Sandbox 124: Difference between revisions
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The entire process takes 4 milliseconds. | The entire process takes 4 milliseconds. | ||
==='''How | ==='''How Do Antibiotics Work?'''=== | ||
The β-lactam antibiotics inhibit bacterial growth by inhibiting PBPs and ultimately cell wall | The β-lactam antibiotics inhibit bacterial growth by inhibiting PBPs and ultimately cell wall | ||
synthesis. Specifically, β-lactams are molecular mimics of D-Ala-D-Ala, which is the normal | synthesis. Specifically, β-lactams are molecular mimics of D-Ala-D-Ala, which is the normal | ||
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inhibited by the β-lactam. As a result, the synthesis of the cell wall is inhibited which leads | inhibited by the β-lactam. As a result, the synthesis of the cell wall is inhibited which leads | ||
to cell lysis. | to cell lysis. | ||
[[Image:Structures on penicillin and b lactam.jpg|thumb|alt= Alt text|Figure 3. Mechanism of action of β-lactams. A. Structure of a β-lactam (penicillin) showing the amide, carboxyl, and β-lactam ring groups β-lactam ring groups. B. Structure of the D-Ala-D-Ala substrate. C. Overlay of the D-Ala-D-Ala substrate in red with penicillin demonstrating molecular mimicry.|550 px]] | |||
==='''PBP2a and Ceftobiprole'''=== | ==='''PBP2a and Ceftobiprole'''=== | ||
