WD repeat-containing protein - Revision history

Michal Harel at 07:30, 4 April 2024

2024-04-04T07:30:11Z

← Older revision		Revision as of 07:30, 4 April 2024
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	*'''WD repeat-containing protein 92''' is a modulator of apoptosis. <br />		*'''WD repeat-containing protein 92''' is a modulator of apoptosis. <br />
	*'''WD repeat-containing protein SLP1''' is required for mad2-dependent spindle checkpoint activation. <br />		*'''WD repeat-containing protein SLP1''' is required for mad2-dependent spindle checkpoint activation. <br />
			*'''WD repeat protein CSA''' or '''DNA excision repair protein ERCC-8''' is part of the transcription-coupled repair complex<ref>PMID:32355176</ref>. <br />
	== Disease ==		== Disease ==
	Mutant WDR is involved in triple-A syndrome<ref>PMID:11062474</ref>.		Mutant WDR is involved in triple-A syndrome<ref>PMID:11062474</ref>.

Michal Harel at 11:20, 25 January 2021

2021-01-25T11:20:54Z

← Older revision		Revision as of 11:20, 25 January 2021
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	*'''WD repeat-containing protein 91''' functions as negative regulator of the PI3 kinase/PI3K activity in endosomal transport<ref>PMID:27126989</ref>. <br />		*'''WD repeat-containing protein 91''' functions as negative regulator of the PI3 kinase/PI3K activity in endosomal transport<ref>PMID:27126989</ref>. <br />
	*'''WD repeat-containing protein 92''' is a modulator of apoptosis. <br />		*'''WD repeat-containing protein 92''' is a modulator of apoptosis. <br />
			*'''WD repeat-containing protein SLP1''' is required for mad2-dependent spindle checkpoint activation. <br />
	== Disease ==		== Disease ==
	Mutant WDR is involved in triple-A syndrome<ref>PMID:11062474</ref>.		Mutant WDR is involved in triple-A syndrome<ref>PMID:11062474</ref>.

Michal Harel at 11:18, 25 January 2021

2021-01-25T11:18:29Z

← Older revision		Revision as of 11:18, 25 January 2021
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	*'''WD repeat-containing protein 55''' is a modulator of rRNA synthesis. <br />		*'''WD repeat-containing protein 55''' is a modulator of rRNA synthesis. <br />
	*'''WD repeat-containing protein 61''' is a component of PAF1 complex which functions during RNA transcription. <br />		*'''WD repeat-containing protein 61''' is a component of PAF1 complex which functions during RNA transcription. <br />
	*'''WD repeat-containing protein 91'' functions as negative regulator of the PI3 kinase/PI3K activity in endosomal transport<ref>PMID:27126989</ref>. <br />		*'''WD repeat-containing protein 91''' functions as negative regulator of the PI3 kinase/PI3K activity in endosomal transport<ref>PMID:27126989</ref>. <br />
	*'''WD repeat-containing protein 92''' is a modulator of apoptosis. <br />		*'''WD repeat-containing protein 92''' is a modulator of apoptosis. <br />
	== Disease ==		== Disease ==

Michal Harel at 11:17, 25 January 2021

2021-01-25T11:17:52Z

← Older revision		Revision as of 11:17, 25 January 2021
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	*'''WD repeat-containing protein 41''' is the non-catalytic component of C9orf72-SMCR8 complex which regulates autophagy<ref>PMID:27193190</ref>. <br />		*'''WD repeat-containing protein 41''' is the non-catalytic component of C9orf72-SMCR8 complex which regulates autophagy<ref>PMID:27193190</ref>. <br />
	*'''WD repeat-containing protein 55''' is a modulator of rRNA synthesis. <br />		*'''WD repeat-containing protein 55''' is a modulator of rRNA synthesis. <br />
	*'''WD repeat-~~conta~~		*'''WD repeat-containing protein 61''' is a component of PAF1 complex which functions during RNA transcription. <br />
	~~ining~~ protein 61''' is a component of PAF1 complex which functions during RNA transcription. <br />
	*'''WD repeat-containing protein 91'' functions as negative regulator of the PI3 kinase/PI3K activity in endosomal transport<ref>PMID:27126989</ref>. <br />		*'''WD repeat-containing protein 91'' functions as negative regulator of the PI3 kinase/PI3K activity in endosomal transport<ref>PMID:27126989</ref>. <br />
	*'''WD repeat-containing protein 92''' is a modulator of apoptosis. <br />		*'''WD repeat-containing protein 92''' is a modulator of apoptosis. <br />

