Sorting nexin - Revision history

Michal Harel at 10:06, 13 August 2024

2024-08-13T10:06:50Z

← Older revision		Revision as of 10:06, 13 August 2024
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	*'''SNX 9''' has a role in endocytosis<ref>PMID:12952949</ref>.<br />		*'''SNX 9''' has a role in endocytosis<ref>PMID:12952949</ref>.<br />
	*'''SNX 10''' induces giant vacuoles in mammalian cells<ref>PMID:17012226</ref>.<br />		*'''SNX 10''' induces giant vacuoles in mammalian cells<ref>PMID:17012226</ref>.<br />
	*'''SNX 11'''and '''SNX 17''' regulate lysosomal degradation of plasma membrane<ref>PMID:26818531</ref>.<br />		*'''SNX 11''' and '''SNX 17''' regulate lysosomal degradation of plasma membrane<ref>PMID:26818531</ref>.<br />
	*'''SNX 12''' regulates BACE1-mediated APP processing <ref>PMID:22709416</ref>.<br />		*'''SNX 12''' regulates BACE1-mediated APP processing <ref>PMID:22709416</ref>.<br />
	*'''SNX 14''' has a role in maintaining normal neuronal excitability.<br />		*'''SNX 14''' has a role in maintaining normal neuronal excitability.<br />

Michal Harel at 09:59, 21 November 2023

2023-11-21T09:59:51Z

← Older revision		Revision as of 09:59, 21 November 2023
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	<StructureSection load='3dyt' size='350' side='right' caption='Structure of human sorting nexin-9 PX domain complex with sulfate (PDB entry [[3dyt]])' scene=''>		<StructureSection load='3dyt' size='350' side='right' caption='Structure of human sorting nexin-9 PX domain complex with sulfate (PDB entry [[3dyt]])' scene=''>

			__TOC__
	== Function ==		== Function ==
	'''Sorting nexins''' (SNX) are proteins which enhance membrane association via their lipid-binding PX domain or via protein-protein association<ref>PMID:25619244</ref>. The PX domain contains a phospholipid-binding motif.		'''Sorting nexins''' (SNX) are proteins which enhance membrane association via their lipid-binding PX domain or via protein-protein association<ref>PMID:25619244</ref>. The PX domain contains a phospholipid-binding motif.

Michal Harel at 09:36, 9 February 2020

2020-02-09T09:36:56Z

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 </StructureSection>
 == References ==
 <references/>
 [[Category:Topic Page]]

Michal Harel at 09:35, 9 February 2020

2020-02-09T09:35:49Z

← Older revision		Revision as of 09:35, 9 February 2020
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	*'''SNX 14''' has a role in maintaining normal neuronal excitability.<br />		*'''SNX 14''' has a role in maintaining normal neuronal excitability.<br />
	*'''SNX 16''' has a role in protein transport from early to late endosomes.<br />		*'''SNX 16''' has a role in protein transport from early to late endosomes.<br />
	*'''SNX 22''', '''SNX 24''' and '''SNX 25''' may have a role in intracellular trafficking.<br />		*'''SNX 22''', '''SNX 24''', '''SNX 25''' and '''SNX 32''' may have a role in intracellular trafficking.<br />
	*'''SNX 27''' modulates synaptic plasticity<ref>PMID:25071192</ref>.<br />		*'''SNX 27''' modulates synaptic plasticity<ref>PMID:25071192</ref>.<br />
	*'''SNX 33''' induces micronucleated phenotype and actin polymerization<ref>PMID:19487689</ref>.<br />		*'''SNX 33''' induces micronucleated phenotype and actin polymerization<ref>PMID:19487689</ref>.<br />
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	== Relevance ==		== Relevance ==
	SNX 2 is a potential marker of hyperfunctioning thyroid disorders<ref>PMID:23531855</ref>.		SNX 2 is a potential marker of hyperfunctioning thyroid disorders<ref>PMID:23531855</ref>.

