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| [[Image:1vsa.gif|left|200px]] | | #REDIRECT [[4v4i]] This PDB entry is obsolete and replaced by 4v4i |
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| {{STRUCTURE_1vsa| PDB=1vsa | SCENE= }}
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| '''Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements. This file, 1VSA, contains the 50S ribosome subunit. 30S ribosome subunit is in the file 2OW8'''
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| ==Overview==
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| Our understanding of the mechanism of protein synthesis has undergone rapid progress in recent years as a result of low-resolution X-ray and cryo-EM structures of ribosome functional complexes and high-resolution structures of ribosomal subunits and vacant ribosomes. Here, we present the crystal structure of the Thermus thermophilus 70S ribosome containing a model mRNA and two tRNAs at 3.7 A resolution. Many structural details of the interactions between the ribosome, tRNA, and mRNA in the P and E sites and the ways in which tRNA structure is distorted by its interactions with the ribosome are seen. Differences between the conformations of vacant and tRNA-bound 70S ribosomes suggest an induced fit of the ribosome structure in response to tRNA binding, including significant changes in the peptidyl-transferase catalytic site.
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| ==About this Structure==
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| 1VSA is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vs9 1vs9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VSA OCA].
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| ==Reference==
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| Crystal structure of a 70S ribosome-tRNA complex reveals functional interactions and rearrangements., Korostelev A, Trakhanov S, Laurberg M, Noller HF, Cell. 2006 Sep 22;126(6):1065-77. Epub 2006 Sep 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16962654 16962654]
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| [[Category: Protein complex]]
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| [[Category: Thermus thermophilus]]
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| [[Category: Korostelev, A.]]
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| [[Category: Laurberg, M.]]
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| [[Category: Noller, H F.]]
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| [[Category: Trakhanov, S.]]
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| [[Category: Crystal structure]]
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| [[Category: E site]]
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| [[Category: Functional complex]]
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| [[Category: P site]]
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| [[Category: Peptidyl transferase center]]
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| [[Category: Ribosome]]
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| [[Category: Trna]]
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| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:51:53 2008''
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