https://proteopedia.org/index.php?action=history&feed=atom&title=Talin_3D_structures Talin 3D structures - Revision history 2026-10-05T07:27:49Z Revision history for this page on the wiki MediaWiki 1.43.8 https://proteopedia.org/index.php?title=Talin_3D_structures&diff=3978559&oldid=prev Michal Harel: New page: Talin Talin is involved in cell-cell contacts. It links integrins to actin. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-ter... 2023-12-12T10:00:00Z <p>New page: Talin Talin is involved in cell-cell contacts. It links integrins to actin. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-ter...</p> <p><b>New page</b></p><div>Talin<br /> <br /> Talin is involved in cell-cell contacts. It links integrins to actin. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3. The F3 subdomains interacts with integrin. Talin contains 3 vinculin binding sites VBS1-VBS3.<br /> <br /> Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}<br /> {{#tree:id=OrganizedByTopic|openlevels=0|<br /> <br /> * Talin mouse subdomains: F1 1-85; F2 86-202; F3 203-405; VBS1 482-655; R4 913-1044; B 1046-1207; C 1207-1357; R7-R8 1359-1659; rod 1359-2293; dimerization 2494-2541 <br /> <br /> **[[6r9t]] – hTal-1 – human – Cryo EM&lt;br /&gt;<br /> **[[6u4k]] – hTal-2 F1-F3&lt;br /&gt;<br /> **[[2kc1]], [[6ba6]] - mTal F1 domain – mouse - NMR&lt;br /&gt;<br /> **[[2kc2]] - mTal F2 domain – NMR&lt;br /&gt;<br /> **[[2kma]] – mTal F1F2 domain – NMR&lt;br /&gt;<br /> **[[3ivf]] – mTal FERM domain F1F2F3 &lt;br /&gt;<br /> **[[4f7g]] - mTal F2F3 domain + rod segment domain residues 1654-1847&lt;br /&gt;<br /> **[[2kgx]] – mTal F3 domain + rod fragment residues 1655-1822 – NMR&lt;br /&gt;<br /> **[[1sj7]], [[1sj8]] - mTal VBS1 domain&lt;br /&gt;<br /> **[[5nl1]] - mTal VBS1 domain + IPAA&lt;br /&gt;<br /> **[[2lqg]] - mTal R4 helix domain – NMR&lt;br /&gt;<br /> **[[2l7n]] – mTal B domain – NMR&lt;br /&gt;<br /> **[[2l10]] – mTal C domain – NMR&lt;br /&gt;<br /> **[[2x0c]] – mTal rod residues 1359-1659 &lt;br /&gt;<br /> **[[5ic0]], [[2kbb]] – mTal triple domain residues 1357-1822&lt;br /&gt;<br /> **[[5ic1]] – mTal triple domain residues 1357-1822 (mutant)&lt;br /&gt;<br /> **[[4w8p]], [[7v1a]] - mTal R7-8 + RIAM peptide&lt;br /&gt;<br /> **[[5fzt]] - mTal R7-8 + Rho GTPase activating protein 7 peptide &lt;br /&gt;<br /> **[[6twn]] - mTal R7-8 + Cdk1 peptide &lt;br /&gt;<br /> **[[8ivz]] - mTal R7-8 + KANK1 peptide &lt;br /&gt;<br /> **[[8as9]] - mTal R7-8 + KANK1 complex &lt;br /&gt;<br /> **[[7zw4]] - mTal R7-8 + Caskin-2 peptide &lt;br /&gt;<br /> **[[3dyj]] - mTal rod residues 1974-2293&lt;br /&gt;<br /> **[[2qdq]] – mTal dimerization domain&lt;br /&gt;<br /> **[[2mwn]] – hTal1 residues 308-400 + RIAM – human - NMR&lt;br /&gt;<br /> **[[2hrj]] - cTal F2 – chicken - NMR &lt;br /&gt;<br /> **[[1mix]] – cTal F2F3 residues 196-400&lt;br /&gt;<br /> <br /> * Talin integrin-binding sites <br /> <br /> **[[2jsw]], [[2qdq]] – mTal IBS – NMR&lt;br /&gt;<br /> **[[3g9w]] – mTal2 F2F3+integrin tail&lt;br /&gt;<br /> **[[1miz]], [[1mk7]], [[1mk9]] - cTal F2F3 residues 200-400 +integrin tail&lt;br /&gt;<br /> **[[2h7d]], [[2h7e]] - cTal FERM F3+integrlin fragment – NMR &lt;br /&gt;<br /> **[[3fyq]] – Tal rod IBS2 residues 1981-2168 – &#039;&#039;Drosophila melanogaster&#039;&#039;<br /> <br /> * Talin vinculin-binding sites <br /> <br /> **[[2kvp]], [[2b0h]] – mTal VBS3 residues 2300-2482 – NMR&lt;br /&gt;<br /> **[[1xwj]], [[1zvz]], [[1zw2]], [[1zw3]] - cTal VBS3+ vinculin head – chicken&lt;br /&gt;<br /> **[[1u6h]] - cTal VBS2 residues 849-879 + vinculin head&lt;br /&gt;<br /> **[[1t01]] - meal VBS1 residues 605-628 + vinculin head&lt;br /&gt;<br /> **[[1syq]] - hTal VBS1+ vinculin head &lt;br /&gt;<br /> **[[1rkc]] - cTal VBS3+ vinculin head&lt;br /&gt;<br /> **[[3s90]] - mTal VBS3 residues 1512-1546 + vinculin head&lt;br /&gt;<br /> **[[1u89]], [[2l7a]] - mTal VBS2 – NMR&lt;br /&gt;<br /> **[[4dj9]] – hTal VBS50 + vinculin head<br /> <br /> *Talin phosphatidylinositol phosphate kinase binding sites <br /> <br /> **[[1y19]] - mTal F2F3+ PIP kinase C-terminal&lt;br /&gt;<br /> **[[6mfs]] - mTal F2F3+ PIP&lt;br /&gt;<br /> **[[2g35]] - mTal F3+PIP kinase peptide – NMR<br /> <br /> *Talin layilin-binding sites<br /> <br /> **[[2k00]] - cTal F3+layilin fragment – NMR<br /> }}<br /> <br /> [[Category:Topic Page]]</div> Michal Harel