Cholesterol esterase: Difference between revisions

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== Function ==

~~{{STRUCTURE_1llf| PDB=1llf | SIZE=400| SCENE= |right|CAPTION=Bovine cholesterol~~ esterase ~~complex with~~ bile ~~acid [[1llf]] }}~~

'''Cholesterol esterase''' (ChoE) also named '''bile-salt activated lipase''' or '''sterol esterase''' catalyzes the hydrolytic cleavage of cholesterol, other sterol esters and triglycerides.<ref>PMID:11563913</ref>

~~'''Cholesterol esterase''' (ChoE) also named bile-acid activated lipase catalyzes the hydrolytic cleavage of cholesterol, other sterol esters and triglycerides.~~ Deficiency of this enzyme causes Wolman’s disease and cholesteryl ester storage disease.

== Disease ==

Deficiency of this enzyme causes Wolman’s disease and cholesteryl ester storage disease.

== Structural highlights ==

ChoE <scene name='52/525136/Cv/9'>ligand-binding tunnel is ca. 30 A long</scene> ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}). ChoE has the <scene name='52/525136/Cv/10'>polar catalytic triad Ser-His-Glu</scene> at the opening and <scene name='52/525136/Cv/11'>hydrophobic residues lining the bottom cup</scene>.<ref>PMID:12499539</ref>

==3D structures of cholesterol esterase==

[[Cholesterol esterase 3D structures]]

~~[[1akn]] – bChoE – bovine~~

</StructureSection>

~~[[2bce]] – bChoE (mutant) ~~

~~[[1jmy]] – hChoE - human ~~

~~[[1f6w]] – hChoE catalytic domain (mutant)~~

~~==Cholesterol esterase complex with bile acids==~~

~~[[1cle]] – CcChoE + cholesteryl linoleate – ''Candida cylindracea'' ~~

== References ==

~~[[1llf]] – CcChoE + tricosanoic acid~~

[[~~1aql~~]] ~~– bChoE + taurocholate~~

[[Category:Topic Page]]

Cholesterol esterase: Difference between revisions

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+<StructureSection load='1llf' size='350' side='right' caption='Glycosylated cholesterol esterase dimer complex with bile acid (PDB entry [[1llf]])' scene='52/525136/Cv/1'>
+== Function ==
-{{STRUCTURE_1llf|  PDB=1llf  | SIZE=400| SCENE= |right|CAPTION=Bovine cholesterol esterase complex with bile acid [[1llf]] }}
+'''Cholesterol esterase''' (ChoE) also named '''bile-salt activated lipase''' or '''sterol esterase''' catalyzes the hydrolytic cleavage of cholesterol, other sterol esters and triglycerides.<ref>PMID:11563913</ref>
-'''Cholesterol esterase''' (ChoE) also named bile-acid activated lipase catalyzes the hydrolytic cleavage of cholesterol, other sterol esters and triglycerides.  Deficiency of this enzyme causes Wolman’s disease and cholesteryl ester storage disease.
+== Disease ==
+Deficiency of this enzyme causes Wolman’s disease and cholesteryl ester storage disease.
+== Structural highlights ==
+ChoE <scene name='52/525136/Cv/9'>ligand-binding tunnel is ca. 30 A long</scene> ({{Template:ColorKey_Hydrophobic}},  {{Template:ColorKey_Polar}}). ChoE has the <scene name='52/525136/Cv/10'>polar catalytic triad Ser-His-Glu</scene> at the opening and <scene name='52/525136/Cv/11'>hydrophobic residues lining the bottom cup</scene>.<ref>PMID:12499539</ref>
 ==3D structures of cholesterol esterase==
+[[Cholesterol esterase 3D structures]]
-[[1akn]] – bChoE – bovine<br />
+</StructureSection>
-[[2bce]] – bChoE (mutant)<br />
-[[1jmy]] – hChoE - human<br />
-[[1f6w]] – hChoE catalytic domain (mutant)
-==Cholesterol esterase complex with bile acids==
-[[1cle]] – CcChoE + cholesteryl linoleate – ''Candida cylindracea''<br />
+== References ==
-[[1llf]] – CcChoE + tricosanoic acid<br />
+<references/>
-[[1aql]] – bChoE + taurocholate
+[[Category:Topic Page]]