Dynamin: Difference between revisions

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== Function ==

'''Dynamin''' (DNM) is a GTPase which mediates endocytosis in membrane scission<ref>PMID:22505844</ref> and organelle division. '''Dynamin 1-like''' mediates outer mitochondrial membrane fission<ref>PMID:11703942</ref>. DNM is a multidomain GTPase. Mammalian genomes contain 3 DNM genes which show ca. 80% homology. '''DNM 1''' is localized to neurons, '''DNM 2''' is expressed ubiquitously and '''DNM 3''' is found predominantly in the brain<ref>PMID:22233676</ref>. The DNM 1 domain structure includes GTPase, middle, Plextrin homology, GTPase effector and ~~phophotransferase regulation~~ domains.

'''Dynamin''' (DNM) is a GTPase which mediates endocytosis in membrane scission<ref>PMID:22505844</ref> and organelle division. '''Dynamin 1-like''' mediates outer mitochondrial membrane fission<ref>PMID:11703942</ref>. DNM is a multidomain GTPase. Mammalian genomes contain 3 DNM genes which show ca. 80% homology. '''DNM 1''' is localized to neurons, '''DNM 2''' is expressed ubiquitously and '''DNM 3''' is found predominantly in the brain<ref>PMID:22233676</ref>. The DNM 1 domain structure includes GTPase, middle, Plextrin homology, GTPase effector and proline- and arginine-rich (PRD) domains.

== Disease ==

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== Structural highlights ==

The GTPase domain of DNM 1 contains several nucleotide binding motifs which interact with the bound GDP. <scene name='80/808513/Cv/6'>Motif GGQSAGKS</scene> residues 38-45; <scene name='80/808513/Cv/7'>Motif TKLD</scene> residues 205-208; <scene name='80/808513/Cv/8'>Motif NRSQKDIDGKK</scene> reidues 236-246<ref>PMID:26612256</ref>. Water molecules are shown as red spheres. <scene name='80/808513/Cv/9'>Whole binding site</scene>.

==Dynamin 3D structures==

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+<StructureSection load='5d3q' size='400' side='right' caption='Human dynamin 1 GTPase+GTPase effector domains complex with GDP and ethylene glycol (PDB code [[5d3q]])' scene='80/808513/Cv/1'>
-<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
 == Function ==
-'''Dynamin''' (DNM) is a GTPase which mediates endocytosis in membrane scission<ref>PMID:22505844</ref> and organelle division.  '''Dynamin 1-like''' mediates outer mitochondrial membrane fission<ref>PMID:11703942</ref>.  DNM is a multidomain GTPase.  Mammalian genomes contain 3 DNM genes which show ca. 80% homology.  '''DNM 1''' is localized to neurons, '''DNM 2''' is expressed ubiquitously and '''DNM 3''' is found predominantly in the brain<ref>PMID:22233676</ref>.  The DNM 1 domain structure includes GTPase, middle, Plextrin homology, GTPase effector and phophotransferase regulation domains.
+'''Dynamin''' (DNM) is a GTPase which mediates endocytosis in membrane scission<ref>PMID:22505844</ref> and organelle division.  '''Dynamin 1-like''' mediates outer mitochondrial membrane fission<ref>PMID:11703942</ref>.  DNM is a multidomain GTPase.  Mammalian genomes contain 3 DNM genes which show ca. 80% homology.  '''DNM 1''' is localized to neurons, '''DNM 2''' is expressed ubiquitously and '''DNM 3''' is found predominantly in the brain<ref>PMID:22233676</ref>.  The DNM 1 domain structure includes GTPase, middle, Plextrin homology, GTPase effector and proline- and arginine-rich (PRD) domains.
 == Disease ==
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 == Structural highlights ==
+The GTPase domain of DNM 1 contains several nucleotide binding motifs which interact with the bound GDP. <scene name='80/808513/Cv/6'>Motif GGQSAGKS</scene> residues 38-45; <scene name='80/808513/Cv/7'>Motif TKLD</scene> residues 205-208; <scene name='80/808513/Cv/8'>Motif NRSQKDIDGKK</scene> reidues 236-246<ref>PMID:26612256</ref>. Water molecules are shown as red spheres. <scene name='80/808513/Cv/9'>Whole binding site</scene>.
 ==Dynamin 3D structures==