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| | <StructureSection load='1aik' size='340' side='right' caption='Core structure of acetylated gp41 from the HIV envelope glycoprotein, [[1aik]].' scene=''> |
| | == Function == |
| | '''Gp41''' is a subunit of the envelope protein of retrovirus<ref>PMID:9630213</ref>. Gp41 is a transmembrane protein and contains several sites which are involved in the infection of the host cells. Gp160 is the cleavable precursor of Gp41 and Gp120. For more details see [[Hiv env proteins|HIV-1 viral envelope proteins]]. |
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| {{STRUCTURE_1aik| PDB=1aik | SIZE=400| SCENE= |right|CAPTION=Gp41 N chain (magenta) and C chain (pink) with acetylated ends, [[1aik]]. }}
| | == Relevance == |
| | | Fusion inhibitory drugs which bind to Gp41 prevent the attachment of the HIV-1 virus to the cell<ref>PMID:15180542</ref>. |
| '''Gp41''' is a subunit of the envelope protein of retrovirus. Gp41 is a transmembrane protein and contains several sites which are involved in the infection of the host cells. Gp160 is the cleavable precursor of Gp41 and Gp120. For more details see [[Hiv env proteins]].
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| == 3D Structures of Gp41 == | | == 3D Structures of Gp41 == |
| | [[Gp41 3D Structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
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| ===Gp41 from HIV-1===
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| [[1aik]] – Gp41 <br />
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| [[1env]], [[3k9a]] – Gp41 (mutant)<br />
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| [[1szt]] – Gp41 thermostable domain<br />
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| [[3cp1]], [[3cyo]] – Gp41 thermostable domain (mutant)<br />
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| [[1df4]], [[1df5]], [[1qr8]], [[1qr9]], [[1dlb]], [[1jpx]] – Gp41 core<br />
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| [[1f23]], [[1k33]], [[1k34]], [[1i5x]], [[1i5y]], [[2ot5]] – Gp41 core (mutant)<br />
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| [[2z2t]], [[2zzo]], [[3aha]], [[3vie]], [[2r3c]], [[2r5b]], [[2r5d]], [[3l36]], [[3l37]], [[3vgy]], [[3vh7]], [[3vtp]], [[3vu5]], [[3vu6]] – Gp41 N-heptad repeat + Gp41 fusion inhibitor peptide<br />
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| [[2zfc]] – Gp41 N-peptide <br />
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| [[4i2l]] – Gp41 N-peptide (mutant)<br />
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| [[3u91]] – Gp41 N-terminal <br />
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| [[4hlr]] – Gp41 N-terminal (mutant) <br />
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| [[3o3x]] – arGp41 - artificial<br />
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| [[4dzu]] – arGp41 + 3-α<br />
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| [[4dzv]] – arGp41 + 4-α/β<br />
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| ===Gp41 from Simian Immunodeficiency Virus===
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| [[2siv]] – Gp41 core<br />
| | == References == |
| [[2ezo]], [[2ezp]], [[2ezq]], [[2ezr]], [[2ezs]], [[1qce]] – Gp41 core - NMR<br />
| | <references/> |
| [[1qbz]], [[1jq0]] – Gp41 core (mutant)<br />
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| [[Category:Topic Page]] | | [[Category:Topic Page]] |
