Spectrin - Revision history

Michal Harel at 06:55, 14 August 2024

2024-08-14T06:55:34Z

← Older revision		Revision as of 06:55, 14 August 2024
Line 5:		Line 5:
	*'''Spectrin β2''' is associated with GABA receptor at dendritic synapses<ref>PMID:36604600</ref>.		*'''Spectrin β2''' is associated with GABA receptor at dendritic synapses<ref>PMID:36604600</ref>.
	*'''Spectrin β4''' is associated with GABA receptor at axon initial segment synapses.		*'''Spectrin β4''' is associated with GABA receptor at axon initial segment synapses.
			*'''Spectrin R16''' is spectrin α first repeat domain<ref>PMID:10481916</ref>.

	== Disease ==		== Disease ==

Michal Harel at 10:31, 13 August 2024

2024-08-13T10:31:35Z

← Older revision		Revision as of 10:31, 13 August 2024
Line 3:		Line 3:
	[[Spectrin]] forms scaffolding in plasma membranes and cytoskeletal structure. It interacts with actin at either end of its tetramer<ref>PMID:17060500</ref>. The SPT dimer is formed by association of α1 and β1 monomers. In invertebrates there are SPT α, β and βH. In vertebrates there are SPT α1 (SPTA1), α2 (SPTA2) and β1 (SPTB1) to β5. SPT contains an SRC Homology 3 domain (SH3), a Pleckstrin Homology (PH) domain and a Calponin Homology (CH) domain.		[[Spectrin]] forms scaffolding in plasma membranes and cytoskeletal structure. It interacts with actin at either end of its tetramer<ref>PMID:17060500</ref>. The SPT dimer is formed by association of α1 and β1 monomers. In invertebrates there are SPT α, β and βH. In vertebrates there are SPT α1 (SPTA1), α2 (SPTA2) and β1 (SPTB1) to β5. SPT contains an SRC Homology 3 domain (SH3), a Pleckstrin Homology (PH) domain and a Calponin Homology (CH) domain.
	*'''Spectrin α2''' is expressed highly in heart muscle cells<ref>PMID:15360127</ref>.		*'''Spectrin α2''' is expressed highly in heart muscle cells<ref>PMID:15360127</ref>.
			*'''Spectrin β2''' is associated with GABA receptor at dendritic synapses<ref>PMID:36604600</ref>.
			*'''Spectrin β4''' is associated with GABA receptor at axon initial segment synapses.

	== Disease ==		== Disease ==

Michal Harel at 10:20, 13 August 2024

2024-08-13T10:20:31Z

← Older revision		Revision as of 10:20, 13 August 2024
Line 2:		Line 2:
	== Function ==		== Function ==
	[[Spectrin]] forms scaffolding in plasma membranes and cytoskeletal structure. It interacts with actin at either end of its tetramer<ref>PMID:17060500</ref>. The SPT dimer is formed by association of α1 and β1 monomers. In invertebrates there are SPT α, β and βH. In vertebrates there are SPT α1 (SPTA1), α2 (SPTA2) and β1 (SPTB1) to β5. SPT contains an SRC Homology 3 domain (SH3), a Pleckstrin Homology (PH) domain and a Calponin Homology (CH) domain.		[[Spectrin]] forms scaffolding in plasma membranes and cytoskeletal structure. It interacts with actin at either end of its tetramer<ref>PMID:17060500</ref>. The SPT dimer is formed by association of α1 and β1 monomers. In invertebrates there are SPT α, β and βH. In vertebrates there are SPT α1 (SPTA1), α2 (SPTA2) and β1 (SPTB1) to β5. SPT contains an SRC Homology 3 domain (SH3), a Pleckstrin Homology (PH) domain and a Calponin Homology (CH) domain.
			*'''Spectrin α2''' is expressed highly in heart muscle cells<ref>PMID:15360127</ref>.

	== Disease ==		== Disease ==

Michal Harel at 09:39, 7 April 2022

2022-04-07T09:39:49Z

@@ Line 9: / Line 9: @@
 [[Spectrin 3D structures]]
 </StructureSection>
 == References ==
 <references/>
 [[Category:Topic Page]]

Michal Harel at 09:37, 7 April 2022

2022-04-07T09:37:14Z

← Older revision		Revision as of 09:37, 7 April 2022
Line 5:		Line 5:
	== Disease ==		== Disease ==
	Mutations in SPT α are found in patients with hereditary elliptocytosis<ref>PMID:2346784</ref>. SPT β deficiency is found in hereditary spherocytosis<ref>PMID:9714702</ref>.		Mutations in SPT α are found in patients with hereditary elliptocytosis<ref>PMID:2346784</ref>. SPT β deficiency is found in hereditary spherocytosis<ref>PMID:9714702</ref>.

