RNase P: Difference between revisions
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<StructureSection load='6ah3' size='350' side='right' caption=Yeast RNase P bound to pre-tRNA (PDB entry [[6ah3]])' scene=' | <StructureSection load='6ah3' size='350' side='right' caption='Yeast RNase P bound to pre-tRNA (PDB entry [[6ah3]])' scene='' pspeed='8> | ||
[[Image:6ah3_labeled_solid.png|left|400px]] | |||
== Function == | == Function == | ||
'''RNase P'' | '''RNase P''' is a [[Ribonuclease|ribonuclease]] that processes the 5′ end of pre-[[Transfer RNA (tRNA)|transfer RNAs]] as well as other RNA molecules.<ref>PMID:28697848</ref>. Most RNase Ps are complexes of proteins and RNAs, termed ribonucleoprotein (RNP) complexes; however, a few protein-only RNase Ps have been described.<ref>PMID:23322041</ref><ref>PMID:25780121</ref> | ||
In eukaryotes, the RNase P proteins have been found to have other roles. For example, many of the proteins are shared with a related RNase P, the small nucleolar RNase MRP, that is involved in processing ribosomal RNA.<ref>PMID:19395864</ref> In yeast, the proteins of RNase P also bind telomerase.<ref>PMID:27156450</ref> | In eukaryotes, the RNase P proteins have been found to have other roles. For example, many of the proteins are shared with a related RNase P, the small nucleolar RNase MRP, that is involved in processing ribosomal RNA.<ref>PMID:19395864</ref> In yeast, the proteins of RNase P also bind telomerase.<ref>PMID:27156450</ref> | ||
Sydney Altman shared in the 1989 Nobel Prize for his work on the catalytic properties of the RNP-based RNase P, as described [[RNase P Nobel Prizes|here]]. | |||
== Structural insights == | == Structural insights == | ||
The active site of RNase P contains metal ions. Specifically, in the | The active site of RNase P contains metal ions. Specifically, in the RNP-based RNase P, the ions at the active site are magnesium, and they seem to be zinc-based metallonucleases in the case of ''Arabidopsis'' proteinaceous RNase P. | ||
Articles in Proteopedia concerning '''RNase P''' include: | |||
* A topic page on the RNP-based ''S. cerevisiae'' RNase P is found [[yeast RNase P|here]] | |||
</StructureSection> | </StructureSection> | ||
== 3D Structures of RNase P == | == 3D Structures of RNase P == | ||
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Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme. | Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme. | ||
[[ | '''RNP-based RNase P''' | ||
[[6ah3]] - RNP-based RNase P bound to pre-tRNA - ''S. cerevisiae'' <br /> | |||
[[6agb]] - RNP-based RNase P - ''S. cerevisiae'' <br /> | |||
[[6ah3]] - RNP-based RNase P bound to pre-tRNA substrate - ''S. cerevisiae'' <br /> | |||
'''Protein-only RNase P''' | |||
[[5diz]] - nuclear PRORP2 - ''Arabidopsis thaliana'' <br /> | |||
[[4g23]] -mitochondrial and chloroplast PRORP1 - ''Arabidopsis thaliana'' <br /> | |||
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6bv8 | 6bv8 | ||
6bv9 | 6bv9 | ||
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1d6t | |||
1nz0 | |||
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1v76 | |||
1v77 | |||
1x0t | |||
2av5 | |||
2czv | |||
2k3r | |||
2ki7 | |||
2ljp | |||
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3dhs | |||
3iab | |||
3q1q | |||
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3wyz | |||
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4g26 | |||
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4xgm | |||
5diz | |||
5ft9 | |||
6agb | |||
6ah3 | |||
6ahr | |||
6ahu | |||
6ahv | |||
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6bv8 | |||
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6cqc | |||
6cwx | |||
6d1r | |||
6k0a | |||
6k0b | |||
6max | |||
==See Also== | ==See Also== | ||
*[[Ribozyme]] | |||
*[[Transfer RNA (tRNA)]] | *[[Transfer RNA (tRNA)]] | ||
*[[Ribosome|The Ribosome]] | *[[Ribosome|The Ribosome]] | ||
*[[Ribonuclease]] | |||
== References == | == References == | ||
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[[Category:Topic Page]] | [[Category:Topic Page]] | ||
[[Category:Rnase_p|RNase P]] | |||
[[Category:Ribonuclease_P|Ribonuclease_P]] | |||
