Sandbox Reserved 431: Difference between revisions

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[[Student Projects for UMass Chemistry 423 Spring 2016]]

~~<StructureSection load='3c6g' size='350' side='right' caption='caption for Molecular Playground (PDB entry [[3c6g]])' scene=''>~~

==Introduction==

Rickets is a disease ~~caused by a~~ vitamin D deficiency. ~~Vitamin~~ D can be ~~obtained from ultra violet radiation and from various food sources. Cytochrome P450 enzymes are involved in the first step~~ to ~~regulate and process vitamin D~~ in ~~the~~ human ~~body~~.

Rickets is a disease resulting from prolonged vitamin D deficiency. As vitamin D is vital for the absorption of phosphorus and calcium, a deficiency would cause weakening of bones. Rickets also causes muscle weakness, skeletal deformities, dental problems, inhibition of growth, and muscle spasms. In some cases, rickets can be inherited due to mutations in genes responsible for coding for human CYP2R1.

~~<scene name='48/483888/Human_p450/1'>Human P450</scene>~~

In the human body, CYP2R1, a member of the cytochrome P450 family, is responsible for the first steps of the conversion of vitamin D into a bioavailable form within the liver. CYP2R1 is also known as Vitamin D 25-hydroxylase as it hydroxylates vitamin D3 into calcidiol, the bioavailable form of the vitamin, which would then be converted to calcitriol via the enzyme 25-hydroxyvitamin D3 1-alpha-hydroxylase, as seen in figure 1.

[[Image:Action_Of_CYP2R1.jpg]]

Fig. 1, the conversion of vitamin D3 into calcidiol via Vitamin D 25-hydroxylase

<scene name='48/483888/Human_p450/1'>Human P450 Cytochrome</scene> is shown with amino acids in teal and the heme center shown as a space filling model, with the nitrogen shown in blue, carbon in gray, oxygen in red, and the iron center shown in orange

==Overall Structure==

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</StructureSection>

==Quiz Question 1==

Sandbox Reserved 431: Difference between revisions

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@@ Line 7: / Line 7: @@
 [[Student Projects for UMass Chemistry 423 Spring 2016]]
-<StructureSection load='3c6g' size='350' side='right' caption='caption for Molecular Playground (PDB entry [[3c6g]])' scene=''>
 ==Introduction==
-Rickets is a disease caused by a vitamin D deficiency.  Vitamin D can be obtained from ultra violet radiation and from various food sources.  Cytochrome P450 enzymes are involved in the first step to regulate and process vitamin D in the human body.
+Rickets is a disease resulting from prolonged vitamin D deficiency. As vitamin D is vital for the absorption of phosphorus and calcium, a deficiency would cause weakening of bones. Rickets also causes muscle weakness, skeletal deformities, dental problems, inhibition of growth, and muscle spasms. In some cases, rickets can be inherited due to mutations in genes responsible for coding for human CYP2R1.
-<scene name='48/483888/Human_p450/1'>Human P450</scene>
+In the human body, CYP2R1, a member of the cytochrome P450 family, is responsible for the first steps of the conversion of vitamin D into a bioavailable form within the liver. CYP2R1 is also known as Vitamin D 25-hydroxylase as it hydroxylates vitamin D3 into calcidiol, the bioavailable form of the vitamin, which would then be converted to calcitriol via the enzyme 25-hydroxyvitamin D3 1-alpha-hydroxylase, as seen in figure 1.
+[[Image:Action_Of_CYP2R1.jpg]]
+Fig. 1, the conversion of vitamin D3 into calcidiol via Vitamin D 25-hydroxylase
+<scene name='48/483888/Human_p450/1'>Human P450 Cytochrome</scene> is shown with amino acids in teal and the heme center shown as a space filling model, with the nitrogen shown in blue, carbon in gray, oxygen in red, and the iron center shown in orange
+<StructureSection load='3c6g' size='350' side='right' caption='Structure of Human Cytochrome p450' scene=''>
 ==Overall Structure==
@@ Line 30: / Line 37: @@
 <scene name='48/483888/Hemegroup/1'>Leu99 and Arg445</scene>
+</StructureSection>
 ==Quiz Question 1==