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| <StructureSection load='' size='450' side='right' caption='Dipeptide:H+ symporter (green) complex with dipeptide (cyan), lipid and phosphate (PDB code [[4d2c]])' scene='70/705726/Cv/1'> | | <StructureSection load='' size='350' side='right' caption='Dipeptide: H+ symporter (green) complex with dipeptide (cyan), lipid and phosphate (PDB code [[4d2c]])' scene='70/705726/Initial/2'> |
| == Function == | | == Function == |
| Symporter (Symp) is a co-transporter membrane protein which transports two or more different molecules across the plasma membrane in the same direction<ref>PMID:12588808</ref>. | | '''Symporter''' (Symp) is a co-transporter membrane protein which transports two or more different molecules across the plasma membrane in the same direction<ref>PMID:12588808</ref>. |
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| == Disease == | | == Disease == |
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| == Structural highlights == | | == Structural highlights == |
| Dipeptide:<scene name='70/705726/Cv/4'>H symporter binds the dipeptide</scene> between its N- and C-terminal bundles<ref>PMID:24916388</ref>. | | Dipeptide: <scene name='70/705726/Cv/5'>H symporter binds the dipeptide</scene> between its N- and C-terminal bundles<ref>PMID:24916388</ref>. |
| </StructureSection>
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| == 3D Structures of symporter == | | == 3D Structures of symporter == |
| | [[Symporter 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *D-xylose/H+ symporter
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| **[[4ja4]], [[4qiq]] – EcSymp – ''Escherichia coli''<BR />
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| **[[4ja3]] – EcSymp (mutant) <BR />
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| **[[4gby]] – EcSymp + xylose <BR />
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| **[[4gbz]], [[4gc0]] – EcSymp + glucose derivative<BR />
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| *Di-or tripeptide:H+ symporter
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| **[[4ja4]], [[4xni]], [[4xnj]], [[4d2b]], [[4aps]], [[5d6k]], [[5mmt]] – StSymp – ''Streptococcus thermophilus''<BR />
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| **[[4d2d]] – StSymp + tripeptide<BR />
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| **[[4d2c]], [[5d58]], [[5d59]] – StSymp + dipeptide<BR />
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| *Oligopeptide/H+ symporter
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| **[[4lep]], [[4tph]] – SoSymp – ''Shewanella oneidensis''<BR />
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| **[[4tpg]], [[4tpj]] – SoSymp + tripeptide<BR />
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| *Sodium/bile acid symporter
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| **[[4n7w]] – YfSymp – ''Yersinia frederiksenii''<BR />
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| **[[4n7x]] – YfSymp (mutant) <BR />
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| *L-fucose/H+ symporter
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| **[[3o7q]] – EcSymp <BR />
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| **[[3o7p]] – EcSymp (mutant)<BR />
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| *Sodium/glucose symporter
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| **[[2xq2]] – VpSymp (mutant) – ''Vibrio parahaemolyticus''<BR />
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| **[[3dh4]] – VpSymp + galactose <BR />
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| *Sodium/citrate symporter
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| **[[5a1s]] – Symp + citrate – ''Salmonella enterica''<BR />
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| **[[5x9r]], [[5xas]], [[5xat]] – KpSymp + citrate – ''Klebsiella pneumoniae''<BR />
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| **[[5xar]] – KpSymp <BR />
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| *Divalent ion/sodium symporter
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| **[[5ul7]], [[5ul9]], [[5uld]], [[5ule]] – Symp + Na – ''Vibrio cholerae''<BR />
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| *Purine/H+ symporter
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| **[[5i6c]] – Symp + xanthine – ''Aspergillus nidulans''<BR />
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| *Glutamate/H+ symporter
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| **[[5dwy]] – TkSymp – ''Thermococcus kodakarensis''<BR />
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| **[[5e9s]] – TkSymp + aspartate<BR />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |
