Transferrin - Revision history

Michal Harel at 08:37, 5 March 2020

2020-03-05T08:37:32Z

@@ Line 15: / Line 15: @@
 </StructureSection>
 == References ==
 <references/>
 [[Category:Topic Page]]

Michal Harel at 08:36, 5 March 2020

2020-03-05T08:36:41Z

← Older revision		Revision as of 08:36, 5 March 2020
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	*<scene name='48/480879/Cv/8'>N-lobe Fe coordination site</scene>.		*<scene name='48/480879/Cv/8'>N-lobe Fe coordination site</scene>.
	*<scene name='48/480879/Cv/9'>C-lobe Fe coordination site</scene>.		*<scene name='48/480879/Cv/9'>C-lobe Fe coordination site</scene>.
			== 3D Structures of Transferrin ==
			[[Transferrin 3D structures]]

	</StructureSection>		</StructureSection>
	== 3D Structures of Transferrin ==		== 3D Structures of Transferrin ==
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	*Transferrin		*Transferrin

	**[[3qyt]], [[3v83]], [[4x1b]] – hTF + Fe+3 - human<br />		**[[3qyt]], [[3v83]], [[4x1b]], [[6jas]], [[6ctc]] – hTF + Fe+3 - human<br />
	**[[4x1d]] – hTF + Yb+3 <br />		**[[4x1d]] – hTF + Yb+3 <br />
	**[[5dyh]], [[5h52]] – hTF + Ti+4 <br />		**[[5dyh]], [[5h52]] – hTF + Ti+4 <br />
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	**[[5x5p]], [[5wtd]] – hTF + Fe+3 + Ru+3<br />		**[[5x5p]], [[5wtd]] – hTF + Fe+3 + Ru+3<br />
	**[[5y6k]] – hTF + Fe+3 + probe<br />		**[[5y6k]] – hTF + Fe+3 + probe<br />
	**[[1suv]] – hTF + TF receptor <br />		**[[1suv]], [[6soy]], [[6soz]] – hTF + TF receptor <br />
	**[[3s9l]], [[3s9m]], [[3s9n]] - hTF (mutant) + TF receptor<br />		**[[3s9l]], [[3s9m]], [[3s9n]] - hTF (mutant) + TF receptor<br />
			**[[1h76]] – TF + Fe+3 - pig<br />
			**[[1tfd]] – rTF + Fe+3 - rabbit<br />
	**[[6d03]], [[6d04]], [[6d05]] – TF + TF receptor - ''Pasmodium vivax'' - Cryo EM<br />		**[[6d03]], [[6d04]], [[6d05]] – TF + TF receptor - ''Pasmodium vivax'' - Cryo EM<br />

	*Transferrin N lobe		*Transferrin N lobe

	**[[1tfd]] – rTF N terminal - rabbit<br />
	**[[1a8e]], [[1a8f]], [[1b3e]], [[1n84]] - hTF N terminal<br />		**[[1a8e]], [[1a8f]], [[1b3e]], [[1n84]] - hTF N terminal<br />
	**[[1dtg]], [[1d3k]], [[1d4n]], [[1fqe]], [[1fqf]], [[1jqf]], [[1n7w]], [[1n7x]], [[1oqg]], [[1oqh]], [[2o7u]], [[2o84]], [[3fgs]] - hTF N terminal (mutant)<br />		**[[1dtg]], [[1d3k]], [[1d4n]], [[1fqe]], [[1fqf]], [[1jqf]], [[1n7w]], [[1n7x]], [[1oqg]], [[1oqh]], [[2o7u]], [[2o84]], [[3fgs]] - hTF N terminal (mutant)<br />
	**[[1ryo]] - hTF N terminal + oxalate		**[[1ryo]] - hTF N terminal + oxalate
			**[[1tfd]] – rTF N terminal <br />

	*Transferrin C lobe		*Transferrin C lobe
Line 44:		Line 49:
	**[[1bp5]], [[1btj]] - hTF N terminal<br />		**[[1bp5]], [[1btj]] - hTF N terminal<br />
	**[[2hau]], [[2hav]] – hTF (mutant)<br />		**[[2hau]], [[2hav]] – hTF (mutant)<br />
	**[[1jnf]] – rTF <br />
	**[[1h76]] – TF - pig

