Sigma factor: Difference between revisions

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== Overview ==

'''Sigma (σ) factor''' is the peoptide subunit needed for the initiation of RNA transcription in prokaryotic organisms <scene name='59/591940/Sigma_factor_in_enzyme/1'>as seen here</scene>. As opposed to eukaryotes, who utilize a variety of proteins to initiate gene transcription, prokaryotic transcription is initiated almost completely by a σ-factor. The large and biologically essential protein, RNA polymerase (RNAP), contains one σ-subunit, which binds <scene name='59/591940/Dna_promoter/3'>DNA promoter sequences</scene>, located upstream of transcription start sites.

'''Sigma (σ) factor''' is the peoptide subunit needed for the initiation of RNA transcription in prokaryotic organisms <scene name='59/591940/Sigma_factor_in_enzyme/1'>as seen here</scene>. As opposed to eukaryotes, who utilize a variety of proteins to initiate gene transcription, prokaryotic transcription is initiated almost completely by a σ-factor. The large and biologically essential protein, RNA polymerase (RNAP), contains one σ-subunit, which binds <scene name='59/591940/Dna_promoter/3'>DNA promoter sequences</scene>, located upstream of transcription start sites.

*'''Sigma factor 70''' or '''RpoD''' is the primary initiation factor during exponential growth.

*'''Sigma factor 45''' or '''RpoN''' is responsible for the expression of genes involved in Arg catabolism.

*'''Sigma factor 38''' or '''RpoS''' acts as the master regulator of the general stress response in ''E. coli'' .

== Function and Structure ==

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== Gene Regulation and Differentiation ==

Since σ-factors are exclusively linked to gene expression in prokaryotic organisms, the variety of σ-factors in a cell dictate how and what genes are transcribed. Specialized function in cells, therefore, is highly moderated by its arsenal of σ-subunits. In fact, cellular development and differentiation are directly impacted and carried out by "cascades" of σ-factors. In the early stages of development, '''early genes'''[2] are transcribed by basic '''bacterial σ-factors'''. These genes are therefore transcribed to give new σ-factors, which in turn activate additional genes, and so on [2]. This process of σ-factor cascades demonstrates the versatile and essential biologic functions of the RNAP subunit, σ.

~~</StructureSection>~~

==3D structures of sigma factor==

[[Sigma factor 3D structures]]

~~Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}~~

</StructureSection>

~~{{#tree:id=OrganizedByTopic|openlevels=0|~~

*Sigma factor

**[[1ku2]] – TaSF region 1.2-3.1 – ''Thermus aquaticus''

**[[1ku3]] – TaSF region 4 (mutant)

**[[3les]] – TaSF residues 93-271

**[[1sig]] – EcSF – ''Escherichia coli''

**[[2mao]] – EcSF region 2 - NMR

**[[1tty]] – TmSF-70 region 4 – ''Thermotoga maritima''

**[[2k6x]] – TmSF-70 region 1.1 (mutant) - NMR

**[[2ahq]] – AaSF-54 C terminal – ''Aquifex aeolicus'' - NMR

**[[2k9l]], [[2k9m]] – AaSF-54 core domain - NMR

**[[3mzy]] – SF-H – ''Fusobacterium nucleatum''

**[[1h3l]] – ScSF N terminal – ''Streptomyces coelicolor''

**[[5fgm]] – ScSF-R region 4

**[[5mww]] – BsSF-A region 1.1 - ''Bacillus subtilis'' - NMR

**[[5xe7]] – MtSF-J – ''Mycobacterium tuberculosis''

*Sigma factor complex with DNA

**[[3ugo]], [[3ugp]] - TaSF region 2 + DNA

**[[4ki2]] - TaSF region 2-3 + DNA

**[[2h27]] – EcSF-E region 4 + DNA

**[[2map]] – EcSF region 2 + DNA - NMR

**[[1ku7]] – EcSF region 4 (mutant) + DNA

**[[2o8k]], [[2o9l]] – AaSF-54 C terminal + DNA - NMR

**[[5ui5]] – AaSF RpoN residues 61-398 + DNA

*Sigma factor complex with protein

**[[3lev]] – TaSF residues 93-271 + antibody

**[[1l9u]] – TaSF region 1.1-4 + RNAP subunits α,β,β’,ω

**[[1or7]] – EcSF-E + σ-E factor negative regulatory protein

**[[4lup]] – EcSF residues 3-92 + EcSF region 2

**[[1tlh]] – EcSF ProD region 4 + anti-σ factor

**[[2p7v]] – EcSF ProD region 4 + regulator of σ D

**[[4yg2]], [[5uag]], [[5uaj]], [[5uaq]] – EcSF ProD + RNAP subunits α,β,β’,ω

**[[5ui8]] – EcSF-45 + RNAP subunits α,β,β’,ω

**[[4mex]], [[4kmu]], [[4kn4]], [[4kn7]], [[5uac]], [[5uah]], [[5ual]], [[4zh3]], [[4zh4]] – EcSF ProD + RNAP subunits α,β,β’,ω + antibiotic