			== 3D Structures of Spectrin ==
			[[Spectrin 3D structures]]
	</StructureSection>		</StructureSection>
	== 3D Structures of Spectrin ==		== 3D Structures of Spectrin ==

Michal Harel at 08:56, 11 November 2020

2020-11-11T08:56:33Z

← Older revision		Revision as of 08:56, 11 November 2020
Line 36:		Line 36:
	**[[1e6g]], [[1e6h]], [[1hd3]], [[1qkx]], [[1pwt]], [[1bk2]], [[1shg]], [[1h8k]], [[3ngp]], [[3m0p]], [[3m0q]], [[3m0r]], [[3m0s]], [[3m0t]], [[3m0u]] - cSPT a chain SH3 domain (mutant)<br />		**[[1e6g]], [[1e6h]], [[1hd3]], [[1qkx]], [[1pwt]], [[1bk2]], [[1shg]], [[1h8k]], [[3ngp]], [[3m0p]], [[3m0q]], [[3m0r]], [[3m0s]], [[3m0t]], [[3m0u]] - cSPT a chain SH3 domain (mutant)<br />
	**[[1uue]], [[1e7o]], [[1g2b]], [[1aey]], [[1tuc]], [[1tud]] - cSPT a chain SH3 domain (mutant) – NMR<br />		**[[1uue]], [[1e7o]], [[1g2b]], [[1aey]], [[1tuc]], [[1tud]] - cSPT a chain SH3 domain (mutant) – NMR<br />
	**[[2lj3]] - cSPT a chain SH3 domain – NMR<br />		**[[2lj3]], [[6scw]] - cSPT a chain SH3 domain – NMR<br />
	**[[1u4q]] – cSPT a chain repeats 15-17 1662-1982<br />		**[[1u4q]] – cSPT a chain repeats 15-17 1662-1982<br />
	**[[1u5p]] - cSPT a chain repeats 15-16 1662-1876<br />		**[[1u5p]] - cSPT a chain repeats 15-16 1662-1876<br />
	**[[1cun]] - cSPT a chain repeats 16-17 (mutant) 1771-1982<br />		**[[1cun]] - cSPT a chain repeats 16-17 (mutant) 1771-1982<br />
	**[[1aj3]] - cSPT a chain repeat 16 1772-1869 - NMR<br />		**[[1aj3]] - cSPT a chain repeat 16 1772-1869 - NMR<br />
			**[[6ro9]] – SPT SH3 domain – sunfish<br />

	* Spectrin β1		* Spectrin β1
Line 57:		Line 58:
	**[[1wjm]] – hSPT β3 chain PH domain 2199-2328 – NMR<br />		**[[1wjm]] – hSPT β3 chain PH domain 2199-2328 – NMR<br />
	**[[6anu]] - hSPT β3 chain actin binding domain 1-284 + actin - Cryo EM<br />		**[[6anu]] - hSPT β3 chain actin binding domain 1-284 + actin - Cryo EM<br />

			* Spectrin β4

			**[[6m3r]] – mSPT b chain 1616-1937 + Ankyrin-3<br />
			**[[6m3q]] – mSPT b chain + Ankyrin-2<br />

	* Spectrin β		* Spectrin β
Line 62:		Line 68:
	**[[1bkr]], [[1aa2]] – hSPT β chain 2nd CH domain 178-291<br />		**[[1bkr]], [[1aa2]] – hSPT β chain 2nd CH domain 178-291<br />
	**[[1dro]], [[1mph]] - mSPT β chain PH domain 2199-2304 – NMR – mouse<br />		**[[1dro]], [[1mph]] - mSPT β chain PH domain 2199-2304 – NMR – mouse<br />
	**[[1btn]] – mSPT β chain PH domain +inositol phosphate<br />		**[[1btn]] – mSPT β chain PH domain + inositol phosphate<br />
			**[[6m3p]] – mSPT β 2 chain 1591-1910 + Ankyrin-3<br />
	**[[2spc]] – SPT fragment 1391-1497 - ''Drosophila melanogaster''		**[[2spc]] – SPT fragment 1391-1497 - ''Drosophila melanogaster''