			==3D structures of sorting nexin==
			[[Sorting nexin 3D structures]]

	</StructureSection>		</StructureSection>

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	*Sorting nexin 3		*Sorting nexin 3

	**[[1ocs]] – ySNX PX domain – yeast<br />
	**[[1ocu]] – ySNX PX domain + phosphatidylinositol-3-phosphate<br />
	**[[2mxc]] – hSNX - NMR <br />		**[[2mxc]] – hSNX - NMR <br />
	**[[2yps]] – hSNX PX domain <br />		**[[2yps]] – hSNX PX domain <br />
	**[[5f0j]] – hSNX PX domain + VPS26 + VPS35<br />		**[[5f0j]] – hSNX PX domain + VPS26 + VPS35<br />
	**[[5f0l]], [[5f0m]], [[5f0p]] – hSNX + VPS26 + VPS35 + DMT1 peptide<br />		**[[5f0l]], [[5f0m]], [[5f0p]] – hSNX + VPS26 + VPS35 + DMT1 peptide<br />
			**[[1ocs]] – ySNX PX domain – yeast<br />
			**[[1ocu]] – ySNX PX domain + phosphatidylinositol-3-phosphate<br />

	*Sorting nexin 5		*Sorting nexin 5

			**[[5tgh]], [[5tgi]], [[5wy2]] – hSNX PX domain + INCE<br />
	**[[3hpb]], [[3hpc]] – rSNX PX domain – rat<br />		**[[3hpb]], [[3hpc]] – rSNX PX domain – rat<br />
	**[[5tgh]], [[5tgi]], [[5wy2]] – hSNX PX domain + INCE<br />
	**[[5tp1]] – mSNX PX domain + INCE<br />		**[[5tp1]] – mSNX PX domain + INCE<br />

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	*Sorting nexin 27		*Sorting nexin 27

			**[[4has]], [[5zn9]] – hSNX PX domain <br />
			**[[6sak]] – hSNX PX domain + otulin<br />
	**[[3qdo]], [[3qe1]] – rSNX PDZ domain/GIRK3 C terminal <br />		**[[3qdo]], [[3qe1]] – rSNX PDZ domain/GIRK3 C terminal <br />
	**[[3qgl]] – rSNX PDZ domain + GIRK3 C terminal <br />		**[[3qgl]] – rSNX PDZ domain + GIRK3 C terminal <br />
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	**[[4p2a]] – rSNX PDZ domain + VPSA26 <br />		**[[4p2a]] – rSNX PDZ domain + VPSA26 <br />
	**[[4z8j]] – rSNX PDZ domain + parathyroid hormone receptor PDZ domain <br />		**[[4z8j]] – rSNX PDZ domain + parathyroid hormone receptor PDZ domain <br />
	**[[~~4has~~]] – hSNX PX domain <br />
			*Sorting nexin 32

			**[[6e8r]] – hSNX PX domain + INCE<br />

	*Sorting nexin 33		*Sorting nexin 33

Michal Harel at 19:24, 20 September 2018

2018-09-20T19:24:34Z

← Older revision		Revision as of 19:24, 20 September 2018
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	**[[3hpb]], [[3hpc]] – rSNX PX domain – rat<br />		**[[3hpb]], [[3hpc]] – rSNX PX domain – rat<br />
	**[[5tgh]], [[5tgi]] – hSNX PX domain + INCE<br />		**[[5tgh]], [[5tgi]], [[5wy2]] – hSNX PX domain + INCE<br />
	**[[5tp1]] – mSNX PX domain + INCE<br />		**[[5tp1]] – mSNX PX domain + INCE<br />

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	**[[4bgj]], [[4pqo]], [[4pqp]] – hSNX PX domain <br />		**[[4bgj]], [[4pqo]], [[4pqp]] – hSNX PX domain <br />