**[[4xsx]], [[4xsy]], [[4xsz]] – EcSF ProD + RNAP subunits α,β,β’,ω + antibiotic

**[[6byu]] – EcSF ProD + RNAP subunits α,β,β’,ω + ppApp

**[[4mey]], [[4ljz]], [[4lk1]], [[6cux]] – EcSF ProD + RNAP subunits α,β,β’,ω

**[[6c9y]], [[6ca0]] – EcSF ProD + RNAP subunits α,β,β’,ω - Cryo EM

**[[5byh]] – EcSF-45 + RNAP subunits α,β,β’,ω

**[[5nwt]] – EcSF-54 + RNAP subunits α,β,β’,ω

**[[5w1s]] – EcSF RpoD + RNAP subunits α,β,β’ + TraR

**[[5vsw]] – EcSF RpoD + RNAP subunits α,β,β’ + DnaK suppressor protein

**[[5w1t]] – EcSF RpoD + RNAP subunits α,β,β’ + RpoZ + DnaK suppressor protein

**[[4lk0]], [[4llg]], [[4yfk]], [[4yfn]], [[4yfx]], [[4zh2]] – EcSF ProD + EcRNAP subunits α,β,β’,ω + RNAP inhibitor

**[[1rp3]], [[1sc5]] – AaSF-28 + anti-σ factor FLGM

**[[5wuq]] – BsSF SIGW + anti-σ factor RSIW

**[[3hug]] – MtSF-L + membrane protein

**[[4nqw]] – MtSF-K region 4 + anti-σ factor

**[[4x8k]] – MtSF-A region 2 + RBPA

**[[6fbv]] – MtSF-A + RNAP subunits α,β,β’,ω - SP Cryo EM

**[[6c05]], [[6c06]] – MtSF-A + RNAP subunits α,β,β’,ω + RbpA - Cryo EM

**[[3wod]], [[2a6e]], [[2cw0]], [[5tmf]] – TtSF + RNAP subunits α,β,β’,ω - ''Thermus thermophilus''

**[[4mq9]], [[2a68]], [[2a69]], [[2a6h]], [[3dxj]], [[3eql]] – TtSF ProD + RNAP subunits α,β,β’,ω + antibiotic

**[[2be5]] – TtSF + RNAP subunits α,β,β’,ω + inhibitor

**[[5tmc]] – TtSF-A + RNAP subunits α,β,β’,ω + protein + G4P

**[[5xj0]] – TtSF-A + RNAP subunits α,β,β’,ω + GP39 + GP76

**[[5x22]] – TtSF-A + RNAP subunits α,β,β’,ω + GpA + CMPcPP

**[[4lk0]], [[4llg]], [[4yfk]], [[4yfn]], [[4yfx]], [[4zh2]] – EcSF ProD + EcRNAP subunits α,β,β’,ω + RNAP inhibitor

**[[4cxf]] – SF CNRH + CNRY – ''Cupriavidus metallidurans''

**[[4g6d]], [[4g8x]], [[4g94]] – SF ProD region 4 + Orf067 – ''Staphylococcus aureus''

**[[5yix]] – SF RpoD + GCRA - ''Caulobacter crescentus''

*Sigma factor complex with protein and DNA

**[[4oio]], [[4g7h]], [[4g7o]], [[4g7z]], [[4q4z]], [[4q5s]] – TtSF SIGA + RNAP subunits α,β,β’,ω + DNA

**[[1smy]] – TtSF + RNAP subunits α,β,β’,ω + G4P

**[[3n97]] – TaSF region 4 + RNAP subunits α + DNA

**[[4xlp]], [[4xlq]], [[5tjg]] – TaSF SIGA + RNAP subunits α,β,β’,ω + DNA

**[[1l9z]] – TaSF + RNAP subunits α,β,β’,ω + DNA – Cryo EM

**[[4xlr]], [[4xls]] – TaSF-A + RNAP subunits α,β,β’,ω + CarD-like transcriptional regulator + DNA

**[[1rio]] - TaSF region 4 + repression protein CI + DNA

**[[3iyd]] – EcSF ProD + EcRNAP subunits α,β,β’,ω + catabolite gene activator + DNA

**[[4jk1]], [[4jk2]], [[4jkr]] – EcSF ProD + EcRNAP subunits α,β,β’,ω + G4P

**[[4yln]], [[4ylo]], [[4ylp]] – EcSF ProD + EcRNAP subunits α,β,β’,ω + DNA

**[[5nss]] – EcSF-54 + EcRNAP subunits α,β,β’,ω + phage shock protein F + DNA - Cryo EM

**[[5nsr]], [[6gh6]], [[6gh5]], [[6gfw]] – EcSF-54 + EcRNAP subunits α,β,β’,ω + DNA - Cryo EM

**[[5voi]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA

**[[5d4c]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + CTP + ATP

**[[5d4d]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + CTP + NAD

**[[5d4e]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + CTP + dephosphate-CoA

**[[5uha]] – MtSF-A + MtRNAP subunits α,β,β’,ω + DNA

**[[6c04]] – MtSF-A + RNAP subunits α,β,β’,ω + RbpA + DNA - Cryo EM

**[[5uhe]], [[5uhf]] – MtSF SIGA + MtRNAP subunits α,β,β’,ω + DNA + inhibitor

**[[5tw1]], [[6cce]] – MsSF-A + MtRNAP subunits α,β,β’,ω + DNA + peptide - ''Mycobacterium smegmatis''

**[[5vi8]] – MsSF-A + MsRNAP subunits α,β,β’,ω + DNA

**[[6ccv]] – MsSF-A + MtRNAP subunits α,β,β’,ω + DNA + peptide + RbpA

*Sigma factor complex with protein and DNA and antibiotics

**[[4oin]], [[4oip]], [[4oiq]], [[4oir]] – TtSF-A + RNAP subunits α,β,β’,ω + antibiotic + DNA

**[[6cuu]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + antibiotic

**[[5uhg]] – MtSF-A + MtRNAP subunits α,β,β’,ω + DNA + antibiotic + inhibitor

**[[5uhb]] – MtSF-A + MtRNAP subunits α,β,β’,ω + DNA + antibiotic

**[[6bzo]] – MtSF-A + RNAP subunits α,β,β’,ω + RbpA + DNA + antibiotic - Cryo EM

**[[6ccf]] – MsSF-A + MtRNAP subunits α,β,β’,ω + DNA + peptide + antibiotic

*Sigma factor complex with protein, DNA and RNA

**[[5vi5]] – MsSF-A + MsRNAP subunits α,β,β’,ω + RbpA + DNA + RNA

**[[4xln]] – TaSF-A + RNAP subunits α,β,β’,ω + DNA + RNA

**[[5ipl]], [[5ipm]], [[5ipn]] – EcSF RpoS + EcRNAP subunits α,β,β’,ω + DNA + RNA

**[[6b6h]] – EcSF RpoD + EcRNAP subunits α,β,β’,ω + DNA + RNA - Cryo EM

**[[5e17]], [[5e18]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + RNA

**[[5x22]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + RNA + CMPPP

**[[5vo8]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + RNA + GTP

**[[5x21]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + RNA + antibiotic

**[[5i2d]] – TtSF-A + TtRNAP subunits α,β,β’,ω + transcriptional regulator + DNA + RNA

**[[5uh5]], [[5uh8]], [[5uh9]] – MtSF-A + MtRNAP subunits α,β,β’,ω + DNA + RNA

**[[5uh6]], [[5uhc]], [[5uhd]], [[5x21]] – MtSF-A + TtRNAP subunits α,β,β’,ω + DNA + RNA + antibiotic

}}

== References ==

@@ Line 3: / Line 3: @@
 == Overview ==
-'''Sigma (σ) factor''' is the peoptide subunit needed for the initiation of RNA transcription in prokaryotic organisms <scene name='59/591940/Sigma_factor_in_enzyme/1'>as seen here</scene>.  As opposed to eukaryotes, who utilize a variety of proteins to initiate gene transcription, prokaryotic transcription is initiated almost completely by a σ-factor.  The large and biologically essential protein, RNA polymerase (RNAP), contains one σ-subunit, which binds <scene name='59/591940/Dna_promoter/3'>DNA promoter sequences</scene>, located upstream of transcription start sites.
+'''Sigma (σ) factor''' is the peoptide subunit needed for the initiation of RNA transcription in prokaryotic organisms <scene name='59/591940/Sigma_factor_in_enzyme/1'>as seen here</scene>.  As opposed to eukaryotes, who utilize a variety of proteins to initiate gene transcription, prokaryotic transcription is initiated almost completely by a σ-factor.  The large and biologically essential protein, RNA polymerase (RNAP), contains one σ-subunit, which binds <scene name='59/591940/Dna_promoter/3'>DNA promoter sequences</scene>, located upstream of transcription start sites. <br />
+*'''Sigma factor 70''' or '''RpoD''' is the primary initiation factor during exponential growth.  <br />
+*'''Sigma factor 45''' or '''RpoN''' is responsible for the expression of genes involved in Arg catabolism.<br />
+*'''Sigma factor 38''' or '''RpoS''' acts as the master regulator of the general stress response in ''E. coli'' .<br />
 == Function and Structure ==
@@ Line 28: / Line 31: @@
 == Gene Regulation and Differentiation ==
 Since σ-factors are exclusively linked to gene expression in prokaryotic organisms, the variety of σ-factors in a cell dictate how and what genes are transcribed.  Specialized function in cells, therefore, is highly moderated by its arsenal of σ-subunits.  In fact, cellular development and differentiation are directly impacted and carried out by "cascades" of σ-factors. In the early stages of development, '''early genes'''[2] are transcribed by basic '''bacterial σ-factors'''.  These genes are therefore transcribed to give new σ-factors, which in turn activate additional genes, and so on [2].  This process of σ-factor cascades demonstrates the versatile and essential biologic functions of the RNAP subunit, σ.
-</StructureSection>
 ==3D structures of sigma factor==
+[[Sigma factor 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Sigma factor
-**[[1ku2]] – TaSF region 1.2-3.1 – ''Thermus aquaticus''<br />
-**[[1ku3]] – TaSF region 4 (mutant)<br />
-**[[3les]] – TaSF residues 93-271<br />
-**[[1sig]] – EcSF – ''Escherichia coli''<br />
-**[[2mao]] – EcSF region 2 - NMR<br />
-**[[1tty]] – TmSF-70 region 4 – ''Thermotoga maritima''<br />
-**[[2k6x]] – TmSF-70 region 1.1 (mutant) - NMR<br />
-**[[2ahq]] – AaSF-54 C terminal – ''Aquifex aeolicus'' - NMR<br />
-**[[2k9l]], [[2k9m]] – AaSF-54 core domain - NMR<br />
-**[[3mzy]] – SF-H – ''Fusobacterium nucleatum''<br />
-**[[1h3l]] – ScSF N terminal – ''Streptomyces coelicolor''<br />
-**[[5fgm]] – ScSF-R region 4<br />
-**[[5mww]] – BsSF-A region 1.1 - ''Bacillus subtilis'' - NMR <br />
-**[[5xe7]] – MtSF-J – ''Mycobacterium tuberculosis''<br />
-*Sigma factor complex with DNA
-**[[3ugo]], [[3ugp]] - TaSF region 2 + DNA<br />
-**[[4ki2]] - TaSF region 2-3 + DNA<br />
-**[[2h27]] – EcSF-E region 4 + DNA<br />
-**[[2map]] – EcSF region 2 + DNA - NMR<br />
-**[[1ku7]] – EcSF region 4 (mutant) + DNA <br />
-**[[2o8k]], [[2o9l]] – AaSF-54 C terminal + DNA - NMR<br />
-**[[5ui5]] – AaSF RpoN residues 61-398 + DNA <br />
-*Sigma factor complex with protein
-**[[3lev]] – TaSF residues 93-271 + antibody<br />
-**[[1l9u]] – TaSF region 1.1-4 + RNAP subunits α,β,β’,ω<br />
-**[[1or7]] – EcSF-E + σ-E factor negative regulatory protein <br />
-**[[4lup]] – EcSF residues 3-92 + EcSF region 2 <br />
-**[[1tlh]] – EcSF ProD region 4 + anti-σ factor<br />
-**[[2p7v]] – EcSF ProD region 4 + regulator of σ D<br />
-**[[4yg2]], [[5uag]], [[5uaj]], [[5uaq]] – EcSF ProD + RNAP subunits α,β,β’,ω  <br />
-**[[5ui8]] – EcSF-45 + RNAP subunits α,β,β’,ω  <br />
-**[[4mex]], [[4kmu]], [[4kn4]], [[4kn7]], [[5uac]], [[5uah]], [[5ual]], [[4zh3]], [[4zh4]] – EcSF ProD + RNAP subunits α,β,β’,ω + antibiotic <br />
-**[[4xsx]], [[4xsy]], [[4xsz]] – EcSF ProD + RNAP subunits α,β,β’,ω + antibiotic <br />
-**[[6byu]] – EcSF ProD + RNAP subunits α,β,β’,ω + ppApp <br />
-**[[4mey]], [[4ljz]], [[4lk1]], [[6cux]] – EcSF ProD + RNAP subunits α,β,β’,ω <br />
-**[[6c9y]], [[6ca0]] – EcSF ProD + RNAP subunits α,β,β’,ω - Cryo EM<br />
-**[[5byh]] – EcSF-45 + RNAP subunits α,β,β’,ω <br />
-**[[5nwt]] – EcSF-54 + RNAP subunits α,β,β’,ω <br />
-**[[5w1s]] – EcSF RpoD + RNAP subunits α,β,β’ + TraR<br />
-**[[5vsw]] – EcSF RpoD + RNAP subunits α,β,β’ + DnaK suppressor protein<br />
-**[[5w1t]] – EcSF RpoD + RNAP subunits α,β,β’ + RpoZ + DnaK suppressor protein<br />
-**[[4lk0]], [[4llg]], [[4yfk]], [[4yfn]], [[4yfx]], [[4zh2]] – EcSF ProD + EcRNAP subunits α,β,β’,ω + RNAP inhibitor<br />
-**[[1rp3]], [[1sc5]] – AaSF-28 + anti-σ factor FLGM <br />
-**[[5wuq]] – BsSF SIGW + anti-σ factor RSIW  <br />
-**[[3hug]] – MtSF-L + membrane protein <br />
-**[[4nqw]] – MtSF-K region 4 + anti-σ factor<br />
-**[[4x8k]] – MtSF-A region 2 + RBPA<br />
-**[[6fbv]] – MtSF-A + RNAP subunits α,β,β’,ω - SP Cryo EM<br />
-**[[6c05]], [[6c06]] – MtSF-A + RNAP subunits α,β,β’,ω + RbpA - Cryo EM<br />
-**[[3wod]], [[2a6e]], [[2cw0]], [[5tmf]] – TtSF + RNAP subunits α,β,β’,ω - ''Thermus thermophilus'' <br />
-**[[4mq9]], [[2a68]], [[2a69]], [[2a6h]], [[3dxj]], [[3eql]] – TtSF ProD + RNAP subunits α,β,β’,ω + antibiotic <br />
-**[[2be5]] – TtSF + RNAP subunits α,β,β’,ω + inhibitor<br />
-**[[5tmc]] – TtSF-A + RNAP subunits α,β,β’,ω + protein + G4P<br />
-**[[5xj0]] – TtSF-A + RNAP subunits α,β,β’,ω + GP39 + GP76<br />
-**[[5x22]] – TtSF-A + RNAP subunits α,β,β’,ω + GpA + CMPcPP<br />
-**[[4lk0]], [[4llg]], [[4yfk]], [[4yfn]], [[4yfx]], [[4zh2]] – EcSF ProD + EcRNAP subunits α,β,β’,ω + RNAP inhibitor<br />
-**[[4cxf]] – SF CNRH + CNRY – ''Cupriavidus metallidurans''<br />
-**[[4g6d]], [[4g8x]], [[4g94]] – SF ProD region 4 + Orf067 – ''Staphylococcus aureus''<br />
-**[[5yix]] – SF RpoD + GCRA - ''Caulobacter crescentus''<br />
-*Sigma factor complex with protein and DNA
-**[[4oio]], [[4g7h]], [[4g7o]], [[4g7z]], [[4q4z]], [[4q5s]] – TtSF SIGA + RNAP subunits α,β,β’,ω + DNA<br />
-**[[1smy]] – TtSF + RNAP subunits α,β,β’,ω + G4P<br />
-**[[3n97]] – TaSF region 4 + RNAP subunits α + DNA<br />
-**[[4xlp]], [[4xlq]], [[5tjg]] – TaSF SIGA + RNAP subunits α,β,β’,ω + DNA   <br />
-**[[1l9z]] – TaSF + RNAP subunits α,β,β’,ω + DNA – Cryo EM  <br />
-**[[4xlr]], [[4xls]] – TaSF-A + RNAP subunits α,β,β’,ω + CarD-like transcriptional regulator + DNA   <br />
-**[[1rio]] - TaSF region 4 + repression protein CI + DNA<br />
-**[[3iyd]] – EcSF ProD + EcRNAP subunits α,β,β’,ω + catabolite gene activator + DNA<br />
-**[[4jk1]], [[4jk2]], [[4jkr]] – EcSF ProD + EcRNAP subunits α,β,β’,ω + G4P<br />
-**[[4yln]], [[4ylo]], [[4ylp]] – EcSF ProD + EcRNAP subunits α,β,β’,ω + DNA<br />
-**[[5nss]] – EcSF-54 + EcRNAP subunits α,β,β’,ω + phage shock protein F + DNA - Cryo EM<br />
-**[[5nsr]], [[6gh6]], [[6gh5]], [[6gfw]] – EcSF-54 + EcRNAP subunits α,β,β’,ω + DNA - Cryo EM<br />
-**[[5voi]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA <br />
-**[[5d4c]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + CTP + ATP<br />
-**[[5d4d]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + CTP + NAD<br />
-**[[5d4e]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + CTP + dephosphate-CoA<br />
-**[[5uha]] – MtSF-A + MtRNAP subunits α,β,β’,ω + DNA <br />
-**[[6c04]] – MtSF-A + RNAP subunits α,β,β’,ω + RbpA + DNA - Cryo EM<br />
-**[[5uhe]], [[5uhf]] – MtSF SIGA + MtRNAP subunits α,β,β’,ω + DNA + inhibitor<br />
-**[[5tw1]], [[6cce]] – MsSF-A + MtRNAP subunits α,β,β’,ω + DNA + peptide - ''Mycobacterium smegmatis''<br />
-**[[5vi8]] – MsSF-A + MsRNAP subunits α,β,β’,ω + DNA <br />
-**[[6ccv]] – MsSF-A + MtRNAP subunits α,β,β’,ω + DNA + peptide + RbpA <br />
-*Sigma factor complex with protein and DNA and antibiotics
-**[[4oin]], [[4oip]], [[4oiq]], [[4oir]] – TtSF-A + RNAP subunits α,β,β’,ω + antibiotic + DNA<br />
-**[[6cuu]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + antibiotic<br />
-**[[5uhg]] – MtSF-A + MtRNAP subunits α,β,β’,ω + DNA + antibiotic + inhibitor<br />
-**[[5uhb]] – MtSF-A + MtRNAP subunits α,β,β’,ω + DNA + antibiotic<br />
-**[[6bzo]] – MtSF-A + RNAP subunits α,β,β’,ω + RbpA + DNA + antibiotic - Cryo EM<br />
-**[[6ccf]] – MsSF-A + MtRNAP subunits α,β,β’,ω + DNA + peptide + antibiotic<br />
-*Sigma factor complex with protein, DNA and RNA
-**[[5vi5]] – MsSF-A + MsRNAP subunits α,β,β’,ω + RbpA + DNA + RNA<br />
-**[[4xln]] – TaSF-A + RNAP subunits α,β,β’,ω + DNA + RNA  <br />
-**[[5ipl]], [[5ipm]], [[5ipn]] – EcSF RpoS + EcRNAP subunits α,β,β’,ω + DNA + RNA<br />
-**[[6b6h]] – EcSF RpoD + EcRNAP subunits α,β,β’,ω + DNA + RNA - Cryo EM<br />
-**[[5e17]], [[5e18]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + RNA<br />
-**[[5x22]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + RNA + CMPPP<br />
-**[[5vo8]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + RNA + GTP<br />
-**[[5x21]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + RNA + antibiotic<br />
-**[[5i2d]] – TtSF-A + TtRNAP subunits α,β,β’,ω + transcriptional regulator + DNA + RNA<br />
-**[[5uh5]], [[5uh8]], [[5uh9]] – MtSF-A + MtRNAP subunits α,β,β’,ω + DNA + RNA<br />
-**[[5uh6]], [[5uhc]], [[5uhd]], [[5x21]] – MtSF-A + TtRNAP subunits α,β,β’,ω + DNA + RNA + antibiotic<br />
-}}
 == References ==

Sigma factor: Difference between revisions

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