Michal Harel at 11:17, 25 January 2021

2021-01-25T11:17:16Z

← Older revision		Revision as of 11:17, 25 January 2021
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	*'''WD repeat-containing protein 41''' is the non-catalytic component of C9orf72-SMCR8 complex which regulates autophagy<ref>PMID:27193190</ref>. <br />		*'''WD repeat-containing protein 41''' is the non-catalytic component of C9orf72-SMCR8 complex which regulates autophagy<ref>PMID:27193190</ref>. <br />
			*'''WD repeat-containing protein 55''' is a modulator of rRNA synthesis. <br />
			*'''WD repeat-conta
			ining protein 61''' is a component of PAF1 complex which functions during RNA transcription. <br />
			*'''WD repeat-containing protein 91'' functions as negative regulator of the PI3 kinase/PI3K activity in endosomal transport<ref>PMID:27126989</ref>. <br />
			*'''WD repeat-containing protein 92''' is a modulator of apoptosis. <br />
	== Disease ==		== Disease ==
	Mutant WDR is involved in triple-A syndrome<ref>PMID:11062474</ref>.		Mutant WDR is involved in triple-A syndrome<ref>PMID:11062474</ref>.

Michal Harel at 11:03, 25 January 2021

2021-01-25T11:03:58Z

← Older revision		Revision as of 11:03, 25 January 2021
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	*'''WD repeat-containing protein 48 and 20''' act as regulators of deubiquinating complexes.		*'''WD repeat-containing protein 48 and 20''' act as regulators of deubiquinating complexes.

			*'''WD repeat-containing protein 41''' is the non-catalytic component of C9orf72-SMCR8 complex which regulates autophagy<ref>PMID:27193190</ref>. <br />
	== Disease ==		== Disease ==
	Mutant WDR is involved in triple-A syndrome<ref>PMID:11062474</ref>.		Mutant WDR is involved in triple-A syndrome<ref>PMID:11062474</ref>.

Michal Harel at 09:43, 28 March 2020

2020-03-28T09:43:41Z

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 </StructureSection>
 == References ==
 <references/>
 [[Category:Topic Page]]

Michal Harel at 09:42, 28 March 2020

2020-03-28T09:42:32Z

← Older revision		Revision as of 09:42, 28 March 2020
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	== Structural highlights ==		== Structural highlights ==
	The <scene name='70/709459/Cv/4'>histone Arg2 residue inserts into the central pore</scene> of the WDR5 β-propellor structure acting like an anchoring pin <scene name='70/709459/Cv/3'>forming numerous hydrogen bonds and cation-π interactions</scene><ref>PMID:16946699</ref>. Water molecules are shown as red spheres.		The <scene name='70/709459/Cv/4'>histone Arg2 residue inserts into the central pore</scene> of the WDR5 β-propellor structure acting like an anchoring pin <scene name='70/709459/Cv/3'>forming numerous hydrogen bonds and cation-π interactions</scene><ref>PMID:16946699</ref>. Water molecules are shown as red spheres.
			== 3D Structures of WD-repeat protein ==
			[[WD-repeat protein 3D structures]]
	</StructureSection>		</StructureSection>