	*Ovotransferrin		*Ovotransferrin
Line 61:		Line 64:
	*Apo ovotransferrin		*Apo ovotransferrin

			**[[1lfc]] – OTF residues 17-41 – bovine - NMR<br />
	**[[1aov]] – dOTF<br />		**[[1aov]] – dOTF<br />
	**[[1aiv]], [[1ryx]]– cOTF<br />		**[[1aiv]], [[1ryx]]– cOTF<br />
	**[[1tfa]] - cOTF N terminal<br />		**[[1tfa]] - cOTF N terminal<br />
	**[[1iq7]] - cOTF C terminal<br />		**[[1iq7]] - cOTF C terminal<br />
	**[[1lfc]] – OTF residues 17-41 – bovine - NMR
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Alexander Berchansky at 12:40, 25 September 2019

2019-09-25T12:40:09Z

← Older revision		Revision as of 12:40, 25 September 2019
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	== Structural highlights ==		== Structural highlights ==

	TF contains <scene name='48/480879/Cv/2'>two lobes</scene>: at the N and C termini. The Fe+3 ion is coordinated to several side chains belonging to both N- and C-lobe, carbonate and sulfate ions<ref>PMID:23256035</ref>.		TF contains <scene name='48/480879/Cv/7'>two lobes</scene>: at the N and C termini. The Fe+3 ion is coordinated to several side chains belonging to both N- and C-lobe, carbonate and sulfate ions<ref>PMID:23256035</ref>.
	*<scene name='48/480879/Cv/5'>N-lobe Fe coordination</scene>.		*<scene name='48/480879/Cv/8'>N-lobe Fe coordination site</scene>.
	*<scene name='48/480879/Cv/6'>C-lobe Fe coordination</scene>.		*<scene name='48/480879/Cv/9'>C-lobe Fe coordination site</scene>.
	</StructureSection>		</StructureSection>
	== 3D Structures of Transferrin ==		== 3D Structures of Transferrin ==

Michal Harel at 22:18, 26 September 2018

2018-09-26T22:18:00Z

← Older revision		Revision as of 22:18, 26 September 2018
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	<StructureSection load='' size='~~400~~' side='right' caption='Glycosylated human transferrin with Fe+3 (light red), carbonate and sulfate (PDB code [[3qyt]]).' scene='48/480879/Cv/1' pspeed='8'>		<StructureSection load='' size='350' side='right' caption='Glycosylated human transferrin with Fe+3 (light red), carbonate and sulfate (PDB code [[3qyt]]).' scene='48/480879/Cv/1' pspeed='8'>
	== Function ==		== Function ==
	'''Transferrin''' or '''serotransferrin''' (TF) is an iron-binding protein. TF delivers iron from absorption centers in the duodendum and white blood cell macrophages to all tissues<ref>PMID:2208733</ref>. '''Ovotransferrin''' (OTF) is a glycosylated TF of egg white. For details see [[Molecular Playground/Transferrin]].		'''Transferrin''' or '''serotransferrin''' (TF) is an iron-binding protein. TF delivers iron from absorption centers in the duodendum and white blood cell macrophages to all tissues<ref>PMID:2208733</ref>. '''Ovotransferrin''' (OTF) is a glycosylated TF of egg white. For details see [[Molecular Playground/Transferrin]].
Line 21:		Line 21:
	**[[3qyt]], [[3v83]], [[4x1b]] – hTF + Fe+3 - human<br />		**[[3qyt]], [[3v83]], [[4x1b]] – hTF + Fe+3 - human<br />
	**[[4x1d]] – hTF + Yb+3 <br />		**[[4x1d]] – hTF + Yb+3 <br />
	**[[5dyh]] – hTF + Ti+4 <br />		**[[5dyh]], [[5h52]] – hTF + Ti+4 <br />
	**[[4h0w]] – hTF + Fe+3 + Bi+3<br />		**[[4h0w]] – hTF + Fe+3 + Bi+3<br />
			**[[5x5p]], [[5wtd]] – hTF + Fe+3 + Ru+3<br />
			**[[5y6k]] – hTF + Fe+3 + probe<br />
	**[[1suv]] – hTF + TF receptor <br />		**[[1suv]] – hTF + TF receptor <br />
	**[[3s9l]], [[3s9m]], [[3s9n]] - hTF (mutant) + TF receptor<br />		**[[3s9l]], [[3s9m]], [[3s9n]] - hTF (mutant) + TF receptor<br />
			**[[6d03]], [[6d04]], [[6d05]] – TF + TF receptor - ''Pasmodium vivax'' - Cryo EM<br />

