Transducin - Revision history

Michal Harel at 06:55, 20 August 2024

2024-08-20T06:55:03Z

← Older revision		Revision as of 06:55, 20 August 2024
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	== Function ==		== Function ==

	'''Transducin''' (TDN) or '''Heterotrimeric G protein''' or '''Guanine nucleotide-binding protein G''' is a <scene name='59/590984/Cv/5'>heterotrimeric G protein containing 3 chains: α, β and γ</scene> which are organized in two subunits: α and βγ<ref>PMID:2534964</ref>. TDN is involved in phototransduction. The absorption of a photon by retinal causes a change in the conformation of rhodopsin into metarhodopsin II. The latter causes activation of TDN. Upon TDN activation the <scene name='59/590984/Cv/6'>GDP bound to its α subunit</scene> is exchanged for the GTP from the cytoplasm. Deactivation of TDN occurs when the GTP bound to the α subunit is hydrolyzed to GDP. Phosducin binds to the βγ subunit of TDN preventing its re-association with the α subunit.		'''Transducin''' (TDN) or '''Heterotrimeric G protein''' or '''Guanine nucleotide-binding protein G''' is a <scene name='59/590984/Cv/5'>heterotrimeric G protein containing 3 chains: α, β and γ</scene> which are organized in two subunits: '''α''' and '''βγ'''<ref>PMID:2534964</ref>. TDN is involved in phototransduction. The absorption of a photon by retinal causes a change in the conformation of rhodopsin into metarhodopsin II. The latter causes activation of TDN. Upon TDN activation the <scene name='59/590984/Cv/6'>GDP bound to its α subunit</scene> is exchanged for the GTP from the cytoplasm. Deactivation of TDN occurs when the GTP bound to the α subunit is hydrolyzed to GDP. Phosducin binds to the βγ subunit of TDN preventing its re-association with the α subunit.

	== Disease ==		== Disease ==

Michal Harel at 06:49, 20 August 2024

2024-08-20T06:49:21Z

← Older revision		Revision as of 06:49, 20 August 2024
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	<StructureSection load='' size='350' side='right' caption='Structure of rat transducin α (deepskyblue), β (green) and γ (gold) subunits complex with GDP (PDB code [[1gp2]]).' scene='59/590984/Cv/1' pspeed='8'>		<StructureSection load='' size='350' side='right' caption='Structure of rat transducin α (deepskyblue), β (green) and γ (gold) subunits complex with GDP (PDB code [[1gp2]]).' scene='59/590984/Cv/1' pspeed='8'>

			__TOC__
	== Function ==		== Function ==

Michal Harel at 09:57, 15 January 2024

2024-01-15T09:57:06Z

← Older revision		Revision as of 09:57, 15 January 2024
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	== Disease ==		== Disease ==
	Congenital stationary night blindness (Nougaret disease) is caused by a mutation in TDN α subunit<ref>PMID:8673138</ref>.		Congenital stationary night blindness (Nougaret disease) is caused by a mutation in TDN α subunit<ref>PMID:8673138</ref>.

	==3D structures of transducin==		==3D structures of transducin==
	[[Transducin 3D structures]]		[[Transducin 3D structures]]

Michal Harel at 08:19, 5 March 2020

2020-03-05T08:19:12Z

@@ Line 13: / Line 13: @@
 </StructureSection>
 == References ==
 <references/>
 [[Category: Topic Page]]

Michal Harel at 08:18, 5 March 2020

2020-03-05T08:18:17Z

← Older revision		Revision as of 08:18, 5 March 2020
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	== Disease ==		== Disease ==
	Congenital stationary night blindness (Nougaret disease) is caused by a mutation in TDN α subunit<ref>PMID:8673138</ref>.		Congenital stationary night blindness (Nougaret disease) is caused by a mutation in TDN α subunit<ref>PMID:8673138</ref>.
			==3D structures of transducin==
			[[Transducin 3D structures]]

	</StructureSection>		</StructureSection>
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	**[[1fqk]] – bTDN + RGS9 + GDP + AlF4<br />		**[[1fqk]] – bTDN + RGS9 + GDP + AlF4<br />
	**[[1fqj]] – bTDN + RGS9 + GMP-PDE γ + GDP + AlF4<br />		**[[1fqj]] – bTDN + RGS9 + GMP-PDE γ + GDP + AlF4<br />