Michal Harel at 09:38, 28 March 2020

2020-03-28T09:38:47Z

← Older revision		Revision as of 09:38, 28 March 2020
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	<StructureSection load='' size='340' side='right' caption='Human WD-repeat protein 5 (deepskyblue) complex with histone H3 peptide (magenta) (PDB code [[2h9m]])' scene='70/709459/Cv/1'>		<StructureSection load='' size='340' side='right' caption='Human WD-repeat protein 5 (deepskyblue) complex with histone H3 peptide (magenta) (PDB code [[2h9m]])' scene='70/709459/Cv/1'>
	== Function ==		== Function ==
	'''WD repeat-containing proteins''' (WDR) contain 4 or more repeating WD units. WD repeats are ca. 40 amino acid long usually bordered by Gly-His and Trp-Asp (WD). All WDRs form a β-propeller structure. WDRs have critical roles in many biological functions like signal transduction, transcription regulation and apoptosis<ref>PMID:11814058</ref>. <br />		'''WD repeat-containing proteins''' or '''ribosome biogenesis protein WDR''' (WDR) contain 4 or more repeating WD units. WD repeats are ca. 40 amino acid long usually bordered by Gly-His and Trp-Asp (WD). All WDRs form a β-propeller structure. WDRs have critical roles in many biological functions like signal transduction, transcription regulation and apoptosis<ref>PMID:11814058</ref>. <br />
	*'''WD-repeat protein 5''' (WDR5) contains 7 WD repeats. WDR5 contributes to histone modification. It may position the N-terminal of histone H3 for efficient methylation at Lys4. This methylation is implicated in the control of activation of cell lineage genes during embryogenesis. WDR5 interacts with histone-lysine N-methyltransferase (MLL)<ref>PMID:21531708</ref>. <br />		*'''WD-repeat protein 5''' (WDR5) contains 7 WD repeats. WDR5 contributes to histone modification. It may position the N-terminal of histone H3 for efficient methylation at Lys4. This methylation is implicated in the control of activation of cell lineage genes during embryogenesis. WDR5 interacts with histone-lysine N-methyltransferase (MLL)<ref>PMID:21531708</ref>. <br />
	*'''WD repeat-containing protein 48 and 20''' act as regulators of deubiquinating complexes.		*'''WD repeat-containing protein 48 and 20''' act as regulators of deubiquinating complexes.
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	**[[3mxx]], [[3n0d]], [[3n0e]] – hWDR5 (mutant)<br />		**[[3mxx]], [[3n0d]], [[3n0e]] – hWDR5 (mutant)<br />
	**[[3smr]], [[3ur4]], [[4ia9]], [[4qqe]], [[4ql1]], [[5eal]], [[5eam]], [[5eap]], [[5ear]] – hWDR5 + piperazine derivative<br />		**[[3smr]], [[3ur4]], [[4ia9]], [[4qqe]], [[4ql1]], [[5eal]], [[5eam]], [[5eap]], [[5ear]] – hWDR5 + piperazine derivative<br />
			**[[6u5m]], [[6u5y]], [[6u6w]], [[6u80]], [[6u8b]], [[6u8l]], [[6u8o]] – hWDR5 + sulfonamide inhibitor<br />
			**[[6ufx]], [[6ucs]], [[6pg3]], [[6pg4]], [[6pg5]], [[6pg6]], [[6pg7]], [[6pg8]], [[6pg9]], [[6pga]], [[6pgb]], [[6pgc]], [[6pgd]], [[6pge]], [[6pgf]], [[5vfc]], [[6dar]], [[6das]], [[6d9x]], [[6dai]], [[6dak]], [[6e1z]], [[6e1y]], [[6e22]], [[6e23]] – hWDR5 + inhibitor<br />
	**[[2cnx]], [[2co0]], [[2h6k]], [[2h6n]], [[2h6q]], [[2h13]], [[2h9m]], [[2h9n]], [[2h9p]], [[2g99]], [[2g9a]], [[2o9k]], [[3psl]], [[4a7j]] – hWDR5 + histone H3 peptide<br />		**[[2cnx]], [[2co0]], [[2h6k]], [[2h6n]], [[2h6q]], [[2h13]], [[2h9m]], [[2h9n]], [[2h9p]], [[2g99]], [[2g9a]], [[2o9k]], [[3psl]], [[4a7j]] – hWDR5 + histone H3 peptide<br />
	**[[5vfc]], [[6dar]], [[6das]], [[6d9x]], [[6dai]], [[6dak]] – hWDR5 + inhibitor<br />
	**[[4gm3]], [[4gm8]], [[4gm9]], [[4gmb]] – hWDR5 + peptide inhibitor<br />		**[[4gm3]], [[4gm8]], [[4gm9]], [[4gmb]] – hWDR5 + peptide inhibitor<br />
	**[[2xl2]], [[2xl3]] – hWDR5 + retinoblastoma-binding protein 5 peptide<br />		**[[2xl2]], [[2xl3]] – hWDR5 + retinoblastoma-binding protein 5 peptide<br />
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	**[[3eg6]], [[3emh]], [[3uvk]], [[3uvl]], [[3uvm]], [[3uvn]], [[3uvo]], [[4erq]], [[4ery]], [[4es0]], [[4esg]], [[4ewr]], [[5sxm]] – hWDR5 + MLL peptide<br />		**[[3eg6]], [[3emh]], [[3uvk]], [[3uvl]], [[3uvm]], [[3uvn]], [[3uvo]], [[4erq]], [[4ery]], [[4es0]], [[4esg]], [[4ewr]], [[5sxm]] – hWDR5 + MLL peptide<br />
	**[[4erz]] – hWDR5 + MLL4<br />		**[[4erz]] – hWDR5 + MLL4<br />
			**[[6kiv]], [[6kiz]], [[6kiu]], [[6kix]] – hWDR5 in MLL1-ubNCP complex - Cryo EM<br />
			**[[6kiw]] – hWDR5 in MLL3-ubNCP complex - Cryo EM<br />
			**[[6pww]], [[6pwv]] – hWDR5 + MLL1 + RbBP5 + histones - Cryo EM<br />
	**[[6byn]] – hWDR5 + monobody<br />		**[[6byn]] – hWDR5 + monobody<br />
	**[[3p4f]] – hWDR5 + retinoblastoma-binding protein 5 peptide + MLL peptide<br />		**[[3p4f]] – hWDR5 + retinoblastoma-binding protein 5 peptide + MLL peptide<br />
			**[[6iam]] – hWDR5 + small ubiquitin-related modifier 5<br />

