Dicer: Difference between revisions

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<StructureSection load='2EB1' size='400' side='right' caption='Human Endoribonuclease Dicer C-terminal complex with Mg+2 ion (green) (PDB code [[2eb1]])' scene=''>
<StructureSection load='2EB1' size='350' side='right' caption='Human Endoribonuclease Dicer C-terminal complex with Mg+2 ion (green) (PDB code [[2eb1]])' scene=''>
 
</StructureSection>


==Introduction==
==Introduction==
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Dicer is known to be a direct cause of macular degeneration. The absence of Dicer in retinal pigment epithelium causes the eye to break down into macular degeneration. It is hypothesized that Dicer has a specific role in maintaining this retinal health.<ref>PMID: 19836333</ref>
Dicer is known to be a direct cause of macular degeneration. The absence of Dicer in retinal pigment epithelium causes the eye to break down into macular degeneration. It is hypothesized that Dicer has a specific role in maintaining this retinal health.<ref>PMID: 19836333</ref>


==3D structures of dicer==
For 3D structures of dicer See [[Ribonuclease 3D structures]]
 
[[2eb1]] - hDic C-terminal + Mg - human<br />
[[4wyq]] - hDic residues 267-389 + RISC-loading complex subunit TARBP2 + peptide<br />
[[4ngb]], [[4ngc]], [[4ngd]], [[4ngf]], [[4ngg]], [[4nh3]], [[4nh5]], [[4nh6]], [[4nha]] - hDic residues 765-1065 (mutant) + DNA<br />
[[2l6m]] - Dic residues 1259-1358 - fission yeast - NMR<br />
[[3c4b]], [[3c4t]] - Dic residues 1638-1900 - mouse<br />
[[2ffl]] - Dic - Giardia intestinalis<br />


== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
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