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[[Image:2jgy.gif|left|200px]]


{{Structure
==The crystal structure of human orotidine-5'-decarboxylase domain of human uridine monophosphate synthetase (UMPS)==
|PDB= 2jgy |SIZE=350|CAPTION= <scene name='initialview01'>2jgy</scene>, resolution 1.95&Aring;
<StructureSection load='2jgy' size='340' side='right' caption='[[2jgy]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2jgy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JGY FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23]  
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgy OCA], [http://pdbe.org/2jgy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jgy RCSB], [http://www.ebi.ac.uk/pdbsum/2jgy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jgy ProSAT]</span></td></tr>
}}
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/2jgy_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jgy ConSurf].
<div style="clear:both"></div>


'''THE CRYSTAL STRUCTURE OF HUMAN OROTIDINE-5'-DECARBOXYLASE DOMAIN OF HUMAN URIDINE MONOPHOSPHATE SYNTHETASE (UMPS)'''
==See Also==
 
*[[Uridine 5'-monophosphate synthase|Uridine 5'-monophosphate synthase]]
 
__TOC__
==Disease==
</StructureSection>
Known disease associated with this structure: Oroticaciduria OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=258900 258900]]
[[Category: Human]]
 
==About this Structure==
2JGY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGY OCA].
[[Category: Homo sapiens]]
[[Category: Orotidine-5'-phosphate decarboxylase]]
[[Category: Orotidine-5'-phosphate decarboxylase]]
[[Category: Single protein]]
[[Category: Arrowsmith, C]]
[[Category: Arrowsmith, C.]]
[[Category: Berg, S van den]]
[[Category: Berg, S Van Den.]]
[[Category: Berglund, H]]
[[Category: Berglund, H.]]
[[Category: Busam, R]]
[[Category: Busam, R.]]
[[Category: Collins, R]]
[[Category: Collins, R.]]
[[Category: Dahlgren, L G]]
[[Category: Dahlgren, L G.]]
[[Category: Edwards, A]]
[[Category: Edwards, A.]]
[[Category: Ericsson, U B]]
[[Category: Ericsson, U B.]]
[[Category: Flodin, S]]
[[Category: Flodin, S.]]
[[Category: Flores, A]]
[[Category: Flores, A.]]
[[Category: Graslund, S]]
[[Category: Graslund, S.]]
[[Category: Hallberg, B M]]
[[Category: Hallberg, B M.]]
[[Category: Hammarstrom, M]]
[[Category: Hammarstrom, M.]]
[[Category: Holmberg-Schiavone, L]]
[[Category: Holmberg-Schiavone, L.]]
[[Category: Johansson, I]]
[[Category: Johansson, I.]]
[[Category: Karlberg, T]]
[[Category: Karlberg, T.]]
[[Category: Kosinska, U]]
[[Category: Kosinska, U.]]
[[Category: Kotenyova, T]]
[[Category: Kotenyova, T.]]
[[Category: Lehtio, L]]
[[Category: Lehtio, L.]]
[[Category: Moche, M]]
[[Category: Moche, M.]]
[[Category: Nilsson, M E]]
[[Category: Nilsson, M E.]]
[[Category: Nordlund, P]]
[[Category: Nordlund, P.]]
[[Category: Nyman, T]]
[[Category: Nyman, T.]]
[[Category: Ogg, D]]
[[Category: Ogg, D.]]
[[Category: Persson, C]]
[[Category: Persson, C.]]
[[Category: Structural genomic]]
[[Category: Sagemark, J.]]
[[Category: Sagemark, J]]
[[Category: Stenmark, P.]]
[[Category: Stenmark, P]]
[[Category: Sundstrom, M.]]
[[Category: Sundstrom, M]]
[[Category: Thorsell, A G.]]
[[Category: Thorsell, A G]]
[[Category: Uppenberg, J.]]
[[Category: Uppenberg, J]]
[[Category: Upsten, M.]]
[[Category: Upsten, M]]
[[Category: Weigelt, J.]]
[[Category: Weigelt, J]]
[[Category: alternative splicing]]
[[Category: Decarboxylase]]
[[Category: decarboxylase]]
[[Category: Disease mutation]]
[[Category: disease mutation]]
[[Category: Glycosyltransferase]]
[[Category: glycosyltransferase]]
[[Category: Lyase]]
[[Category: lyase]]
[[Category: Multifunctional enzyme]]
[[Category: multifunctional enzyme]]
[[Category: Orotidine-5'-decarboxylase]]
[[Category: orotidine-5'-decarboxylase]]
[[Category: Pyrimidine biosynthesis]]
[[Category: polymorphism]]
[[Category: Tim barrel dimer]]
[[Category: pyrimidine biosynthesis]]
[[Category: Transferase]]
[[Category: tim barrel dimer]]
[[Category: transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:41:47 2008''
Retrieved from "https://proteopedia.org/2jgy"