	*WDR9		*WDR9

	**[[2q2e]] – hWDR9 residues 1310-1430<br />		**[[2q2e]] – hWDR9 residues 1310-1430<br />

			*WDR12

			**[[6p0q]] – hWDR12 UBL domain residues 1-87<br />
			**[[6n31]] – hWDR12 residues 90-422<br />

	*WDR20		*WDR20

	**[[5k19]] – hWDR20<br />		**[[5k19]] – hWDR20<br />

			*WDR33 or pre-mRNA 3' end processing protein WDR33

			**[[6f9n]] – hWDR33 residues 35-410 + CPSF160<br />
			**[[6urg]] – hWDR33 + CPSF160 + CPSF30 + CPSF100 - Cryo EM<br />
			**[[6fbs]], [[6fuw]], [[6uro]] – hWDR33 + CPSF160 + CPSF30 + PAS motif - Cryo EM<br />

	*WDR48		*WDR48
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	**[[5l8w]], [[5cvn]], [[5cvo]] – hWDR48 + ubiquitin + ubiquitin carboxyl-terminal hydrolase<br />		**[[5l8w]], [[5cvn]], [[5cvo]] – hWDR48 + ubiquitin + ubiquitin carboxyl-terminal hydrolase<br />
	**[[5k1a]], [[5k1b]] – hWDR48 + ubiquitin carboxyl-terminal hydrolase<br />		**[[5k1a]], [[5k1b]] – hWDR48 + ubiquitin carboxyl-terminal hydrolase<br />
	**[[5k1c]] – hWDR48 + WDR20 + ubiquitin carboxyl-terminal hydrolase<br />		**[[5k1c]], [[6jlq]] – hWDR48 + WDR20 + ubiquitin carboxyl-terminal hydrolase<br />

			*WDR60

			**[[6rlb]], [[6sc2]] – hWDR60 + WDR34 + dynein + O6-alkylguanine-DNA alkyktransferase - Cryo EM<br />

	*WDR61		*WDR61

	**[[3ow8]] – hWDR61<br />		**[[3ow8]] – hWDR61<br />

			*WDR91

			**[[6vyc]] – hWDR91 residues 392-747<br />

	*WDR92		*WDR92

	**[[~~2q2e~~]] – hWDR92<br />		**[[3i2n]] – hWDR92<br />

	*WDR SLP1		*WDR SLP1

Alexander Berchansky at 12:03, 22 October 2019

2019-10-22T12:03:31Z

← Older revision		Revision as of 12:03, 22 October 2019
Line 9:		Line 9:

	== Structural highlights ==		== Structural highlights ==
	The <scene name='70/709459/Cv/2'>histone Arg2 residue inserts into the central pore</scene> of the WDR5 β-propellor structure acting like an anchoring pin <scene name='70/709459/Cv/3'>forming numerous hydrogen bonds and cation-π interactions</scene><ref>PMID:16946699</ref>.		The <scene name='70/709459/Cv/4'>histone Arg2 residue inserts into the central pore</scene> of the WDR5 β-propellor structure acting like an anchoring pin <scene name='70/709459/Cv/3'>forming numerous hydrogen bonds and cation-π interactions</scene><ref>PMID:16946699</ref>. Water molecules are shown as red spheres.

	</StructureSection>		</StructureSection>