55/552185/Cv/3'>Ca coordination site</scene>.
	</StructureSection>		</StructureSection>

Alexander Berchansky at 11:24, 28 August 2016

2016-08-28T11:24:36Z

← Older revision		Revision as of 11:24, 28 August 2016
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	<StructureSection load='1g1r' size='~~350~~' side='right' caption='Structure of P-selectin EGF domain complex with tetrasaccharide (stick model) and Ca+2 ion (green) (PDB entry [[1g1r]])' scene=''>		<StructureSection load='1g1r' size='450' side='right' caption='Structure of P-selectin EGF domain complex with tetrasaccharide (stick model) and Ca+2 ion (green) (PDB entry [[1g1r]])' scene='55/552185/Cv/1'>
	== Function ==		== Function ==
	'''Selectin''' or '''CD62''' are cell adhesion molecules which bind sugar moieties and thus are regarded as lectins. The structure of selectin consists of extracellular calcium-dependent lectin domain, an EGF-like domain and a number of concensus repeat units, a transmembranal domain and a intracellular domain<ref>PMID:7542213</ref>. Three types of selectins are found:<br />		'''Selectin''' or '''CD62''' are cell adhesion molecules which bind sugar moieties and thus are regarded as lectins. The structure of selectin consists of extracellular calcium-dependent lectin domain, an EGF-like domain and a number of concensus repeat units, a transmembranal domain and a intracellular domain<ref>PMID:7542213</ref>. Three types of selectins are found:<br />

Michal Harel at 06:54, 24 August 2016

2016-08-24T06:54:48Z

← Older revision		Revision as of 06:54, 24 August 2016
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	<StructureSection load='1g1r' size='350' side='right' caption='Structure of P-selectin EGF domain complex with tetrasaccharide and Ca+2 ion (green) (PDB entry [[1g1r]])' scene=''>		<StructureSection load='1g1r' size='350' side='right' caption='Structure of P-selectin EGF domain complex with tetrasaccharide (stick model) and Ca+2 ion (green) (PDB entry [[1g1r]])' scene=''>
	== Function ==		== Function ==
	'''Selectin''' or '''CD62''' are cell adhesion molecules which bind sugar moieties and thus are regarded as lectins. The structure of selectin consists of extracellular calcium-dependent lectin domain, an EGF-like domain and a number of concensus repeat units, a transmembranal domain and a intracellular domain<ref>PMID:7542213</ref>. Three types of selectins are found:<br />		'''Selectin''' or '''CD62''' are cell adhesion molecules which bind sugar moieties and thus are regarded as lectins. The structure of selectin consists of extracellular calcium-dependent lectin domain, an EGF-like domain and a number of concensus repeat units, a transmembranal domain and a intracellular domain<ref>PMID:7542213</ref>. Three types of selectins are found:<br />
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	== Relevance ==		== Relevance ==
	Selectins are involved in inflammation processes. The L-selectins on the surface of leukocytes bind to carbohydrates causing the cells to roll along the blood vessel walls, slowing their motion and enabling them to enter the site of infection<ref>PMID:12829015</ref>. E-selectin levels correlate with disease activity in psoriasis patients<ref>PMID:10233646</ref>. L-selectin levels correlate with disease activity in type I diabetes<ref>PMID:10692053</ref>.		Selectins are involved in inflammation processes. The L-selectins on the surface of leukocytes bind to carbohydrates causing the cells to roll along the blood vessel walls, slowing their motion and enabling them to enter the site of infection<ref>PMID:12829015</ref>. E-selectin levels correlate with disease activity in psoriasis patients<ref>PMID:10233646</ref>. L-selectin levels correlate with disease activity in type I diabetes<ref>PMID:10692053</ref>.

			== Structural insight ==
			The tetrasaccharide binding interactions to P-selectin are electrostatic<ref>PMID:11081633</ref>.
	</StructureSection>		</StructureSection>

Michal Harel at 10:20, 23 August 2016

2016-08-23T10:20:34Z

← Older revision		Revision as of 10:20, 23 August 2016
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	<StructureSection load='1g1r' size='350' side='right' caption='Structure of P-selectin EGF domain complex with tetrasaccharide and Ca+2 ion (green) (PDB entry [[1g1r]])' scene=''>		<StructureSection load='1g1r' size='350' side='right' caption='Structure of P-selectin EGF domain complex with tetrasaccharide and Ca+2 ion (green) (PDB entry [[1g1r]])' scene=''>
			== Function ==
	'''Selectin''' or '''CD62''' are cell adhesion molecules which bind sugar moieties and thus are regarded as lectins. The structure of selectin consists of extracellular calcium-dependent lectin domain, an EGF-like domain		'''Selectin''' or '''CD62''' are cell adhesion molecules which bind sugar moieties and thus are regarded as lectins. The structure of selectin consists of extracellular calcium-dependent lectin domain, an EGF-like domain and a number of concensus repeat units, a transmembranal domain and a intracellular domain<ref>PMID:7542213</ref>. Three types of selectins are found:<br />
	and a number of concensus repeat units, a transmembranal domain and a intracellular domain. Three types of selectins are found: '''E-selectin''' found in endothelial cells; '''L-selectin''' found in leukocytes; '''P-selectin''' found in platelets. Selectins are involved in inflammation processes. The L-selectins on the surface of leukocytes bind to carbohydrates causing the cells to roll along the ~~bleed~~ vessel walls, slowing their motion and enabling them to enter the site of infection.		*'''E-selectin''' found in endothelial cells<br />
			*'''L-selectin''' found in leukocytes<br />
			*'''P-selectin''' found in platelets.<br />