			*Sorting nexin 15

			**[[6mbi]], [[6ecm]] – hSNX PX domain <br />

	*Sorting nexin 16		*Sorting nexin 16
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	**[[2ett]] – hSNX PX domain - NMR<br />		**[[2ett]] – hSNX PX domain - NMR<br />

			*Sorting nexin 23

			**[[6ee0]] – hSNX PX domain <br />

	*Sorting nexin 24		*Sorting nexin 24
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	**[[5xdz]] – SNX PX domain - zebrafish<br />		**[[5xdz]] – SNX PX domain - zebrafish<br />
			**[[5woe]] – hSNX Phox hiomology domain - NMR<br />

	*Sorting nexin 27		*Sorting nexin 27

Michal Harel at 22:48, 4 October 2017

2017-10-04T22:48:52Z

← Older revision		Revision as of 22:48, 4 October 2017
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	*'''SNX 11'''and '''SNX 17''' regulate lysosomal degradation of plasma membrane<ref>PMID:26818531</ref>.<br />		*'''SNX 11'''and '''SNX 17''' regulate lysosomal degradation of plasma membrane<ref>PMID:26818531</ref>.<br />
	*'''SNX 12''' regulates BACE1-mediated APP processing <ref>PMID:22709416</ref>.<br />		*'''SNX 12''' regulates BACE1-mediated APP processing <ref>PMID:22709416</ref>.<br />
			*'''SNX 14''' has a role in maintaining normal neuronal excitability.<br />
			*'''SNX 16''' has a role in protein transport from early to late endosomes.<br />
			*'''SNX 22''', '''SNX 24''' and '''SNX 25''' may have a role in intracellular trafficking.<br />
	*'''SNX 27''' modulates synaptic plasticity<ref>PMID:25071192</ref>.<br />		*'''SNX 27''' modulates synaptic plasticity<ref>PMID:25071192</ref>.<br />
	*'''SNX 33''' induces micronucleated phenotype and actin polymerization<ref>PMID:19487689</ref>.<br />		*'''SNX 33''' induces micronucleated phenotype and actin polymerization<ref>PMID:19487689</ref>.<br />

Michal Harel at 22:35, 4 October 2017

2017-10-04T22:35:17Z

← Older revision		Revision as of 22:35, 4 October 2017
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	**[[2mxc]] – hSNX - NMR <br />		**[[2mxc]] – hSNX - NMR <br />
	**[[2yps]] – hSNX PX domain <br />		**[[2yps]] – hSNX PX domain <br />
			**[[5f0j]] – hSNX PX domain + VPS26 + VPS35<br />
			**[[5f0l]], [[5f0m]], [[5f0p]] – hSNX + VPS26 + VPS35 + DMT1 peptide<br />

	*Sorting nexin 5		*Sorting nexin 5

	**[[3hpb]], [[3hpc]] – rSNX PX domain – rat<br />		**[[3hpb]], [[3hpc]] – rSNX PX domain – rat<br />
			**[[5tgh]], [[5tgi]] – hSNX PX domain + INCE<br />
			**[[5tp1]] – mSNX PX domain + INCE<br />

	*Sorting nexin 7		*Sorting nexin 7
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	**[[4bgj]], [[4pqo]], [[4pqp]] – hSNX PX domain <br />		**[[4bgj]], [[4pqo]], [[4pqp]] – hSNX PX domain <br />

			*Sorting nexin 16

			**[[5gw0]], [[5gw1]] – hSNX PX-coiled coll domain <br />

	*Sorting nexin 17		*Sorting nexin 17

	**[[3fog]], [[3lui]] – hSNX PX domain <br />		**[[3fog]], [[3lui]] – hSNX PX domain <br />
	**[[4gxb]], [[~~4tkh~~]] – hSNX FERM domain + NPXY motif<br />		**[[4gxb]], [[4tkn]] – hSNX FERM domain + NPXY motif<br />

	*Sorting nexin 21		*Sorting nexin 21
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	**[[4az9]] – hSNX PX domain <br />		**[[4az9]] – hSNX PX domain <br />

