Syntaxin - Revision history

Michal Harel at 07:04, 18 August 2024

2024-08-18T07:04:38Z

← Older revision		Revision as of 07:04, 18 August 2024
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	*'''Stx-13''' has a role in membrane expansion during neuronal development <ref>PMID:10886332</ref>.		*'''Stx-13''' has a role in membrane expansion during neuronal development <ref>PMID:10886332</ref>.
	*'''Stx-17''' is required for autophagosome-lysosome fusion<ref>PMID:23466629</ref>.		*'''Stx-17''' is required for autophagosome-lysosome fusion<ref>PMID:23466629</ref>.
			*'''Stx-VAM3P''' is involved invacuolar assembly<ref>PMID:9202390</ref>.

	== Relevance ==		== Relevance ==

Michal Harel at 06:56, 18 August 2024

2024-08-18T06:56:19Z

← Older revision		Revision as of 06:56, 18 August 2024
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	*'''Stx-12''' is a SNARE protein localised to the endosome<ref>PMID:9507000</ref>.		*'''Stx-12''' is a SNARE protein localised to the endosome<ref>PMID:9507000</ref>.
	*'''Stx-13''' has a role in membrane expansion during neuronal development <ref>PMID:10886332</ref>.		*'''Stx-13''' has a role in membrane expansion during neuronal development <ref>PMID:10886332</ref>.
			*'''Stx-17''' is required for autophagosome-lysosome fusion<ref>PMID:23466629</ref>.

	== Relevance ==		== Relevance ==

Michal Harel at 06:53, 18 August 2024

2024-08-18T06:53:37Z

← Older revision		Revision as of 06:53, 18 August 2024
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	*'''Stx-10''' is a SNARE protein localised to the trans-Golgi network<ref>PMID:16154903</ref>.		*'''Stx-10''' is a SNARE protein localised to the trans-Golgi network<ref>PMID:16154903</ref>.
	*'''Stx-12''' is a SNARE protein localised to the endosome<ref>PMID:9507000</ref>.		*'''Stx-12''' is a SNARE protein localised to the endosome<ref>PMID:9507000</ref>.
			*'''Stx-13''' has a role in membrane expansion during neuronal development <ref>PMID:10886332</ref>.

	== Relevance ==		== Relevance ==

Michal Harel at 06:49, 18 August 2024

2024-08-18T06:49:18Z

← Older revision		Revision as of 06:49, 18 August 2024
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	*'''Stx-7''' is involved in endosomal membrane fusion<ref>PMID:34408265</ref>.		*'''Stx-7''' is involved in endosomal membrane fusion<ref>PMID:34408265</ref>.
	*'''Stx-10''' is a SNARE protein localised to the trans-Golgi network<ref>PMID:16154903</ref>.		*'''Stx-10''' is a SNARE protein localised to the trans-Golgi network<ref>PMID:16154903</ref>.
			*'''Stx-12''' is a SNARE protein localised to the endosome<ref>PMID:9507000</ref>.

	== Relevance ==		== Relevance ==

Michal Harel at 06:46, 18 August 2024

2024-08-18T06:46:29Z

← Older revision		Revision as of 06:46, 18 August 2024
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	*'''Stx-6''' is a SNARE protein involved in a variety of internal membrane fusion events.		*'''Stx-6''' is a SNARE protein involved in a variety of internal membrane fusion events.
	*'''Stx-7''' is involved in endosomal membrane fusion<ref>PMID:34408265</ref>.		*'''Stx-7''' is involved in endosomal membrane fusion<ref>PMID:34408265</ref>.
			*'''Stx-10''' is a SNARE protein localised to the trans-Golgi network<ref>PMID:16154903</ref>.

	== Relevance ==		== Relevance ==

Michal Harel at 06:41, 18 August 2024

2024-08-18T06:41:08Z

← Older revision		Revision as of 06:41, 18 August 2024
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	*'''Stx-1''' is essential for the formation of the SNARE complex involved in the fusion machinery in the brain. Stx-1 forms a 4-helical bundle complex with proteins SNAP-25 and VAMP2 which drives fusion of vesicles with the plasma membrane<ref>PMID:26903802</ref>. The coiled-coil bundle structure is formed by the interactions of the complex SNARE motifs<ref>PMID:24218570</ref>.		*'''Stx-1''' is essential for the formation of the SNARE complex involved in the fusion machinery in the brain. Stx-1 forms a 4-helical bundle complex with proteins SNAP-25 and VAMP2 which drives fusion of vesicles with the plasma membrane<ref>PMID:26903802</ref>. The coiled-coil bundle structure is formed by the interactions of the complex SNARE motifs<ref>PMID:24218570</ref>.
	*'''Stx-1A''' regulates the function of transmembrane proteins like ion channels and neurotransmitter transporters<ref>PMID:18617632</ref>.		*'''Stx-1A''' regulates the function of transmembrane proteins like ion channels and neurotransmitter transporters<ref>PMID:18617632</ref>.
			*'''Stx-6''' is a SNARE protein involved in a variety of internal membrane fusion events.
			*'''Stx-7''' is involved in endosomal membrane fusion<ref>PMID:34408265</ref>.