			*Transducin-β

			**[[6n9g]] – TDN + RGS7 - mouse<br />

	*Transducin-βγ		*Transducin-βγ

			**[[5he0]], [[5he1]], [[5he2]], [[5he3]], [[5ukk]], [[5ukl]], [[5ukm]] – hTDN + β-adrenergic receptor kinase 1 + inhibitor<br />
			**[[4kfm]] – hTDN + G-protein activated inward rectifier K+ channel<br />
			**[[6m8s]] – hTDN + KCTD12<br />
			**[[6nbi]], [[6nbh]], [[6nbf]] – hTDN + PTH/PTHRP + long-acting parathyroid hormone + GS protein a subunit + nanobody – Cryo EM<br />
			**[[4pnk]] – h/bTDN + bγ (mutant)+ β-adrenergic receptor kinase 1 + inhibitor<br />
	**[[1tbg]] – bTDN <br />		**[[1tbg]] – bTDN <br />
	**[[2trc]], [[1a0r]], [[1b9x]], [[1b9y]] – bTDN + phosducin<br />		**[[2trc]], [[1a0r]], [[1b9x]], [[1b9y]] – bTDN + phosducin<br />
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	**[[3v5w]] – bTDN (mutant) + G-protein coupled receptor kinase 2<br />		**[[3v5w]] – bTDN (mutant) + G-protein coupled receptor kinase 2<br />
	**[[3psc]], [[3pvu]], [[3pvw]], [[4mk0]] – bTDN + β-adrenergic receptor kinase 1<br />		**[[3psc]], [[3pvu]], [[3pvw]], [[4mk0]] – bTDN + β-adrenergic receptor kinase 1<br />
	**[[5he0]], [[5he1]], [[5he2]], [[5he3]], [[5ukk]], [[5ukl]], [[5ukm]] – hTDN + β-adrenergic receptor kinase 1 + inhibitor<br />
	**[[4pnk]] – TDN hβ + bγ (mutant)+ β-adrenergic receptor kinase 1 + inhibitor<br />
	**[[2bcj]] – bTDN (mutant) + β-adrenergic receptor kinase 1<br />		**[[2bcj]] – bTDN (mutant) + β-adrenergic receptor kinase 1<br />
	**[[3uzs]] – bTDN + β-adrenergic receptor kinase 1 + RNA<br />		**[[3uzs]] – bTDN + β-adrenergic receptor kinase 1 + RNA<br />
	**[[3krw]], [[3krx]] – bTDN + G-protein coupled receptor kinase 2 + inhibitor<br />		**[[3krw]], [[3krx]], [[6c2y]], [[5wg5]], [[5wg4]], [[5wg3]] – bTDN + G-protein coupled receptor kinase 2 + inhibitor<br />
	**[[1xhm]] – bTDN + peptide<br />		**[[1xhm]] – bTDN + peptide<br />
	**[[~~4kfm~~]] – ~~hTDN~~ + ~~G-protein activated inward rectifier K~~+ ~~channel~~<br />		**[[6pcv]] – bTDN + RAC exchanger – Cryo EM<br />
			**[[6b20]] – bTDN + nanobody<br />

	*Transducin-α+βγ		*Transducin-α+βγ

			**[[6eg8]] – hTDN + GDP<br />
			**[[6ddf]], [[6dde]] – hTDN + mu opioid receptor + DAMGO – Cryo EM<br />
			**[[6d9h]] – hTDN + AChR/adenosine receptor – Cryo EM<br />
			**[[6p9x]] – hTDN + CRFR-1 + corticliberin – Cryo EM<br />
			**[[6osa]] – hTDN + NTR1 + JMV449 – Cryo EM<br />
			**[[6g79]] – hTDN + serotonin receptor – Cryo EM<br />
			**[[6oy9]] – bTDN + rhodopsin + retinal – Cryo EM<br />
			**[[6oya]] – bTDN + antibody + rhodopsin + retinal – Cryo EM<br />
	**[[1got]] – bTDN + GDP<br />		**[[1got]] – bTDN + GDP<br />
	**[[1gg2]] – ~~TDN rα~~ (mutant) + ~~bβγ~~ + GDP - ~~rat~~<br />		**[[1gp2]], [[5kdo]], [[1gg2]] – r/bTDN + GDP - rat<br />
	**[[~~1gp2~~]], [[~~5kdo~~]] – ~~TDN rα~~ + ~~bβγ~~ + ~~GDP~~ <br />		**[[3ah8]] – r/bTDN (mutant) + GDP + inhibitor<br />
	**[[~~3ah8~~]] – ~~TDN rα + bβ~~ + ~~bγ (mutant)~~ + ~~GDP~~ + ~~inhibitor~~<br />		**[[5tdh]] – h/r/bTDN (mutant) + GDP<br />
	**[[~~3sn6~~]] – ~~TDN bα (mutant)~~ + ~~rβ (mutant)~~ +~~bγ + endolysine~~ + antibody fragment<br />
	**[[~~5tdh~~]] – ~~TDN hα (mutant)~~ + rβ + bγ + ~~GDP~~<br />		*Transducin-α+βγ complex with antibody