Michal Harel at 10:32, 8 November 2020

2020-11-08T10:32:00Z

← Older revision		Revision as of 10:32, 8 November 2020
Line 22:		Line 22:

	**[[3f31]] – hSPT a2 chain N-terminal tetramerization domain<br />		**[[3f31]] – hSPT a2 chain N-terminal tetramerization domain<br />
			**[[5fwc]], [[5fwb]] - hSPT a2 chain SH3 domain (mutant)<br />
	**[[3fb2]] – hSPT a2 chain repeats 15-16 1337-1544<br />		**[[3fb2]] – hSPT a2 chain repeats 15-16 1337-1544<br />
	**[[5fw9]], [[5fwb]], [[5fwc]], [[5ihi]], [[5ihk]], [[5ihn]] – hSPT a2 chain SH3 domain (mutant)<br />		**[[5fw9]], [[5fwb]], [[5fwc]], [[5ihi]], [[5ihk]], [[5ihn]] – hSPT a2 chain SH3 domain (mutant)<br />

Michal Harel at 11:19, 5 November 2020

2020-11-05T11:19:50Z

← Older revision		Revision as of 11:19, 5 November 2020
Line 11:		Line 11:
	{{#tree:id=OrganizedByTopic\|openlevels=0\|		{{#tree:id=OrganizedByTopic\|openlevels=0\|

	* Spectrin α1		* Spectrin α1; Domains – N-terminal tetramerization 1-156; SH3 969-1025; C-terminal tetramerization 1902-2084

	**[[3lbx]] – ~~hSPTA1~~+~~hSPTB1~~ – human<br />		**[[3lbx]] – hSPT a chain N-terminal tetramerization domain +hSPT b chain C-terminal tetramerization domain – human<br />
	**~~[[3i9q]],~~ [[2rot]], [[2oaw]], [[2nuz]], [[1u06]] - ~~cSPTA1~~ SH3 domain – chicken<br />		**[[2rot]], [[2oaw]], [[2nuz]], [[1u06]] - cSPT a chain SH3 domain – chicken<br />
	**[[2jm8]], [[2jm9]], [[2cdt]], [[2f2v]], [[2f2w]], [[2f2x]] - ~~cSPTA1~~ SH3 domain (mutant)<br />		**[[2jm8]], [[2jm9]], [[2cdt]], [[2f2v]], [[2f2w]], [[2f2x]], [[3i9q]] - cSPT a chain SH3 domain (mutant)<br />
	**[[~~2jma~~]], [[~~2jmc~~]] - ~~cSPTA1~~ SH3 domain ~~(mutant)+P41 peptide~~<br />		**[[2rmo]], [[1neg]], [[1m8m]] - cSPT a chain SH3 domain – NMR<br />
	**[[~~2rmo~~]], [[~~1neg]], [[1m8m~~]] - ~~cSPTA1~~ SH3 domain ~~– NMR~~		**[[2jma]], [[2jmc]] - cSPT a chain SH3 domain (mutant)+P41 peptide<br />

	* Spectrin α2		* Spectrin α2

	**[[3f31]] – ~~hSPTA2~~ tetramerization domain<br />		**[[3f31]] – hSPT a2 chain N-terminal tetramerization domain<br />
	**[[5fw9]], [[5fwb]], [[5fwc]], [[5ihi]], [[5ihk]], [[5ihn]] – ~~hSPTA2~~ SH3 domain (mutant)<br />		**[[3fb2]] – hSPT a2 chain repeats 15-16 1337-1544<br />
	**[[~~1qkw~~]] ~~– cSPTA2 SH3~~ domain ~~(mutant)<br />~~		**[[5fw9]], [[5fwb]], [[5fwc]], [[5ihi]], [[5ihk]], [[5ihn]] – hSPT a2 chain SH3 domain (mutant)<br />
	**[[2fot]] - ~~SPTA2~~+calmodulin – bovine<br />		**[[2fot]] - SPT a2 chain calmodulin-binding domain 1172-1211 +calmodulin – bovine<br />
	**[[~~3fb2~~]] ~~– hSPTA2 repeats 15~~-~~16<br />~~		**[[3thk]] - SPT a2 chain SH3 domain + polypeptide - rat
	**[[~~3thk~~]] ~~- SPTA2~~ SH3 domain ~~+ polypeptide - rat~~		**[[1qkw]] – cSPT a2 chain SH3 domain (mutant)<br />

