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| {{STRUCTURE_3ohm| PDB=3ohm | SCENE= }}
| | #REDIRECT [[7sq2]] This PDB entry is obsolete and replaced by 7sq2 |
| ===Crystal structure of activated G alpha Q bound to its effector phospholipase C beta 3===
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| {{ABSTRACT_PUBMED_20966218}}
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| ==Function==
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| [[http://www.uniprot.org/uniprot/GNAQ_MOUSE GNAQ_MOUSE]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro).<ref>PMID:17938235</ref> <ref>PMID:20624888</ref> [[http://www.uniprot.org/uniprot/PLCB3_HUMAN PLCB3_HUMAN]] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. | |
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| ==About this Structure==
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| [[3ohm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OHM OCA].
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| ==Reference==
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| <ref group="xtra">PMID:020966218</ref><references group="xtra"/><references/>
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| [[Category: Homo sapiens]]
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| [[Category: Mus musculus]]
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| [[Category: Phosphoinositide phospholipase C]]
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| [[Category: Harden, T K.]]
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| [[Category: Sondek, J.]]
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| [[Category: Waldo, G L.]]
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| [[Category: Alf4 binding]]
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| [[Category: C2 domain]]
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| [[Category: Calcium binding]]
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| [[Category: Ef hand]]
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| [[Category: Gtp binding]]
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| [[Category: Gtpase]]
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| [[Category: Lipase]]
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| [[Category: Ph domain]]
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| [[Category: Signaling protein - hydrolase complex]]
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| [[Category: Tim barrel]]
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