Ton: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| (7 intermediate revisions by one other user not shown) | |||
| Line 5: | Line 5: | ||
==Function== | ==Function== | ||
The Ton proteins are involved in the uptake of vitamin B12 and chelated-iron into the cell.<ref>PMID: | The Ton proteins are involved in the uptake of vitamin B12 and chelated-iron into the cell<ref>PMID: 17347522</ref>, and the system as a whole is known to be an energy-transducing system. Each of the three proteins involved have their separate role<ref name='Held'>PMID: 12193634</ref>. For more information, see the respective pages for TonB, ExbB and ExbD. | ||
The Ton system can be exploited by group B Colicins {see [[Colicin]] for more details) which include<ref name="Cascales">PMID: 17347522</ref><ref name='Davies'>PMID: 124727</ref>: | |||
*[[Colicin 5]] | |||
*[[Colicin 6]] | |||
*[[Colicin 7]] | |||
*[[Colicin 8]] | |||
*[[Colicin 9]] | |||
*[[Colicin 10]] | |||
*[[Colicin Ia]] | |||
*[[Colicin Ib]] | |||
*[[Colicin B]] | |||
*[[Colicin D]] | |||
*[[Colicin M]] | |||
*[[Colicin V]] | |||
*[[Colicin Js]] | |||
*[[Colicin Y]] | |||
It is interesting to note that the name 'Ton' comes its resistance to the T1 phage<ref name='Davies'>PMID: 124727</ref>. | |||
==Interaction | ==Interaction of Ton proteins== | ||
Like in the [[Tol]] complex, the Ton system proteins interact with each other<ref>PMID: 9811664</ref>: | |||
# the transmembrane domain of TonB interacts with both ExbB and ExbD, which contribute to the stability of the protein and support the TonB-dependent active transport across the outer membrane. | |||
# ExbB and ExbD interact with each other, which has been suggested to play a part in the mechanism of energy transduction | |||
== | ==3D structures of TonB== | ||
[[TonB]] | |||
== References== | == References== | ||
<references/> | <references/> | ||
