Estrogens: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| (10 intermediate revisions by one other user not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load='1gwr' size='275' side='right' scene='' caption='Human estrogen receptor-ligand binding domain (grey) complex with transcription intermediate factor-2 peptide (pink) and estradiol (PDB code [[1gwr]])'> | <StructureSection load='1gwr' size='275' side='right' scene='' caption='Human estrogen receptor-ligand binding domain (grey) complex with transcription intermediate factor-2 peptide (pink) and estradiol (PDB code [[1gwr]])'> | ||
Estrogens, their receptors and relevant proteins | '''Estrogens, their receptors and relevant proteins.''' | ||
There are three major endogenous estrogens that have estrogenic hormonal activity: estrone (E1), estradiol (E2), and estriol (E3). Estradiol, an estrane, is the most potent and prevalent. <scene name='89/895670/Cv/1'>Estradiol</scene> is an important estrogen steroid hormone in both women and men. It is a typical steroid with core four-ring system (ABCD), composed of 17 carbon atoms. Another estrogen called estetrol (E4) is produced only during pregnancy. | |||
*[[Estrogen receptor]] | *[[Estrogen receptor]] | ||
<scene name='Estrogen_receptor/Cv/1'>Click here to see the difference between conformations</scene> of estrogen receptor α complexed with raloxifene and a corepressor peptide (morph was taken from [http://molmovdb.org/cgi-bin/movie.cgi Gallery of Morphs] of the [http://molmovdb.org Yale Morph Server]). | <scene name='Estrogen_receptor/Cv/1'>Click here to see the difference between conformations</scene> of estrogen receptor α complexed with raloxifene and a corepressor peptide (morph was taken from [http://molmovdb.org/cgi-bin/movie.cgi Gallery of Morphs] of the [http://molmovdb.org Yale Morph Server]). | ||
| Line 45: | Line 47: | ||
Upon visualizing the estrogen receptor in an <scene name='48/483891/Arrow_view/1'>arrow representation</scene>, the structure can be classified as parallel or anti-parallel. Here is the zoomed <scene name='48/483891/Hydrophobic_pocket/3'>primarily hydrophobic pocket</scene>. | Upon visualizing the estrogen receptor in an <scene name='48/483891/Arrow_view/1'>arrow representation</scene>, the structure can be classified as parallel or anti-parallel. Here is the zoomed <scene name='48/483891/Hydrophobic_pocket/3'>primarily hydrophobic pocket</scene>. | ||
*[[Estrogen-related receptor]] | *[[Estrogen-related receptor]] | ||
*[[Tamoxifen|Tamoxifen and the Estrogen Receptor/Tamoxifen and the Estrogen-related receptor]] | |||
<scene name='50/501401/Cv/4'>Binding of nuclear receptor corepressor 2 peptide and 4-hydroxytamoxifen</scene> to human estrogen-related receptor γ. The chemotherapeutic drugs bisphenol and <scene name='50/501401/Cv/5'>tamoxifen</scene> are nestled between 4 alpha helices in the ERR active site. | <scene name='50/501401/Cv/4'>Binding of nuclear receptor corepressor 2 peptide and 4-hydroxytamoxifen</scene> to human estrogen-related receptor γ. The chemotherapeutic drugs bisphenol and <scene name='50/501401/Cv/5'>tamoxifen</scene> are nestled between 4 alpha helices in the ERR active site. | ||
* [[Estrogen sulfotransferase]] | * [[Estrogen sulfotransferase]] | ||
*[[Aromatase]] | *[[Aromatase]] | ||
*[[Finasteride]] | *[[Finasteride]] | ||
'''Estrone''' | |||
*[[Estrogen receptor 3D structures]] | |||
*[[Estrone sulfatase]] | |||
*[[Sulfatase 3D structures]] | |||
*[[ABC transporter 3D structures]] | |||
*[[ABCG2 multidrug transporter]] | |||
Substrates, such as estrone sulfate, <scene name='83/832932/Cavity_1_-_use2/4'>form hydrogen bonds and stacking interactions</scene> with residues from each subunit in Cavity 1 of ABCG2 multidrug transporter. | |||
*[[Hydroxysteroid dehydrogenase]] | |||
*[[Hydroxysteroid dehydrogenase 3D structures]] | |||
*[[Prostaglandin F synthase]] | |||
'''Estradiol''' | |||
*[[Lipids: structure and classification]] | |||
*[[Estrogen receptor]] | |||
*[[Ivan Koutsopatriy estrogen receptor]] | |||
*[[Estradiol 17-beta-dehydrogenase]] | |||
*[[Student Project 10 for UMass Chemistry 423 Spring 2015]] | |||
*[[Aromatase]] | |||
*[[Sulfotransferase]] | |||
*[[ATPase family AAA domain-containing protein 2]] | |||
*[[Hypoxia-Inducible Factors]] | |||
'''Estriol''' | |||
*[[Cytochrome P450 3D structures]]: [[1x8v]] - MtP450 CYP51 (mutant)+estriol<br /> | |||
'''Estetrol''' | |||
*[[3l03]] - Crystal Structure of human Estrogen Receptor alpha Ligand-Binding Domain in complex with a Glucocorticoid Receptor Interacting Protein 1 Nr Box II peptide and Estetrol (Estra-1,3,5(10)-triene-3,15 alpha,16alpha,17beta-tetrol) | |||
</StructureSection> | </StructureSection> | ||
See also: | See also: | ||
*[[Estrogen receptor]] | |||
*[[Nuclear receptors]] | *[[Nuclear receptors]] | ||
*[[Steroid Hormones and their receptors]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
