Prp24: Difference between revisions
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<StructureSection load='2ghp' size='450' side='right' scene='Sandbox_Reserved_340/2ghp/1' caption=''> | <StructureSection load='2ghp' size='450' side='right' scene='Sandbox_Reserved_340/2ghp/1' caption='Yeast N-terminal 3 RNA binding domains of splicing factor Prp24 (PDB code [[2ghp]]).'> | ||
'''Prp24''' ('''Pr'''e-mRNA splicing '''P'''rotein '''24''') is a [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae ''Saccharomyces cerevisiae''] yeast protein that functions in the formation of base pair interactions between the [http://en.wikipedia.org/wiki/U6_spliceosomal_RNA U6] and [http://en.wikipedia.org/wiki/U4_spliceosomal_RNA U4] [http://en.wikipedia.org/wiki/SnRNP snRNPs (small nuclear ribonucleoproteins)] to form the U4/U6 di-snRNP during the assembly of the [http://en.wikipedia.org/wiki/Spliceosome spliceosome] <ref name="Bae">PMID:17320109</ref>. This protein contains four RNA recognition motifs (RRMs) that function in the binding of Prp24 to U6 snRNA <ref name="Bae"/>. These RRM domains are conserved in structure and sequence in proteins orthologous to Prp24 in ''Homo sapiens'' and ''Schizosaccharomyces pombe'', as well as in other proteins containing RRMs <ref name="Rader">PMID:12458792</ref>. | '''Prp24''' ('''Pr'''e-mRNA splicing '''P'''rotein '''24''') is a [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae ''Saccharomyces cerevisiae''] yeast protein that functions in the formation of base pair interactions between the [http://en.wikipedia.org/wiki/U6_spliceosomal_RNA U6] and [http://en.wikipedia.org/wiki/U4_spliceosomal_RNA U4] [http://en.wikipedia.org/wiki/SnRNP snRNPs (small nuclear ribonucleoproteins)] to form the U4/U6 di-snRNP during the assembly of the [http://en.wikipedia.org/wiki/Spliceosome spliceosome] <ref name="Bae">PMID:17320109</ref>. This protein contains four RNA recognition motifs (RRMs) that function in the binding of Prp24 to U6 snRNA <ref name="Bae"/>. These RRM domains are conserved in structure and sequence in proteins orthologous to Prp24 in ''Homo sapiens'' and ''Schizosaccharomyces pombe'', as well as in other proteins containing RRMs <ref name="Rader">PMID:12458792</ref>. | ||
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== Introduction == | == Introduction == | ||
[[Image:Spliceosome.jpg |frame|left| Figure 1. Assembly and disassembly of the spliceosome in ''Saccharomyces cerevisiae'' (after Staley and Guthrie 1998 <ref name="Staley"/>)]] | [[Image:Spliceosome.jpg |frame|left| Figure 1. Assembly and disassembly of the spliceosome in ''Saccharomyces cerevisiae'' (after Staley and Guthrie 1998 <ref name="Staley"/>)]] | ||
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[[Image:Transester.jpg |frame|left| Figure 2. The transesterificiation reactions of pre-mRNA splicing (after Brow 2002<ref name="Brow review"/>) ]] | [[Image:Transester.jpg |frame|left| Figure 2. The transesterificiation reactions of pre-mRNA splicing (after Brow 2002<ref name="Brow review"/>) ]] | ||
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=== Pre-mRNA Splicing === | === Pre-mRNA Splicing === | ||