			**[[6pt0]], [[6n4b]], [[6kpg]], [[6kpf]] – hTDN + cannaboid receptor + antibody fragment – Cryo EM<br />
			**[[6pb1]], [[6pb0]] – hTDN + CRFR-2 + urocortin + nanobody – Cryo EM<br />
			**[[6os9]] – hTDN + NTR1 + JMV449 + antibody fragment – Cryo EM<br />
			**[[6oik]], [[6oij]] – hTDN + AChR + antibody fragment – Cryo EM<br />
			**[[6crk]] – hTDN + antibody fragment <br />
			**[[6niy]], [[6e3y]] – hTDN + calcitonin receptor + calcitonin + nanobody – Cryo EM<br />
	**[[5uz7]] – hTDN + calcitonin receptor + antibody fragment - Cryo EM<br />		**[[5uz7]] – hTDN + calcitonin receptor + antibody fragment - Cryo EM<br />
	**[[~~5vai~~]] – ~~TDN hα~~ + rβ + bγ+ glucagon-like peptide + antibody fragment - Cryo EM<br />		**[[6ni3]] – hTDN + endolysin/adrenergic receptor + nanobody – Cryo EM<br />
			**[[6omm]] – hTDN + formyl peptide receptor + peptide agonist + antibody fragment – Cryo EM<br />
			**[[6p9y]] – hTDN + PACAP + nanobody – Cryo EM<br />
			**[[6li3]] – hTDN + GPR52 + nanobody – Cryo EM<br />
			**[[6gdg]] – hTDN + adenosine A2A receptor + nanobody – Cryo EM<br />
			**[[6b3j]] – hTDN + GLP-1R + exendin-p5 + nanobody – Cryo EM<br />
			**[[6ot0]] – hTDN + antibody + smoothened homolog – Cryo EM<br />
			**[[6cmo]] – hTDN + antibody + rhodopsin/cytochrome b562 – Cryo EM<br />
			**[[6qno]] – h/bTDN + antibody + rhodopsin + retinal – Cryo EM<br />
			**[[5vai]] – h/r/bTDN + glucagon-like peptide + antibody fragment - Cryo EM<br />
			**[[3sn6]] – TDN ba (mutant) + rb (mutant) + bc + endolysine + antibody fragment<br />

	}}		}}
	== References ==		== References ==

Alexander Berchansky at 12:36, 25 September 2019

2019-09-25T12:36:08Z

← Older revision		Revision as of 12:36, 25 September 2019
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	== Function ==		== Function ==

	'''Transducin''' (TDN) or '''Heterotrimeric G protein''' or '''Guanine nucleotide-binding protein G''' is a <scene name='59/590984/Cv/2'>heterotrimeric G protein containing 3 chains: α, β and γ</scene> which are organized in two subunits: α and βγ<ref>PMID:2534964</ref>. TDN is involved in phototransduction. The absorption of a photon by retinal causes a change in the conformation of rhodopsin into metarhodopsin II. The latter causes activation of TDN. Upon TDN activation the <scene name='59/590984/Cv/4'>GDP bound to its α subunit</scene> is exchanged for the GTP from the cytoplasm. Deactivation of TDN occurs when the GTP bound to the α subunit is hydrolyzed to GDP. Phosducin binds to the βγ subunit of TDN preventing its re-association with the α subunit.		'''Transducin''' (TDN) or '''Heterotrimeric G protein''' or '''Guanine nucleotide-binding protein G''' is a <scene name='59/590984/Cv/5'>heterotrimeric G protein containing 3 chains: α, β and γ</scene> which are organized in two subunits: α and βγ<ref>PMID:2534964</ref>. TDN is involved in phototransduction. The absorption of a photon by retinal causes a change in the conformation of rhodopsin into metarhodopsin II. The latter causes activation of TDN. Upon TDN activation the <scene name='59/590984/Cv/6'>GDP bound to its α subunit</scene> is exchanged for the GTP from the cytoplasm. Deactivation of TDN occurs when the GTP bound to the α subunit is hydrolyzed to GDP. Phosducin binds to the βγ subunit of TDN preventing its re-association with the α subunit.

