RNA Interference: Difference between revisions

}}

[[RNA Interference]] (RNAi) is a system in living cells that helps control the level of activity of genes. In RNAi, a long double stranded [[RNA]] is cleaved into shorter strands. One strand known as the guide strand is complimentary to the mRNA gene product of a gene of interest. This guide strand is incorporated into an RNA-induced silencing complex (RISC) and subsequently binds the mRNA of the gene of interest. After binding, the RNA/RISC complex subsequently silences the mRNA of interest via cleavage of the mRNA strand.  

[[Image:500px-ShRNA Lentivirus.png|350px|left|thumb| Schematic of RNAi Interference in Mammalian Cells]]

{{Structure

|PDB= 1rpu |SIZE=300|ALIGN='left'|SCENE=User:Wayne_Decatur/Plant_Viral_Protein_p19_Suppression_of_RNA_Silencing/View1/2|CAPTION= viral silencing suppressor bound to a siRNA ([[1rpu]]), resolution 2.50&Aring; (<scene name='User:Wayne_Decatur/Plant_Viral_Protein_p19_Suppression_of_RNA_Silencing/View1/2'>initial scene</scene>)

|RESOURCES=<span class='plainlinks'><!--[http://www-unix.oit.umass.edu/~wdecatur/p19tutorial/ Explorable Tour], Eric Martz felt no one would look here-->[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpu OCA], [http://www.ebi.ac.uk/pdbsum/1rpu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rpu RCSB]</span>

}}

<br />