	* Spectrin α		* Spectrin α

	**[[2kr3]], [[4f17]], [[4f16]] - ~~cSPTA~~ SH3 domain<br />		**[[1owa]] - hSPT a chain N-terminal tetramerization domain – NMR<br />
	**[[1e6g]], [[1e6h]], [[1hd3]], [[1qkx]], [[1pwt]], [[1bk2]], [[1shg]], [[1h8k]], [[3ngp]], [[3m0p]], [[3m0q]], [[3m0r]], [[3m0s]], [[3m0t]], [[3m0u]] - ~~cSPTA~~ SH3 domain (mutant)<br />		**[[5j4o]] - hSPT a chain repeats 16-17 1599-1826<br />
	**[[1uue]], [[1e7o]], [[1g2b]], [[1aey]], [[1tuc]], [[1tud]] - ~~cSPTA~~ SH3 domain (mutant) – NMR<br />		**[[2kr3]], [[4f17]], [[4f16]] - cSPT a chain SH3 domain<br />
	**[[2lj3]] - ~~cSPTA~~ SH3 domain – NMR<br />		**[[1e6g]], [[1e6h]], [[1hd3]], [[1qkx]], [[1pwt]], [[1bk2]], [[1shg]], [[1h8k]], [[3ngp]], [[3m0p]], [[3m0q]], [[3m0r]], [[3m0s]], [[3m0t]], [[3m0u]] - cSPT a chain SH3 domain (mutant)<br />
	**[[1u4q]] – ~~cSPTA~~ repeats 15-17 <br />		**[[1uue]], [[1e7o]], [[1g2b]], [[1aey]], [[1tuc]], [[1tud]] - cSPT a chain SH3 domain (mutant) – NMR<br />
	**[[1u5p]] - ~~cSPTA~~ repeats 15-16<br />		**[[2lj3]] - cSPT a chain SH3 domain – NMR<br />
	**[[1cun]] - ~~cSPTA~~ repeats 16-17<br />		**[[1u4q]] – cSPT a chain repeats 15-17 1662-1982<br />
	**[[1aj3]] - ~~cSPTA~~ repeat 16 - ~~NMR<br />~~		**[[1u5p]] - cSPT a chain repeats 15-16 1662-1876<br />
	**[[1owa]] - ~~hSPTA tetramerization domain –~~ NMR~~<br />~~		**[[1cun]] - cSPT a chain repeats 16-17 (mutant) 1771-1982<br />
	**[[5j4o]] - hSPTA repeats 16-17<br />		**[[1aj3]] - cSPT a chain repeat 16 1772-1869 - NMR<br />

	* Spectrin β1		* Spectrin β1

	**[[~~3bkt~~]], [[3kbu]] - ~~hSPTB1~~+ankyrin<br />		**[[3kbt]], [[3kbu]] - hSPT β1 chain repeats 13-15 1583-1906 +ankyrin<br />
	**[[3f57]], [[3edu]] - ~~hSPTB1 ankyrin binding domain~~<br />		**[[3f57]], [[3edu]] - hSPT β1 chain repeats 14-15 1686-1906<br />
	**[[1s35]] – ~~hSPTB1~~ repeats 8-9		**[[1s35]] – hSPT β1 chain repeats 8-9 1063-1275 (mutant)

	* Spectrin β2		* Spectrin β2

	**[[3edv]] – ~~hSPTB2~~ repeats 14-16		**[[3edv]] – hSPT β2 chain repeats 14-16 1697-2015

	* Spectrin β3		* Spectrin β3

	**[[1wyq]] – ~~hSPTB3~~ CH domain – NMR<br />		**[[1wyq]] – hSPT β3 chain 2nd CH domain – NMR<br />
	**[[1wjm]] – ~~hSPTB3~~ – NMR<br />		**[[1wjm]] – hSPT β3 chain PH domain 2199-2328 – NMR<br />
	**[[6anu]] - ~~hSPTB3 ankyrin~~ binding domain + actin - Cryo EM<br />		**[[6anu]] - hSPT β3 chain actin binding domain 1-284 + actin - Cryo EM<br />

