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| <StructureSection load='' size='350' side='right' caption='Dipeptide: H+ symporter (green) complex with dipeptide (cyan), lipid and phosphate (PDB code [[4d2c]])' scene='70/705726/Initial/2'> | | <StructureSection load='' size='350' side='right' caption='Dipeptide: H+ symporter (green) complex with dipeptide (cyan), lipid and phosphate (PDB code [[4d2c]])' scene='70/705726/Initial/2'> |
| == Function == | | == Function == |
| Symporter (Symp) is a co-transporter membrane protein which transports two or more different molecules across the plasma membrane in the same direction<ref>PMID:12588808</ref>. | | '''Symporter''' (Symp) is a co-transporter membrane protein which transports two or more different molecules across the plasma membrane in the same direction<ref>PMID:12588808</ref>. |
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| == Disease == | | == Disease == |
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| == Structural highlights == | | == Structural highlights == |
| Dipeptide: <scene name='70/705726/Cv/5'>H symporter binds the dipeptide</scene> between its N- and C-terminal bundles<ref>PMID:24916388</ref>. | | Dipeptide: <scene name='70/705726/Cv/5'>H symporter binds the dipeptide</scene> between its N- and C-terminal bundles<ref>PMID:24916388</ref>. |
| </StructureSection>
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| == 3D Structures of symporter == | | == 3D Structures of symporter == |
| | [[Symporter 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *D-xylose/H+ symporter
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| **[[4ja4]], [[4qiq]] – EcSymp – ''Escherichia coli''<BR />
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| **[[4ja3]] – EcSymp (mutant) <BR />
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| **[[4gby]] – EcSymp + xylose <BR />
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| **[[4gbz]], [[4gc0]] – EcSymp + glucose derivative<BR />
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| *Di-or tripeptide/H+ symporter
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| **[[4ja4]], [[4xni]], [[4xnj]], [[4d2b]], [[4aps]], [[5d6k]], [[5mmt]], [[5d6k]], [[5oxo]], [[5oxp]], [[5oxq]], [[6eia]], [[6fmr]], [[6fmy]] – StSymp – ''Streptococcus thermophilus''<BR />
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| **[[4d2d]], [[6ghj]] – StSymp + tripeptide<BR />
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| **[[4d2c]], [[5d58]], [[5d59]], [[5oxk]], [[5oxl]], [[5oxm]], [[5oxn]] – StSymp + dipeptide<BR />
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| *Oligopeptide/H+ symporter
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| **[[4lep]], [[4tph]] – SoSymp – ''Shewanella oneidensis''<BR />
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| **[[2xut]] – SoSymp (mutant) <BR />
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| **[[4tpg]], [[4tpj]] – SoSymp + tripeptide<BR />
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| *Bile acid/Na+ symporter
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| **[[4n7w]] – YfSymp – ''Yersinia frederiksenii''<BR />
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| **[[4n7x]] – YfSymp (mutant) <BR />
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| **[[3zuy]] – Symp - ''Neisseria meningitidis''<BR />
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| **[[3zux]] – Symp (mutant) <BR />
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| *L-fucose/H+ symporter
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| **[[3o7q]] – EcSymp <BR />
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| **[[3o7p]] – EcSymp (mutant)<BR />
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| *Lactose/H+ symporter
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| **[[1pv6]] – EcSymp (mutant)<BR />
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| **[[1pv7]], [[4oaa]] – EcSymp (mutant) + thiodigalactoside<BR />
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| *Glucose/Na+ symporter
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| **[[2xq2]] – VpSymp (mutant) – ''Vibrio parahaemolyticus''<BR />
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| **[[3dh4]] – VpSymp + galactose <BR />
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| **[[4m64]] – Symp (mutant) - ''Salmonella typhimurium''<BR />
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| *Citrate/Na+ symporter
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| **[[5a1s]] – Symp + citrate + Na – ''Salmonella enterica''<BR />
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| **[[5x9r]], [[5xas]], [[5xat]] – KpSymp + citrate + Na – ''Klebsiella pneumoniae''<BR />
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| **[[4bpq]], [[5xar]] – KpSymp <BR />
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| *Neurotransmitter/leucine symporter LeuT
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| **[[5jaf]], [[5jae]] – AaSymp - ''Aquifex aeolicus''<BR />
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| **[[5jag]] – AaSymp (mutant) <BR />
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| **[[3gjd]] – AaSymp + Na <BR />
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| **[[3f48]] – AaSymp + alaine + Na<BR />
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| **[[3tu0]] – AaSymp (mutant) + alanine + Na <BR />
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| **[[3f4j]] – AaSymp + glycine + Na<BR />
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| **[[2a65]], [[3f3e]], [[3usg]], [[3usi]], [[3usj]], [[3usk]] – AaSymp + leucine + Na<BR />
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| **[[3mpn]], [[3mpq]], [[3gjc]], [[4hmk]], [[4hod]], [[4fxz]] – AaSymp (mutant) + leucine + Na<BR />
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| **[[3f3a]] – AaSymp + tryptophan + Na <BR />
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| **[[3qs4]], [[3qs5]], [[3qs6]] – AaSymp (mutant) + tryptophan + Na <BR />
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| **[[3f3c]] – AaSymp + phenylalanine + Na <BR />
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| **[[3f3d]], [[3f4i]], [[3usl]], [[3usm]], [[3uso]] – AaSymp + methionine derivative + Na <BR />
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| **[[4fy0]] – AaSymp (mutant) + methionine + Na <BR />
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| **[[2qei]] – AaSymp + alaine + clomipramine + Na<BR />
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| **[[3gwu]] – AaSymp + sertraline + Na<BR />
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| **[[3gwv]], [[3gww]], [[2qb4]], [[2q6h]], [[2q72]], [[2qju]] – AaSymp + drug + Na<BR />
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| **[[4mm4]] – AaSymp (mutant) + drug + Na<BR />
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| **[[3usp]] – AaSymp + glucoside derivative + Na <BR />
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| **[[3tt1]], [[3tt3]] – AaSymp (mutant) + antibody + Na <BR />
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| *Divalent ion/Na+ symporter
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| **[[5ul7]], [[5ul9]], [[5uld]], [[5ule]], [[4f35]] – Symp + Na – ''Vibrio cholerae''<BR />
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| *Purine/H+ symporter
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| **[[5i6c]] – Symp + xanthine – ''Aspergillus nidulans''<BR />
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| *Glutamate/H+ symporter
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| **[[5dwy]], [[4ky0]] – TkSymp – ''Thermococcus kodakarensis''<BR />
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| **[[5e9s]] – TkSymp + aspartate<BR />
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| **[[4oyf]] – PhSymp - ''Pyrococcus horikishii'' <BR />
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| **[[2nwl]] – PhSymp (mutant) + aspartate<BR />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |
