Complexin: Difference between revisions
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<StructureSection load='3rk3' size='350' side='right' caption='Human complexin (magenta) as part of the SNARE complex (VAMP2 - cyan; syntaxin - green; SNAP25 (pink and yellow) (PDB entry [[3rk3]])' scene='46/466533/Cv/1'> | |||
== Function == | |||
'''Complexin''' (CPLX) is the protein which binds the SNARE protein complex with high affinity. CPLX acts as both inhibitor and facilitator of vesicle fusion and neurotransmitter release at the synapse. CPLX clamps SNARE complexes to prevent vesicle fusion while in another conformation it releases the SNARE complex allowing fusion.<ref>PMID:12200427</ref> | |||
== Structural highlights == | |||
<scene name='46/466533/Cv/2'>CPLX binds to v-SNARE protein VAMP2 and to t-SNARE proteins SNAP25 and syntaxin</scene> (PDB entry [[3rk3]]).<ref>PMID:21785414</ref> | |||
</StructureSection> | </StructureSection> | ||
==3D structures of complexin== | ==3D structures of complexin== | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[1kil]] – | [[3rk3]], [[3rl0]] - CPLX + Vamp2 + Syntaxin 1A + Snap25 – human<br /> | ||
[[1kil]] – rCPLX + Vamp2 + Syntaxin 1A + Snap25 – rat<br /> | |||
[[ | [[5w5c]], [[5w5d]] - rCPLX + Vamp2 + Syntaxin 1A + Snap25 + synaptotagmin <br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 07:59, 7 July 2020
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3D structures of complexin
Updated on 07-July-2020
3rk3, 3rl0 - CPLX + Vamp2 + Syntaxin 1A + Snap25 – human
1kil – rCPLX + Vamp2 + Syntaxin 1A + Snap25 – rat
5w5c, 5w5d - rCPLX + Vamp2 + Syntaxin 1A + Snap25 + synaptotagmin