	== Disease ==		== Disease ==

Michal Harel at 22:02, 26 September 2018

2018-09-26T22:02:35Z

← Older revision		Revision as of 22:02, 26 September 2018
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	<StructureSection load='' size='~~400~~' side='right' caption='Structure of rat transducin α (deepskyblue), β (green) and γ (gold) subunits complex with GDP (PDB code [[1gp2]]).' scene='59/590984/Cv/1' pspeed='8'>		<StructureSection load='' size='350' side='right' caption='Structure of rat transducin α (deepskyblue), β (green) and γ (gold) subunits complex with GDP (PDB code [[1gp2]]).' scene='59/590984/Cv/1' pspeed='8'>

Joel L. Sussman at 05:07, 16 October 2017

2017-10-16T05:07:56Z

← Older revision		Revision as of 05:07, 16 October 2017
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	<StructureSection load='~~1gp2~~' size='400' side='right' caption='Structure of rat transducin α (deepskyblue), β (green) and γ (gold) subunits complex with GDP (PDB code [[1gp2]]).' scene='59/590984/Cv/1' pspeed='8'>		<StructureSection load='' size='400' side='right' caption='Structure of rat transducin α (deepskyblue), β (green) and γ (gold) subunits complex with GDP (PDB code [[1gp2]]).' scene='59/590984/Cv/1' pspeed='8'>

Michal Harel at 17:26, 11 October 2017

2017-10-11T17:26:06Z

← Older revision		Revision as of 17:26, 11 October 2017
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	**[[3v5w]] – bTDN (mutant) + G-protein coupled receptor kinase 2<br />		**[[3v5w]] – bTDN (mutant) + G-protein coupled receptor kinase 2<br />
	**[[3psc]], [[3pvu]], [[3pvw]], [[4mk0]] – bTDN + β-adrenergic receptor kinase 1<br />		**[[3psc]], [[3pvu]], [[3pvw]], [[4mk0]] – bTDN + β-adrenergic receptor kinase 1<br />
	**[[5he0]], [[5he1]], [[5he2]], [[5he3]] – hTDN + β-adrenergic receptor kinase 1 + inhibitor<br />		**[[5he0]], [[5he1]], [[5he2]], [[5he3]], [[5ukk]], [[5ukl]], [[5ukm]] – hTDN + β-adrenergic receptor kinase 1 + inhibitor<br />
	**[[4pnk]] – TDN hβ + bγ (mutant)+ β-adrenergic receptor kinase 1 + inhibitor<br />		**[[4pnk]] – TDN hβ + bγ (mutant)+ β-adrenergic receptor kinase 1 + inhibitor<br />
	**[[2bcj]] – bTDN (mutant) + β-adrenergic receptor kinase 1<br />		**[[2bcj]] – bTDN (mutant) + β-adrenergic receptor kinase 1<br />
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	**[[3sn6]] – TDN bα (mutant) + rβ (mutant) +bγ + endolysine + antibody fragment<br />		**[[3sn6]] – TDN bα (mutant) + rβ (mutant) +bγ + endolysine + antibody fragment<br />
	**[[5tdh]] – TDN hα (mutant) + rβ + bγ + GDP<br />		**[[5tdh]] – TDN hα (mutant) + rβ + bγ + GDP<br />
			**[[5uz7]] – hTDN + calcitonin receptor + antibody fragment - Cryo EM<br />
			**[[5vai]] – TDN hα + rβ + bγ+ glucagon-like peptide + antibody fragment - Cryo EM<br />
	}}		}}
	== References ==		== References ==

Alexander Berchansky at 08:31, 2 July 2017

2017-07-02T08:31:27Z

← Older revision		Revision as of 08:31, 2 July 2017
Line 4:		Line 4:
	== Function ==		== Function ==

	'''Transducin''' (TDN) or '''Heterotrimeric G protein''' or '''Guanine nucleotide-binding protein G''' is a <scene name='59/590984/Cv/2'>heterotrimeric G protein containing 3 chains: α, β and γ</scene> which are organized in two subunits: α and βγ<ref>PMID:2534964</ref>. TDN is involved in phototransduction. The absorption of a photon by retinal causes a change in the conformation of rhodopsin into metarhodopsin II. The latter causes activation of TDN. Upon TDN activation the GDP bound to its α subunit is exchanged for the GTP from the cytoplasm. Deactivation of TDN occurs when the GTP bound to the α subunit is hydrolyzed to GDP. Phosducin binds to the βγ subunit of TDN preventing its re-association with the α subunit.		'''Transducin''' (TDN) or '''Heterotrimeric G protein''' or '''Guanine nucleotide-binding protein G''' is a <scene name='59/590984/Cv/2'>heterotrimeric G protein containing 3 chains: α, β and γ</scene> which are organized in two subunits: α and βγ<ref>PMID:2534964</ref>. TDN is involved in phototransduction. The absorption of a photon by retinal causes a change in the conformation of rhodopsin into metarhodopsin II. The latter causes activation of TDN. Upon TDN activation the <scene name='59/590984/Cv/4'>GDP bound to its α subunit</scene> is exchanged for the GTP from the cytoplasm. Deactivation of TDN occurs when the GTP bound to the α subunit is hydrolyzed to GDP. Phosducin binds to the βγ subunit of TDN preventing its re-association with the α subunit.

	== Disease ==		== Disease ==