	*Transferrin N lobe		*Transferrin N lobe

Joel L. Sussman at 05:06, 16 October 2017

2017-10-16T05:06:13Z

← Older revision		Revision as of 05:06, 16 October 2017
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	<StructureSection load='~~3qyt~~' size='400' side='right' caption='Glycosylated human transferrin with Fe+3 (light red), carbonate and sulfate (PDB code [[3qyt]]).' scene='48/480879/Cv/1' pspeed='8'>		<StructureSection load='' size='400' side='right' caption='Glycosylated human transferrin with Fe+3 (light red), carbonate and sulfate (PDB code [[3qyt]]).' scene='48/480879/Cv/1' pspeed='8'>
	== Function ==		== Function ==
	'''Transferrin''' or '''serotransferrin''' (TF) is an iron-binding protein. TF delivers iron from absorption centers in the duodendum and white blood cell macrophages to all tissues<ref>PMID:2208733</ref>. '''Ovotransferrin''' (OTF) is a glycosylated TF of egg white. For details see [[Molecular Playground/Transferrin]].		'''Transferrin''' or '''serotransferrin''' (TF) is an iron-binding protein. TF delivers iron from absorption centers in the duodendum and white blood cell macrophages to all tissues<ref>PMID:2208733</ref>. '''Ovotransferrin''' (OTF) is a glycosylated TF of egg white. For details see [[Molecular Playground/Transferrin]].

Michal Harel at 17:35, 11 October 2017

2017-10-11T17:35:10Z

← Older revision		Revision as of 17:35, 11 October 2017
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	*Transferrin		*Transferrin

	**[[1jnf]] – rTF - rabbit<br />
	**[[3qyt]], [[3v83]], [[4x1b]] – hTF + Fe+3 - human<br />		**[[3qyt]], [[3v83]], [[4x1b]] – hTF + Fe+3 - human<br />
	**[[4x1d]] – hTF + Yb+3 <br />		**[[4x1d]] – hTF + Yb+3 <br />
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	**[[1suv]] – hTF + TF receptor <br />		**[[1suv]] – hTF + TF receptor <br />
	**[[3s9l]], [[3s9m]], [[3s9n]] - hTF (mutant) + TF receptor<br />		**[[3s9l]], [[3s9m]], [[3s9n]] - hTF (mutant) + TF receptor<br />
	**[[1h76]] – TF - pig

	*Transferrin N lobe		*Transferrin N lobe

	**[[1tfd]] – rTF N terminal<br />		**[[1tfd]] – rTF N terminal - rabbit<br />
	**[[1a8e]], [[1a8f]], [[1b3e]], [[1n84]] - hTF N terminal<br />		**[[1a8e]], [[1a8f]], [[1b3e]], [[1n84]] - hTF N terminal<br />
	**[[1dtg]], [[1d3k]], [[1d4n]], [[1fqe]], [[1fqf]], [[1jqf]], [[1n7w]], [[1n7x]], [[1oqg]], [[1oqh]], [[2o7u]], [[2o84]], [[3fgs]] - hTF N terminal (mutant)<br />		**[[1dtg]], [[1d3k]], [[1d4n]], [[1fqe]], [[1fqf]], [[1jqf]], [[1n7w]], [[1n7x]], [[1oqg]], [[1oqh]], [[2o7u]], [[2o84]], [[3fgs]] - hTF N terminal (mutant)<br />
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	**[[1bp5]], [[1btj]] - hTF N terminal<br />		**[[1bp5]], [[1btj]] - hTF N terminal<br />
	**[[2hau]], [[2hav]] – hTF (mutant)		**[[2hau]], [[2hav]] – hTF (mutant)<br />
			**[[1jnf]] – rTF <br />
			**[[1h76]] – TF - pig