	* Spectrin β		* Spectrin β

	**[[1bkr]], [[1aa2]] – ~~hSPTB~~ CH domain<br />		**[[1bkr]], [[1aa2]] – hSPT β chain 2nd CH domain 178-291<br />
	**[[~~1mph~~]] ~~– SPTB Pleckstrin Homology domain – NMR<br />~~		**[[1dro]], [[1mph]] - mSPT β chain PH domain 2199-2304 – NMR – mouse<br />
	**[[~~1dro~~]] - ~~mSPTB~~ PH domain – NMR – mouse<br />		**[[1btn]] – mSPT β chain PH domain +inositol phosphate<br />
	**[[1btn]] – ~~mSPTB~~+inositol phosphate<br />		**[[2spc]] – SPT fragment 1391-1497 - ''Drosophila melanogaster''
	**[[2spc]] – SPT fragment - ''Drosophila melanogaster''

	* Spectrin R16		* Spectrin R16

Michal Harel at 19:35, 20 September 2018

2018-09-20T19:35:22Z

← Older revision		Revision as of 19:35, 20 September 2018
Line 54:		Line 54:

	**[[1wyq]] – hSPTB3 CH domain – NMR<br />		**[[1wyq]] – hSPTB3 CH domain – NMR<br />
	**[[1wjm]] – hSPTB3 – NMR		**[[1wjm]] – hSPTB3 – NMR<br />
			**[[6anu]] - hSPTB3 ankyrin binding domain + actin - Cryo EM<br />

	* Spectrin β		* Spectrin β
Line 66:		Line 67:
	* Spectrin R16		* Spectrin R16

	**[[~~3e5m6s~~]] – SPT - ''Escherichia coli''<br />		**[[5m6s]] – SPT - ''Escherichia coli''<br />

	}}		}}

Michal Harel at 17:14, 5 October 2017

2017-10-05T17:14:37Z

← Older revision		Revision as of 17:14, 5 October 2017
Line 30:		Line 30:
	* Spectrin α		* Spectrin α

			**[[2kr3]], [[4f17]], [[4f16]] - cSPTA SH3 domain<br />
			**[[1e6g]], [[1e6h]], [[1hd3]], [[1qkx]], [[1pwt]], [[1bk2]], [[1shg]], [[1h8k]], [[3ngp]], [[3m0p]], [[3m0q]], [[3m0r]], [[3m0s]], [[3m0t]], [[3m0u]] - cSPTA SH3 domain (mutant)<br />
	**[[1uue]], [[1e7o]], [[1g2b]], [[1aey]], [[1tuc]], [[1tud]] - cSPTA SH3 domain (mutant) – NMR<br />		**[[1uue]], [[1e7o]], [[1g2b]], [[1aey]], [[1tuc]], [[1tud]] - cSPTA SH3 domain (mutant) – NMR<br />
	**[[2lj3]] - cSPTA SH3 domain – NMR<br />		**[[2lj3]] - cSPTA SH3 domain – NMR<br />
	**[[1e6g]], [[1e6h]], [[1hd3]], [[1qkx]], [[1pwt]], [[1bk2]], [[1shg]] - cSPTA SH3 domain (mutant)<br />
	**[[1u4q]] – cSPTA repeats 15-17 <br />		**[[1u4q]] – cSPTA repeats 15-17 <br />
	**[[1u5p]] - cSPTA repeats 15-16<br />		**[[1u5p]] - cSPTA repeats 15-16<br />
Line 38:		Line 39:
	**[[1aj3]] - cSPTA repeat 16 - NMR<br />		**[[1aj3]] - cSPTA repeat 16 - NMR<br />
	**[[1owa]] - hSPTA tetramerization domain – NMR<br />		**[[1owa]] - hSPTA tetramerization domain – NMR<br />
	**[[~~1h8k]], [[3ngp]], [[3m0p]], [[3m0q]], [[3m0r]], [[3m0s]], [[3m0t]], [[3m0u]] – cSPTA SH3 domain (mutant)<br />~~		**[[5j4o]] - hSPTA repeats 16-17<br />
	**[[2kr3]], [[4f17]], [[4f16]] - ~~cSPTA SH3 domain~~<br />

	* Spectrin β1		* Spectrin β1