			*Sorting nexin 25

			**[[5xdz]] – SNX PX domain - zebrafish<br />

	*Sorting nexin 27		*Sorting nexin 27
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	**[[3qdo]], [[3qe1]] – rSNX PDZ domain/GIRK3 C terminal <br />		**[[3qdo]], [[3qe1]] – rSNX PDZ domain/GIRK3 C terminal <br />
	**[[3qgl]] – rSNX PDZ domain + GIRK3 C terminal <br />		**[[3qgl]] – rSNX PDZ domain + GIRK3 C terminal <br />
			**[[5elq]] – rSNX PDZ domain + DGKζ C terminal <br />
			**[[5em9]], [[5ema]], [[5emb]], [[4z8j]] – rSNX PDZ domain + PDZ-binding motif <br />
	**[[4p2a]] – rSNX PDZ domain + VPSA26 <br />		**[[4p2a]] – rSNX PDZ domain + VPSA26 <br />
	**[[4z8j]] – rSNX PDZ domain + parathyroid hormone receptor PDZ domain <br />		**[[4z8j]] – rSNX PDZ domain + parathyroid hormone receptor PDZ domain <br />

Michal Harel at 11:56, 30 August 2016

2016-08-30T11:56:29Z

← Older revision		Revision as of 11:56, 30 August 2016
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	**[[4gxb]], [[4tkh]] – hSNX FERM domain + NPXY motif<br />		**[[4gxb]], [[4tkh]] – hSNX FERM domain + NPXY motif<br />

	*~~SNX-~~21		*Sorting nexin 21

	**[[4ymr]] – mSNX PX/TPR domain <br />		**[[4ymr]] – mSNX PX/TPR domain <br />

Michal Harel at 11:55, 30 August 2016

2016-08-30T11:55:40Z

← Older revision		Revision as of 11:55, 30 August 2016
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	**[[1ocs]] – ySNX PX domain – yeast<br />		**[[1ocs]] – ySNX PX domain – yeast<br />
	**[[1ocu]] – ySNX PX domain + phosphatidylinositol-3-phosphate<br />		**[[1ocu]] – ySNX PX domain + phosphatidylinositol-3-phosphate<br />
			**[[2mxc]] – hSNX - NMR <br />
	**[[2yps]] – hSNX PX domain <br />		**[[2yps]] – hSNX PX domain <br />

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	**[[3fog]], [[3lui]] – hSNX PX domain <br />		**[[3fog]], [[3lui]] – hSNX PX domain <br />
	**[[4gxb]], [[4tkh]] – hSNX FERM domain + NPXY motif<br />		**[[4gxb]], [[4tkh]] – hSNX FERM domain + NPXY motif<br />

			*SNX-21

			**[[4ymr]] – mSNX PX/TPR domain <br />

	*Sorting nexin 22		*Sorting nexin 22
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	**[[3qgl]] – rSNX PDZ domain + GIRK3 C terminal <br />		**[[3qgl]] – rSNX PDZ domain + GIRK3 C terminal <br />
	**[[4p2a]] – rSNX PDZ domain + VPSA26 <br />		**[[4p2a]] – rSNX PDZ domain + VPSA26 <br />
			**[[4z8j]] – rSNX PDZ domain + parathyroid hormone receptor PDZ domain <br />
	**[[4has]] – hSNX PX domain <br />		**[[4has]] – hSNX PX domain <br />

Michal Harel at 11:43, 30 August 2016

2016-08-30T11:43:22Z

← Older revision		Revision as of 11:43, 30 August 2016
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	== Relevance ==		== Relevance ==
	SNX 2 is a potential marker of ~~hyper functioning~~ thyroid disorders<ref>PMID:23531855</ref>.		SNX 2 is a potential marker of hyperfunctioning thyroid disorders<ref>PMID:23531855</ref>.
	</StructureSection>		</StructureSection>