	== Relevance ==		== Relevance ==

Michal Harel at 06:23, 18 August 2024

2024-08-18T06:23:48Z

← Older revision		Revision as of 06:23, 18 August 2024
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	<StructureSection load='3ipd' size='450' side='right' caption='Rat Syntaxin 1a SNARE motif (green) complex with VAMP2 SNARE motif (cyan) and SNAP25 SNARE motif (pink and yellow) (PDB code [[3ipd]])' scene='80/801795/Cv/5'>		<StructureSection load='3ipd' size='450' side='right' caption='Rat Syntaxin 1a SNARE motif (green) complex with VAMP2 SNARE motif (cyan) and SNAP25 SNARE motif (pink and yellow) (PDB code [[3ipd]])' scene='80/801795/Cv/5'>
			__TOC__
	== Function ==		== Function ==

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	==3D structures of syntaxin==		==3D structures of syntaxin==
	[[Syntaxin 3D structures]]		[[Syntaxin 3D structures]]

	~~</StructureSection>~~

	== References ==		== References ==
	<references/>		<references/>
			</StructureSection>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 06:22, 18 August 2024

2024-08-18T06:22:41Z

← Older revision		Revision as of 06:22, 18 August 2024
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	== Function ==		== Function ==

	'''Syntaxin''' (Stx) are membrane-integrated proteins that are instrumental in exocytosis of vesicles. Stx-1 is essential for the formation of the SNARE complex involved in the fusion machinery in the brain. Stx-1 forms a 4-helical bundle complex with proteins SNAP-25 and VAMP2 which drives fusion of vesicles with the plasma membrane<ref>PMID:26903802</ref>. The coiled-coil bundle structure is formed by the interactions of the complex SNARE motifs<ref>PMID:24218570</ref>.		'''Syntaxin''' (Stx) are membrane-integrated proteins that are instrumental in exocytosis of vesicles.
			*'''Stx-1''' is essential for the formation of the SNARE complex involved in the fusion machinery in the brain. Stx-1 forms a 4-helical bundle complex with proteins SNAP-25 and VAMP2 which drives fusion of vesicles with the plasma membrane<ref>PMID:26903802</ref>. The coiled-coil bundle structure is formed by the interactions of the complex SNARE motifs<ref>PMID:24218570</ref>.
			*'''Stx-1A''' regulates the function of transmembrane proteins like ion channels and neurotransmitter transporters<ref>PMID:18617632</ref>.

	== Relevance ==		== Relevance ==

Michal Harel at 11:29, 12 February 2020

2020-02-12T11:29:06Z

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 </StructureSection>
 == References ==
 <references/>
 [[Category:Topic Page]]

Michal Harel at 11:28, 12 February 2020

2020-02-12T11:28:07Z

← Older revision		Revision as of 11:28, 12 February 2020
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	<scene name='80/801795/Cv/8'>Syntaxin 1a SNARE motif complex with VAMP2 SNARE motif and SNAP25 SNARE motif</scene> (PDB code [[3hd7]]). The interactions of the syntaxin 1a and VAMP2 SNARE motives consist of hydrogen bond and polar interactions<ref>PMID:19571812</ref>. <scene name='80/801795/Cv/0'>The interactions of the syntaxin 1a with AMP2 SNARE motif and SNAP25 SNARE motives</scene> (PDB code [[3ipd]]).		<scene name='80/801795/Cv/8'>Syntaxin 1a SNARE motif complex with VAMP2 SNARE motif and SNAP25 SNARE motif</scene> (PDB code [[3hd7]]). The interactions of the syntaxin 1a and VAMP2 SNARE motives consist of hydrogen bond and polar interactions<ref>PMID:19571812</ref>. <scene name='80/801795/Cv/0'>The interactions of the syntaxin 1a with AMP2 SNARE motif and SNAP25 SNARE motives</scene> (PDB code [[3ipd]]).

			==3D structures of syntaxin==
			[[Syntaxin 3D structures]]

	</StructureSection>		</StructureSection>
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	*Syntaxin 1		*Syntaxin 1

	**[[2xhe]] – Stx1 + Unc18 – Monosiga brevicollis<br />		**[[2xhe]] – Stx1 + Unc18 – ''Monosiga brevicollis''<br />

	*Syntaxin 1A		*Syntaxin 1A; domains: N-terminal 1-150; SNARE motif 190-264

	**[[1ez3]] – rStx1a N-terminal – rat<br />		**[[1ez3]] – rStx1a N-terminal – rat<br />
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	**[[1urq]] – rStx1a SNARE motif + SNAP25 + tomosyn<br />		**[[1urq]] – rStx1a SNARE motif + SNAP25 + tomosyn<br />
	**[[1n7s]], [[3hd7]], [[1sfc]], [[3ipd]], [[3rk2]], [[3rl0]] – rStx1a SNARE motif + SNAP25 + VAMP2<br />		**[[1n7s]], [[3hd7]], [[1sfc]], [[3ipd]], [[3rk2]], [[3rl0]] – rStx1a SNARE motif + SNAP25 + VAMP2<br />
			**[[6mti]] – rStx1a SNARE motif + synaptotagmin C2A+C2B domains + VAMP2 + SNAP25 – Cryo EM<br />
			**[[6ip1]] – rStx1a + NAPA + VAMP2 + SNAP25 – Cryo EM<br />
	**[[3rk3]], [[1kil]] – rStx1a SNARE motif + SNAP25 + complexin-1 + VAMP2<br />		**[[3rk3]], [[1kil]] – rStx1a SNARE motif + SNAP25 + complexin-1 + VAMP2<br />
	**[[5ccg]], [[5cch]], [[5cci]] – rStx1a SNARE motif + SNAP25 + synaptotagmin + VAMP2 <br />		**[[5ccg]], [[5cch]], [[5cci]] – rStx1a SNARE motif + SNAP25 + synaptotagmin + VAMP2 <br />
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	*Syntaxin 6		*Syntaxin 6

			**[[4j2c]] – hStx6 + vacuolar protein sorting-associated protein peptide – human<br />
	**[[1lvf]] – rStx6 N-terminal <br />		**[[1lvf]] – rStx6 N-terminal <br />
	**[[4j2c]] – hStx6 + vacuolar protein sorting-associated protein peptide – human<br />

	*Syntaxin 7		*Syntaxin 7