			== Relevance ==
			Selectins are involved in inflammation processes. The L-selectins on the surface of leukocytes bind to carbohydrates causing the cells to roll along the blood vessel walls, slowing their motion and enabling them to enter the site of infection<ref>PMID:12829015</ref>. E-selectin levels correlate with disease activity in psoriasis patients<ref>PMID:10233646</ref>. L-selectin levels correlate with disease activity in type I diabetes<ref>PMID:10692053</ref>.
	</StructureSection>		</StructureSection>

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	}}		}}
			== References ==
			<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 10:48, 14 June 2015

2015-06-14T10:48:56Z

← Older revision		Revision as of 10:48, 14 June 2015
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	**[[1esl]] – hCD62E EGF domain <br />		**[[1esl]] – hCD62E EGF domain <br />
	**[[1g1t]] – hCD62E EGF domain + tetrasaccharide<br />		**[[1g1t]] – hCD62E EGF domain + tetrasaccharide<br />
			**[[4c16]] – hCD62 EGF+SCR domains + antagonist <br />
			**[[4csy]] – hCD62 EGF+SCR domains + ligand <br />

	}}		}}
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 07:57, 10 December 2014

2014-12-10T07:57:25Z

← Older revision		Revision as of 07:57, 10 December 2014
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	'''Selectin''' or '''CD62''' are cell adhesion molecules which bind sugar moieties and thus are regarded as lectins. The structure of selectin consists of extracellular calcium-dependent lectin domain, an EGF-like domain		'''Selectin''' or '''CD62''' are cell adhesion molecules which bind sugar moieties and thus are regarded as lectins. The structure of selectin consists of extracellular calcium-dependent lectin domain, an EGF-like domain
	and a number of concensus repeat units, a transmembranal domain and a intracellular domain. Three types of selectins are found: '''E-selectin''' found in endothelial cells; '''L-selectin''' found in leukocytes; '''P-selectin''' found in platelets. Selectins are involved in inflammation processes. The L-selectins on the surface of leukocytes bind to carbohydrates causing the cells to roll along the bleed vessel walls, slowing their motion and enabling them to enter the site of infection.		and a number of concensus repeat units, a transmembranal domain and a intracellular domain. Three types of selectins are found: '''E-selectin''' found in endothelial cells; '''L-selectin''' found in leukocytes; '''P-selectin''' found in platelets. Selectins are involved in inflammation processes. The L-selectins on the surface of leukocytes bind to carbohydrates causing the cells to roll along the bleed vessel walls, slowing their motion and enabling them to enter the site of infection.
			</StructureSection>

	==3D structures of selectin==		==3D structures of selectin==

	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
			{{#tree:id=OrganizedByTopic\|openlevels=0\|

	~~===~~P-selectin~~===~~		*P-selectin

	[[1fsb]] – hCD62P EGF domain – human - NMR<br />		**[[1fsb]] – hCD62P EGF domain – human - NMR<br />
	[[1g1q]] – hCD62P EGF domain <br />		**[[1g1q]] – hCD62P EGF domain <br />
	[[1g1r]] – hCD62P EGF domain + tetrasaccharide<br />		**[[1g1r]] – hCD62P EGF domain + tetrasaccharide<br />
	[[1g1s]] – hCD62P EGF domain +P-selectin glycoprotein ligand peptide<br />		**[[1g1s]] – hCD62P EGF domain +P-selectin glycoprotein ligand peptide<br />
	[[4gxb]] – hCD62P intracellular domain + sorting nexin-17<br />		**[[4gxb]] – hCD62P intracellular domain + sorting nexin-17<br />

	~~===~~L-selectin~~===~~		*L-selectin

	[[3cfw]] – hCD62L EGF domain <br />		**[[3cfw]] – hCD62L EGF domain <br />
	[[2lgf]] – hCD62L calmodulin-binding domain + calmodulin<br />		**[[2lgf]] – hCD62L calmodulin-binding domain + calmodulin<br />

	~~===~~E-selectin~~===~~		*E-selectin

	[[1esl]] – hCD62E EGF domain <br />		**[[1esl]] – hCD62E EGF domain <br />
	[[1g1t]] – hCD62E EGF domain + tetrasaccharide<br />		**[[1g1t]] – hCD62E EGF domain + tetrasaccharide<br />
			}}
	[[Category:Topic Page]]		[[Category:Topic Page]]