CHEM2052 Tutorial Example4: Difference between revisions
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This inhibitor does not just bind to the catalytic residues there are many other amino acids at the active site of the enzyme. First predict possible interaction types you would expect with this structure. Then look at the 2-dimensional "map" of the active site provided on your tutorial sheet and compare this to the 3-dimensional representations here. | This inhibitor does not just bind to the catalytic residues there are many other amino acids at the active site of the enzyme. First predict possible interaction types you would expect with this structure. Then look at the 2-dimensional "map" of the active site provided on your tutorial sheet and compare this to the 3-dimensional representations here. | ||
This view shows the amino acid residues on the <scene name='59/596437/Renin_interactions_rhs/ | This view shows the amino acid residues on the <scene name='59/596437/Renin_interactions_rhs/2'>right hand side</scene> of your "map". You should notice that these amino acids are fairly hydrophobic and interact with the hydrophobic parts of the inhibitor. If you prefer to view the structure where the inhibitor atoms are colour coded you will <scene name='59/596437/Renin_interactions_rhs_again/1'>find it here. </scene> | ||
Similarly this view shows the amino acid residues on the | Similarly this view shows the amino acid residues on the | ||
<scene name='59/596437/Lhs_aminoacids_representation/2'>left hand side</scene> of your "map". Again you can view this with the atoms of the inhibitor colour coded | |||
<scene name='59/596437/Lhs_aminoacids_representation/3'>find it here</scene>. | |||
== References == | == References == | ||
<references/> | <references/> | ||