	*Ovotransferrin		*Ovotransferrin

Alexander Berchansky at 10:12, 20 April 2017

2017-04-20T10:12:45Z

← Older revision		Revision as of 10:12, 20 April 2017
Line 10:		Line 10:
	TF contains <scene name='48/480879/Cv/2'>two lobes</scene>: at the N and C termini. The Fe+3 ion is coordinated to several side chains belonging to both N- and C-lobe, carbonate and sulfate ions<ref>PMID:23256035</ref>.		TF contains <scene name='48/480879/Cv/2'>two lobes</scene>: at the N and C termini. The Fe+3 ion is coordinated to several side chains belonging to both N- and C-lobe, carbonate and sulfate ions<ref>PMID:23256035</ref>.
	*<scene name='48/480879/Cv/5'>N-lobe Fe coordination</scene>.		*<scene name='48/480879/Cv/5'>N-lobe Fe coordination</scene>.
			*<scene name='48/480879/Cv/6'>C-lobe Fe coordination</scene>.
	</StructureSection>		</StructureSection>
	== 3D Structures of Transferrin ==		== 3D Structures of Transferrin ==

Alexander Berchansky at 10:02, 20 April 2017

2017-04-20T10:02:38Z

← Older revision		Revision as of 10:02, 20 April 2017
Line 9:		Line 9:

	TF contains <scene name='48/480879/Cv/2'>two lobes</scene>: at the N and C termini. The Fe+3 ion is coordinated to several side chains belonging to both N- and C-lobe, carbonate and sulfate ions<ref>PMID:23256035</ref>.		TF contains <scene name='48/480879/Cv/2'>two lobes</scene>: at the N and C termini. The Fe+3 ion is coordinated to several side chains belonging to both N- and C-lobe, carbonate and sulfate ions<ref>PMID:23256035</ref>.
			*<scene name='48/480879/Cv/5'>N-lobe Fe coordination</scene>.
	</StructureSection>		</StructureSection>
	== 3D Structures of Transferrin ==		== 3D Structures of Transferrin ==

Alexander Berchansky at 09:45, 20 April 2017

2017-04-20T09:45:53Z

← Older revision		Revision as of 09:45, 20 April 2017
Line 8:		Line 8:
	== Structural highlights ==		== Structural highlights ==

	TF contains two lobes: at the N and C termini. The Fe+3 ion is coordinated to several side chains belonging to both N- and C-lobe, carbonate and sulfate ions<ref>PMID:23256035</ref>.		TF contains <scene name='48/480879/Cv/2'>two lobes</scene>: at the N and C termini. The Fe+3 ion is coordinated to several side chains belonging to both N- and C-lobe, carbonate and sulfate ions<ref>PMID:23256035</ref>.
	</StructureSection>		</StructureSection>
	== 3D Structures of Transferrin ==		== 3D Structures of Transferrin ==

Alexander Berchansky at 09:41, 20 April 2017

2017-04-20T09:41:42Z

← Older revision		Revision as of 09:41, 20 April 2017
Line 1:		Line 1:
	<StructureSection load='3qyt' size='400' side='right' caption='Glycosylated human transferrin with Fe+3 (light red), carbonate and sulfate (PDB code [[3qyt]]).' scene=''>		<StructureSection load='3qyt' size='400' side='right' caption='Glycosylated human transferrin with Fe+3 (light red), carbonate and sulfate (PDB code [[3qyt]]).' scene='48/480879/Cv/1' pspeed='8'>
	== Function ==		== Function ==
	'''Transferrin''' or '''serotransferrin''' (TF) is an iron-binding protein. TF delivers iron from absorption centers in the duodendum and white blood cell macrophages to all tissues<ref>PMID:2208733</ref>. '''Ovotransferrin''' (OTF) is a glycosylated TF of egg white. For details see [[Molecular Playground/Transferrin]].		'''Transferrin''' or '''serotransferrin''' (TF) is an iron-binding protein. TF delivers iron from absorption centers in the duodendum and white blood cell macrophages to all tissues<ref>PMID:2208733</ref>. '''Ovotransferrin''' (OTF) is a glycosylated TF of egg white. For details see [[Molecular Playground/Transferrin]].