UvrABC - Revision history

Michal Harel at 07:52, 17 March 2024

2024-03-17T07:52:52Z

@@ Line 11: / Line 11: @@
 == Structural highlights ==
 UvrA contains several domains: <scene name='53/536710/Cv/2'>UvrB-binding, DNA-binding and two ATP-binding domains</scene><ref>PMID:21240268</ref>.
 ==3D structures of UvrABC==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+[[UvrABC 3D structures]]
 ==References==
 <references />
 [[Category:Topic Page]]

Michal Harel at 09:39, 21 June 2022

2022-06-21T09:39:15Z

← Older revision		Revision as of 09:39, 21 June 2022
Line 31:		Line 31:
	*UvrB		*UvrB

	**[[1d2m]], [[1c4o]] – ~~UvrB~~ – ''Thermus thermophilus'' <br />		**[[1d2m]], [[1c4o]] – TtUvrB – ''Thermus thermophilus'' <br />
	**[[1d9x]] – BcUvrB – ''Bacillus caldotenax'' <br />		**[[1d9x]] – BcUvrB – ''Bacillus caldotenax'' <br />
	**[[1t5l]] – BcUvrB (mutant) <br />		**[[1t5l]] – BcUvrB (mutant) <br />
Line 57:		Line 57:
	**[[3fpn]] – BstUvrA + UvrB <br />		**[[3fpn]] – BstUvrA + UvrB <br />
	**[[3uwx]] – GeUvrA + UvrB <br />		**[[3uwx]] – GeUvrA + UvrB <br />

			*UvrB-UvrD

			**[[7egt]] – TtUvrB N-terminal + UvrD C-terminal <br />
	}}		}}
	==References==		==References==
	<references />		<references />
	[[Category:Topic Page]]		[[Category:Topic Page]]

Alexander Berchansky at 12:06, 13 January 2022

2022-01-13T12:06:11Z

← Older revision		Revision as of 12:06, 13 January 2022
Line 1:		Line 1:
	<StructureSection load='3pih' size='340' side='right' caption='UvrA complex with DNA, pyrophosphate and Zn+2 ion (grey) [[3pih]]' scene='' >		<StructureSection load='3pih' size='340' side='right' caption='UvrA complex with DNA, pyrophosphate and Zn+2 ion (grey) [[3pih]]' scene='53/536710/Cv/3' >
	== Function ==		== Function ==
	'''UvrABC''' endonuclease is an ''E. coli'' enzyme complex involved in DNA repair. UvrABC removes 12 nucleotides around a DNA mutation replacing them with the correct one<ref>PMID:11004168</ref>.<br />		'''UvrABC''' endonuclease is an ''E. coli'' enzyme complex involved in DNA repair. UvrABC removes 12 nucleotides around a DNA mutation replacing them with the correct one<ref>PMID:11004168</ref>.<br />

Alexander Berchansky at 11:58, 13 January 2022

2022-01-13T11:58:55Z

← Older revision		Revision as of 11:58, 13 January 2022
Line 1:		Line 1:
	<StructureSection load='3pih' size='~~350~~' side='right' caption='UvrA complex with DNA, pyrophosphate and Zn+2 ion (grey) [[3pih]]' scene='' >		<StructureSection load='3pih' size='340' side='right' caption='UvrA complex with DNA, pyrophosphate and Zn+2 ion (grey) [[3pih]]' scene='' >
	== Function ==		== Function ==
	'''UvrABC''' endonuclease is an ''E. coli'' enzyme complex involved in DNA repair. UvrABC removes 12 nucleotides around a DNA mutation replacing them with the correct one<ref>PMID:11004168</ref>.<br />		'''UvrABC''' endonuclease is an ''E. coli'' enzyme complex involved in DNA repair. UvrABC removes 12 nucleotides around a DNA mutation replacing them with the correct one<ref>PMID:11004168</ref>.<br />
Line 11:		Line 11:
	== Structural highlights ==		== Structural highlights ==
	UvrA contains several domains: <scene name='53/536710/Cv/2'>UvrB-binding, DNA-binding and two ATP-binding domains</scene><ref>PMID:21240268</ref>.		UvrA contains several domains: <scene name='53/536710/Cv/2'>UvrB-binding, DNA-binding and two ATP-binding domains</scene><ref>PMID:21240268</ref>.

	</StructureSection>		</StructureSection>

	==3D structures of UvrABC==		==3D structures of UvrABC==

Alexander Berchansky at 11:57, 13 January 2022

2022-01-13T11:57:58Z

← Older revision		Revision as of 11:57, 13 January 2022
Line 1:		Line 1:
	<StructureSection load='3pih' size='3		<StructureSection load='3pih' size='350' side='right' caption='UvrA complex with DNA, pyrophosphate and Zn+2 ion (grey) [[3pih]]' scene='' >
	50' side='right' caption='UvrA complex with DNA, pyrophosphate and Zn+2 ion (grey) [[3pih]]' scene='' >
	== Function ==		== Function ==
	'''UvrABC''' endonuclease is an ''E. coli'' enzyme complex involved in DNA repair. UvrABC removes 12 nucleotides around a DNA mutation replacing them with the correct one<ref>PMID:11004168</ref>.<br />		'''UvrABC''' endonuclease is an ''E. coli'' enzyme complex involved in DNA repair. UvrABC removes 12 nucleotides around a DNA mutation replacing them with the correct one<ref>PMID:11004168</ref>.<br />

Michal Harel at 09:13, 24 March 2020

2020-03-24T09:13:53Z

← Older revision		Revision as of 09:13, 24 March 2020
Line 21:		Line 21:

	**[[3pih]] – TmUvrA + DNA – ''Thermotoga maritima'' <br />		**[[3pih]] – TmUvrA + DNA – ''Thermotoga maritima'' <br />
			**[[6n9l]] - TmUvrA (mutant) + ADP<br />
	**[[3zqj]] – UvrA – ''Mycobacterium tuberculosis''<br />		**[[3zqj]] – UvrA – ''Mycobacterium tuberculosis''<br />
	**[[4dfc]] – EcUvrA + Transcription-repair-coupling factor – ''Escherichia coli'' <br />		**[[4dfc]] – EcUvrA + Transcription-repair-coupling factor – ''Escherichia coli'' <br />
Line 35:		Line 36:
	**[[1e52]] – EcUvrB C terminal - NMR<br />		**[[1e52]] – EcUvrB C terminal - NMR<br />
	**[[1d9z]] – BcUvrB + ATP <br />		**[[1d9z]] – BcUvrB + ATP <br />
	**[[2fdc]] – BcUvrB + DNA <br />		**[[2fdc]], [[6o8f]], [[6o8g]], [[6o8h]] – BcUvrB + DNA <br />
			**[[6o8e]] – BcUvrB + DNA + ADP<br />
	**[[2d7d]], [[2nmv]], [[3v4r]] – BsUvrB + DNA – ''Bacillus subtilis'' <br />		**[[2d7d]], [[2nmv]], [[3v4r]] – BsUvrB + DNA – ''Bacillus subtilis'' <br />

Alexander Berchansky at 12:22, 10 October 2019

2019-10-10T12:22:36Z

← Older revision		Revision as of 12:22, 10 October 2019
Line 11:		Line 11:

	== Structural highlights ==		== Structural highlights ==
	UvrA contains several domains: <scene name='53/536710/Cv/1'>UvrB-binding, DNA-binding and two ATP-binding domains</scene><ref>PMID:21240268</ref>.		UvrA contains several domains: <scene name='53/536710/Cv/2'>UvrB-binding, DNA-binding and two ATP-binding domains</scene><ref>PMID:21240268</ref>.
	</StructureSection>		</StructureSection>
	==3D structures of UvrABC==		==3D structures of UvrABC==

Michal Harel at 18:36, 5 October 2018

2018-10-05T18:36:12Z

← Older revision		Revision as of 18:36, 5 October 2018
Line 1:		Line 1:
	<StructureSection load='3pih' size='~~450~~' side='right' caption='UvrA complex with DNA, pyrophosphate and Zn+2 ion (grey) [[3pih]]' scene='' >		<StructureSection load='3pih' size='3
			50' side='right' caption='UvrA complex with DNA, pyrophosphate and Zn+2 ion (grey) [[3pih]]' scene='' >
	== Function ==		== Function ==
	'''UvrABC''' endonuclease is an ''E. coli'' enzyme complex involved in DNA repair. UvrABC removes 12 nucleotides around a DNA mutation replacing them with the correct one<ref>PMID:11004168</ref>.<br />		'''UvrABC''' endonuclease is an ''E. coli'' enzyme complex involved in DNA repair. UvrABC removes 12 nucleotides around a DNA mutation replacing them with the correct one<ref>PMID:11004168</ref>.<br />
	* '''UvrA''' is the protein which locates the DNA damage.<br />		* '''UvrA''' is the protein which locates the DNA damage<ref>PMID:21240268</ref>.<br />
	* '''UvrB''' is involved in distinguishing damaged from undamaged DNA<ref>PMID:10946234</ref>.<br />		* '''UvrB''' is involved in distinguishing damaged from undamaged DNA<ref>PMID:10946234</ref>.<br />
	* The C-terminal region of '''UvrC''' is involved in DNA binding and incisions at the 5'-side of a DNA damage during nucleotide excision repair<ref>PMID:9421501</ref>.		* The C-terminal region of '''UvrC''' is involved in DNA binding and incisions at the 5'-side of a DNA damage during nucleotide excision repair<ref>PMID:9421501</ref>.

Michal Harel at 22:07, 13 October 2017

2017-10-13T22:07:35Z

← Older revision		Revision as of 22:07, 13 October 2017
Line 47:		Line 47:
	**[[3c65]] – BstUvrC <br />		**[[3c65]] – BstUvrC <br />

	*UvrD or DNA helicase II		*UvrD or DNA helicase II see [[Helicase]]

	**[[~~3lfu~~]] ~~– EcUvrD <br />~~
	**[[2is1]], [[2is2]] – EcUvrD (mutant) + DNA<br />
	**[[2is4]] – EcUvrD (mutant) + DNA + ADPNP<br />
	**[[2is6]] – EcUvrD (mutant) + DNA + ADP<br />
	**[[4c2u]] – DrUvrD + DNA<br />
	**[[4c30]] – DrUvrD + DNA + ADPNP<br />
	**[[4c2t]] – DrUvrD (mutant) + DNA + ADPNP<br />

	*UvrA-UvrB		*UvrA-UvrB

Michal Harel at 22:06, 13 October 2017

2017-10-13T22:06:21Z

← Older revision		Revision as of 22:06, 13 October 2017
Line 24:		Line 24:
	**[[2r6f]] – BstUvrA – ''Bacillus stearothermophilus'' <br />		**[[2r6f]] – BstUvrA – ''Bacillus stearothermophilus'' <br />
	**[[3ux8]] – GeUvrA - ''Geobacillus''<br />		**[[3ux8]] – GeUvrA - ''Geobacillus''<br />
			**[[2vf7]], [[2vf8]] – DrUvrA2 - ''Deinococcus radiodurans''<br />

	*UvrB		*UvrB
Line 38:		Line 39:
	*UvrC		*UvrC

	**[[1kft]] – EcUvrC C terminal <br />		**[[1kft]], [[1qoj]] – EcUvrC C terminal <br />
			**[[1e52]] – EcUvrC C terminal - NMR<br />
	**[[2nrr]], [[2nrt]], [[2nrv]], [[2nrw]], [[2nrx]], [[2nrz]] – TmUvrC C terminal <br />		**[[2nrr]], [[2nrt]], [[2nrv]], [[2nrw]], [[2nrx]], [[2nrz]] – TmUvrC C terminal <br />
	**[[1ycz]], [[1yd0]], [[1yd1]] – TmUvrC N terminal <br />		**[[1ycz]], [[1yd0]], [[1yd1]] – TmUvrC N terminal <br />
Line 44:		Line 46:
	**[[1yd6]] – BcUvrC N terminal <br />		**[[1yd6]] – BcUvrC N terminal <br />
	**[[3c65]] – BstUvrC <br />		**[[3c65]] – BstUvrC <br />

			*UvrD or DNA helicase II

			**[[3lfu]] – EcUvrD <br />
			**[[2is1]], [[2is2]] – EcUvrD (mutant) + DNA<br />
			**[[2is4]] – EcUvrD (mutant) + DNA + ADPNP<br />
			**[[2is6]] – EcUvrD (mutant) + DNA + ADP<br />
			**[[4c2u]] – DrUvrD + DNA<br />
			**[[4c30]] – DrUvrD + DNA + ADPNP<br />
			**[[4c2t]] – DrUvrD (mutant) + DNA + ADPNP<br />

	*UvrA-UvrB		*UvrA-UvrB