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== Functions ==

IL-6 is a potent polyfunctional [[Wiktionary:cytokine|cytokine]] that plays a vital role in host defense. It is released in response to infection, burns, trauma, and neoplasia<ref>Janeway, et al. 2001. Immunobiology: The Immune System in Health and Disease. New York(NY): Garland Science.</ref>. Its polyfunctional role is demonstrated by the ability to induce responses in the immune system, hematopoietic system, and in acute-phase reactions. In the immune system, IL-6 is an essential factor for antibody production in B cells and acts as a potent growth factor for myeloma cells. IL-6 also acts on the final maturation stage of activated B cells, can be effective on resting T cells, and induces differentiation of cytotoxic T cells. In the hematopoietic system, IL-6 (in combination with Interleukin-3) activates and accelarates the growth of hematopoietic stem cells during the G0 phase causing them to enter the G1 phase. With respect to acute-phase reactions, IL-6 plays a key role in enhancing the innate immune system by inducing the expression of mRNA's for proteins associated with acute-phase reactions. These proteins are resleased into blood plasma by liver cells and protect against tissue damage. Moreover, IL-6 is thought to cross the blood brain barrier and induce synthesis of Prostaglandin E2 (PGE2) in the hypothalmus which changes the body's temperature setpoint resulting in fever (Citation).

IL-6 is a potent polyfunctional [[Wiktionary:cytokine|cytokine]] that plays a vital role in host defense. It is released in response to infection, burns, trauma, and neoplasia<ref>Janeway, et al. 2001. Immunobiology: The Immune System in Health and Disease. New York(NY): Garland Science.</ref>. Its polyfunctional role is demonstrated by the ability to induce responses in the immune system, hematopoietic system, and in acute-phase reactions. In the immune system, IL-6 is an essential factor for antibody production in B cells and acts as a potent growth factor for myeloma cells. IL-6 also acts on the final maturation stage of activated B cells, can be effective on resting T cells, and induces differentiation of cytotoxic T cells. In the hematopoietic system, IL-6 (in combination with Interleukin-3) activates and accelarates the growth of hematopoietic stem cells during the G0 phase causing them to enter the G1 phase of the cell cycle. With respect to acute-phase reactions, IL-6 plays a key role in enhancing the innate immune system by inducing the expression of mRNA's for proteins associated with acute-phase reactions. These proteins are resleased into blood plasma by liver cells and protect against tissue damage. Moreover, IL-6 is thought to cross the blood brain barrier and induce synthesis of Prostaglandin E2 (PGE2) in the hypothalmus which changes the body's temperature setpoint resulting in fever (Citation).

== IL-6 Receptor Complex ==

Sandbox Reserved 162: Difference between revisions

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 == Functions ==
-IL-6 is a potent polyfunctional [[Wiktionary:cytokine|cytokine]] that plays a vital role in host defense. It is released in response to infection, burns, trauma, and neoplasia<ref>Janeway, et al. 2001. Immunobiology: The Immune System in Health and Disease. New York(NY): Garland Science.</ref>. Its polyfunctional role is demonstrated by the ability to induce responses in the immune system, hematopoietic system, and in acute-phase reactions. In the immune system, IL-6 is an essential factor for antibody production in B cells and acts as a potent growth factor for myeloma cells. IL-6 also acts on the final maturation stage of activated B cells, can be effective on resting T cells, and induces differentiation of cytotoxic T cells. In the hematopoietic system, IL-6 (in combination with Interleukin-3) activates and accelarates the growth of hematopoietic stem cells during the G0 phase causing them to enter the G1 phase. With respect to acute-phase reactions, IL-6 plays a key role in enhancing the innate immune system by inducing the expression of mRNA's for proteins associated with acute-phase reactions. These proteins are resleased into blood plasma by liver cells and protect against tissue damage. Moreover, IL-6 is thought to cross the blood brain barrier and induce synthesis of Prostaglandin E2 (PGE2) in the hypothalmus which changes the body's temperature setpoint resulting in fever (Citation).
+IL-6 is a potent polyfunctional [[Wiktionary:cytokine|cytokine]] that plays a vital role in host defense. It is released in response to infection, burns, trauma, and neoplasia<ref>Janeway, et al. 2001. Immunobiology: The Immune System in Health and Disease. New York(NY): Garland Science.</ref>. Its polyfunctional role is demonstrated by the ability to induce responses in the immune system, hematopoietic system, and in acute-phase reactions. In the immune system, IL-6 is an essential factor for antibody production in B cells and acts as a potent growth factor for myeloma cells. IL-6 also acts on the final maturation stage of activated B cells, can be effective on resting T cells, and induces differentiation of cytotoxic T cells. In the hematopoietic system, IL-6 (in combination with Interleukin-3) activates and accelarates the growth of hematopoietic stem cells during the G0 phase causing them to enter the G1 phase of the cell cycle. With respect to acute-phase reactions, IL-6 plays a key role in enhancing the innate immune system by inducing the expression of mRNA's for proteins associated with acute-phase reactions. These proteins are resleased into blood plasma by liver cells and protect against tissue damage. Moreover, IL-6 is thought to cross the blood brain barrier and induce synthesis of Prostaglandin E2 (PGE2) in the hypothalmus which changes the body's temperature setpoint resulting in fever (Citation).
 == IL-6 Receptor Complex ==